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Steven R. Messé, MD

Steven R. Messé, MD Physician

Associate Professor of Neurology at the Hospital of the University of Pennsylvania

Dr. Messé is employed by Penn Medicine.

About Dr. Steven R. Messé

Recognized by Best Doctors in America 2005-2006, 2007-2008, 2009-2010, 2011-2012

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties


  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 2003
  • Vascular Neurology, 2006

Clinical Expertise:

  • Cerebrovascular Disease

Description of Clinical Expertise

Dr. Messe specializes in caring for inpatients with acute stroke and neurologic illnesses requiring critical care. He is also a member of the intraoperative monitoring team providing neurophysiologic testing to surgical patients at risk of brain, spinal cord, or nerve injury. In the outpatient setting, he primarily cares for patients with stroke and cerebrovascular disease.

Practice Locations and Appointments

  • Penn Neurology

    Penn Neuroscience Center Perelman Center for Advanced Medicine, South Pavilion, 2nd Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Michigan
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Academy of Neurology, International American Heart Association/American Stroke Association, International

Hospital Affiliation

Dr. Messé is employed by Penn Medicine.

Hospital Privileges:

  • Chester County Hospital: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Messe has performed research on risk of carotid endarterectomy, tPA dosing errors, and the management of patients with stroke and PFO. He is currently investigating ischemic neuroprotection medications for high risk surgical patients.

Selected Publications:

Lansky Alexandra J, Messé Steven R, Brickman Adam M, Dwyer Michael, van der Worp H Bart, Lazar Ronald M, Pietras Cody G, Abrams Kevin J, McFadden Eugene, Petersen Nils H, Browndyke Jeffrey, Prendergast Bernard, Ng Vivian G, Cutlip Donald E, Kapadia Samir, Krucoff Mitchell W, Linke Axel, Moy Claudia Scala, Schofer Joachim, van Es Gerrit-Anne, Virmani Renu, Popma Jeffrey, Parides Michael K, Kodali Susheel, Bilello Michel, Zivadinov Robert, Akar Joseph, Furie Karen L, Gress Daryl, Voros Szilard, Moses Jeffrey: Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative. Journal of the American College of Cardiology 69 (6): 679-691,2017.

Mack Michael J, Acker Michael A, Gelijns Annetine C, Overbey Jessica R, Parides Michael K, Browndyke Jeffrey N, Groh Mark A, Moskowitz Alan J, Jeffries Neal O, Ailawadi Gorav, Thourani Vinod H, Moquete Ellen G, Iribarne Alexander, Voisine Pierre, Perrault Louis P, Bowdish Michael E, Bilello Michel, Davatzikos Christos, Mangusan Ralph F, Winkle Rachelle A, Smith Peter K, Michler Robert E, Miller Marissa A, O'Sullivan Karen L, Taddei-Peters Wendy C, Rose Eric A, Weisel Richard D, Furie Karen L: Effect of Cerebral Embolic Protection Devices on CNS Infarction in Surgical Aortic Valve Replacement: A Randomized Clinical Trial. JAMA 318 (6): 536-547,2017.

Messé Steven R: Improving Outcomes From Transcatheter Aortic Valve Implantation: Protecting the Brain From the Heart. JAMA 316 (6): 587-8,2016.

Homma Shunichi, Messé Steven R, Rundek Tatjana, Sun Yee-Ping, Franke Jennifer, Davidson Karina, Sievert Horst, Sacco Ralph L: Patent foramen ovale. Nature reviews. Disease primers 2 : 15086,2016.

Messé Steven R, Khatri Pooja, Reeves Mathew J, Smith Eric E, Saver Jeffrey L, Bhatt Deepak L, Grau-Sepulveda Maria V, Cox Margueritte, Peterson Eric D, Fonarow Gregg C: Why are acute ischemic stroke patients not receiving IV tPA? Results from a national registry. Neurology 87 (15): 1565-1574,2016.

Wilson CA, Mullen MT, Jackson BP, Ishida K: Etiology of Corpus Callosum Lesions with Restricted Diffusion Clinical Neuroradiology : 2015.

Messé SR, Fonarow GC, Smith EE, Kaltenbach L, Olson DM, Kasner SE: Use of Tissue-Type Plasminogen Activator Before and After Publication of the European Cooperative Acute Stroke Study III in Get With The Guidelines-Stroke. Circ Cardiovasc Qual Outcomes. : 2012.

Messé SR, McGarvey ML, Bavaria JE, Pochettino A, Szeto WY, Cheung AT, Leitner E, Miller SW: A Pilot Study of Darbepoetin Alfa for Prophylactic Neuroprotection in Aortic Surgery Neurocritical Care : 2012.

Raser J M, Mullen M T, Kasner S E, Cucchiara B L: Cervical carotid artery dissection is associated with styloid process length. Neurology 77 (23): 2061-6,2011.

Messé Steven R, Kasner Scott E, Cucchiara Brett L, Demchuk Andrew, Tanne David, Ouyang Bichun: Dosing errors did not have a major impact on outcome in the NINDS t-PA stroke study. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20 (3): 236-40,2011.

View all publications

Academic Contact Info

HUP Neurology
Dept. of Stroke and Neurocritical Care
3 W. Gates

Philadelphia, PA 19104
Phone: (215) 662-3363
Patient appointments: 800-789-7366 (PENN)

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