About me
- Associate Dean for Animal Research, Perelman School of Medicine
- Associate Professor of Medicine (Infectious Diseases)
Dr. Isaacs sees patients at the Philadelphia VA Medical Center.
At Penn, Dr. Isaacs services as Associate Dean for Animal Research for the Perelman School of Medicine.
Education and training
- Medical School: Yale University
- Residency: Temple University Hospital
- Fellowship: National Institutes of Health
- Fellowship: Tufts University
My Locations
Penn Medicine hospital privileges
- Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.
Qualifications and experience
- Internal Medicine, 1988
- Advisory Committee on Immunization Practices (ACIP) Orthopoxvirus Vaccine Working Group, National
- American Association for the Advancement of Science, National
- American Society for Microbiology, National
- American Society for Virology, National
- Global Virus Network (GVN), International
- Global Virus Network (GVN), International
- Infectious Diseases Society of America, National
- International Committee on Taxonomy of Viruses (ICTV), International
- Veterans Administration Central Biospecimen and Data Repository Working Group, National
Treatments and Conditions
My research
Isaacs SN Asymptomatic Infection? Another Reason to Consider Monkeypox a Disease of Public Health Concern. , Ann Intern Med: 2022
Rao AK, Petersen BW, Whitehill F, Razeq JH, Isaacs SN, Merchlinsky MJ, Campos-Outcalt D, Morgan RL, Damon I, Sánchez PJ, Bell BB Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022 , MMWR Morb Mortal Wkly Rep, 71(22): 2022,734-742
Xiao, Y., Zeng, Y., Schande, C., Joshi, S.B., Buchman, G.W., Volkin, D.B., Middaugh, C.R., Isaacs, S.N. Short-term and longer-term protective immune responses generated by subunit vaccination with smallpox A33, B5, L1 or A27 proteins adjuvanted with aluminum hydroxide and CpG in mice challenged with vaccinia virus , Vaccine, 38(38): 2020,6007-6018
Isaacs, S.N. Monkeypox , UpToDate: 2021
Nuth M, Guan H, Xiao Y, Kulp JL, Parker MH, Strobel ED, Isaacs SN, Scott RW, Reitz AB, Ricciardi RP Mutation and structure guided discovery of an antiviral small molecule that mimics an essential C-terminal tripeptide of the vaccinia D4 processivity factor , Antiviral Research, 162: 2019,178-185
Guan, H., Nuth, M., Zhukovskaya, N., Saw, Y.L., Bell, E., Isaacs, S.N., Ricciardi, R.P. A novel target and approach for identifying antivirals against molluscum contagiosum virus , Antimicrobial Agents and Chemotherapy, 58(12): 2014,7383-9
Xiao, Y., Zeng, Y., Alexander, E., Mehta, S., Joshi, S.B., Buchman, G.W., Volkin, D.B., Middaugh, C.R., Isaacs, S.N. Adsorption of recombinant poxvirus L1-protein to aluminum hydroxide/CpG vaccine adjuvants enhances immune responses and protection of mice from vaccinia virus challenge , Vaccine, 31(2): 2013,319-326
Hudson, P.N., Self, J., Weiss, S., Braden, Z., Xiao, Y., Girgis, N.M., Emerson, G., Hughes, C., Sammons, S.A., Isaacs, S.N., Damon, I.K., Olson, V.A. Elucidating the role of the complement control protein in monkeypox pathogenicity. , PLoS One, 7(4): 2012,e35086
Girgis, N.M., DeHaven, B.C., Xiao, Y., Alexander, E., Viner, K.M., Isaacs, S.N. The vaccinia virus complement control protein modulates adaptive immune responses during infection. , Journal of Virology, 85(6): 2011,2547-56
Weaver JR, Isaacs SN Monkeypox virus and insights into its immunomodulatory proteins , Immunological Reviews, 225(1): 2008,96-113