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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Not accepting new patients
Recognized by America's Top Doctors for 2017
Recognized in Philadelphia magazine's annual Top Docs issues from 2018 to 2020
Perelman Center for Advanced Medicine
East Pavilion, 2nd Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
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Thomas Cappola is Herbert C. Rorer Professor in Medical Sciences and Chief, Cardiovascular Medicine, University of Pennsylvania Perelman School of Medicine. His research aims to uncover heart failure mechanisms in human subjects and to use these insights to improve treatment. This has involved diverse approaches, including applied genomics, population science, laboratory studies, and clinical trials. He has established and leads a multicenter cohort study of advanced heart failure (Penn Heart Failure Study, PHFS); co-loads a multicenter consortium for human myocardial transcriptomics and systems genetics (Myocardial Applied Genomics Network, MAGNet); serves as a Principal Investigator on the NHLBI Heart Failure Clinical Research Network; and is a contributing member of numerous international genomics consortia. Within the Cardiovascular Division, he has established collaborative leadership to create programs integrating science and clinical care, and has used these as a platform for research and training. In his clinical role, he treats patients with advanced heart failure on the inpatient and outpatient heart failure/transplant service.
Nayor M, Short MI, Rasheed H, Lin H, Jonasson C, Yang Q, Hveem K, Felix JF, Morrison AC, Wild PS, Morley MP, Cappola TP, Benson MD; CHARGE-Heart Failure Working Group; CHARGE-EchoGen Consortium, Ngo D, Sinha S, Keyes MJ, Shen D, Wang TJ, Larson MG, Brumpton BM, Gerszten RE, Omland T, Vasan R: Aptamer-based proteomic platform identifies novel protein predictors of incident heart failure and echocardiographic traits Circ Heart Fail 13 (5): 2020 In Press.
Chirinos JA, Zhao L, Jia Y, Frej C, Adamo L, Mann D, Shewale SV, Millar JS, Rader DJ, French B, Brandimarto J, Margulies KB, Parks JS, Wang Z, Seiffert DA, Fang J, Sweitzer N, Chistoffersen C, Dahlbäck B, Car BD, Gordon DA, Cappola TP, Javaheri A: Reduced apolipoprotein M and adverse outcomes across the spectrum of human heart failure Circulation 141 (18): 1463-1476,2020.
Chirinos JA, Orlenko A, Zhao L, Basso MD, Cvijic ME, Li Z, Spires TE, Yarde M, Wang Z, Seiffert DA, Prenner S, Zamani P, Bhattacharya P, Kumar A, Margulies KB, Car BD, Gordon DA, Moore JH, Cappola TP: Multiple plasma biomarkers for risk stratification in patients with heart failure and preserved ejection fraction JACC 75 (11): 1281-1295,2020.
Cohen JB, Schrauben SJ, Zhao L, Basso MD, Cvijic ME, Li Z, Yarde M, Wang Z, Bhattacharya PT, Chirinos DA, Prenner S, Zamani P, Seiffert DA, Car BD, Gordon DA, Margulies K, Cappola T, Chirinos JA: Clinical phenogroups in heart failure with preserved ejection fraction: detailed phenotypes, prognosis, and response to spironolactone JACC Heart Fail 8 (3): 172-184,2020.
Patel N, Russell GK, Musunuru K, Gutierrez OM, Halade G, Kain V, Prabhu SD, Margulies KB, Cappola TP, Arora G, Wang TJ, Arora P: Race, Natriuretic Peptides, and High-Carbohydrate Challenge: A Clinical Trial Circulation Research : [Epub ahead of print],2019.
Lyle MA, Iyer SR, Redfield MM, Reddy YNV, Felker GM, Cappola TP, Hernandez AF, Scott CG, Burnett JC Jr, Pereira NL: Circulating Neprilysin in Patients with Heart Failure with Preserved Ejection Fraction JACC Heart Fail
19 : [Epub ahead of print],2019.
Celik S, Karbalaei Sadegh M, Morley M, Roselli C, Ellinor PT, Cappola T, Smith JG, Gidlof O: Antisense regulation of atrial natriuretic peptide expression
JCI Insight : 130978,2019.
Haggerty CM, Damrauer SM, Levin MG, Birtwell D, Carey DJ, Golden AM, Hartzel DN, Hu Y, Judy R, Kelly MA, Kember RL, Lester Kirchner H, Leader JB, Liang L, McDermott-Roe C, Babu A, Morley M, Nealy Z, Person TN, Pulenthiran A, Small A, Smelser DT, Stahl RC, Sturm AC, Williams H, Baras A, Margulies KB, Cappola TP, Dewey FE, Verma A, Zhang X, Correa A, Hall ME, Wilson JG, Ritchie MD, Rader DJ, Murray MF, Fornwalt BK, Arany Z.: Genomics-first evaluation of heart disease associated with titin-truncating variants. Circulation 140 (1): 42-50,2019.
Cordero P, Parikh V, Chin E, Erbilgin A, Gloudemans M, Ching S, Chang ACH, Huang Y, Smith K, Dewey F, Zaleta-Rivera K, Morley M, Brandimarto J, Glazer N, Waggott D, Pavlovic A, Moravec C, Zhao M, Tang WHW, Skreen J, Malloy C, Hannenhalli S, Li H, Ritter S, Li M, Bernstein D, Connolly A, Hakonarson H, Lusis A, Marguiles KB, Depaoli-Roach A, Montgomery S, Wheeler M, Cappola TP, Ashley: Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure-overload heart failure Nat Commun 10 (1): 2760,2019.
Michael MP, Wang X, Hu R; Brandimarto J, Tucker, NR, Felix JF, Smith NL, van der Harst P, Ellinor PT, Margulies KB, Musunuru K, Cappola TP: Cardioprotective effects of MTSS1 enhancer variants Circulation 139 (17): 2073–2076,2019.
Perelman Center for Advanced MedicineDivision of Cardiovascular Medicine11-113 South Pavilion3400 Civic Center Boulevard
Patient appointments: 800-789-7366