Penn Medicine Provider
Anesthesiology
Thomas T. Joseph, MD, PhD
Make an appointmentCall 800-789-7366

About me

  • Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania

As an anesthesiologist and computational biophysicist, I study anesthetic-protein binding with a focus on the lipid-embedded environment using molecular dynamics simulations. I also run various informatics projects in the Department of Anesthesiology and Critical Care at Penn Medicine, focused on clinical workflow improvement.

Education and training

  • Medical School: Mount Sinai School of Medicine
  • Residency: Mount Sinai Medical Center

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Joseph is a Penn Medicine physician.

Qualifications and experience

My research

Joseph TT, Bu W, Haji-Ghassemi O, Chen YS, Woll K, Allen PD, Brannigan G, van Petegem F, Eckenhoff R. Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1) , British Journal of Anaesthesia: 2024

Johanna Becker-Baldus, Alexei Yeliseev, Thomas T. Joseph, Snorri Th. Sigurdsson, Lioudmila Zoubak, Kirk Hines, Malliga R. Iyer, Arjen van den Berg, Sam Stepnowski, Jon Zmuda, Klaus Gawrisch, and Clemens Glaubitz Probing the Conformational Space of the Cannabinoid Receptor 2 and a Systematic Investigation of DNP-Enhanced MAS NMR Spectroscopy of Proteins in Detergent Micelles , ACS Omega, 8(36): 2023,32963-32976

John T Petroff, Noah M Dietzen, Ezry Santiago-McRae, Brett Deng, Maya S Washington, Lawrence J Chen, K Trent Moreland, Zengqin Deng, Michael Rau, James AJ Fitzpatrick, Peng Yuan, Thomas T Joseph, Jérôme Hénin, Grace Brannigan, Wayland WL Cheng Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation , Nature Communications, 13(1): 2022,7017

Joseph TT Best practices for resilient automation of biomolecular simulations , Methods in Cell Biology, 169: 2022

Joseph TT, Bu W, Lin W, Zoubak L, Yeliseev A, Liu R, Eckenhoff RG, Brannigan G Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors , ACS Chem Neurosci, 12(9): 2021,1487–1497

Yeliseev A, Iyer MR, Joseph TT, Coffey NJ, Cinar R, Zoubak L, Kunos G, Gawrisch K Cholesterol as a modulator of cannabinoid receptor CB2 signaling , Scientific Reports, 11(Article number: 3706): 2021

Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia B, Nimigean CM, Eckenhoff RG, Riegelhaupt PM Mechanistic insights into volatile anesthetic modulation of K2P channels , eLife, 9: 2020,e59839

Wenric S, Jeff JM, Joseph T, Yee M-C, Belbin GM, Owusu Obeng A, Ellis SB, Bottinger EP, Gottesman O, Levin MA, Kenny EE Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry , Pharmacogenomics Journal, 21: 2020,174–189

Thomas T Joseph, David B Wax, Raymond Goldstein, Jia Huang, Patrick J McCormick, Matthew A Levin A Web-Based Perioperative Dashboard as a Platform for Anesthesia Informatics Innovation , Anesthesia and Analgesia, 131(5): 2020,1640-1645

McKinstry-Wu Andrew, Woll Kellie A, Joseph Thomas, Bu Weiming, White E Railey, Bhanu Natarajan V, Garcia Benjamin A, Brannigan Grace, Dailey William P, Eckenhoff Roderic G Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand. , ACS Chemical Neuroscience, 10(11): 2019,4716-4728

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