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Steven Brem, MD

Steven Brem, MD Physician

Co-Director, Brain Tumor Center Director of Neurosurgical Oncology Professor of Neurosurgery at the Hospital of the University of Pennsylvania

Languages spoken:

  • French
  • Spanish

Dr. Brem is employed by Penn Medicine.

About Dr. Steven Brem

Recognized by America's Top Doctors, 2012 - 2017

Recognized by Best Doctors in America 2015 - 2018

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Neurosurgery

Programs & Centers:

Board Certification:

  • Neurological Surgery, 1983

Clinical Expertise:

  • Abnormal Vertebrae
  • Absent Vertebrae
  • Accessory Nerve Injury
  • Acoustic Neurofibromatosis
  • Acoustic Neuroma (Vestibular Schwannoma)
  • Acoustic Neuroma Removal
  • Acromegaly
  • Anaplastic Astrocytoma
  • Anaplastic Ependymoma
  • Anaplastic Mixed Glioma
  • Anaplastic Oligoastrocytoma
  • Aneurysms
  • Ankylosing Spondylitis
  • Anterior Temporal Lobectomy
  • Anterior Vertebral Body Tethering
  • Aqueductal Stenosis
  • Arachnoid Cyst
  • Arnold Chiari Malformation
  • Arterial Malformation of the Brain
  • Arteriovenous Malformations (AVM)
  • Artificial Disc Replacement Surgery in the Cervical Spine
  • Artificial Disc Replacement Surgery in the Lumbar Spine
  • Astrocytic Cancer
  • Astrocytoma Tumors
  • Auditory Brainstem Implant
  • AVM Embolization
  • Awake Craniotomy
  • Back Injuries
  • Back Surgery
  • Benign Neoplasm of Brain
  • Berry Aneurysm
  • Biological Enhancement of Spinal Fusion
  • Biopsy of the Brain
  • Biopsy of the Skull
  • Bone Cyst
  • Bone Growth Stimulator
  • Bone Tumors
  • Brachial Nerve Tumors
  • Brachial Plexus Injury
  • Brain Cancer Genomics
  • Brain Laceration
  • Brain Metastasis
  • Brain Surgery
  • Brain Tumor Bleeding
  • Brain Tumors
  • Broken Coccyx
  • Bulging Disc
  • Burr Hole
  • Carotid Stenosis
  • Cauda Equina Syndrome
  • Cavernous Hemangioma
  • Cavernous Sinus Thrombosis
  • Central Nervous System Tumors
  • Central Venous Stenosis
  • Cerebellar Tumor
  • Cerebral Aneurysm
  • Cerebral Angiogram
  • Cerebral Angiogram with Aneurysm Embolization
  • Cerebral Angiogram with Coiling
  • Cerebral Angiogram with Stenting
  • Cerebral Artery Bypass Surgery
  • Cerebral Cyst
  • Cerebral Decompression
  • Cerebral Edema
  • Cerebral Hernia
  • Cerebral Revascularization
  • Cerebrospinal Fluid (CSF) Leak
  • Cerebrovascular Accident
  • Cerebrovascular Bypass Surgery
  • Cervical Arthritis
  • Cervical Bone Spur
  • Cervical Compression Fracture
  • Cervical Decompression
  • Cervical Deformity
  • Cervical Disc Degeneration
  • Cervical Disc Disease
  • Cervical Disc Displacement
  • Cervical Disc Herniation
  • Cervical Laminoplasty
  • Cervical Laminotomy
  • Cervical Radiculopathy
  • Cervical Revision Surgery
  • Cervical Spinal Fracture
  • Cervical Spinal Fusion Surgery
  • Cervical Spinal Stenosis
  • Cervical Spine Surgery
  • Cervical Steroid Injection
  • Chiari Decompression
  • Cholesteatoma
  • Chordoma
  • Choroid Plexus Tumor
  • Cingulotomy
  • Clipping of Brain Aneurysm
  • Clivus Chondroma
  • CNS Lymphoma
  • Coccyx Injury
  • Colloid Cyst
  • Common Carotid Artery Embolization
  • Complex Spinal Deformities
  • Complex Spinal Surgery
  • Compression Fractures
  • Congenital Malformation of the Spine
  • Congenital Scoliosis
  • Cordotomy
  • Corpus Callosotomy Surgery
  • Cortical Mapping
  • Cranial Nerve Disorders
  • Cranial Nerve Injuries
  • Cranial Nerve Palsy
  • Cranial Nerve Repair
  • Cranial Puncture
  • Craniectomy
  • Craniocele
  • Craniocervical Junction Surgery
  • Craniopharyngioma
  • Craniotomy
  • CSF Shunt Removal
  • Decompression Laminectomy
  • Decompression Median Nerve At Elbow
  • Deep Brain Stimulation
  • Deep Brain Stimulation for Dystonia
  • Deep Brain Stimulation while Asleep
  • Deep Brain Stimulation while Awake
  • Degenerative Spine Conditions
  • Disc Arthroplasty
  • Disc Replacement
