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Steven Brem, MD

Steven Brem, MD Physician

Chief, Neurosurgical Oncology Co-Director, Penn Brain Tumor Center Course Director, Annual Penn Brain Tumor CME Site Director, Perelman School of Medcine, Surgery Rotation- Neurosurgery/HUP Professor of Neurosurgery at the Hospital of the University of Pennsylvania

Languages spoken:

  • French
  • Spanish

Dr. Brem is employed by Penn Medicine.

About Dr. Steven Brem

Recognized by America's Top Doctors, 2012 - 2017

Recognized by Best Doctors in America 2015 - 2018

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Neurosurgery

Programs & Centers:

Board Certification:

  • Neurological Surgery, 1983

Clinical Expertise:

  • Acoustic Neurofibromatosis
  • Acoustic Neuroma (Vestibular Schwannoma)
  • Acoustic Neuroma Removal
  • Anaplastic Astrocytoma
  • Anaplastic Ependymoma
  • Anaplastic Mixed Glioma
  • Anaplastic Oligoastrocytoma
  • Anterior Temporal Lobectomy
  • Aqueductal Stenosis
  • Arachnoid Cyst
  • Arnold Chiari Malformation
  • Astrocytic Cancer
  • Astrocytoma Tumors
  • Awake Craniotomy
  • Back Injuries
  • Benign Neoplasm of Brain
  • Biopsy of the Brain
  • Biopsy of the Skull
  • Brain Cancer Genomics
  • Brain Laceration
  • Brain Metastasis
  • Brain Surgery
  • Brain Tumor Bleeding
  • Brain Tumors
  • Burr Hole
  • Cavernous Sinus Thrombosis
  • Central Nervous System Infection
  • Central Nervous System Tumors
  • Cerebellar Tumor
  • Cerebral Cyst
  • Cerebral Decompression
  • Cerebral Edema
  • Cerebral Hernia
  • Cerebrospinal Fluid (CSF) Leak
  • Cervical Decompression
  • Cervical Laminotomy
  • Cervical Spinal Stenosis
  • Chiari Decompression
  • Cholesteatoma
  • Chordoma
  • Choroid Plexus Tumor
  • Cingulotomy
  • Clivus Chondroma
  • CNS Lymphoma
  • Colloid Cyst
  • Cortical Mapping
  • Cranial Nerve Disorders
  • Cranial Nerve Injuries
  • Cranial Nerve Palsy
  • Cranial Nerve Repair
  • Cranial Puncture
  • Craniectomy
  • Craniocele
  • Craniocervical Junction Surgery
  • Craniopharyngioma
  • Craniotomy
  • CSF Shunt Removal
  • Decompression Laminectomy
  • Degenerative Spine Conditions
  • Dural Based Tumor
  • EGFR Translocation
  • Electrocorticography
  • Embryonal Cell Tumors of the Brain
  • Embryonal Tumors
  • Encephalocele Repair
  • Endodermal Sinus Tumor
  • Endonasal Transsphenoidal Approach
  • Ependymoma
  • Epidural Hematoma
  • Epidural Hemorrhage
  • Epilepsy
  • Epilepsy Surgery
  • Extradural Abscess
  • Facial Nerve Schwannoma
  • Facial Pain
  • Facial Spasm
  • Fibrillary Astrocytoma
  • Gamma Knife
  • Gamma Knife Perfexion
  • Ganglioglioneurocytoma
  • Ganglioma
  • Ganglioneuroblastoma
  • Ganglioneurocytoma
  • Germ Cell Tumors
  • Germinoma
  • Glioblastoma
  • Glioma
  • Gliomatosis Cerebri
  • Gliosarcoma
  • Glomus Jugulare Tumor
  • Glossopharyngeal Neuralgia
  • Head and Neck Osteoma
  • Head Reconstruction
  • Hemangioblastoma
  • Hemangiopericytoma
  • Herniated Disc
  • Hydrocephalus
  • Hypothalamic Hamartoma
  • Injury of Optic Chiasm
  • Intracranial Abscess
  • Intracranial Hemorrhage
  • Intracranial Mass
  • Intraoperative MRI
  • Intraspinal Abscess
  • Intraventricular Endoscopy
  • Intraventricular Tumor
  • Laminectomy
  • Leptomeningeal Carcinomatosis
  • Leptomeningeal Disease
  • Lesionectomies
