Steven Brem, MD

Headshot of Steven Brem, MD
Penn Medicine Provider

About me

  • Course Director, Annual Penn Brain Tumor CME
  • Site Director, Perelman School of Medicine Surgery Rotation - Neurosurgery at HUP
  • Director, Neurosurgery Medical Student Education
  • Professor CE of Neurosurgery

My education and training

  • Medical School: Harvard University
  • Residency: Massachusetts General Hospital
  • Fellowship: NewYork-Presbyterian/Weill Cornell Medical Center
  • Fellowship: Ronald Reagan UCLA Medical Center

Spoken languages

English
English
Español
Spanish
Français
French

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.
  • Pennsylvania Hospital: On the medical staff, but does not have privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: On the medical staff, but does not have privileges to treat patients in the hospital.
Dr. Brem is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

Richardson TE, Samanamud J, Virata MC, Mir E, Kandoi S, Slocum CC, Shi DD, Savani MR, Yokoda RT, Sharma S, Yong RL, Bederson JB, Silva-Hurtado TJ, Nguyen P, Hiya S, Maldonado- Díaz, Clare K, Vij M, Nishikawa Y, Umphlett M, Hatanpaa KJ, Brem S, Viapiano MS, Snuderl M, Hambardzumyan D, Walker JM, Abdullah KG, McBrayer SK, Tsankova NM. Validation of proposed cIMPACT‑NOW update 12 molecular grading criteria for IDH‑mutant astrocytoma. , Acta Neuropathologica, 152: 2026,9


Virata MC, Samanamud J, Slocum CC, Kandoi S, Nguyen P, Savani MR, Shi DD, Sharma S, Hiya S, Maldonado-Díaz C, Clare K, Yokoda RT, Vij M, Mir E, Nishikawa Y, Umphlett, Yong RL, Bederson JB, Silva-Hurtado TJ, Brem S, Hambardzumyan D, Snuderl, Viapiano MS, Abdullah KG, McBrayer SK, Hatanpaa, Walker JM, Tsankova NM, Richardson TE. Expanding the molecular grading criteria in IDH-mutant astrocytoma. , NeuroOncology, Mar 28:: 2026,noag069


Li EJ, Kraya A, Costa-Pinheiro P, Scheuermann J, Young AJ, Schubert E, Aboian M, Doot R, Ware JB, Pantel A, Storm PB, Resnick AC, Amankulor NM, O’Rourke DM, Desai A, Nasrallah MP, Brem S, Bagley SJ, Mankoff D, Nabavizadeh A Metabolic imaging and molecular signatures reveal metabolic phenotypes in recurrent glioblastoma. , J Nucl Med, 67(6): 2026,849-856


Almasri S, Gandi OH, Wei KL, Rashad MS, Edavettal MJ, Yu N, Ahmed W, Tierradentro-Garcia LO, Feroze A, Brem S, Bagley L, Choudhri O Management strategies and clinical outcomes for thalamic neuroepithelial cysts: 10-year single center experience. , J Clin Neurosci: 2026


Cordell EC, Mansour M, Pantel AR, Schubert E, Nabavizadeh A, Mohan S, Maloney E, Prior T, Angeloni N, Blessing C, Frangos S, Coghlan L, Wileyto EP, O’Rourke DM, Brem S, Desai AS, Bagley SJ. A phase 2 study of niraparib concomitant with tumor treating fields in patients with recurrent grade 4 glioma , Neurooncol Advances, 8(1): 2026


Gujral J, Gandhi OH, Amanullah AA, Singh SB, Ayubcha C, Patil S, Werner TJ, Revheim M-E, Brem S, Alavi A Somatostatin receptor PET in meningioma: diagnosis, therapy, and surveillance , Nucl Med Commun. , 47(5): 2026


181., Wei S, Deng Y, Lee J, Lan H, Yang Z, Labrie M, Betts CB, Duan H, Tate B, Pucilowska J, Frederick D, Lawless AR, Sharova T, Yang Y, Hu W, Beasley GM, Schuchter LM, Wang X, Xu W, Yong G, Vandenberg MEG, Torigian DA, Sivagnanam, Du K, Sugarman E, McGettigan S, Zhen C, Al-Rohil RN, Selim MA, Datto MB, Lopez G, Nair SK, Ashley DM, Xu X, Amaravadi RK, Karakousis GC, O’Rourke DM, Brem S, O’Malley BW, Demirkan G, Yu S, Lu Y, Camp T, Patterson JA, Wei Z, Corless C, Gabrilovich DI, Mou Y, Flaherty KT, Coussens LM, Boland G, Herlyn M, Mills G, Liu L, Zhang G. A longitudinal, multi-omic atlas reveals the emergence of a spatially organized immunosuppressive ecosystem in resistant melanoma. , Cell Rep Med. , 7(4): 2026,102716


Friedes C, Berger M, Linkowski L, Hollawell C, Hubbeling H, Alexander D, Kurtz G, Lustig RA, Dorsey JF, Desai AS, Phillips RE, Brem S, Davatzikos, Nasrallah M, O’Rourke DM, Jackson C, Amankulor NM, Alonso-Basanta, Mohan S, Bagley SJ, Lebow ES Clinical, molecular, and immunologic determinants of survival in WHO-defined IDH-wildtype glioblastoma treated with radiotherapy: a large real-world cohort study. , J Neurooncol, 177(3): 2026


Akbari H, Mohan S, Liu F, Jiang C, Kazerooni AF, Berger M, Rathore S, Bilello M, Sako C, Garcia J, Brem S, Bakas S, Mamourian E, Pepin A, James P, Dorsey J, Singh A, Parker D, Verma R, Cao Q, Bagley SJ, Desai A, O’Rourke DM, Shinohara RT, Nasrallah MP, Teo BK, Kurtz G, Shukla G, Alonso-Basanta M, Lustig RA, Davatzikos C. Personalized machine learning-guided radiation dose escalation in newly diagnosed glioblastoma: A prospective clinical trial with matched controls. , Nature Communications, 17(1): 2026,6413


Kotecha R, Chiang V, Tom MC, Parent EE, Nabavizadeh A, Siegel BA, Huang J, Zan E, Peddi S, Brem S, Ware M, Sulman EP, Kesari S, Pope WB, Holmes R, Chau A, Teoh EJ, Chao ST, Aboian M, and the PURSUE Study Group 18F-fluciclovine-PET for detection of recurrent brain metastases after radiation therapy: Image interpretation criteria and diagnostic performance from the PURSUE study. , Int J Radiat Oncol Biol Phys, 125(5): 2026


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