Penn Medicine Provider
Stuart N. Isaacs, MD
Sees patients age 18 and up

About me

  • Associate Dean for Animal Research, Perelman School of Medicine
  • Associate Professor of Medicine (Infectious Diseases)

Dr. Isaacs sees patients at the Philadelphia VA Medical Center.

At Penn, Dr. Isaacs services as Associate Dean for Animal Research for the Perelman School of Medicine.

Education and training

  • Medical School: Yale University
  • Residency: Temple University Hospital
  • Fellowship: National Institutes of Health
  • Fellowship: Tufts University

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.
Dr. Isaacs is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Isaacs SN Asymptomatic Infection? Another Reason to Consider Monkeypox a Disease of Public Health Concern. , Ann Intern Med: 2022


Rao AK, Petersen BW, Whitehill F, Razeq JH, Isaacs SN, Merchlinsky MJ, Campos-Outcalt D, Morgan RL, Damon I, Sánchez PJ, Bell BB Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022 , MMWR Morb Mortal Wkly Rep, 71(22): 2022,734-742


Xiao, Y., Zeng, Y., Schande, C., Joshi, S.B., Buchman, G.W., Volkin, D.B., Middaugh, C.R., Isaacs, S.N. Short-term and longer-term protective immune responses generated by subunit vaccination with smallpox A33, B5, L1 or A27 proteins adjuvanted with aluminum hydroxide and CpG in mice challenged with vaccinia virus , Vaccine, 38(38): 2020,6007-6018


Isaacs, S.N. Monkeypox , UpToDate: 2021


Nuth M, Guan H, Xiao Y, Kulp JL, Parker MH, Strobel ED, Isaacs SN, Scott RW, Reitz AB, Ricciardi RP Mutation and structure guided discovery of an antiviral small molecule that mimics an essential C-terminal tripeptide of the vaccinia D4 processivity factor , Antiviral Research, 162: 2019,178-185


Guan, H., Nuth, M., Zhukovskaya, N., Saw, Y.L., Bell, E., Isaacs, S.N., Ricciardi, R.P. A novel target and approach for identifying antivirals against molluscum contagiosum virus , Antimicrobial Agents and Chemotherapy, 58(12): 2014,7383-9


Xiao, Y., Zeng, Y., Alexander, E., Mehta, S., Joshi, S.B., Buchman, G.W., Volkin, D.B., Middaugh, C.R., Isaacs, S.N. Adsorption of recombinant poxvirus L1-protein to aluminum hydroxide/CpG vaccine adjuvants enhances immune responses and protection of mice from vaccinia virus challenge , Vaccine, 31(2): 2013,319-326


Hudson, P.N., Self, J., Weiss, S., Braden, Z., Xiao, Y., Girgis, N.M., Emerson, G., Hughes, C., Sammons, S.A., Isaacs, S.N., Damon, I.K., Olson, V.A. Elucidating the role of the complement control protein in monkeypox pathogenicity. , PLoS One, 7(4): 2012,e35086


Girgis, N.M., DeHaven, B.C., Xiao, Y., Alexander, E., Viner, K.M., Isaacs, S.N. The vaccinia virus complement control protein modulates adaptive immune responses during infection. , Journal of Virology, 85(6): 2011,2547-56


Weaver JR, Isaacs SN Monkeypox virus and insights into its immunomodulatory proteins , Immunological Reviews, 225(1): 2008,96-113


View all publications