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Xiaowei Xu, MD, PhD Physician

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania Professor of Dermatology

Languages spoken:

  • Mandarin Chinese

Dr. Xu is employed by Penn Medicine.

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About Dr. Xiaowei Xu

My clinical expertise is in pigmented lesion, vasculitis, and dermatopathology.

Recognized by America's Top Doctors for 2017

Recognized in Philadelphia magazine's annual Top Docs issues for 2018 and 2019

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Dermatology - Dermatopathology, 2002
  • Pathology - Anatomic and Clinical Pathology, 2001

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Shanghai Medical University
Fellowship: Wake Forest Baptist Medical Center
Residency: Hospital of the University of Pennsylvania
Fellowship: Massachusetts General Hospital


American Cancer Society, National Chinese National Natural Science Foundation of China, International Chinese National Science Foundation of China, International International Society of Stem Cell Research, International Melanoma Research Foundation, National NCI review, Targeted Radionuclide Therapy, National NCI SPORE III Review Committee, National NCI Study Section (ZCA1 TCRB-3 C1 B, TEP-1A), National NCI study section, 2016/01 ZCA1 RPRB-B (J1) P, National NIH study section (RPRB-B (O1)), National NIH study section, National NIH Study section, special emphasis panel (SEP-9), National Scottish Chief Scientist Office, International Society for Melanoma Research, National The North American Chinese Dermatologist Association, International

Hospital Affiliation

Dr. Xu is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Skin stem cells and melanoma

Selected Publications:

Yang R, Jiang M, Kumar SM, Xu T, Wang F, Xiang L, Xu X: Generation of melanocytes from Induced pluripotent stem cells J Invest Dermatol 131 (12): 2458-66,2011 .

Yang R, Xu X: Isolation of neural crest stem cells from human hair follicles J Vis Exp 74 : 3194,2013 .

Guo J, Si L, Kong Y, Flaherty KT, Xu X, Zhu Y, Corless CL, Li L, Li H, et al: A Phase II, Open Label, Single-arm Trial of Imatinib Mesylate in Patients with Metastatic Melanoma Harboring c-Kit Mutation or Amplification J Clin Onco 29 (21): 2904-9,2011.

Yun SJ, Gimotty PA, Hwang WT, Dawson P, Van Belle P, Elder DE, Elenitsas R, Schuchter L, Guerry D, Xu X: High Lymphatic Vessel Density and Lymphatic Invasion Underlie the Adverse Prognostic Effect of Radial Growth Phase Regression in Melanoma Am J Surg Path 35 (3): 235-42,2011.

Yu H, Kumar SM, Kossenkov AV, Showe L, Xu X: Stem Cells with Neural Crest Characteristics Derived from the Bulge Region of Cultured Human Hair Follicles J Invest Dermatol 130 (5): 1227-36,2010.

Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton B, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KYJ, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D’Andrea K, Koehler A, Stumm M, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K: Clinical efficacy of a RAF inhibitor requires comprehensive ERK pathway inhibition in BRAF-mutant melanoma Nature 467 (7315): 596-9,2010 .

Villanueva J, Vultur A, Lee JT, Somasundaram R, Fukunaga-Kalabis1 M, Cipolla1 AK, Wubenhorst B, Xu X, Gimotty PA, Kee D, Santiago-Walker1 AE, Letrero R, Pushparajan A, Hayden JE, Laquerre S, McArthur GA, Sosman JA, Nathanson KL, Herlyn M: Acquired resistance to BRAF inhibitors mediated by an A/B/C RAF kinase switch in melanoma can be overcome by co-targeting MEK and IGF-1R/PI3K Cancer Cell 18 (6): 683-95,2010.

Li, L., Fulunaga-Kalabis, M., Yu, H., Xu, X., Kong, J., Lee, J.T. Herlyn, M.:: Melanocyte stem cells can be isolated from the human dermis. J Cell Sci 123 (6): 853-60,2010.

Zhang G, Zhang H, Wang Q, Lal P, Carroll A, de la Llera-Moya M, Xu X, Greene MI.: Suppression of human prostate tumor growth by a prostate-specific monoclonal antibody F77 targeting a unique cell surface marker Proc Natl Acad Sci U S A 107 (2): 732-7,2010.

Yu H., Fang D., Kumar SM., Li L., Nguyen TK., Acs G., Herlyn M., Xu X.: Isolation of a novel population of multipotent adult stem cells from human hair follicles American Journal of Pathology 168 (6): 1879-88,2006.

Academic Contact Info

Hospital of University of Pennsylvania
Dept. of Pathology and Laboratory Medicine
6 Founders Pavilion

Philadelphia, PA 19104-4283
Phone: (215) 662-6503
Patient appointments: 800-789-7366 (PENN)

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