  • Disc Surgery
  • Diskectomy
  • Dorsal Column Stimulator
  • Dural Arteriovenous Fistula
  • Dural Based Tumor
  • Dural Sinus Thrombosis
  • Dystonia
  • EGFR Translocation
  • Electrocorticography
  • Embryonal Cell Tumors of the Brain
  • Embryonal Tumors
  • Encephalocele Repair
  • Endodermal Sinus Tumor
  • Endonasal Transsphenoidal Approach
  • Endoscopic Endonasal Approach
  • Endoscopic Fusion
  • Endoscopic Neurosurgery
  • Endoscopic Third Ventriculostomy
  • Ependymoma
  • Epidural Hematoma
  • Epidural Hemorrhage
  • Epidural Injection
  • Epilepsy
  • Epilepsy Surgery
  • Erdheim-Chester Disease
  • Essential Tremor
  • Evaluation for Epilepsy Surgery
  • Extradural Abscess
  • Extreme Lateral Interbody Fusion
  • Facet Injection
  • Facet Surgery
  • Facial Nerve Schwannoma
  • Facial Pain
  • Facial Spasm
  • Failed Back Surgery Syndrome (FBSS)
  • Fibrillary Astrocytoma
  • Flatback Syndrome Post Harrington Rods
  • Flow Diversion for Cerebral Aneurysms
  • Foot Drag
  • Gamma Knife
  • Gamma Knife Perfexion
  • Ganglioglioneurocytoma
  • Ganglioma
  • Ganglioneuroblastoma
  • Ganglioneurocytoma
  • Germ Cell Tumors
  • Germinoma
  • Glioblastoma
  • Glioma
  • Gliomatosis Cerebri
  • Gliosarcoma
  • Glomus Jugulare Tumor
  • Glossopharyngeal Neuralgia
  • Growing Rods
  • Head and Neck Osteoma
  • Head Reconstruction
  • Hemangioblastoma
  • Hemangiopericytoma
  • Hemispherectomy
  • Herniated Disc
  • Hydrocephalus
  • Hypothalamic Hamartoma
  • Image Guided Biopsy of the Spine
  • Injury of Optic Chiasm
  • Intracranial Abscess
  • Intracranial Arterial Bypass
  • Intracranial Arterial Occlusion
  • Intracranial Hemangioma
  • Intracranial Hemorrhage
  • Intracranial Hypotension
  • Intracranial Mass
  • Intraoperative MRI
  • Intraspinal Abscess
  • Intraventricular Endoscopy
  • Intraventricular Tumor
  • Junctional Kyphosis
  • Juvenile Nasopharyngeal Angiofibroma (JNA)
  • Kyphosis
  • Laminectomy
  • Laminoplasty
  • Lateral Access Spine Surgery
  • Leptomeningeal Carcinomatosis
  • Leptomeningeal Disease
  • Lesion of Median Nerve
  • Lesion of Popliteal Nerve
  • Lesion of Posterior Tibial Nerve
  • Lesion of Sciatic Nerve
  • Lesionectomies
  • Lesionectomy
  • Lhermitte-Duclos Disease
  • Lipomyelomeningocele
  • Lobectomy of Brain
  • Low Back Surgery
  • Lower Back Injuries
  • Lower Back Pain
  • Lumbar Drain
  • Lumbar Scoliosis
  • Lumbar Spinal Fracture
  • Lumbar Spinal Fusion
  • Lumbar Spinal Injury
  • Lumbar Spinal Mass
  • Lumbar Spinal Stenosis
  • Lumbar Spinal Tumor
  • Lumbar Stress Fracture
  • Lumboperitoneal Shunt Placement
  • Lumbosacral Plexus Lesion
  • Lumbosacral Radiculopathy
  • Malignant Neoplasm of the Brain Stem
  • Malignant Neoplasm of the Cerebellum
  • Malignant Neoplasm of the Frontal Lobe
  • Malunion Fracture of the Spine
  • Medulloblastoma
  • Medulloepithelioma
  • Meningioma
  • Meningocele
  • Metastatic Brain Cancer
  • Microdiscectomy
  • Microneurosurgery
  • Microsurgery
  • Microvascular Decompression
  • Microvascular Surgery
  • Minimally Invasive Partial Lumbar Discectomy
  • Minimally Invasive Spinal Fusion
  • Minimally Invasive Spine Surgery
  • Minimally Invasive Surgery
  • Moyamoya
  • Myelopathy
  • Myelopathy Surgery
  • Myxopapillary Ependymoma
  • Neck Masses and Lumps
  • Neck Tumors
  • Needle Biopsy of Brain
  • Needle Biopsy of Cerebral Meninges
  • Neoplasm of Brain Stem
  • Nerve Sheath Tumor
  • Neuroblastoma
  • Neurocutaneous Disorders
  • Neuroectodermal Tumor
  • Neuroendocrine Tumors
  • Neuroendoscopy
  • Neurofibromatosis
  • Neurofibromatosis Type 1 (NF1)
  • Neurofibromatosis Type 2
  • Neurofibrosarcoma
  • Neurogenic Claudication
  • Neurointerventional Biplane Angiography System
  • Neuromuscular Scoliosis
  • Neuronal Glial Tumors
  • Nonruptured Cerebral Aneurysm
  • Normal Pressure Hydrocephalus
  • Occipito-Cervical Fusion
  • Olfactory Neuroblastoma
  • Oligoastrocytoma
  • Oligodendroglioma
