Description of Research Expertise:
My current research interests are in the translation of various gene transfer technologies into large animal models, up to and including non-human primates.
McCullough BA, Yudkoff M, Batshaw ML, Wilson JM, Raper SE: Genotype spectrum of ornithine transcarbamylase deficiency: correlation with the clinical and biochemical phenotype. American Journal of Medical Genetics 93 (4): 313-9,2000.
Chirmule N, Raper SE, Burkly L, Thomas D, Tazelaar J, Hughes JV: Readministration of adenoviral vector in non-human primate lungs by blockade of CD-40-CD40L interactions.
Journal of Virology 74 : 3345-3352,2000.
Acute pancreatitis secondary to dehydration: Case report and review of the literature.
American Surgeon 65 (11): 1084-1087,1999.
Nunes, FA, Furth EE, Wilson JM, Raper: Gene transfer into the liver of non-human primates with E1-deleted recombinant adenoviral vectors: Safety of readministration.
Human Gene Therapy 10 (15): 2515-2526,1999.
Burke CV, Buettger CW, Davis EA, McClane SJ, Matschinsky FM: Cell biological assessment of human glucokinase mutants causing maturity onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinemia. Biochemical Journal 342 (Pt 2): 345-352,1999.
Chirmule N, Truneh A, Haecker SE, Tazelaar J, Gao G-P, Raper SE, Hughes JV: Repeated administration of adenoviral vectors in lungs of human CD4 transgenic mice treated with a non-depleting CD4 antibody. Journal of Immunology 163 (1): 448-55,1999.
DeMatteo RP, Yeh H, Friscia M, Capparelli D, Burke CV, Desai N, Chu G, Markmann JF, Raper SE: Cellular immunity delimits adenoviral gene therapy strategies for the treatment of neoplastic diseases. Annals of Surgical Oncology 6 (1): 88-94,1999.
Hashimoto M, Kothary P: Phenobarbital in comparison with carbon tetrachloride and phenobarbital induced cirrhosis in rat liver regeneration.
Journal of Surgical Research 81 (2): 164-169,1998.
Hashimoto M, Kothary P: Treatment of cirrhotic rats with epidermal growth factor and insulin accelerates liver DNA synthesis after partial hepatectomy.
Journal of Gastroenterology & Hepatology 13 (12): 1259-1265,1998.
Ye X, Gao G-P, Pabin C, Raper SE: Evaluating the Potential of Germline Transmission after Intravenous Administration of Recombinant Adenovirus in the C3H Mouse.
Human Gene Therapy 9 (14): 2135-2142,1998.
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