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Thomas P. Cappola, MD, ScM

Thomas P. Cappola, MD, ScM Physician

Chief, Division of Cardiovascular Medicine Herbert C. Rorer Professor in Medical Sciences

Dr. Cappola is employed by Penn Medicine.

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About Dr. Thomas P. Cappola

Recognized by America's Top Doctors for 2017

Recognized in Philadelphia magazine's annual Top Docs issues for 2018 and 2019

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Advanced Heart Failure and Transplant Cardiology, 2010
  • Cardiovascular Disease, 2002

Clinical Expertise:

  • Advanced Heart Failure
  • Alcoholic Cardiomyopathy
  • Arrhythmogenic Right Ventricular Dysplasia
  • Arterial Insufficiency
  • Cardiac Amyloid
  • Cardiac Sarcoidosis
  • CardioMEMS
  • Cardiomyopathy
  • Chronic Inotropic Therapy
  • Circulatory Assist Devices
  • Congestive Heart Failure
  • Cor Pulmonale
  • Diabetic Cardiomyopathy
  • Dilated Cardiomyopathy
  • Familial Cardiomyopathy
  • Genetic Cardiomyopathy
  • Giant Cell Myocarditis
  • Heart Biopsy
  • Heart Transplant Rejection
  • Heart Transplantation
  • Home Inotropes
  • Hypertrophic Cardiomyopathy
  • Idiopathic Hypertrophic Subaortic Stenosis
  • Infiltrative Disorders of the Heart
  • Ischemic Cardiomyopathy
  • Left Heart Failure
  • Left Ventricular Assist Device
  • Mechanical Circulatory Support
  • Muscular Dystrophy
  • Myocarditis
  • Peripartum Cardiomyopathy
  • Pulmonary Edema
  • Pulmonary Hypertension
  • Restrictive Cardiomyopathy
  • Rheumatic Heart Failure
  • Right Heart Failure
  • Right Ventricular Cardiomyopathy
  • Tachycardia-Induced Cardiomyopathy
  • Takatsubo Cardiomyopathy
  • Thalassemias
  • Transplant Evaluation
  • Valvular Heart Disease
  • Viral Cardiomyopathy
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Harvard University
Residency: Brigham and Women's Hospital
Fellowship: Johns Hopkins Hospital


American Heart Association, National Association of Professors of Cardiology, National British Heart Foundation Centre of Excellence, Kings College, London, UK, International Heart Failure Society of America, National International Society for Heart Research, International International Society of Heart and Lung Transplantation, International National Center for Advancing Translational Science: Clinical and Translational Science Award Review ZTR1 CI-9 (01), National National Heart, Lung, and Blood Institute Special Emphasis Panel ZHL1 CSR-H (F1): Single-or Multi-Site Clinical Trials Phase I, II, III, National

Hospital Affiliation

Dr. Cappola is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Thomas Cappola is Herbert C. Rorer Professor in Medical Sciences and Chief, Cardiovascular Medicine, University of Pennsylvania Perelman School of Medicine. His research aims to uncover heart failure mechanisms in human subjects and to use these insights to improve treatment. This has involved diverse approaches, including applied genomics, population science, laboratory studies, and clinical trials. He has established and leads a multicenter cohort study of advanced heart failure (Penn Heart Failure Study, PHFS); co-loads a multicenter consortium for human myocardial transcriptomics and systems genetics (Myocardial Applied Genomics Network, MAGNet); serves as a Principal Investigator on the NHLBI Heart Failure Clinical Research Network; and is a contributing member of numerous international genomics consortia. Within the Cardiovascular Division, he has established collaborative leadership to create programs integrating science and clinical care, and has used these as a platform for research and training. In his clinical role, he treats patients with advanced heart failure on the inpatient and outpatient heart failure/transplant service.

Selected Publications:

Patel N, Russell GK, Musunuru K, Gutierrez OM, Halade G, Kain V, Prabhu SD, Margulies KB, Cappola TP, Arora G, Wang TJ, Arora P: Race, Natriuretic Peptides, and High-Carbohydrate Challenge: A Clinical Trial Circulation Research : [Epub ahead of print],2019.

Lyle MA, Iyer SR, Redfield MM, Reddy YNV, Felker GM, Cappola TP, Hernandez AF, Scott CG, Burnett JC Jr, Pereira NL: Circulating Neprilysin in Patients with Heart Failure with Preserved Ejection Fraction JACC Heart Fail 19 : [Epub ahead of print],2019.

