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Steven Brem, MD

Steven Brem, MD Surgeon

Co-Director, Brain Tumor Center
Director of Neurosurgical Oncology
Professor of Neurosurgery at the Hospital of the University of Pennsylvania

Languages spoken:

  • French
  • Spanish

Dr. Brem is a Penn Medicine employed physician.

About Dr. Steven Brem

Recognized by America's Top Doctors, 2012-14

Clinical Specialties

Specialty:

  • Neurosurgery

Programs & Centers:

Board Certification:

  • Neurological Surgery, 1983

Clinical Expertise:

  • Acoustic Neuromas
  • Brain Cancer
  • Brain Cancer Gene Therapy
  • Brain Metastasis
  • Brain Tumors
  • Cancer Clinical Trials
  • Cancer Surgery
  • Gamma Knife®
  • Glioma
  • Meningioma
  • Neuro-Oncology
  • Radiosurgery
  • Skull Base Cancer
  • Spinal Tumor
  • Spondylosis

Description of Clinical Expertise

Complex Brain Tumor Surgery; Surgery of Intrinsic and Metastatic Brain Tumors; Pituitary Tumors; Acoustic Neuromas; Meningiomas; Skull Base Surgery; Brain Mapping; Health Outcomes; Evidence-Based Medicine;

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Harvard Medical School
Residency: Massachusetts General Hospital
Fellowship: NewYork-Presbyterian/Weill Cornell Medical Center
Fellowship: University of California, Los Angeles

Memberships

Advisory Board, Institute of Surgical Excellence, National American Brain Tumor Association, National Appointed to NIH Review Panel, ZRG1 OTC-T(12)B, Small Business: Cancer Diagnostics and Treatments, National Central Brain Tumor Registry of the United States (CBTRUS), National Co-Chair, AACR/SNO - Neuro Tumor Club, National NCI Review Panel, Cancer Center Support Grant, P30, MD Anderson Comprehensive Cancer Center, National NCI Review Panel, Cancer Center Support Grant, P30, UCSF, National NCI SPORE Review Panel II, ZCA1 RPRB-0, National NIH / NCI, Brain Tumor Program Project Grant, National NIH Review Panel, ZRG1 OTC-T(12)B, Small Business: Cancer Diagnostics and Treatments, National NIH/NCATS-ZTR1 CI-6 - New Therapeutic Uses (NU) X02 Special Emphasis Panel - Grant Review, National Society of Neuro-Oncology, National

Hospital Affiliation

Dr. Brem is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Angiogenesis, Neuro-Oncology, Translational Drug Discovery, Personalized Medicine, Genomics, Biomarkers, Experimental Therapeutics, Brain Mapping, Health Outcomes, Brain Metastases, Clinical Guidelines, Clinical Pathways, Glioma Invasion, Targeted Brain Tumor Therapies

Selected Publications:

O’Rourke DM, Nasrallah MP, Morrissette J, Melenhorst JJ, Lacey SF, Mansfield K, Martinez-Lage M, Desai A, Brem S, Maloney E, Mohan S, Wang S, Verma G, Navenot J-M, Shen A, Zheng Z, Levine BL, Okada H, June CH, Maus M: Phase I study of T cells redirected to EGFRvIII with a chimeric antigen receptor in patients with EGFRvIII+ glioblastoma. AACR Annual Meeting : 2016.

Brem S, Wong E, Desai A, Fan Y, Pan E: Angiogenesis and brain tumors. Youmans and Winn Neurological Surgery : 2016.

Thawani JP, Brem S: The story of glioblastoma: History and modern correlates. Glioblastoma : 2016.

Abdullah KG, Miller JA, Brem S: Recurrent glioblastoma. Glioblastoma : 2016.

Abdullah KG, Brem S: The molecular pathogenesis of glioblastoma. Glioblastoma : 2016.

Verma G, Poptani H, Nasrallah M, Thomas A, Brem S, Mohan S.: Chemical Shift Imaging (CSI) for detection of 2-hydroxyglutarate (2HG) in human gliomas at 3T. Radiol Soc North Amer (RSNA) : 2015.

Verma G, Mohan S, Nasrallah M, Thomas MA, Desai A, Desiderio L, Poptani H.: Two-dimensional localized correlated spectroscopy (2D L-COSY) at 7T for detection of 2-hydroxyglutarate in gliomas with IDH mutations. Radiol Soc North Amer (RSNA) : 2015.

O’Rourke DM, Desai A, Morrissette JD, Martinez-Lage M, Nasrallah M, Brem S, Maloney E, Shen A, Mohan S, Wang S, Verma G, Lacey S, Melenhorst J, Navenot J-M, Zheng Z, Levine BL, Okada H, June C, Maus M.: IMCT-15*Pilot study of T cells redirected to EGFRvIII with a chimeric antigen receptor in patients with EGFRvIII+ glioblastoma. Neuro-Oncology : 2015.

Alonso-Basanta M, Lee J, Miller D, Kurtz K, Dorsey J, Kolker J, Nagda S, Geiger G, Brem S, O’Rourke D, Zager E: Novel prognostic scores for survival and intracranial failure in patients treated with radiosurgery alone to melanoma brain metastases. American Society of Therapeutic Radiology and Oncology (ASTRO) : 2015.

Ulyanova A, Lee J-H, Brem S, Lucas T, O’Rourke D, Grovola M, Wang J, Na Y, Singh J, Smith D, Kim J, Eberwine J, Sul J-Y, Grady S, Wolf J: Electrophysiological phenotyping of human neurons in slices and dissociated culture. National Neurotrauma Society : 2015.

Academic Contact Info

3400 Spruce Street, 3rd Floor Silverstein
Department of Neurosurgery

Philadelphia, PA 19104
Phone: (215) 662-7854
Patient appointments: 800-789-PENN (7366)

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