  • Lesionectomy
  • Lipomyelomeningocele
  • Lobectomy of Brain
  • Lumbar Drain
  • Lumbar Spinal Mass
  • Lumbar Spinal Stenosis
  • Lumbar Spinal Tumor
  • Lumboperitoneal Shunt Placement
  • Lumbosacral Radiculopathy
  • Malignant Neoplasm of the Brain Stem
  • Malignant Neoplasm of the Cerebellum
  • Malignant Neoplasm of the Frontal Lobe
  • Medulloblastoma
  • Medulloepithelioma
  • Meningioma
  • Meningocele
  • Metastatic Brain Cancer
  • Microdiscectomy
  • Microneurosurgery
  • Microsurgery
  • Microvascular Decompression
  • Microvascular Surgery
  • Myelopathy
  • Myelopathy Surgery
  • Myxopapillary Ependymoma
  • Neck Masses and Lumps
  • Neck Tumors
  • Needle Biopsy of Brain
  • Needle Biopsy of Cerebral Meninges
  • Neoplasm of Brain Stem
  • Nerve Sheath Tumor
  • Neuroblastoma
  • Neurocutaneous Disorders
  • Neuroectodermal Tumor
  • Neuroendocrine Tumors
  • Neuroendoscopy
  • Neurofibromatosis
  • Neurofibromatosis Type 1 (NF1)
  • Neurofibromatosis Type 2
  • Neurofibrosarcoma
  • Neurogenic Claudication
  • Neuronal Glial Tumors
  • Normal Pressure Hydrocephalus
  • Olfactory Neuroblastoma
  • Oligoastrocytoma
  • Oligodendroglioma
  • Open Biopsy of the Brain
  • Optic Nerve Decompression
  • Optic Nerve Glioma
  • Optic Nerve Sheath Meningioma
  • Optic Nerve Surgery
  • Orbital Nerve Decompression
  • Orbital Tumors
  • Paraganglioma
  • Periventricular Lesion
  • Periventricular Mass
  • Personal History of Malignant Neoplasm of Brain
  • Petrous Apex Tumor
  • Pilocytic Astrocytoma
  • Pineal Gland Parenchymal Tumor
  • Pineal Tumor
  • Pineoblastoma
  • Pituitary Adenoma
  • Pituitary Surgery
  • Pituitary Tumors
  • Posterior Lumbar Laminectomy
  • Primary Brain Tumor
  • Prolactinoma
  • Radiculopathy
  • Rathke's Cleft Cysts
  • Repair of Brain
  • Retinoblastoma
  • Ruptured Brain Aneurysm
  • Ruptured Intervertebral Disc
  • Scheuermann Disease
  • Scheuermann's Kyphosis
  • Schwannomatosis
  • Sinonasal Undifferentiated Carcinoma
  • Skull Base Approach
  • Skull Base Tumors
  • Skull Fracture
  • Spinal Abscess
  • Spinal Abscess Surgery
  • Spinal Cord Cancer
  • Spinal Cord Compression
  • Spinal Cord Disorder
  • Spinal Cord Surgery
  • Spinal Cord Tumors
  • Spinal Deformity
  • Spinal Dural Graft
  • Spinal Fracture
  • Spinal Mass
  • Spinal Meningioma
  • Spinal Microsurgery
  • Spinal Schwannoma
  • Spinal Stenosis
  • Spinal Tumor
  • Spine Decompression
  • Spondylosis
  • Spondylosis With Myelopathy
  • Spongioblastoma
  • Standard Transsphenoidal Approach
  • Stereotactic Brain Biopsy
  • Stereotactic Radiosurgery
  • Stereotactic Radiotherapy
  • Subdural Hematoma
  • Subdural Hemorrhage
  • Subependymal Giant Cell Astrocytoma
  • Subpial Transection
  • Surgery for Sciatica
  • Surgical Treatment of Myelopathy
  • Temporal Tumor
  • Thoracic Laminectomy
  • Thoracic Spinal Mass
  • Thoracic Spinal Stenosis
  • Thoracic Spinal Tumor
  • Topectomy
  • Transpetrosal Approaches
  • Trigeminal Nerve Disorders
  • Vascular Brain Tumors
  • Ventricular Shunt
  • Ventriculo Peritoneal Shunt
  • Ventriculostomy
  • Vertebrae Surgery
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Harvard University
Residency: Massachusetts General Hospital
Fellowship: NewYork-Presbyterian/Weill Cornell Medical Center
Fellowship: University of California, Los Angeles