  • Open Biopsy of the Brain
  • Optic Nerve Decompression
  • Optic Nerve Glioma
  • Optic Nerve Sheath Meningioma
  • Optic Nerve Surgery
  • Orbital Nerve Decompression
  • Orbital Tumors
  • Osteoarthritis of the Spine
  • Paraganglioma
  • Parkinson's Disease
  • Parkinson's Surgery
  • Percutaneous Trigeminal Rhizotomy
  • Peripheral Nerve Disorders
  • Peripheral Nerve Surgery
  • Peripheral Nerve Tumors
  • Peripheral Schwannoma
  • Periventricular Lesion
  • Periventricular Mass
  • Personal History of Malignant Neoplasm of Brain
  • Petrous Apex Tumor
  • Pilocytic Astrocytoma
  • Pineal Gland Parenchymal Tumor
  • Pineal Tumor
  • Pineoblastoma
  • Pituitary Adenoma
  • Pituitary Surgery
  • Pituitary Tumors
  • Posterior Cervical Laminectomy and Fusion
  • Posterior Lumbar Laminectomy
  • Post-Laminectomy Kyphosis
  • Post-Laminectomy Syndrome
  • Primary Brain Tumor
  • Prolactinoma
  • Radiculopathy
  • Rathke's Cleft Cysts
  • Repair of Brain
  • Resection of Cerebral Arteriovenous Malformation
  • Retinoblastoma
  • Revision of Spinal Surgery
  • Rhizotomy
  • Robotic Spine Surgery
  • Ruptured Brain Aneurysm
  • Ruptured Intervertebral Disc
  • Sacral Nerve Stimulation
  • Sacroiliac Joint Block
  • Sacroiliac Joint Fusion
  • Sacroiliac Joint Surgery
  • Scheuermann Disease
  • Scheuermann's Kyphosis
  • Schwannomatosis
  • Sciatica
  • Scoliosis Surgery
  • Selective Dorsal Rhizotomy
  • Sinonasal Undifferentiated Carcinoma
  • Skull Base Approach
  • Skull Base Tumors
  • Skull Fracture
  • Spina Bifida
  • Spinal Abscess
  • Spinal Abscess Surgery
  • Spinal Cord Cancer
  • Spinal Cord Compression
  • Spinal Cord Disorder
  • Spinal Cord Stimulator
  • Spinal Cord Surgery
  • Spinal Cord Tumors
  • Spinal Cyst Removal
  • Spinal Deformity
  • Spinal Dural Graft
  • Spinal Embolization
  • Spinal Fracture
  • Spinal Fusion
  • Spinal Mass
  • Spinal Meningioma
  • Spinal Microsurgery
  • Spinal Reconstruction
  • Spinal Schwannoma
  • Spinal Stenosis
  • Spinal Tethering for Scoliosis
  • Spinal Tumor
  • Spine Decompression
  • Spine Deformity
  • Spine Deformity Correction Surgery
  • Spine Injuries
  • Spine Stapling
  • Spondylectomy
  • Spondyloarthropathy
  • Spondylolisthesis
  • Spondylosis
  • Spondylosis Surgery
  • Spondylosis With Myelopathy
  • Spondylosyndesis
  • Spongioblastoma
  • Standard Transsphenoidal Approach
  • Stereotactic Brain Biopsy
  • Stereotactic EEG
  • Stereotactic Radiosurgery
  • Stereotactic Radiotherapy
  • Subarachnoid Hemorrhage
  • Subcaudate Tractotomy
  • Subdural Hematoma
  • Subdural Hemorrhage
  • Subependymal Giant Cell Astrocytoma
  • Subpial Transection
  • Superior Canal Dehiscence
  • Surgery for Sciatica
  • Surgery for Spasticity
  • Surgical Treatment of Myelopathy
  • Sympathectomy
  • Syringobulbia
  • Syringomyelia
  • Tarlov Cysts
  • Temporal Tumor
  • Tethered Spinal Cord
  • Thoracic Disc Herniation
  • Thoracic Laminectomy
  • Thoracic Spinal Fracture
  • Thoracic Spinal Fusion
  • Thoracic Spinal Injury
  • Thoracic Spinal Mass
  • Thoracic Spinal Stenosis
  • Thoracic Spinal Tumor
  • Topectomy
  • Transnasal Repair CSF Leak
  • Transpetrosal Approaches
  • Trigeminal Nerve Disorders
  • Ulnar Nerve Decompression
  • Ulnar Nerve Surgery
  • Vagal Nerve Stimulator
  • Vagal Stimulation
  • Vascular Brain Tumors
  • Vascular Malformations of the Brain
  • Vascular Malformations of the Spine
  • Vein of Galen Malformation
  • Venous Malformation Brain
  • Ventricular Shunt
  • Ventriculo Peritoneal Shunt
  • Ventriculocisternostomy
  • Ventriculostomy
  • Vertebrae Surgery
  • Vertebral Epiphysitis
  • Vertebral Fracture
  • Vertebral Stapling
  • Visualase MRI-Guided Laser Ablation
  • X-Stop Surgery
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Harvard University
Residency: Massachusetts General Hospital
Fellowship: NewYork-Presbyterian/Weill Cornell Medical Center
Fellowship: University of California, Los Angeles


