Penn Medicine Provider
Wayne William Hancock, MD, PhD, FRCPA
Sees patients age 18 and up

About me

  • Professor of Pathology and Laboratory Medicine

Insurance accepted

My Locations

Qualifications and experience

Treatments and Conditions

My research

Yardeni T, Olali AZ, Chen HW, Wang L, Halton J, Zenab A, Morrow R, Butic A, Murdock DG, Waymire KG, MacGregor G, Boursi B, Beier U, Hancock WW, Wallace DC. Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling , Proceedings of the National Academy of Sciences, 122: 2025,e2417252121


Pace J, Goddard L, Hong C, Wang L, Yang J, Chen M, Xu Y, Dominguez M, Gao S, Chen X, Mericko P, Yu W, Tan K, Hancock WW, Ferrari G, Kahn ML Hemodynamic forces prevent myxomatous valve disease through KLF2/4 signaling , Journal of Clinical Investigation: 2025


Concors SJ, Hernandez PT, O’Brien C, DePaolo J, Murken DR, Aufhauser DD, Wang Z, Xiong Y, Krumeich L, Ge G, Beier UH, Bhatti TR, Kozikowski AP, Avelar L, Kurz T, Hancock WW, Levine MH. Differential effects of HDAC6 inhibition versus knockout during hepatic ischemia reperfusion injury highlight importance of HDAC6 C-terminal zinc-finger ubiquitin-binding domain. , Transplantation: 2024,In press


Akimova T, Wang L, Bartosh Z, Christensen L, Eruslanov E, Singhal S, Aishwarya V, Hancock WW. Antisense targeting of FOXP3+ Tregs to boost anti-tumor immunity. , Frontiers in Immunology, 15: 2024,1426657


Christensen LM, Akimova T, Wang L, Han R, Samanta A, Di Giorgio E, Hancock WW. T-regulatory cells require Sin3a for stable expression of Foxp3. , Frontiers in Immunology, 15: 2024,1444937


Thomas RM, Pahl MC, Wang L, Grant SFA, Hancock WW, Wells AD. Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function. , eLife: 2024,RP91392


Cravedi P, Riella LV, Ford M, Valujskikh A, Menon MC, Kirk AD, Alegre ML, Feng S, Kehn P, Najafian N, Hancock W, Heeger PS, Maltzman J, Mannon RB, Nadig S, Odim J, Turnquist H, Shaw J, West L, Luo X, Chong A, Bromberg J, on behalf of the AST COTS MOuse MOdels in Transplantation (MOMOT) work group. Advancing mouse models for transplantation research. , American Journal of Transplantation: 2024,https://doi.org/10.1016/j.ajt.2024.01.006


Patterson KC, Miller WT, Hancock WW, Akimova T. FOXP3+ regulatory T cells are associated with the severity and prognosis of sarcoidosis. , Frontiers in Immunology, 14: 2023,1301991


Lax E, Do Carmo S, Enuka Y, Sapozhnikov DM, Welikovitch LA, Mahmood N, Rabbani SA, Wang L, Britt JP, Hancock WW, Yarden Y, Szyf M. Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition. , Translational Psychiatry, 13: 2023,259


Hernandez P, O’Brien C, Concors SJ, Wang Z, Ge G, Hancock WW, Levine MH. The selective estrogen receptor modulator, Raloxifene, is protective against renal ischemia reperfusion injury. , Transplantation, 106: 2022,2166-2171


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