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My clinical focus is evaluation and treatment of advance heart failure including medical therapy, device therapy, investigational therapy, and cardiac transplantation

Medical School: Harvard Medical School
Residency: Brigham and Women's Hospital
Fellowship: Johns Hopkins Hospital

American Heart Association Cardiovascular Genome Phenome Study (CVGPS) Study Section, National American Heart Association, National Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Echocardiography and Heart Failure Working Groups, International Heart Failure Society of America, National International Society for Heart Research, International International Society of Heart and Lung Transplantation, International Medical Research Council, United Kingdom, International National Heart Lung and Blood Institute Program Project (P01) 1P01HL084157-01A1 Review, National National Heart, Lung, and Blood Institute Candidate Gene Association Resource (CARe) Heart Failure and Echocardiography Working Group, National National Heart, Lung, and Blood Institute Cardiovascular Health Study Genetics and Biomarkers Working Group, National National Heart, Lung, and Blood Institute Working Group: Strategies to Prevent the Morphologic and Clinical Manifestations of Genetically Mediated Hypertrophic Cardiomyopathy, National National Institute of Allergy and Infectious Diseases Special Emphasis Panel ZAI1 QV-I(M2): Genomics of Transplantation Cooperative Research Program, National National Institute of Drug Abuse Special Emphasis Panel ZDA GXM-A (03)1 Functional Characterization of Genetic Variants and Interactions: The Genes, Environment and Health Initiative, National National Institutes of Health Center for Scientific Review Special Emphasis Panel ZRG1 HOP-Y (50)R: Rare Diseases Clinical Research Consortia (RDCRC) , National SwissTransMed, University of Bern, Switzerland, International Translational Biology and Observational Epidemiology Peer Review Study Group, American Heart Association, National

Hospital Privileges:

• Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
• Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.

Description of Research Expertise:

My laboratory uses clinical investigation and applied genomics to reveal mechanisms of human heart failure. This has included establishing a multicenter cohort study of advanced heart failure (Penn Heart Failure Study; PHFS) and a multicenter consortium for human myocardial transcriptomics and eQTL mapping (Myocardial Applied Genomics Network; MAGNet). Notable discoveries include the first demonstration that peripheral blood gene expression provides a clinical biomarker to track cardiac allograft rejection, identification of abnormalities in forkhead signaling and neuregulin signaling in common forms of human heart failure, and discovery of the 1p36 HSPB7/CLCNKA locus as the first bonafide genetic risk factor for non-familial heart failure. More recent work focuses on investigational therapeutics for heart failure. In my clinical role I treat patients with advanced heart failure on the inpatient and outpatient heart failure/transplant service.

Selected Publications:

Chirinos JA, Londono-Hoyos F, Zamani P, Beraun M, Haines P, Vasim I, Varakantam S, Phan TS, Cappola TP, Margulies KB, Townsend RR, Segers P: Effects of organic and inorganic nitrate on aortic and carotid hemodynamics in heart failure and preserved ejection fraction Eur J Heart Fail : epub,2017.

Wild P, Janine Felix, Schillert A, Teumer A, Cappola TP, Hirschhorn J, Mitchell GF, Smith N, Fox ER, Dueker ND, Jaddoe VW, Melander O, Russ M, Lehtimäki T, Ciullo M, Hicks A, Lind L, Gudnason V, Pieske B, Barron AJ, Zweiker R, Schunkert H, Ingelsson E, Liu K, Arnett DK, Psaty B, Blankenberg S, Larson M, Felix S, Franco OH, Zeller T, Vasan R, Dörr M: Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function JCI 127 (5): 1798-1812,2017.

de Denus S, Rouleau J, Mann D, Huggins G, Naveen P, Shah S, Cappola TP, Fouodjio R, Mongrain M, Dubé: CYP3A4 genotype is associated with sildenafil concentrations in patients with heart failure with preserved ejection fraction. Pharmacogenomics J : epub,2017.

Esslinger U, Garnier S, Korniat A, Proust C, Kararigas G, Müller-Nurasyid M, Empana JP, Morley MP, Perret C, Stark K, Bick AG, Prasad SK, Kriebel J, Li J, Tiret L, Strauch K, O'Regan DP, Marguiles KB, Seidman JG, Boutouyrie P, Lacolley P, Jouven X, Hengstenberg C, Komajda M, Hakonarson H, Isnard R, Arbustini E, Grallert H, Cook SA, Seidman CE, Regitz-Zagrosek V, Cappola TP, Charron P, Cambien F, Villard E: Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy PLoS One 12 (3): e0172995,2017.

Dubin RF, Deo R, Bansal N, Anderson AH, Yang P, Go AS, Keane M, Townsend R, Porter A, Budoff M, Malik S, He J, Rahman M, Wright J, Cappola TP, Kallem R, Roy J, Sha D, Shlipak MG: Associations of conventional echocardiographic measures with incident heart failure and mortality: The Chronic Renal Insufficiency Cohort Clin J Am Soc Nephrol 12 (1): 60-68,2017.

Zamani P, Tan V, Soto-Calderon H, Beraun M, Brandimarto JA, Trieu L, Varakantam S, Doulias P, Townsend RR, Chittams J, Margulies KB, Cappola TP, Poole DC, Ischiropoulos H, Chirinos JA: Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction. Circ Research : 2016.

Zamani P, French B, Brandimarto JA; Douliasm P, Javaheri A, Chirinos JA, Margulies KB, Townsend RR, Sweitzer NK, Fang JC; Ischiropoulos H, Cappola TP: Effect of heart failure with preserved ejection fraction on nitric oxide metabolites Am J Cardiol 118 (12): 1855-1860,2016.

Chirinos JA, Akers SR, Trieu L; Ischiropoulos H, Paschalis-Thomas D, Tariq A, Vassim I, Maheswara KR, Syed AA, Soto-Calderon H, Townsend RR Cappola TP, Margulies KB, Zamani P: Heart failure, left ventricular remodeling, and circulating nitric oxide metabolites J Am Heart Assoc 5 (10): e004133,2016.

Margulies KB, Hernandez A, Redfield M, Givertz M, Oliveira G, Cole R, Mann D, Whellan D, Kiernan M, Felker GM, McNulty S, Anstrom K, Shah S, Eugene Braunwald E, Cappola TP: Effects of liraglutide on clinical stability in advanced heart failure with reduced ejection fraction: a randomized clinical trial JAMA 316 (5): 500-508,2016.

AbouEzzeddine OF, French B, Mirzoyev SA, Jaffe AS, Levy WC, Fang JC, Sweitzer NK, Cappola TP, Redfield MM: From statistical significance to clinical relevance: a simple algorithm to integrate brain natriuretic peptide and the Seattle Heart Failure Model for risk stratification in heart failure. J Heart Lung Transplant 35 (6): 714-21,2016.

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Penn Heart and Vascular website

Heart Transplant Program website