Advisory Board, Institute of Surgical Excellence, National American Brain Tumor Association, National American Brain Tumor Association, National Appointed to NIH Review Panel, ZRG1 OTC-T(12)B, Small Business: Cancer Diagnostics and Treatments, National Central Brain Tumor Registry of the United States (CBTRUS), National Co-Chair, AACR/SNO-Neuro Tumor Club, National NCI Review Panel, Cancer Center Support Grant, P30, MD Anderson Comprehensive Cancer Center, National NCI Review Panel, Cancer Center Support Grant, P30, UCSF, National NCI SPORE Review Panel II, ZCA1 RPRB-0, National NCI-UCSF Cancer Center-Core Grant-CCSG-, National NIH / NCI, Brain Tumor Program Project Grant, National NIH Review Panel, ZRG1 OTC-T(12)B, Small Business: Cancer Diagnostics and Treatments, National NIH/NCATS Bench Testing Therapeutic/Indication Pairing Strategies (HU2/UH3) Review Special Emphasis Panel, National NIH/NCATS-ZTR1 CI-6-New Therapeutic Uses (NU) X02 Special Emphasis Panel-Grant Review, National NIH/NCI Spore Review-ZCA1 RPRB-7(MI) Group, National Society of Neuro-Oncology, National

Hospital Affiliation

Dr. Brem is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Angiogenesis, Neuro-Oncology, Translational Drug Discovery, Personalized Medicine, Genomics, Biomarkers, Experimental Therapeutics, Brain Mapping, Health Outcomes, Brain Metastases, Clinical Guidelines, Clinical Pathways, Glioma Invasion, Targeted Brain Tumor Therapies

Selected Publications:

Liu Tianrun, Ma Wenjuan, Xu Haineng, Huang Menggui, Zhang Duo, He Zhenqiang, Zhang Lin, Brem Steven, O'Rourke Donald M, Gong Yanqing, Mou Yonggao, Zhang Zhenfeng, Fan Yi: PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma. Nature communications 9 (1): 3439,2018.

