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Steven R. Messé, MD

Steven R. Messé, MD Physician

Associate Professor of Neurology at the Hospital of the University of Pennsylvania

Dr. Messé is employed by Penn Medicine.

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About Dr. Steven R. Messé

Recognized by Best Doctors in America 2005-2006, 2007-2008, 2009-2010, 2011-2012

Clinical Specialties


  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 2003
  • Vascular Neurology, 2006

Clinical Expertise:

  • Cerebrovascular Disease

Description of Clinical Expertise

Dr. Messe specializes in caring for inpatients with acute stroke and neurologic illnesses requiring critical care. He is also a member of the intraoperative monitoring team providing neurophysiologic testing to surgical patients at risk of brain, spinal cord, or nerve injury. In the outpatient setting, he primarily cares for patients with stroke and cerebrovascular disease.

Practice Locations and Appointments

  • Penn Neurology

    Penn Neuroscience Center Perelman Center for Advanced Medicine, South Pavilion, 2nd Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Michigan
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Academy of Neurology, International American Heart Association/American Stroke Association, International

Hospital Affiliation

Dr. Messé is employed by Penn Medicine.

Hospital Privileges:

  • Chester County Hospital: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Messe has performed research on risk of carotid endarterectomy, tPA dosing errors, and the management of patients with stroke and PFO. He is currently investigating ischemic neuroprotection medications for high risk surgical patients.

Selected Publications:

Wilson CA, Mullen MT, Jackson BP, Ishida K, Messé SR: Etiology of Corpus Callosum Lesions with Restricted Diffusion Clinical Neuroradiology : 2015.

Messé SR, Fonarow GC, Smith EE, Kaltenbach L, Olson DM, Kasner SE, Schwamm LH.: Use of Tissue-Type Plasminogen Activator Before and After Publication of the European Cooperative Acute Stroke Study III in Get With The Guidelines-Stroke. Circ Cardiovasc Qual Outcomes. : 2012.

Messé SR, McGarvey ML, Bavaria JE, Pochettino A, Szeto WY, Cheung AT, Leitner E, Miller SW, Kasner SE: A Pilot Study of Darbepoetin Alfa for Prophylactic Neuroprotection in Aortic Surgery Neurocritical Care : 2012.

Raser J M, Mullen M T, Kasner S E, Cucchiara B L, Messé S R: Cervical carotid artery dissection is associated with styloid process length. Neurology 77 (23): 2061-6,2011.

Sansing L H, Messe S R, Cucchiara B L, Lyden P D, Kasner S E: Anti-adrenergic medications and edema development after intracerebral hemorrhage. Neurocritical care 14 (3): 395-400,2011.

Messé Steven R, Kasner Scott E, Cucchiara Brett L, Demchuk Andrew, Tanne David, Ouyang Bichun, Levine Steven R,: Dosing errors did not have a major impact on outcome in the NINDS t-PA stroke study. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20 (3): 236-40,2011.

Cucchiara Brett, Kasner Scott, Tanne David, Levine Steven, Demchuk Andrew, Messe Steve, Sansing Lauren, Lees Kennedy, Lyden Patrick,: Validation assessment of risk scores to predict postthrombolysis intracerebral haemorrhage. International journal of stroke : official journal of the International Stroke Society 6 (2): 109-11,2011.

Kurella Tamura Manjula, Xie Dawei, Yaffe Kristine, Cohen Debbie L, Teal Valerie, Kasner Scott E, Messé Steven R, Sehgal Ashwini R, Kusek John, DeSalvo Karen B, Cornish-Zirker Denise, Cohan Janet, Seliger Stephen L, Chertow Glenn M, Go Alan S: Vascular risk factors and cognitive impairment in chronic kidney disease: the Chronic Renal Insufficiency Cohort (CRIC) study. Clinical journal of the American Society of Nephrology : CJASN 6 (2): 248-56,2011.

McKinney James S, Raser Jonathan M, Guzman Miguel A, Schlaepfer William W, Cucchiara Brett L, Messé Steven R, Sansing Lauren H, Kasner Scott E: Noninflammatory Cerebral Vasculopathy Associated with Recurrent Ischemic Strokes. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association : 2010.

Beslow Lauren A, Ichord Rebecca N, Kasner Scott E, Mullen Michael T, Licht Daniel J, Smith Sabrina E, Storm Phillip B, Jordan Lori C, Messé Steven R: ABC/XYZ estimates intracerebral hemorrhage volume as a percent of total brain volume in children. Stroke; a journal of cerebral circulation 41 (4): 691-4,2010.

View all publications

Academic Contact Info

HUP Neurology
Dept. of Stroke and Neurocritical Care
3 W. Gates

Philadelphia, PA 19104
Phone: (215) 662-3363
Patient appointments: 800-789-7366 (PENN)

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