Description of Research Expertise

Angiogenesis, Neuro-Oncology, Translational Drug Discovery, Personalized Medicine, Genomics, Biomarkers, Experimental Therapeutics, Brain Mapping, Health Outcomes, Brain Metastases, Clinical Guidelines, Clinical Pathways, Glioma Invasion, Targeted Brain Tumor Therapies, Connectomics, IL-6, cytokines, Viral Oncolytics,

Selected Publications

Fathi Kazerooni A, Saxena S, Toorens E, Tu D, Bashyam V, Akbari H, Mamourian E, Sako C, Koumenis C, Verginadis I, Verma R, Shinohara RT, Desai AS, Lustig RA, Brem S, Mohan S, Bagley SJ, Ganguly T, O'Rourke DM, Bakas S, Nasrallah MP, Davatzikos C.: Clinical measures, radiomics, and genomics offer synergistic value in AI-based prediction of overall survival in patients with glioblastoma Sci Rep 12 : 8784,2022.

Reed-Guy L, Desai AS, Phillips RE, Croteau D, Albright K, O'Neill M, Brem S, O'Rourke DM, Amankulor NM, Bagley SJ.: Risk of intracranial hemorrhage with direct oral anticoagulants versus low molecular weight heparin in glioblastoma: A retrospective cohort study Neuro Oncol : 2022.

Dimentberg R, Borja AJ, Glauser G, Brem S, Choudhri OA.: Endoscopic fenestration of a giant frontal arachnoid cyst: Operative technique and anatomical nuances Clin Case Rep 10 : e05386,2022.

Nazem A, Guiry SC, Pourfathi M, Ware JB, Anderson H, Iyer SK, Moon BF, Fan Y, Witschey WR, Rizi R, Bagley SJ, Desai A, O'Rourke DM, Brem S, Nasrallah M, Nabavizadeh A.: MR susceptibility imaging for detection of tumor-associated macrophages in�glioblastoma J Neurooncol : 2022.

Chawla S, Asadollahi S, Gupta PK, Nath K, Brem S, Mohan S.: Advanced magnetic resonance imaging and spectroscopy in a case of neurocysticercosis from North America Neuroradiol J : 2022.

Lucas A, Eberwine JH, Bagley SJ, Fan Y, Nasrallah MP, Brem S.: Commentary: "Zooming in" on Glioblastoma: Understanding Tumor Heterogeneity and Its Clinical Implications in the Era of Single-Cell Ribonucleic Acid Sequencing Neurosurgery 89 : E262-E263,2021.

Lucas A, Eberwine JH, Bagley SJ, Fan Y, Nasrallah M, Brem S.: Withdrawn as duplicate: Commentary: "Zooming in" on Glioblastoma: Understanding Tumor Heterogeneity and its Clinical Implications in the Era of Single-Cell Ribonucleic Acid Sequencing Neurosurgery 89 : E237-E238,2021.

Ellingson BM, Sampson J, Achrol AS, Aghi MK, Bankiewicz K, Wang C, Bexon M, Brem S, Brenner A, Chowdhary S, Floyd JR, Han S, Kesari S, Randazzo D, Vogelbaum MA, Vrionis F, Zabek M, Butowski N, Coello M, Merchant N, Merchant F.: Modified RANO, Immunotherapy RANO, and Standard RANO Response to Convection-Enhanced Delivery of IL4R-Targeted Immunotoxin MDNA55 in Recurrent Glioblastoma Clin Cancer Res 27 : 3916-3925,2021.

Samani ZR, Parker D, Wolf R, Hodges W, Brem S, Verma R.: Distinct tumor signatures using deep learning-based characterization of the peritumoral microenvironment in glioblastomas and brain metastases Sci Rep 11 : 14469,2021.

Henderson F Jr, Parker D, Vijayakumari AA, Elliott M, Lucas T, McGarvey ML, Karpf L, Desiderio L, Harsch J, Levy S, Maloney-Wilensky E, Wolf RL, Hodges WB, Brem S, Verma R.: Enhanced Fiber Tractography Using Edema Correction: Application and Evaluation in High-Grade Gliomas Neurosurgery 89 : 246-256,2021.

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Academic Contact Information

Department of Neurosurgery
PCAM South - Room 15-141
3400 Civic Center Blvd
Philadelphia, PA 19104
Phone: 215-662-3487
Patient appointments: 800-789-7366