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Susan M. Domchek, MD

Susan M. Domchek, MD Physician

Director, MacDonald Women’s Cancer Risk Evaluation Center Executive Director, Basser Center for BRCA Basser Professor in Oncology

Dr. Domchek is employed by Penn Medicine.

About Dr. Susan M. Domchek

Recognized by America's Top Doctors, 2012 - 2018

Recognized by Best Doctors in America 2009 - 2012, 2015- 2018

Recognized in Philadelphia magazine's Top Docs issues from 2011 - 2013, 2018 and 2019

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Medical Oncology

Programs & Centers:

Board Certification:

  • Medical Oncology, 2001

Clinical Expertise:

  • Adjuvant Chemotherapy
  • Aromatase Inhibitor
  • ATM Mutation
  • Brca
  • Breast Cancer Chemotherapy
  • Breast Cancer During Pregnancy
  • Breast Cancer Follow Up
  • Breast Cancer High-Risk Counseling
  • Breast Cancer in Young Women
  • Family History of Breast Cancer
  • Herceptin
  • Hereditary Breast and Ovarian Cancer
  • Immunotherapy
  • Invasive Breast Cancer
  • Male Breast Cancer
  • Neoadjuvant Chemotherapy
  • PALB2
  • PTEN
  • Sentinel Lymph Node Biopsy
  • Tamoxifen
  • Triple-Negative Breast Cancer
Show All Expertise

Practice Locations and Appointments

  • Rena Rowan Breast Center

    Abramson Cancer Center Perelman Center for Advanced Medicine, West Pavilion, 3rd Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Harvard University
Residency: Massachusetts General Hospital
Fellowship: Dana-Farber Cancer Institute


Advanced Clinical Research Award (ACRA) Subcommittee, International American Association for Cancer Research (AACR) Annual Meeting Clinical Trials Committee Member, International American Association for Cancer Research (AACR) Breast Cancer Research Grant Review Committee Chairperson, International American Society of Clinical Oncology, International Breast Cancer Research Foundation, National Cancer Prevention, Hereditary Genetics, and Epidemiolgy (ASCO), International Facing our risk of cancer empowered (FORCE), National Komen Career Catalyst Research-Redefining Metastatic Cancer through Liquid Biopsy, International Living Beyond Breast Cancer (Medical Advisory Board), National Living Beyond Breast Cancer, National National Academy of Medicine, National Pennsylvania Cancer Control, Prevention and Research Advisory Board, Cancer Genetics/Genomics Committee, National Susan G. Komen for the Cure®, International The New York Stem Cell Foundation Research Institute's Women Reproductive Cancer Initiative, National Triple Negative Breast Cancer Foundation, National

Hospital Affiliation

Dr. Domchek is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Breast cancer genetics
Breast cancer prevention and screening
Breast cancer immunotherapy clinical trials

Selected Publications:

Robson M, Domchek S.: Broad Application of Multigene Panel Testing for Breast Cancer Susceptibility-Pandora's Box Is Opening Wider. JAMA Oncol : 2019.

Upshaw JN, Finkelman B, Hubbard RA, Smith AM, Narayan HK, Arndt L, Domchek S, DeMichele A, Fox K, Shah P, Clark A, Bradbury A, Matro J, Adusumalli S, Carver JR, Ky B.: Comprehensive Assessment of Changes in Left Ventricular Diastolic Function With Contemporary Breast Cancer Therapy. JACC Cardiovasc Imaging : 2019.

Gaieski JB, Patrick-Miller L, Egleston BL, Maxwell KN, Walser S, DiGiovanni L, Brower J, Fetzer D, Ganzak A, McKenna D, Long JM, Powers J, Stopfer JE, Nathanson KL, Domchek SM, Bradbury AR.: Research participants' experiences with return of genetic research results and preferences for web-based alternatives. Mol Genet Genomic Med. 7 (9): e898,2019.

Max Wattenberg, Daniella Asch, Shun Yu, Peter O’Dwyer, Susan Domchek, Katherine Nathanson, Mark Rosen, Gregory L Beatty, Evan Siegelman, and Kim Reiss: Platinum response characteristics of patients with pancreatic ductal adenocarcinoma and a germline BRCA1, BRCA2 or PALB2 mutation British Journal of Cancer : 2019.

Page EC, Bancroft EK, Brook MN, Assel M, Hassan Al Battat M, Thomas S, Taylor N, Chamberlain A, Pope J, Raghallaigh HN, ...Domchek S, ...Moynihan C, Rennert G, Suri M, Wilson P, Dudderidge T; IMPACT Study Collaborators, Offman J, Kote-Jarai Z, Vickers A, Lilja H, Eeles RA.: Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers. Eur Urol : 2019.

Gaieski JB, Patrick-Miller L, Egleston BL, Maxwell KN, Walser S, DiGiovanni L, Brower J, Fetzer D, Ganzak A, McKenna D, Long JM, Powers J, Stopfer JE, Nathanson KL, Domchek SM, Bradbury AR.: Research participants' experiences with return of genetic research results and preferences for web-based alternatives. Mol Genet Genomic Med : 2019.

Robson M, Ruddy KJ, Im SA, Senkus E, Xu B, Domchek SM, Masuda N, Li W, Tung N, Armstrong A, Delaloge S, Bannister W, Goessl C, Degboe A, Hettle R, Conte P.: Patient-reported outcomes in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer receiving olaparib versus chemotherapy in the OlympiAD trial. Eur J Cancer : 20-30,2019.

Shun Yu, MD1, 2; Parul Agarwal, MD1; Ronac Mamtani, MD1, 2; Heather Symecko, MPH2; Kelsey Spielman, MS2; Mark O’Hara, MD1, 2; Peter J. O’Dwyer, MD1, 2; Charles Schneider, MD1, 2; Ursina Teitelbaum, MD1, 2; Katherine L. Nathanson, MD1, 2; Susan M. Domchek, MD1, 2; and Kim A. Reiss, MD1, 2: Retrospective Survival Analysis of Patients With Resected Pancreatic Ductal Adenocarcinoma and a Germline BRCA or PALB2 Mutation JCO Precision Oncology : 2019.

Clark DF, Maxwell KN, Powers J, Lieberman DB, Ebrahimzadeh J, Long JM, McKenna D, Shah P, Bradbury A, Morrissette JJD, Nathanson KL, Domchek SM.: Identification and Confirmation of Potentially Actionable Germline Mutations in Tumor-Only Genomic Sequencing JCO Precision Oncology : 2019.

Jada G. Hamilton, PhD, MPH; Jessica M. Long, MS, LCG; Amanda C. Brandt, MS, LC; Jamie Brower, MS; Heather Symecko, MPH; Erin E. Salo-Mullen, MS, MPH, CGC; Stephanie N. Christian, MPH; Tricia Harstad, MA; Fergus J. Couch, PhD; Judy E. Garber, MD, MPH; Kenneth Offit, MD, MPH; Mark E. Robson, MD; and Susan M. Domchek, MD: Patients’ Medical and Psychosocial Experiences After Detection of a CDH1 Variant With Multigene Panel Testing JCO Precision Oncology : 2019.

Academic Contact Info

Division of Hematology Oncology
10th Floor, South Pavilion
Office #10-150
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 615-3360
Patient appointments: 800-789-7366 (PENN)

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