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Steven S. Scherer, MD, PhD

Steven S. Scherer, MD, PhD Physician

Chief, Neuromuscular Division Vice Chair for Academic Development, Department of Neurology Ruth Wagner Van Meter and J. Ray Van Meter Professor of Neurology

Dr. Scherer is employed by Penn Medicine.

About Dr. Steven S. Scherer

Recognized by Best Doctors in America 2007 - 2018

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties


  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 1990
  • Neuromuscular Medicine, 2012

Clinical Expertise:

  • Autoimmune Neuropathy
  • Charcot Marie Tooth Disease (CMT)
  • Diabetic Neuropathy
  • Facial Nerve Rejuvenation
  • Finger Numbness
  • Hand and Finger Weakness
  • Nerve Conduction Studies (NCS)
  • Nerve Disease
  • Neuropathic Pain
  • Peripheral Nerve Disease
  • Peripheral Nerve Disorders
  • Peripheral Neuropathy
  • Sensory Neuropathy

Description of Clinical Expertise

My clinical work is focused on people who are known (or are suspected to have) a peripheral neuropathy. To diagnose neuropathy, I perform a comprehensive history and focused neurological examination, typically including clinical neurophysiology ("EMG"). This assessment enables me classify someone's neuropathy (examples - diabetic, inherited, chronic inflammatory demyelinating polyneuropathy (CIDP), Guillain-Barre syndrome (GBS), vasculitic, toxic, idiopathic, "small fiber"), and guides further testing. Establishing the correct diagnosis can lead to treatments for neuropathies caused by compression, inflammation, vitamin deficiencies, amyloid, or toxins. In addition, I work with people to reduce their neuropathic pain.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Michigan
Residency: Hospital of the University of Pennsylvania
Fellowship: University of Pennsylvania School of Medicine


American Academy of Neurology, National American Association for the Advancement of Science, International American Association of Electrodiagnostic Medicine, National American Neurological Association, International Charcot-Marie-Tooth Association, National Peripheral Nerve Society, International Society for Neuroscience, International

Hospital Affiliation

Dr. Scherer is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My main interest is the pathogenesis of demyelinating diseases, particularly those caused by mutations in the genes that encode the gap junction proteins Cx32 and Cx47. My current projects in my scientific laboratory relate to (1) the role of Cx32 in the pathogenesis of inherited demyelinating neuropathy, (2) how gap junctions between astrocytes and oligodendrocytes affect the structure/function of CNS myelin, (3) how the myelin sheath organizes the structure of the axon, and (4) animal models of inherited neuropathies. In the clinic, I also participate in a large effort in finding new genetic causes of inherited neuropathies.

Selected Publications:

Panosyan, F.B., M. Laura, A.M. Rossor, C. Pisciotta, G. Piscosquito, J. Burns, J. Li, S. Yum, R.A. Lewis, J.W. Day, R. Horvath, D.N. Herrmann, M.E. Shy, D. Pareyson, M.M. Reilly, and S.S. Scherer: Cross-sectional analysis of a large cohort of patients with X-linked Charcot-Marie-Tooth disease (CMTX1). Neurology (in press) : 2017.

Fehmi, J., S.S. Scherer, H.J. Willison, and S. Rinaldi: Nodes, paranodes, and neuropathy. J. Neurol. Neurosurg. Psychiat. (in press) : 2017.

E. Burnor, E., L. Yang, H. Zhou, K.R. Patterson, C. Quinn, M.M. Reilly, A.M. Rossor, S.S. Scherer, and E. Lancaster: Neurofascin antibodies in autoimmune, genetic, and idiopathic neuropathies. Neurology (in press) : 2017.

Abrams, C. K., M. Goman, S. Wong, S.S. Scherer, K.A. Kleopa, A. Peinado, and M. Freidin: Loss of coupling distinguishes GJB1 mutations associated with CNS manifestations of CMT1X from those without CNS manifestations. Sci. Rep. 7 : 40166,2017.

Rossor, A.M., A.S. Carr, H. Devine, A.L. Pelayo-Negro, D. Pareyson, M.E. Shy, S.S. Scherer, and M.M. Reilly: Peripheral neuropathy in complex inherited diseases: an approach to diagnosis. J. Neurol. Neurosurg. Psychiat. (in press) : 2017.

Laura, M., D. Singh, G. Ramdharry, J. Morrow, M. Skorupinska, D. Pareyson, J. Burns, R.A. Lewis, S.S. Scherer, D.N. Herrmann, N. Cullen, C. Bradish, L. Gaiani, N. Martinelli, P. Gibbons, G. Pfeffer, P. Phisitkul, K. Wapner, J. Sanders, S. Flemister, M.E. Shy, M.M. Reilly, and the Inherited Neuropathies Consortium: Prevalence and orthopedic management of foot and ankle deformities in Charcot-Marie-Tooth disease. Muscle Nerve (in press) : 2017.

Zhao, H. T., S. Damle, K. Ikeda-Lee, S. Kuntz, J. Li, A. Mohan, A. Kim, G. Hung, M.A. Scheideler, S.S. Scherer, J. Svaren, E. E. Swayze, H.B. Kordasiewicz: PMP22 antisense oligonucleotides reverse clinical, pathological, and molecular features of Charcot-Marie-Tooth disease type 1A. J. Clin. Invest. (in press) : 2017.

Thomas, F.P., V. Guergueltcheva, F.A.A. Gondim, I. Tournev, C.V. Rao, B. Ishpekova, L.J. Kinsella, Y. Pan, T.J. Geller, I. Litvinenko, P. Jonghe, S.S. Scherer, and A. Jordanova: Clinical, neurophysiological and morphological study of dominant intermediate Charcot-Marie-Tooth type C neuropathy. J. Neurol. 263 : 467-476,2016.

Kagiava, A., I. Sargiannidou, G. Theophilidis, C. Karaiskos, J. Richter, A. Bashiardes, N. Schiza, M. Nearchou, C. Christodoulou, S.S. Scherer, and K.A. Kleopa: Intrathecal gene delivery rescues a model of demyelinating peripheral neuropathy. Proc. Natl. Acad. Sci. USA 113 : E2421-2429,2016.

Motley, W.W., P. Palaima, S.W. Yum, M.A. Gonzalez, F. Tao, J.V. Wanschitz, A.V. Strickland, W.N. Löscher, E. De Vriendt, S. Koppi, L. Medne, A. Janecke, A. Jordanova, S. Züchner, S.S. Scherer: De novo PMP2 mutations in families with type 1 Charcot-Marie-Tooth disease. Brain 139 : 1649-1656,2016.

View all publications

Academic Contact Info

165 Johnson Pavilion
Philadelphia, PA 19104-6077
Phone: (215) 349-8032
Patient appointments: 800-789-7366 (PENN)

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