Description of Research Expertise:
My laboratory uses clinical investigation and applied genomics to reveal mechanisms of human heart failure. This has included establishing a multicenter cohort study of advanced heart failure (Penn Heart Failure Study; PHFS) and a multicenter consortium for human myocardial transcriptomics and eQTL mapping (Myocardial Applied Genomics Network; MAGNet). Notable discoveries include the first demonstration that peripheral blood gene expression provides a clinical biomarker to track cardiac allograft rejection, identification of abnormalities in forkhead signaling and neuregulin signaling in common forms of human heart failure, and discovery of the 1p36 HSPB7/CLCNKA locus as the first bonafide genetic risk factor for non-familial heart failure. More recent work focuses on investigational therapeutics for heart failure. In my clinical role I treat patients with advanced heart failure on the inpatient and outpatient heart failure/transplant service.
Selected Publications:
Baggio LL, Yusta B, Mulvihill EE, Cao X, Streutker CJ, Butany J, Cappola TP, Margulies KB, Drucker DJ: GLP-1 receptor expression within the human heart Endocrinology 159 (4): 1570-1584,2018.
Tereshchenko LG, Sotoodehnia N, Sitlani CM, Ashar FN, Kabir M, Biggs ML, Morley MP, Waks JW, Soliman EZ, Buxton AE, Biering-Sørensen T, Solomon SD, Post WS, Cappola TP, Siscovick DS, Arking DE: Genome-Wide Associations of Global Electrical Heterogeneity ECG Phenotype: The ARIC (Atherosclerosis Risk in Communities) Study and CHS (Cardiovascular Health Study) J Am Heart Assoc
7 (8): e008160,2018.
Hu R, Morley, MP, Brandimarto J, Tucker, NR; Parsons VA, Zhao SD, Meder B, Katus HA, Rühle F, Stoll M, Villard E, Cambien F, Lin H, Smith NL, Felix JF, Vasan RS, van der Harst P MD, Newton-Cheh C, Li J, Kim CE, Hakonarson H, Hannenhalli S, Ashley EA, Moravec CS, Tang, WHW, Maillet M, Molkentin JD, Ellinor PT, Margulies KB, Cappola TP: Genetic reduction in left ventricular protein kinase C alpha and adverse ventricular remodeling in human subjects Circ Genom Precis Med 11 : e001901,2018.
Chirinos JA, Londono-Hoyos F, Zamani P, Beraun M, Haines P, Vasim I, Varakantam S, Phan TS, Cappola TP, Margulies KB, Townsend RR, Segers P: Effects of organic and inorganic nitrate on aortic and carotid hemodynamics in heart failure and preserved ejection fraction Eur J Heart Fail : epub,2017.
Wild P, Janine Felix, Schillert A, Teumer A, Cappola TP, Hirschhorn J, Mitchell GF, Smith N, Fox ER, Dueker ND, Jaddoe VW, Melander O, Russ M, Lehtimäki T, Ciullo M, Hicks A, Lind L, Gudnason V, Pieske B, Barron AJ, Zweiker R, Schunkert H, Ingelsson E, Liu K, Arnett DK, Psaty B, Blankenberg S, Larson M, Felix S, Franco OH, Zeller T, Vasan R, Dörr M: Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function JCI 127 (5): 1798-1812,2017.
de Denus S, Rouleau J, Mann D, Huggins G, Naveen P, Shah S, Cappola TP, Fouodjio R, Mongrain M, Dubé: CYP3A4 genotype is associated with sildenafil concentrations in patients with heart failure with preserved ejection fraction. Pharmacogenomics J : epub,2017.
Esslinger U, Garnier S, Korniat A, Proust C, Kararigas G, Müller-Nurasyid M, Empana JP, Morley MP, Perret C, Stark K, Bick AG, Prasad SK, Kriebel J, Li J, Tiret L, Strauch K, O'Regan DP, Marguiles KB, Seidman JG, Boutouyrie P, Lacolley P, Jouven X, Hengstenberg C, Komajda M, Hakonarson H, Isnard R, Arbustini E, Grallert H, Cook SA, Seidman CE, Regitz-Zagrosek V, Cappola TP, Charron P, Cambien F, Villard E: Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy PLoS One 12 (3): e0172995,2017.
Dubin RF, Deo R, Bansal N, Anderson AH, Yang P, Go AS, Keane M, Townsend R, Porter A, Budoff M, Malik S, He J, Rahman M, Wright J, Cappola TP, Kallem R, Roy J, Sha D, Shlipak MG: Associations of conventional echocardiographic measures with incident heart failure and mortality: The Chronic Renal Insufficiency Cohort Clin J Am Soc Nephrol 12 (1): 60-68,2017.
Zhao SD, Cai TT, Cappola TP, Margulies KB, Li H: Sparse simultaneous signal detection for identifying genetically controlled disease genes. J Am Stat Assoc 112 (519): 1032-1046,2017.
Zamani P, Tan V, Soto-Calderon H, Beraun M, Brandimarto JA, Trieu L, Varakantam S, Doulias P, Townsend RR, Chittams J, Margulies KB, Cappola TP, Poole DC, Ischiropoulos H, Chirinos JA: Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction. Circ Research : 2016.
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