Advisory Board, Institute of Surgical Excellence, National American Brain Tumor Association, National American Brain Tumor Association, National Appointed to NIH Review Panel, ZRG1 OTC-T(12)B, Small Business: Cancer Diagnostics and Treatments, National Central Brain Tumor Registry of the United States (CBTRUS), National Co-Chair, AACR/SNO-Neuro Tumor Club, National NCI Review Panel, Cancer Center Support Grant, P30, MD Anderson Comprehensive Cancer Center, National NCI Review Panel, Cancer Center Support Grant, P30, UCSF, National NCI SPORE Review Panel II, ZCA1 RPRB-0, National NCI-UCSF Cancer Center-Core Grant-CCSG-, National NIH / NCI, Brain Tumor Program Project Grant, National NIH Review Panel, ZRG1 OTC-T(12)B, Small Business: Cancer Diagnostics and Treatments, National NIH/NCATS Bench Testing Therapeutic/Indication Pairing Strategies (HU2/UH3) Review Special Emphasis Panel, National NIH/NCATS-ZTR1 CI-6-New Therapeutic Uses (NU) X02 Special Emphasis Panel-Grant Review, National NIH/NCI Spore Review-ZCA1 RPRB-7(MI) Group, National Society of Neuro-Oncology, National

Hospital Affiliation

Dr. Brem is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Angiogenesis, Neuro-Oncology, Translational Drug Discovery, Personalized Medicine, Genomics, Biomarkers, Experimental Therapeutics, Brain Mapping, Health Outcomes, Brain Metastases, Clinical Guidelines, Clinical Pathways, Glioma Invasion, Targeted Brain Tumor Therapies

Selected Publications:

Makhlin Igor, Salinas Ryan D, Zhang Daniel, Jacob Fadi, Ming Gou-Li, Song Hongjun, Saxena Deeksha, Dorsey Jay F, Nasrallah MacLean P, Morrissette Jennifer Jd, Binder Zev A, O'Rourke Donald M, Desai Arati S, Brem Steven, Bagley Stephen J: Clinical activity of the tyrosine kinase inhibitor osimertinib in -mutant glioblastoma. CNS oncology 8 (3): CNS43,2019.

Hoffman Daniel I, Abdullah Kalil G, McCoskey Makayla, Binder Zev A, O'Rourke Donald M, Desai Arati S, Nasrallah MacLean P, Bigdeli Ashkan, Morrissette Jennifer J D, Brem Steven, Bagley Stephen J: Negative prognostic impact of epidermal growth factor receptor copy number gain in young adults with isocitrate dehydrogenase wild-type glioblastoma. Journal of neuro-oncology 145 (2): 321-328,2019.

