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Susan M. Domchek, MD

Susan M. Domchek, MD Physician

Director, MacDonald Women’s Cancer Risk Evaluation Center Executive Director, Basser Center for BRCA Basser Professor in Oncology

Dr. Domchek is employed by Penn Medicine.

About Dr. Susan M. Domchek

Recognized by America's Top Doctors, 2012 - 2018

Recognized by Best Doctors in America 2009 - 2012, 2015- 2018

Recognized in Philadelphia magazine's Top Docs issues from 2011 - 2013, and 2018

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Medical Oncology

Programs & Centers:

Board Certification:

  • Medical Oncology, 2001

Clinical Expertise:

  • Breast Cancer
  • Breast Cancer Genetics

Description of Clinical Expertise

Breast cancer prevention, screening and treatment
Breast cancer genetics

Practice Locations and Appointments

  • Rena Rowan Breast Center

    Abramson Cancer Center Perelman Center for Advanced Medicine, West Pavilion, 3rd Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Harvard University
Residency: Massachusetts General Hospital
Fellowship: Dana-Farber Cancer Institute


American Association for Cancer Research (AACR), International American Society of Clinical Oncology, International Breast Cancer Research Foundation, National Eastern Cooperative Oncology Group (PrECOG), National Facing our risk of cancer empowered (FORCE), National Living Beyond Breast Cancer, National Pennsylvania Cancer Control, Prevention, and Research Advisory Board, National Susan G. Komen for the Cure®, International Triple Negative Breast Cancer Foundation, National White House Cancer Moonshot Summit, National

Hospital Affiliation

Dr. Domchek is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Breast cancer genetics
Breast cancer prevention and screening
Breast cancer immunotherapy clinical trials

Selected Publications:

Cruz C, Llop-Guevara A1, Garber JE, Arun BK1, Pérez Fidalgo JA, Lluch A, Telli ML, Fernández C, Kahatt C, Galmarini CM1, Soto-Matos A1, Alfaro V, Pérez de la Haza A, Domchek SM, Antolin S, Vahdat L, Tung NM, Lopez R, Arribas J, Vivancos A, Baselga J, Serra V, Balmaña J, Isakoff SJ.: Multicenter Phase II Study of Lurbinectedin in BRCA-Mutated and Unselected Metastatic Advanced Breast Cancer and Biomarker Assessment Substudy. Journal of Clinical Oncology : 2018.

MacFarland SP, Zelley K, Long JM, McKenna D, Mamula P, Domchek SM, Nathanson KL, Brodeur GM, Rustgi AK, Katona BW, Maxwell KN.: Earlier colorectal cancer screening may be necessary in patients with Li-Fraumeni Syndrome. Gastroenterology 5085 (18): 2018.

Murciano-Goroff YR, McCarthy AM, Bristol MN, Groeneveld P, Domchek SM, Motanya UN, Armstrong K.: Uptake of BRCA 1/2 and oncotype DX testing by medical and surgical oncologists. Breast Cancer Research Treatment 171 (1): 173-180,2018.

Francis PA1, Pagani O1, Fleming GF1, Walley BA1, Colleoni M1, Láng I1, Gómez HL1, Tondini C1, Ciruelos E1, Burstein HJ1, Bonnefoi HR1, Bellet M1, Martino S1, Geyer CE Jr1, Goetz MP1, Stearns V1, Pinotti G1, Puglisi F1, Spazzapan S1, Climent MA1, Pavesi L1, Ruhstaller T1, Davidson NE1, Coleman R1, Debled M1, Buchholz S1, Ingle JN1, Winer EP1, Maibach R1, Rabaglio-Poretti M1, Ruepp B1, Di Leo A1, Coates AS1, Gelber RD1, Goldhirsch A1, Collaborators:, Blacher L, Hiltbrunner A, Kammler R, Loibl S, Martinez J: Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer. The New England Journal of Medicine 379 (2): 122-137,2018.

Yingchang Lu, Alicia Beeghly-Fadiel, Lang Wu, Xingyi Guo, Bingshan Li, Joellen M. Schildkraut, Hae Kyung Im, Yian Ann Chen, Jennifer B Permuth, Brett M. Reid, Jamie K. Teer, Kirsten B. Moysich, Irene L. Andrulis, Hoda Anton-Culver, Banu K Arun, Elisa V. Bandera, Rosa B Barkardottir, Daniel R. Barnes, Javier Benitez, Line Bjørge, James Brenton, Ralf Butzow, Trinidad Caldes, Maria A. Caligo, Ian G. Campbell, Jenny Chang-Claude, Kathleen B.M Claes, Fergus J. Couch, Daniel W. Cramer, Mary B. Daly, Anna DeFazio: A transcriptome-wide association study among 97,898 women to identify candidate susceptibility genes for epithelial ovarian cancer risk American Association for Cancer Research : 2018.

JL Chan, S Senapati, LNC Johnson, L DiGiovanni, C Voong, SF Butts, , S Domchek: Risk factors for sexual dysfunction in BRCA mutation carriers after risk-reducing salpingo-oophorectomy. Menopause : 2018.

Kilbride MK, Domchek SM, Bradbury AR: Ethical Implications of Direct-to-Consumer Hereditary Cancer Tests. JAMA Oncology : 2018.

Thiruchelvam PTR, Fisher CS, Leff DR, Domchek SM.: Pervasive genetic testing The Lancet 391 (10135): 2089-2091,2018.

Murciano-Goroff YR, McCarthy AM, Bristol MN, Domchek SM, Groeneveld PW, Motanya UN, Armstrong K.: Medical oncologists' willingness to participate in bundled payment programs BMC Health Services Research 18 (1): 391,2018.

Shroff RT, Hendifar A, McWilliams RR, Geva R, Epelbaum E, Rolfe L, Goble S, Lin KK, Biankin AV, Giordano H, Vonderheide RH, Domchek SM: Rucaparib Monotherapy in Patients with Pancreatic Cancer and a Known Deleterious BRCA Mutation JCO Precision Oncology : 2018.

Academic Contact Info

Division of Hematology Oncology
10th Floor, South Pavilion
Office #10-150
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 615-3360
Patient appointments: 800-789-7366 (PENN)

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