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Steven S. Scherer, MD, PhD

Steven S. Scherer, MD, PhD Physician

Chief, Neuromuscular Division
Vice Chair for Academic Development, Department of Neurology
Ruth Wagner Van Meter and J. Ray Van Meter Professor of Neurology

Dr. Scherer is a Penn Medicine employed physician.

About Dr. Steven S. Scherer

Recognized by Best Doctors in America 2007-2008, 2009-2010, 2011-2012, 2013-2014

Clinical Specialties


  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 1990
  • Neuromuscular Medicine, 2012

Clinical Expertise:

  • Autoimmune Neuropathy
  • Diabetic Neuropathy
  • Facial Nerve Rejuvenation
  • Finger Numbness
  • Hand and Finger Weakness
  • Nerve Conduction Studies
  • Nerve Disease
  • Neuropathic Pain
  • Peripheral Nerve Disease
  • Peripheral Nerve Disorders
  • Peripheral Neuropathy
  • Sensory Neuropathy

Description of Clinical Expertise

My clinical work is focused on people who are known (or are suspected to have) a peripheral neuropathy. To diagnose neuropathy, I perform a comprehensive history and focused neurological examination, typically including clinical neurophysiology ("EMG"). This assessment enables me classify someone's neuropathy (examples - diabetic, inherited, chronic inflammatory demyelinating polyneuropathy (CIDP), Guillain-Barre syndrome (GBS), vasculitic, toxic, idiopathic, "small fiber"), and guides further testing. Establishing the correct diagnosis can lead to treatments for neuropathies caused by compression, inflammation, vitamin deficiencies, amyloid, or toxins. In addition, I work with people to reduce their neuropathic pain.

Practice Locations and Appointments

  • Penn Neurology

    Penn Neuroscience Center Perelman Center for Advanced Medicine, South Pavilion, 2nd Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-PENN (7366)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Michigan
Residency: Hospital of the University of Pennsylvania
Fellowship: University of Pennsylvania School of Medicine


American Academy of Neurology, National American Association for the Advancement of Science, International American Association of Electrodiagnostic Medicine, National American Neurological Association, International Charcot-Marie-Tooth Association, National Peripheral Nerve Society, International Society for Neuroscience, International

Hospital Affiliation

Dr. Scherer is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My main interest is the pathogenesis of demyelinating diseases, particularly those caused by mutations in the genes that encode the gap junction proteins Cx32 and Cx47. My current projects in my scientific laboratory relate to (1) the role of Cx32 in the pathogenesis of inherited demyelinating neuropathy, (2) how gap junctions between astrocytes and oligodendrocytes affect the structure/function of CNS myelin, (3) how the myelin sheath organizes the structure of the axon, and (4) animal models of inherited neuropathies. In the clinic, I also participate in a large effort in finding new genetic causes of inherited neuropathies.

Selected Publications:

Scherer, S.S., K.A. Kleopa, and M.D. Benson: Peripheral Neuropathies. In: Rosenberg’s Molecular and Genetic Basis of Neurological and Psychiatric Disease, 5th edition. (in press) : 2015.

Fridman, V., B. Bundy, M.M. Reilly, D. Pareyson, C. Bacon, J. Burns, J. Day, S. Feely, R.S. Finkel, T. Grider, C. Kirk, D.N. Herrmann, M. Laurá, J. Li, T. Lloyd, C. Sumner, F. Muntoni, S. Ramchandren, R. Shy, C.E. Siskind, S. Yum, I. Moroni, E. Pagliano, S. Zuchner, S.S. Scherer, and M.E. Shy: CMT Subtypes and disease burden in patients enrolled in the INC natural history study (6601) from 2009-2013. J. Neurol. Neurosurg. Psychiat. (in press) : 2015.

Baets, J., Duan, X., Wu, Y., Smith, G., Seeley, W., Mademan, I., McGrath, N.M., Beadell, N.C., Khoury, J., Botuyan, M.-V., Mer, G., Worrell, G.A., Hojo, K., Laura, M., Liu, Y.-T., Senderek, J.P., Weis, J., Van den Bergh, P., Merrill, S.L., Reilly, M.M., Houlden, H., Scherer, S.S., De Jonghe, P, Dyck, P. J., Klein, C.J.: Maintenance methyltransferase defect causes a spectrum of neurological diseases. Brain (in press) : 2015.

Abrams, C.K., S.S. Scherer, R. Flores-Obando, S. Wong, E. Lamantea, L. Farina, V. Scaioli, D. Pareyson, E. Salsano: A new mutation in GJC2 associated with subclinical leukodystrophy. J. Neurology 261 : 1929-1938,2014.

King, C.H., E. Lancaster, D. Salomon, E. Peles, S.S. Scherer: Kv7.2 regulates the function of peripheral sensory neurons. J. Comp. Neurol. 522 : 3262-3280,2014.

Willison, H.J. and S.S. Scherer: Ranvier revisited: Novel nodal antigens stimulate interest in GBS pathogenesis. Neurology 83 : 106-108,2014.

Caramins, M., J.G. Colebatch, M.N. Bainbridge, S.S. Scherer, C.K. Abrams, E.L. Hackett, M.M. Freidin, S.N. Jhangiani, M. Wang, Y. Wu, D.M. Muzny, R. Lindeman, R.A. Gibbs.: Exome sequencing identification of a GJB1 missense mutation in a kindred with X-linked spinocerebellar ataxia (SCA-X1). Hum. Mol. Genet. 22 : 4329-4338,2013.

Niu, J., L. Ding, J. Li, H. Kim, J. Liu, H. Li, T. Badea, I.D. Duncan, Y.-J. Son, S.S. Scherer, W. Luo: Modality-based segregation of ascending somatosensory axons in the spinal cord dorsal column. J. Neurosci. 33 : 17691-17709,2013.

Fleisher, J., M. Richie, R. Price, S.S. Scherer, J. Dalmau, and E. Lancaster: Acquired neuromyotonia heralding recurrent thymoma in myasthenia gravis. Arch. Neurol. 69 : 303-311,2013.

Abrams, C.K. and S.S. Scherer: Gap junctions in inherited disorders of the central nervous system. Biochim. Biophys. Acta 1818 : 2030-2047,2012.

View all publications

Academic Contact Info

450 Stemmler Hall
Philadelphia, PA 19104-6077
Phone: (215) 349-5313
Fax: (215) 573-4454
Patient appointments: 800-789-PENN (7366)

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