Steven Brem, MD
Penn Medicine Provider
About me
- Course Director, Annual Penn Brain Tumor CME
- Site Director, Perelman School of Medicine Surgery Rotation - Neurosurgery at HUP
- Director, Neurosurgery Medical Student Education
- Professor CE of Neurosurgery
My education and training
- Medical School: Harvard University
- Residency: Massachusetts General Hospital
- Fellowship: NewYork-Presbyterian/Weill Cornell Medical Center
- Fellowship: Ronald Reagan UCLA Medical Center
Spoken languages
English
English
Español
Spanish
Français
French
Insurance accepted
Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.
Locations
Penn Medicine hospital privileges
- Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.
- Pennsylvania Hospital: On the medical staff, but does not have privileges to treat patients in the hospital.
- Penn Presbyterian Medical Center: On the medical staff, but does not have privileges to treat patients in the hospital.
Qualifications and experience
- Neurological Surgery, 1983
- Advisory Board, Institute of Surgical Excellence, National
- American Brain Tumor Association, National
- American Brain Tumor Association, National
- American Brain Tumor Association-Discovery Grant Panel, National
- Appointed to NIH Review Panel, ZRG1 OTC-T(12)B, Small Business: Cancer Diagnostics and Treatments, National
- Central Brain Tumor Registry of the United States (CBTRUS), National
- Co-Chair, AACR/SNO-Neuro Tumor Club, National
- NCI Review Panel, Cancer Center Support Grant, P30, MD Anderson Comprehensive Cancer Center, National
- NCI Review Panel, Cancer Center Support Grant, P30, UCSF, National
- NCI SPORE Review Panel II, ZCA1 RPRB-0, National
- NCI-UCSF Cancer Center-Core Grant-CCSG-, National
- NIH / NCI, Brain Tumor Program Project Grant, National
- NIH Review Panel, ZRG1 OTC-T(12)B, Small Business: Cancer Diagnostics and Treatments, National
- NIH/NCATS Bench Testing Therapeutic/Indication Pairing Strategies (HU2/UH3) Review Special Emphasis Panel, National
- NIH/NCATS-ZTR1 CI-6-New Therapeutic Uses (NU) X02 Special Emphasis Panel-Grant Review, National
- NIH/NCI Spore Review-ZCA1 RPRB-7(MI) Group, National
- NIH-NCI, Brain Tumor SPORE (P50), ZCA1 RPRB-7 (MI),, National
- Society of Neuro-Oncology, National
Treatments and conditions
Research
Publications
Richardson TE, Samanamud J, Virata MC, Mir E, Kandoi S, Slocum CC, Shi DD, Savani MR, Yokoda RT, Sharma S, Yong RL, Bederson JB, Silva-Hurtado TJ, Nguyen P, Hiya S, Maldonado- Díaz, Clare K, Vij M, Nishikawa Y, Umphlett M, Hatanpaa KJ, Brem S, Viapiano MS, Snuderl M, Hambardzumyan D, Walker JM, Abdullah KG, McBrayer SK, Tsankova NM. Validation of proposed cIMPACT‑NOW update 12 molecular grading criteria for IDH‑mutant astrocytoma. , Acta Neuropathologica, 152: 2026,9
Virata MC, Samanamud J, Slocum CC, Kandoi S, Nguyen P, Savani MR, Shi DD, Sharma S, Hiya S, Maldonado-Díaz C, Clare K, Yokoda RT, Vij M, Mir E, Nishikawa Y, Umphlett, Yong RL, Bederson JB, Silva-Hurtado TJ, Brem S, Hambardzumyan D, Snuderl, Viapiano MS, Abdullah KG, McBrayer SK, Hatanpaa, Walker JM, Tsankova NM, Richardson TE. Expanding the molecular grading criteria in IDH-mutant astrocytoma. , NeuroOncology, Mar 28:: 2026,noag069
