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Steven S. Scherer, MD, PhD

Steven S. Scherer, MD, PhD Physician

Vice Chair for Academic Development, Department of Neurology Ruth Wagner Van Meter and J. Ray Van Meter Professor of Neurology

Dr. Scherer is employed by Penn Medicine.

About Dr. Steven S. Scherer

Recognized by Best Doctors in America 2007 - 2018

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties

Specialty:

  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 1990

Clinical Expertise:

  • Amyloid Neuropathy
  • Amyotrophic Lateral Sclerosis (ALS)
  • Autoimmune Neuropathy
  • Becker Muscular Dystrophy
  • Charcot Marie Tooth Disease (CMT)
  • Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
  • Congenital Myopathies
  • Diabetic Neuropathy
  • Electrodiagnostic Medicine
  • Electromyography
  • Facioscapulohumeral Muscular Dystrophy
  • Guillain-Barré Syndrome (GBS)
  • Inclusion Body Myositis
  • Kennedy'S Disease
  • Lambert-Eaton Syndrome
  • Limb-Girdle Muscular Dystrophy
  • Lumbosacral Plexus Lesion
  • Motor Neuron Disease
  • Muscular Diseases
  • Muscular Disorders
  • Muscular Dystrophy
  • Myasthenia Gravis (MG)
  • Myopathies
  • Myositis
  • Myotonia
  • Myotonia Congenita
  • Myotonic Dystrophy
  • Nemaline Myopathy
  • Nerve Conduction Studies
  • Neuromuscular Disorders
  • Neuromuscular Therapy
  • Neuropathy
  • Peripheral Nerve Disorders
  • Peripheral Neuropathy
  • Peroneal Muscular Atrophy
  • Peroneal Neuropathy
  • Plexopathy
  • Primary Lateral Sclerosis
  • Progressive Muscular Atrophy
  • Small Fiber Neuropathy
  • Spinal Muscular Atrophy
  • Tibial Neuropathy
  • Toxic Myopathy
  • Ulnar Neuropathy
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Michigan
Residency: Hospital of the University of Pennsylvania
Fellowship: University of Pennsylvania School of Medicine

Memberships

American Academy of Neurology, National American Association for the Advancement of Science, International American Association of Electrodiagnostic Medicine, National American Neurological Association, International Charcot-Marie-Tooth Association, National Peripheral Nerve Society, International Society for Neuroscience, International

Hospital Affiliation

Dr. Scherer is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

RESEARCH INTERESTS
My main interest is the pathogenesis of demyelinating diseases, particularly those caused by mutations in the genes that encode the gap junction proteins Cx32 and Cx47. My current projects in my scientific laboratory relate to (1) the role of Cx32 in the pathogenesis of inherited demyelinating neuropathy, (2) how gap junctions between astrocytes and oligodendrocytes affect the structure/function of CNS myelin, (3) how the myelin sheath organizes the structure of the axon, and (4) animal models of inherited neuropathies. In the clinic, I also participate in a large effort in finding new genetic causes of inherited neuropathies.



Selected Publications:

Dankwa, L., Richardson, J., Motley, W.W., Scavina, M., Bardakjian, T., Züchner, S., Scherer, S.S.: A novel MFN2 mutation causes variable clinical severity in a multi-generational CMT2 family. Neuromusc Dis 29 : 134-137,2019.

Pareyson D., T. Stojkovic, M.M. Reilly, S. Leonard-Louis, M. Laura, J. Blake, Y. Parman, E. Battaloglu, M. Tazir, M. Bellatache, N. Bonello-Palot, M. Levy, S. Sacconi, R. Guimaraes-Costa, S. Attarian, P. Latour, G. Sole, A. Megarbane, R. Horvath, G. Ricci, B.O. Choi, A. Schenone, C. Gemelli, A. Geroldi, M. Sabatelli, M. Luigetti, L. Santoro, R. Manganelli, A. Quattrone, P. Valentino, T. Murakami, S.S. Scherer, L. Dankwa, M.E. Shy, C.J. Bacon, D.N. Herrmann, A. Zambon, I. Tramacere, C. Pisciotta, S. Magri: A multicentre retrospective study of Charcot-Marie-Tooth disease type 4B (CMT4B) due to mutations in myotubularin-related proteins (MTMRs). Ann Neurol. 86 : 55-67,2019.

Tao, F., Beecham, G. W., Rebelo, A. P., Svaren, J., Blanton, S. H., Moran, J. J., Lopez-Anido, C., Morrow, J. M., Abreu, L., Rizzo, D., Kirk, C. A., Wu, X., Feely, S., Verhamme, C., Saporta, M. A., Herrmann, D. N., Day, J. W., Sumner, C. J., Lloyd, T. E., Li, J., Yum, S. W., Taroni, F., Baas, F., Choi, B. O., Pareyson, D., Scherer, S. S., Reilly, M. M., Shy, M. E., Zuchner, S., Inherited Neuropathy, Consortium: Variation in SIPA1L2 is correlated with phenotype modification in Charcot- Marie- Tooth disease type 1A Ann Neurol 85 (3): 316-330,2019.

Phillips, J., Courel, S., Bis-Brewer, D., Rebelo, A., Bardakjian, T., Dankwa, L., Hamedani, A., Züchner, S., Scherer, S.: POLG mutations presenting as CMT. J. Periph. Nerv. Syst. 24 : 214-218,2019.

A. Horga, E. Bugiardini, A. Manole, F. Bremner, Z. Jaunmuktane, L. Dankwa, A.P. Rebelo, C.E. Woodward, I.P. Hargreaves, A. Cortese, A.M. Pittman, S. Brandner, J.M. Polke, R.D.S. Pitceathly, S. Züchner, M.G. Hanna, S.S. Scherer, H. Houlden, M.M. Reilly: Autosomal dominant optic atrophy and cataract “plus” phenotype including axonal neuropathy. Neurol. Genet. 5 : e322,2019.

Allard, D. E., Wang, Y., Li, J. J., Conley, B., Xu, E. W., Sailer, D., Kimpston, C., Notini, R., Smith, C. J., Koseoglu, E., Starmer, J., Zeng, X. L., Howard, J. F., Jr., Hoke, A., Scherer, S. S., Su, M. A.: Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment J Clin Invest 128 (10): 4727-4741,2018.

Lancaster, E., Li, J., Hanania, T., Liem, R., Scheideler, M. A., Scherer, S. S.: Myelinated axons fail to develop properly in a genetically authentic mouse model of Charcot-Marie-Tooth disease type 2E Exp Neurol 308 : 13-25,2018.

Dankwa, L., Richardson, J., Motley, W.W., Züchner, S., Scherer, S.S.: A mutation in the heptad repeat 2 domain of MFN2 in a large CMT2A family J. Periph. Nerv. Syst. 23 : 36-39,2018.

Burnor, E., Yang, L., Zhou, H., Patterson, K. R., Quinn, C., Reilly, M. M., Rossor, A. M., Scherer, S. S., Lancaster, E.: Neurofascin antibodies in autoimmune, genetic, and idiopathic neuropathies Neurology 90 (1): e31-e38,2018.

Bardakjian, TM, Helbig, I, Quinn, C, Elman, LB, McCluskey, LF, Scherer, SS, Gonzalez-Alegre, P: Genetic test utilization and diagnostic yield in adult patients with neurological disorders. Neurogenetics 19 : 105-110,2018.

View all publications

Academic Contact Info

165 Johnson Pavilion
Philadelphia, PA 19104-6077
Phone: (215) 349-8032
Patient appointments: 800-789-7366 (PENN)

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