Celik S, Karbalaei Sadegh M, Morley M, Roselli C, Ellinor PT, Cappola T, Smith JG, Gidlof O: Antisense regulation of atrial natriuretic peptide expression JCI Insight : 130978,2019.

Haggerty CM, Damrauer SM, Levin MG, Birtwell D, Carey DJ, Golden AM, Hartzel DN, Hu Y, Judy R, Kelly MA, Kember RL, Lester Kirchner H, Leader JB, Liang L, McDermott-Roe C, Babu A, Morley M, Nealy Z, Person TN, Pulenthiran A, Small A, Smelser DT, Stahl RC, Sturm AC, Williams H, Baras A, Margulies KB, Cappola TP, Dewey FE, Verma A, Zhang X, Correa A, Hall ME, Wilson JG, Ritchie MD, Rader DJ, Murray MF, Fornwalt BK, Arany Z.: Genomics-first evaluation of heart disease associated with titin-truncating variants. Circulation 140 (1): 42-50,2019.

Cordero P, Parikh V, Chin E, Erbilgin A, Gloudemans M, Ching S, Chang ACH, Huang Y, Smith K, Dewey F, Zaleta-Rivera K, Morley M, Brandimarto J, Glazer N, Waggott D, Pavlovic A, Moravec C, Zhao M, Tang WHW, Skreen J, Malloy C, Hannenhalli S, Li H, Ritter S, Li M, Bernstein D, Connolly A, Hakonarson H, Lusis A, Marguiles KB, Depaoli-Roach A, Montgomery S, Wheeler M, Cappola TP, Ashley: Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure-overload heart failure Nat Commun 10 (1): 2760,2019.

Michael MP, Wang X, Hu R; Brandimarto J, Tucker, NR, Felix JF, Smith NL, van der Harst P, Ellinor PT, Margulies KB, Musunuru K, Cappola TP: Cardioprotective effects of MTSS1 enhancer variants Circulation 139 (17): 2073–2076,2019.

Kannan L, Shaw PA, Morley MP, Brandimarto J, Fang JC, Sweitzer NK, Cappola TP, Cappola AR: Thyroid Dysfunction in Heart Failure and Cardiovascular Outcomes Circ Heart Fail. 2018 Dec;11(12) 11 (12): e005266,2018.

Levin MG, Kember RL, Judy R, Birtwell D, Williams H, Arany Z, Giri J, Guerraty M, Cappola T; Regeneron Genetics Center, Chen J, Rader DJ, Damrauer SM: Genomic Risk Stratification Predicts All-Cause Mortality After Cardiac Catheterization Circ Genom Precis Med 11 (11): e002352,2018.

Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, Almgren P, Alonso A, Anderson CD, Aragam KG, Arking DE, Barnard J, Bartz TM, Benjamin EJ, Bihlmeyer NA, Bis JC, Bloom HL, Boerwinkle E, Bottinger EB, Brody JA, Calkins H, Campbell A, Cappola TP…Lubitz SA, Lunetta KL, Ellinor PT.: Multi-ethnic genome-wide association study for atrial fibrillation Nat Genet 50 (9): 1225-1233,2018.

Macri V, Brody JA, Arking DE, Hucker WJ, Yin X, Lin H, Mills RW, Sinner MF, Lubitz SA, Liu CT, Morrison AC, Alonso A, Li N, Fedorov VV, Janssen PM, Bis JC, Heckbert SR, Dolmatova EV, Lumley T, Sitlani CM, Cupples LA, Pulit SL, Newton-Cheh C, Barnard J, Smith JD, Van Wagoner DR, Chung MK, Vlahakes GJ, O'Donnell CJ, Rotter JI, Margulies KB, Morley MP, Cappola TP, Benjamin EJ, Muzny D, Gibbs RA, Jackson RD, Magnani JW, Herndon CN, Rich SS, Psaty BM, Milan DJ, Boerwinkle E, Mohler PJ, Sotoodehnia N, Ellinor PT: Common Coding Variants in SCN10A Are Associated With the Nav1.8 Late Current and Cardiac Conduction Circ Genom Precis Med 11 (5): e001663,2018.

View all publications

Academic Contact Info

Perelman Center for Advanced Medicine
Division of Cardiovascular Medicine
11-113 South Pavilion
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 662-3140
Patient appointments: 800-789-7366 (PENN)

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