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Steven C. Pugliese, MD

Steven C. Pugliese, MD Physician

Director, Pulmonary Embolism Response Team, Hospital University of Pennsylvania Assistant Professor of Clinical Medicine

Dr. Pugliese is employed by Penn Medicine.

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Clinical Specialties


  • Pulmonary Medicine

Programs & Centers:

Board Certification:

  • Critical Care Medicine, 2014
  • Internal Medicine, 2011
  • Pulmonary Disease, 2013

Clinical Expertise:

  • Cardiogenic Shock
  • CT Scan (Computed Tomography)
  • Dyspnea
  • Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu Syndrome)
  • Needle Procedure
  • Pulmonary Embolism (Pulmonary Embolus)
  • Pulmonary Hypertension
  • Pulmonary Veno Occlusive Disease

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Drexel University Center City Hahnemann Campus
Residency: Johns Hopkins Hospital
Fellowship: University of Colorado Medical Center


American Thoracic Society Member, International Pulmonary Vascular Research Institute, Member, International

Hospital Affiliation

Dr. Pugliese is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Selected Publications:

Pugliese SC, Kawut SM.: The Post-Pulmonary Embolism Syndrome: Real or Ruse? Ann Am Thorac Soc 16 (7): 811-814,2019.

Nathan AS, Geng Z, Dayoub EJ, Khatana SAM, Eberly LA, Kobayashi T, Pugliese SC, Adusumalli S, Giri J, Groeneveld PW.: Racial, Ethnic, and Socioeconomic Inequities in the Prescription of Direct Oral Anticoagulants in Patients With Venous Thromboembolism in the United States. Circ Cardiovasc Qual Outcomes 12 (4): 2019.

Pugliese Steven C, Kumar Sushil, Janssen William J, Graham Brian B, Frid Maria G, Riddle Suzette R, El Kasmi Karim C, Stenmark Kurt R: A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension. Journal of immunology (Baltimore, Md. : 1950) 198 (12): 4802-4812,2017.

Mouradian GC, Gaurav R, Pugliese S, El Kasmi K, Hartman B, Hernandez-Lagunas L, Stenmark KR, Bowler RP, Nozik-Grayck E.: Superoxide Dismutase 3 R213G Single-Nucleotide Polymorphism Blocks Murine Bleomycin-Induced Fibrosis and Promotes Resolution of Inflammation. Am J Respir Cell Mol Biol 56 (3): 362,2017.

Robinson Jeffrey C, Pugliese Steven C, Fox Daniel L, Badesch David B: Anticoagulation in Pulmonary Arterial Hypertension. Current hypertension reports 18 (6): 47,2016.

Pugliese S, Janssen W, El Kasmi K, Stenmark KR: Transcriptomic Profiling of Lung Macrophage Subsets in Hypoxic Pulmonary Hypertension Reveals a Time and Compartment Specific Activation. ATS Meeting : 2016.

Pugliese Steven C, Bull Todd M: Clinical use of extended-release oral treprostinil in the treatment of pulmonary arterial hypertension. Integrated blood pressure control 9 : 1-7,2016.

Pugliese SC, Poth JM, Janssen WJ, Simonian PL, El Kasmi KC, Stenmark KR.: HIF1 and STAT3 Activated Macrophages Are Spatially and Temporally Regulated In Hypoxic Pulmonary Hypertension ATS A1926 : 2015.

Pugliese Steven C, Poth Jens M, Fini Mehdi A, Olschewski Andrea, El Kasmi Karim C, Stenmark Kurt R: The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes. American journal of physiology. Lung cellular and molecular physiology 308 (3): L229-52,2015.

Stenmark KR, Pugliese S, Poth J, Frid MG, Gerasimovskaya E, Nozik-Grayck E, El Kasmi KC: The effects of hypoxia on inflammation and pulmonary vascular function. Pulmonary Hypertension Basic Science to Clinical Medicine. : 83-103,2015.

Academic Contact Info

831 Gates building, 3400 Spruce Street
Philadelphia, PA 19104
Phone: (215) 614-1527
Patient appointments: 800-789-7366 (PENN)