Cho Steve S, Salinas Ryan, De Ravin Emma, Teng Clare W, Li Carrie, Abdullah Kalil G, Buch Love, Hussain Jasmin, Ahmed Fahad, Dorsey Jay, Mohan Suyash, Brem Steven, Singhal Sunil, Lee John Y K: Near-Infrared Imaging with Second-Window Indocyanine Green in Newly Diagnosed High-Grade Gliomas Predicts Gadolinium Enhancement on Postoperative Magnetic Resonance Imaging. Molecular imaging and biology : 2019.

Bagley Stephen J, Nabavizadeh S Ali, Mays Jazmine J, Till Jacob E, Ware Jeffrey B, Levy Scott, Sarchiapone Whitney, Hussain Jasmin, Prior Timothy, Guiry Samantha, Christensen Theresa, Yee Stephanie S, Nasrallah MacLean P, Morrissette Jennifer J D, Binder Zev A, O'Rourke Donald M, Cucchiara Andrew J, Brem Steven, Desai Arati S, Carpenter Erica L: Clinical Utility of Plasma Cell-Free DNA in Adult Patients with Newly Diagnosed Glioblastoma: A Pilot Prospective Study. Clinical cancer research : an official journal of the American Association for Cancer Research : 2019.

Nabavizadeh S Ali, Akbari Hamed, Ware Jeffrey B, Nasrallah MacLean, Guiry Samantha, Bagley Stephen J, Desai Arati, Levy Scott, Sarchiapone Whitney, Prior Timothy, Detre John, Wolf Ronald L, O'Rourke Donald M, Brem Steven, Davatzikos Christos: Arterial Spin Labeling and Dynamic Susceptibility Contrast-enhanced MR Imaging for evaluation of arteriovenous shunting and tumor hypoxia in glioblastoma. Scientific reports 9 (1): 8747,2019.

Ramayya Ashwin G, Chen H Isaac, Marcotte Paul J, Brem Steven, Zager Eric L, Osiemo Benjamin, Piazza Matthew, Sharma Nikhil, McClintock Scott D, Schuster James M, Ali Zarina S, Connolly Patrick, Heuer Gregory G, Grady M Sean, Kung David K, Ozturk Ali K, O'Rourke Donald M, Malhotra Neil R: Assessing variability in surgical decision making among attending neurosurgeons at an academic center. Journal of neurosurgery : 1-7,2019.

Ahmed Fahad I, Abdullah Kalil G, Durgin Joseph, Salinas Ryan D, O'Rourke Donald M, Brem Steven: Evaluating the Association Between the Extent of Resection and Survival in Gliosarcoma. Cureus 11 (4): e4374,2019.

Nasrallah MacLean P, Binder Zev A, Oldridge Derek A, Zhao Jianhua, Lieberman David B, Roth Jacquelyn J, Watt Christopher D, Sukhadia Shrey, Klinman Eva, Daber Robert D, Desai Arati, Brem Steven, O'Rourke Donald M, Morrissette Jennifer J D: Molecular Neuropathology in Practice: Clinical Profiling and Integrative Analysis of Molecular Alterations in Glioblastoma. Academic pathology 6 : 2374289519848353,2019.

Bagley Stephen J, Hwang Wei-Ting, Brem Steven, Linette Gerald P, O'Rourke Donald M, Desai Arati S: RNA-seq for identification of therapeutically targetable determinants of immune activation in human glioblastoma. Journal of neuro-oncology 141 (1): 95-102,2019.

Bagley Stephen J, Schwab Robert D, Nelson Ernest, Viaene Angela N, Binder Zev A, Lustig Robert A, O'Rourke Donald M, Brem Steven, Desai Arati S, Nasrallah MacLean P: Histopathologic quantification of viable tumor versus treatment effect in surgically resected recurrent glioblastoma. Journal of neuro-oncology 141 (2): 421-429,2019.

View all publications

Academic Contact Info

3400 Spruce Street, 3rd Floor Silverstein
Department of Neurosurgery

Philadelphia, PA 19104
Phone: (215) 662-3487
Patient appointments: 800-789-7366 (PENN)

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