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Steven C. Pugliese, MD

Steven C. Pugliese, MD Physician

Director, Pulmonary Embolism Response Team, Hospital University of Pennsylvania Assistant Professor of Clinical Medicine

Dr. Pugliese is employed by Penn Medicine.

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Clinical Specialties


  • Pulmonary Medicine

Programs & Centers:

Board Certification:

  • Critical Care Medicine, 2014
  • Internal Medicine, 2011
  • Pulmonary Disease, 2013

Clinical Expertise:

  • Altitude Sickness (High Altitude Medicine)
  • Cardiopulmonary Disease
  • Critical Care Medicine
  • Dyspnea
  • Lung Disease
  • Pulmonary Hypertension
  • Pulmonary Vascular Diseases
  • Respiratory Disorders
  • Respiratory Gas Exchange
  • Respiratory Physiology
  • Thromboembolism
  • Unexplained Dyspnea

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Drexel University Center City Hahnemann Campus
Residency: Johns Hopkins Hospital
Fellowship: University of Colorado Medical Center


American Thoracic Society Member, International Pulmonary Vascular Research Institute, Member, International

Hospital Affiliation

Dr. Pugliese is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Selected Publications:

Pugliese Steven C, Kumar Sushil, Janssen William J, Graham Brian B, Frid Maria G, Riddle Suzette R, El Kasmi Karim C, Stenmark Kurt R: A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension. Journal of immunology (Baltimore, Md. : 1950) 198 (12): 4802-4812,2017.

Mouradian GC, Gaurav R, Pugliese S, El Kasmi K, Hartman B, Hernandez-Lagunas L, Stenmark KR, Bowler RP, Nozik-Grayck E.: Superoxide Dismutase 3 R213G Single-Nucleotide Polymorphism Blocks Murine Bleomycin-Induced Fibrosis and Promotes Resolution of Inflammation. Am J Respir Cell Mol Biol 56 (3): 362,2017.

Robinson Jeffrey C, Pugliese Steven C, Fox Daniel L, Badesch David B: Anticoagulation in Pulmonary Arterial Hypertension. Current hypertension reports 18 (6): 47,2016.

Pugliese S, Janssen W, El Kasmi K, Stenmark KR: Transcriptomic Profiling of Lung Macrophage Subsets in Hypoxic Pulmonary Hypertension Reveals a Time and Compartment Specific Activation. ATS Meeting : 2016.

Pugliese Steven C, Bull Todd M: Clinical use of extended-release oral treprostinil in the treatment of pulmonary arterial hypertension. Integrated blood pressure control 9 : 1-7,2016.

Pugliese SC, Poth JM, Janssen WJ, Simonian PL, El Kasmi KC, Stenmark KR.: HIF1 and STAT3 Activated Macrophages Are Spatially and Temporally Regulated In Hypoxic Pulmonary Hypertension ATS A1926 : 2015.

Pugliese Steven C, Poth Jens M, Fini Mehdi A, Olschewski Andrea, El Kasmi Karim C, Stenmark Kurt R: The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes. American journal of physiology. Lung cellular and molecular physiology 308 (3): L229-52,2015.

Stenmark KR, Pugliese S, Poth J, Frid MG, Gerasimovskaya E, Nozik-Grayck E, El Kasmi KC: The effects of hypoxia on inflammation and pulmonary vascular function. Pulmonary Hypertension Basic Science to Clinical Medicine. : 83-103,2015.

Robinson JC, Fox DL, Pugliese S, Dempsey JE, Graham BB, Bull T, Badesch D.: Endothelin Receptor Antagonists. Pulmonary Circulation: Diseases and Their Treatment, 4th Ed. : 337-342,2015.

El Kasmi Karim C, Pugliese Steven C, Riddle Suzette R, Poth Jens M, Anderson Aimee L, Frid Maria G, Li Min, Pullamsetti Soni S, Savai Rajkumar, Nagel Maria A, Fini Mehdi A, Graham Brian B, Tuder Rubin M, Friedman Jacob E, Eltzschig Holger K, Sokol Ronald J, Stenmark Kurt R: Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension. Journal of immunology (Baltimore, Md. : 1950) 193 (2): 597-609,2014.

Academic Contact Info

831 Gates building, 3400 Spruce Street
Philadelphia, PA 19104
Phone: (215) 662-6217
Patient appointments: 800-789-7366 (PENN)