Description of Research Expertise:
Thomas Cappola is Herbert C. Rorer Professor in Medical Sciences and Chief, Cardiovascular Medicine, University of Pennsylvania Perelman School of Medicine. His research aims to uncover heart failure mechanisms in human subjects and to use these insights to improve treatment. This has involved diverse approaches, including applied genomics, population science, laboratory studies, and clinical trials. He has established and leads a multicenter cohort study of advanced heart failure (Penn Heart Failure Study, PHFS); co-loads a multicenter consortium for human myocardial transcriptomics and systems genetics (Myocardial Applied Genomics Network, MAGNet); serves as a Principal Investigator on the NHLBI Heart Failure Clinical Research Network; and is a contributing member of numerous international genomics consortia. Within the Cardiovascular Division, he has established collaborative leadership to create programs integrating science and clinical care, and has used these as a platform for research and training. In his clinical role, he treats patients with advanced heart failure on the inpatient and outpatient heart failure/transplant service.
Selected Publications:
Haggerty CM, Damrauer SM, Levin MG, Birtwell D, Carey DJ, Golden AM, Hartzel DN, Hu Y, Judy R, Kelly MA, Kember RL, Lester Kirchner H, Leader JB, Liang L, McDermott-Roe C, Babu A, Morley M, Nealy Z, Person TN, Pulenthiran A, Small A, Smelser DT, Stahl RC, Sturm AC, Williams H, Baras A, Margulies KB, Cappola TP, Dewey FE, Verma A, Zhang X, Correa A, Hall ME, Wilson JG, Ritchie MD, Rader DJ, Murray MF, Fornwalt BK, Arany Z.: Genomics-first evaluation of heart disease associated with titin-truncating variants. Circulation 140 (1): 42-50,2019.
Cordero P, Parikh V, Chin E, Erbilgin A, Gloudemans M, Ching S, Chang ACH, Huang Y, Smith K, Dewey F, Zaleta-Rivera K, Morley M, Brandimarto J, Glazer N, Waggott D, Pavlovic A, Moravec C, Zhao M, Tang WHW, Skreen J, Malloy C, Hannenhalli S, Li H, Ritter S, Li M, Bernstein D, Connolly A, Hakonarson H, Lusis A, Marguiles KB, Depaoli-Roach A, Montgomery S, Wheeler M, Cappola TP, Ashley: Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure-overload heart failure Nat Commun 10 (1): 2760,2019.
Michael MP, Wang X, Hu R; Brandimarto J, Tucker, NR, Felix JF, Smith NL, van der Harst P, Ellinor PT, Margulies KB, Musunuru K, Cappola TP: Cardioprotective effects of MTSS1 enhancer variants Circulation 139 (17): 2073–2076,2019.
Kannan L, Shaw PA, Morley MP, Brandimarto J, Fang JC, Sweitzer NK, Cappola TP, Cappola AR: Thyroid Dysfunction in Heart Failure and Cardiovascular Outcomes Circ Heart Fail. 2018 Dec;11(12) 11 (12): e005266,2018.
Levin MG, Kember RL, Judy R, Birtwell D, Williams H, Arany Z, Giri J, Guerraty M, Cappola T; Regeneron Genetics Center, Chen J, Rader DJ, Damrauer SM: Genomic Risk Stratification Predicts All-Cause Mortality After Cardiac Catheterization Circ Genom Precis Med 11 (11): e002352,2018.
Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, Almgren P, Alonso A, Anderson CD, Aragam KG, Arking DE, Barnard J, Bartz TM, Benjamin EJ, Bihlmeyer NA, Bis JC, Bloom HL, Boerwinkle E, Bottinger EB, Brody JA, Calkins H, Campbell A, Cappola TP…Lubitz SA, Lunetta KL, Ellinor PT.: Multi-ethnic genome-wide association study for atrial fibrillation Nat Genet 50 (9): 1225-1233,2018.
Macri V, Brody JA, Arking DE, Hucker WJ, Yin X, Lin H, Mills RW, Sinner MF, Lubitz SA, Liu CT, Morrison AC, Alonso A, Li N, Fedorov VV, Janssen PM, Bis JC, Heckbert SR, Dolmatova EV, Lumley T, Sitlani CM, Cupples LA, Pulit SL, Newton-Cheh C, Barnard J, Smith JD, Van Wagoner DR, Chung MK, Vlahakes GJ, O'Donnell CJ, Rotter JI, Margulies KB, Morley MP, Cappola TP, Benjamin EJ, Muzny D, Gibbs RA, Jackson RD, Magnani JW, Herndon CN, Rich SS, Psaty BM, Milan DJ, Boerwinkle E, Mohler PJ, Sotoodehnia N, Ellinor PT: Common Coding Variants in SCN10A Are Associated With the Nav1.8 Late Current and Cardiac Conduction Circ Genom Precis Med 11 (5): e001663,2018.
Baggio LL, Yusta B, Mulvihill EE, Cao X, Streutker CJ, Butany J, Cappola TP, Margulies KB, Drucker DJ: GLP-1 receptor expression within the human heart Endocrinology 159 (4): 1570-1584,2018.
Tereshchenko LG, Sotoodehnia N, Sitlani CM, Ashar FN, Kabir M, Biggs ML, Morley MP, Waks JW, Soliman EZ, Buxton AE, Biering-Sørensen T, Solomon SD, Post WS, Cappola TP, Siscovick DS, Arking DE: Genome-Wide Associations of Global Electrical Heterogeneity ECG Phenotype: The ARIC (Atherosclerosis Risk in Communities) Study and CHS (Cardiovascular Health Study) J Am Heart Assoc
7 (8): e008160,2018.
Hu R, Morley, MP, Brandimarto J, Tucker, NR; Parsons VA, Zhao SD, Meder B, Katus HA, Rühle F, Stoll M, Villard E, Cambien F, Lin H, Smith NL, Felix JF, Vasan RS, van der Harst P MD, Newton-Cheh C, Li J, Kim CE, Hakonarson H, Hannenhalli S, Ashley EA, Moravec CS, Tang, WHW, Maillet M, Molkentin JD, Ellinor PT, Margulies KB, Cappola TP: Genetic reduction in left ventricular protein kinase C alpha and adverse ventricular remodeling in human subjects Circ Genom Precis Med 11 : e001901,2018.
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