Penn Medicine Provider
Xianxin Hua, MD, PhD
About me
- Professor of Cancer Biology
My Locations
Qualifications and experience
- American Association for Cancer Research, National
- American Association for the Advancement of Science, National
- American Society for Biochemistry and Molecular Biology, National
- Faculty of 1000 (Member), International
- Federation of American Societies for Experimental Biology, National
- Penn Neuroendocrine Tumor Program
My research
Thiel, A.T., Blessington, P., Zou, T., Feather, D, Wu, X., Zhang, H., Liu, L., Koretzky, G., Ernst, P., and Hua, X MLL-AF9-induced leukemic transformation requires co-expression of wild type MLL allele , Cancer Cell, 17(2): 2010,148-159
Jing Huang, Buddha Gurung, Bingbing Wan, Smita Matkar, Natalia A. Veniaminova, Ke Wan, Juanita L. Merchant, Xianxin Hua*, and Ming Lei* (*co-corresponding author) The same pocket in menin binds both MLL and JunD, but oppositely regulates transcription , Nature, 432(7386): 2012,542-6
Matkar S, Sharma P, Gao S, Gurung B, Katona BW, Liao J, Muhammad AB, Kong XC, Wang L, Jin G, Dang CV, Hua X An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc Axis , Cancer Cell, 28(4): 2015,472-85
Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, Barsyte-Lovejoy D, Al-awar R, Katona BW, Shilatifard A, Huang J, Hua X, Arrowsmith CH, Berger SL Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth , Nature, 525(7568): 2015,206-11
Zijie Feng, Lei Wang, Yanmei Sun, Zongzhe Jiang, Bowen Xing, John Domsic, Jingjing Tian, David C. Metz, Xiaolu Yang, Ronen Marmostein, Xiaosong Ma and Xianxin Hua Menin and Daxx Interact to Control Pancreatic Neuroendocrine Tumors via Epigenetic Regulation of Membrane Metallo-Endopeptidase , Cancer Research, 77(2): 2017,401-411
Katona BW, Glynn RA, Paulosky KE, Feng Z, Davis CI, Ma J, Berry CT, Szigety KM, Matkar S, Liu Y, Wang H, Wu Y, He X, Freedman BD, Brady DC, Hua X Combined Menin and EGFR Inhibitors Synergize to Suppress Colorectal Cancer via EGFR-Independent and Calcium-Mediated Repression of SKP2 Transcription , Cancer Research, 79(9): 2019,2195-2207
Wu Y, Doepner M, Hojnacki T, Feng Z, Katona BW, He X, Ma J, Cao Y, Busino L, Zhou F, Hua X Disruption of the menin-MLL interaction triggers menin protein degradation via ubiquitin-proteasome pathway , Am. J. Cancer Res, 9(8): 2019,1682-1694
Ma J, He X, Cao Y, O’Dwyer K, Szigety KM, Wu Y, Gurung B, Feng Z, Katona BW, Hua X Islet-specific Prmt5 excision leads to reduced insulin expression and glucose intolerance in mice , J. Endocrinol., 244(1): 2020,41-52
He X, Feng Z, Ma J, Ling S, Cao Y, Gurung B, Wu Y, Katona BW, O'Dwyer KP, Siegel DL, June CH, Hua X. Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia. , Blood, 135(10): 2020,713-723
Zijie Feng, Xin He, Xuyao Zhang, Yuan Wu, Bowen Xing, Alison Knowles, Qiaonan Shan, Samuel Miller, Taylor Hojnacki, Jian Ma, Bryson W. Katona, Terence P. F. Gade, Jörg Schrader, David C. Metz, Carl H. June & Xianxin Hua Potent suppression of neuroendocrine tumors and gastrointestinal cancers by CDH17CAR T cells without toxicity to normal tissues , Nature Cancer: 2022