Li EJ, Kraya A, Costa-Pinheiro P, Scheuermann J, Young AJ, Schubert E, Aboian M, Doot R, Ware JB, Pantel A, Storm PB, Resnick AC, Amankulor NM, O’Rourke DM, Desai A, Nasrallah MP, Brem S, Bagley SJ, Mankoff D, Nabavizadeh A Metabolic imaging and molecular signatures reveal metabolic phenotypes in recurrent glioblastoma. , J Nucl Med, 67(6): 2026,849-856
Almasri S, Gandi OH, Wei KL, Rashad MS, Edavettal MJ, Yu N, Ahmed W, Tierradentro-Garcia LO, Feroze A, Brem S, Bagley L, Choudhri O Management strategies and clinical outcomes for thalamic neuroepithelial cysts: 10-year single center experience. , J Clin Neurosci: 2026
Cordell EC, Mansour M, Pantel AR, Schubert E, Nabavizadeh A, Mohan S, Maloney E, Prior T, Angeloni N, Blessing C, Frangos S, Coghlan L, Wileyto EP, O’Rourke DM, Brem S, Desai AS, Bagley SJ. A phase 2 study of niraparib concomitant with tumor treating fields in patients with recurrent grade 4 glioma , Neurooncol Advances, 8(1): 2026
Gujral J, Gandhi OH, Amanullah AA, Singh SB, Ayubcha C, Patil S, Werner TJ, Revheim M-E, Brem S, Alavi A Somatostatin receptor PET in meningioma: diagnosis, therapy, and surveillance , Nucl Med Commun. , 47(5): 2026
181., Wei S, Deng Y, Lee J, Lan H, Yang Z, Labrie M, Betts CB, Duan H, Tate B, Pucilowska J, Frederick D, Lawless AR, Sharova T, Yang Y, Hu W, Beasley GM, Schuchter LM, Wang X, Xu W, Yong G, Vandenberg MEG, Torigian DA, Sivagnanam, Du K, Sugarman E, McGettigan S, Zhen C, Al-Rohil RN, Selim MA, Datto MB, Lopez G, Nair SK, Ashley DM, Xu X, Amaravadi RK, Karakousis GC, O’Rourke DM, Brem S, O’Malley BW, Demirkan G, Yu S, Lu Y, Camp T, Patterson JA, Wei Z, Corless C, Gabrilovich DI, Mou Y, Flaherty KT, Coussens LM, Boland G, Herlyn M, Mills G, Liu L, Zhang G. A longitudinal, multi-omic atlas reveals the emergence of a spatially organized immunosuppressive ecosystem in resistant melanoma. , Cell Rep Med. , 7(4): 2026,102716
Friedes C, Berger M, Linkowski L, Hollawell C, Hubbeling H, Alexander D, Kurtz G, Lustig RA, Dorsey JF, Desai AS, Phillips RE, Brem S, Davatzikos, Nasrallah M, O’Rourke DM, Jackson C, Amankulor NM, Alonso-Basanta, Mohan S, Bagley SJ, Lebow ES Clinical, molecular, and immunologic determinants of survival in WHO-defined IDH-wildtype glioblastoma treated with radiotherapy: a large real-world cohort study. , J Neurooncol, 177(3): 2026
Akbari H, Mohan S, Liu F, Jiang C, Kazerooni AF, Berger M, Rathore S, Bilello M, Sako C, Garcia J, Brem S, Bakas S, Mamourian E, Pepin A, James P, Dorsey J, Singh A, Parker D, Verma R, Cao Q, Bagley SJ, Desai A, O’Rourke DM, Shinohara RT, Nasrallah MP, Teo BK, Kurtz G, Shukla G, Alonso-Basanta M, Lustig RA, Davatzikos C. Personalized machine learning-guided radiation dose escalation in newly diagnosed glioblastoma: A prospective clinical trial with matched controls. , Nature Communications, 17(1): 2026,6413
Kotecha R, Chiang V, Tom MC, Parent EE, Nabavizadeh A, Siegel BA, Huang J, Zan E, Peddi S, Brem S, Ware M, Sulman EP, Kesari S, Pope WB, Holmes R, Chau A, Teoh EJ, Chao ST, Aboian M, and the PURSUE Study Group 18F-fluciclovine-PET for detection of recurrent brain metastases after radiation therapy: Image interpretation criteria and diagnostic performance from the PURSUE study. , Int J Radiat Oncol Biol Phys, 125(5): 2026