Liau Linda M, Ashkan Keyoumars, Tran David D, Campian Jian L, Trusheim John E, Cobbs Charles S, Heth Jason A, Salacz Michael, Taylor Sarah, D'Andre Stacy D, Iwamoto Fabio M, Dropcho Edward J, Moshel Yaron A, Walter Kevin A, Pillainayagam Clement P, Aiken Robert, Chaudhary Rekha, Goldlust Samuel A, Bota Daniela A, Duic Paul, Grewal Jai, Elinzano Heinrich, Toms Steven A, Lillehei Kevin O, Mikkelsen Tom, Walbert Tobias, Abram Steven R, Brenner Andrew J, Brem Steven, Ewend Matthew G, Khagi Simon, Portnow Jana: Correction to: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma. Journal of translational medicine 16 (1): 179,2018.

Liau Linda M, Ashkan Keyoumars, Tran David D, Campian Jian L, Trusheim John E, Cobbs Charles S, Heth Jason A, Salacz Michael, Taylor Sarah, D'Andre Stacy D, Iwamoto Fabio M, Dropcho Edward J, Moshel Yaron A, Walter Kevin A, Pillainayagam Clement P, Aiken Robert, Chaudhary Rekha, Goldlust Samuel A, Bota Daniela A, Duic Paul, Grewal Jai, Elinzano Heinrich, Toms Steven A, Lillehei Kevin O, Mikkelsen Tom, Walbert Tobias, Abram Steven R, Brenner Andrew J, Brem Steven, Ewend Matthew G, Khagi Simon, Portnow Jana: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma. Journal of translational medicine 16 (1): 142,2018.

Chawla Sanjeev, Wang Sumei, Mohan Suyash, Nasrallah MacLean, Verma Gaurav, Brem Steven, O'Rourke Donald M, Wolf Ronald L, Poptani Harish, Nabavizadeh S Ali: Differentiation of brain infection from necrotic glioblastoma using combined analysis of diffusion and perfusion MRI. Journal of magnetic resonance imaging : JMRI : 2018.

Wang Qirui, He Zhenqiang, Huang Menggui, Liu Tianrun, Wang Yanling, Xu Haineng, Duan Hao, Ma Peihong, Zhang Lin, Zamvil Scott S, Hidalgo Juan, Zhang Zhenfeng, O'Rourke Donald M, Dahmane Nadia, Brem Steven, Mou Yonggao, Gong Yanqing, Fan Yi: Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α. Nature communications 9 (1): 559,2018.

Prateek Agarwal, Arka N. Mallela, Nicholas Goel, Joseph Durgin, Donald M. O’Rourke, Kalil G. Abdullah, Steven Brem: Factors Associated with Ventriculoperitoneal Shunt Dependency Following Glioblastoma Resection Proceedings of AANS : 2018.

Ahmed FI, Durgin J, Agarwal P, MacFawn, O, Barrow M, O’Rourke DM, Abdullah KG, Brem S: Quantifying Extent of Resection Thresholds for Increased Survival in Elderly Patients with Glioblastoma Proceedings of AANS : 2018.

Ahmed FI, Abdullah KG, Durgin J, Jayaram M, Biggiani G, O’Rourke DM, Brem S: Evaluating the Association Between Extent of Resection and Survival in Gliosarcoma Proceedings of AANS : 2018.

Snyder KJG, Ahmed FI, Brem S, Abdullah KG: Use of decision analytics modeling to assist in neurosurgical decision making: a feasibility study in elderly patients undergoing glioblastoma resection versus biopsy Proceedings of AANS : 2018.

Kalil G. Abdullah1, Nicholas J. Goel1, Prateek Agarwal1, Arka N. Mallela, Eileen Maloney Wilensky, Donald M. O’Rourke, Steven Brem: Factors associated with increased survival in patients undergoing 3 or more resections of recurrent glioblastoma Proceedings of AANS : 2018.

Academic Contact Info

3400 Spruce Street, 3rd Floor Silverstein
Department of Neurosurgery

Philadelphia, PA 19104
Phone: (215) 662-3487
Patient appointments: 800-789-7366 (PENN)

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