Description of Research Expertise

Thomas Cappola is the William Smilow Professor and Chief, Cardiovascular Medicine, University of Pennsylvania Perelman School of Medicine. His research aims to uncover heart failure mechanisms in human subjects and to use these insights to improve treatment. This has involved diverse approaches, including applied genomics, population science, laboratory studies, and clinical trials. He has established and leads a multicenter cohort study of advanced heart failure (Penn Heart Failure Study, PHFS); co-loads a multicenter consortium for human myocardial transcriptomics and systems genetics (Myocardial Applied Genomics Network, MAGNet); serves as a Principal Investigator on the NHLBI Heart Failure Clinical Research Network; and is a contributing member of numerous international genomics consortia. Within the Cardiovascular Division, he has established collaborative leadership to create programs integrating science and clinical care, and has used these as a platform for research and training. In his clinical role, he treats patients with advanced heart failure on the inpatient and outpatient heart failure/transplant service.

Selected Publications

Lumbers RT, Shah S...Cappola TP, Ellinor PT, Vasan RS, Smith JG: The genomics of heart failure: design and rationale of the HERMES consortium ESC Heart Fail 8 (6): 5531-5541,2021.

McAfee Q, Chen CY, Yang Y, Caporizzo MA, Morley M, Babu A, Jeong S, Brandimarto J, Bedi KC Jr, Flam E, Cesare J, Cappola TP, Margulies K, Prosser B, Arany Z.: Truncated titin proteins in dilated cardiomyopathy Sci Transl Med 13 (618): eabd7287,2021.

Parcha V, Patel N, Musunuru K, Margulies KB, Cappola TP, Halade G, Wang TJ, Arora G, Arora P: Natriuretic peptide deficiency in obese individuals: mechanistic insights from healthy organ donor cohort. J Am Coll Cardiol 77 (24): 3138-3140,2021.

Parcha V, Patel N, Gutierrez OM, Li P, Gamble KL, Musunuru K, Margulies KB, Cappola TP, Wang TJ, Arora G, Arora P.: Chronobiology of natriuretic peptides and blood pressure in lean and obese individuals. J Am Coll Cardiol 77 (18): 2291-2303,2021.

Goli R, Li J, Brandimarto J, Levine LD, Riis V, McAfee Q, DePalma S, Haghighi A, Seidman JG, Seidman CE, Jacoby D, Macones G, Judge DP, Rana S, Margulies KB, Cappola TP, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Alexis JD, Boehmer J, Kamiya C, Gustafsson F, Damm P, Ersbøll AS, Goland S, Hilfiker-Kleiner D, McNamara DM, Arany Z; IMAC-2 and IPAC investigators.: Genetic and phenotypic landscape of peripartum cardiomyopathy Circulation : 2021.

Garnier S, Harakalova M, Weiss S, Mokry M, Regitz-Zagrosek V, Hengstenberg C, Cappola TP, Isnard R, Arbustini E, Cook SA, van Setten J, Calis JJA, Hakonarson H, Morley MP, Stark K, Prasad SK, Li J, O'Regan DP, Grasso M, Müller-Nurasyid M, Meitinger T, Empana JP, Strauch K, Waldenberger M, Marguiles KB, Seidman CE, Kararigas G, Meder B, Haas J, Boutouyrie P, Lacolley P, Jouven X, Erdmann J, Blankenberg S, Wichter T, Ruppert V, Tavazzi L, Dubourg O, Roizes G, Dorent R, de Groote P, Fauchier L, Trochu JN, Aupetit JF, Bilinska ZT, Germain M, Völker U, Hemerich D, Raji I, Bacq-Daian D, Proust C, Remior P, Gomez-Bueno M, Lehnert K, Maas R, Olaso R, Saripella GV, Felix SB, McGinn S, Duboscq-Bidot L, van Mil A, Besse C, Fontaine V, Blanché H, Ader F, Keating B, Curjol A, Boland A, Komajda M, Cambien F, Deleuze JF, Dörr M, Asselbergs FW, Villard E, Trégouët DA, Charron P: Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23 Eur Heart J epub : 2021.

Hanff TC, Cohen JB, Zhao L, Javaheri A, Zamani P, Prenner S, Rietzschel E, Jia Y, Walsh A, Maranville J, Wang Z, Adam L, Ramirez-Valle, F, Schafer P, Seiffert D, Gordon DA, Cvijic ME, Cappola TP, Chirinos JA: Quantitative proteomic analysis of diabetes mellitus in heart failure with preserved ejection fraction JACC Basic Transl Sci 6 (2): 89-99,2021.

Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R: Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes Cell Stem Cell : S1934,2021.

Puckelwartz MJ, Pesce LL, Dellefave-Castillo LM, Wheeler MT, Pottinger TD, Robinson AC, Kearns SD, Gacita AM, Schoppen ZJ, Pan W, Kim G, Wilcox JE, Anderson AS, Ashley EA, Day SM, Cappola T, Dorn GW 2nd, McNally EM: Genomic context differs between human dilated cardiomyopathy and hypertrophic cardiomyopathy J Am Heart Assoc 10 (7): e019944,2021.

Eberly LA, Kallan MJ, Julien HM, Haynes N, Khatana SAM, Nathan AS, Snider C, Chokshi NP, Eneanya ND, Takvorian SU, Anastos-Wallen R, Chaiyachati K, Ambrose M, O'Quinn R, Seigerman M, Goldberg LR, Leri D, Choi K, Gitelman Y, Kolansky DM, Cappola TP, Ferrari VA, Hanson CW, Deleener ME, Adusumalli S: Patient Characteristics Associated With Telemedicine Access for Primary and Specialty Ambulatory Care During the COVID-19 Pandemic JAMA Netw Open 3 (12): e2031640,2020.

View all publications

Academic Contact Information

Perelman Center for Advanced Medicine
Division of Cardiovascular Medicine
11-113 South Pavilion
3400 Civic Center Boulevard
Philadelphia, PA 19104
Phone: 215-662-3140
Patient appointments: 800-789-7366