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Steven Brem, MD

Steven Brem, MD Surgeon

Co-Director, Brain Tumor Center Director of Neurosurgical Oncology Professor of Neurosurgery at the Hospital of the University of Pennsylvania

Languages spoken:

  • French
  • Spanish

Dr. Brem is employed by Penn Medicine.

About Dr. Steven Brem

Recognized by America's Top Doctors, 2012-14

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties

Specialty:

  • Neurosurgery

Programs & Centers:

Board Certification:

  • Neurological Surgery, 1983

Clinical Expertise:

  • Acoustic Neuromas
  • Brain Cancer
  • Brain Cancer Gene Therapy
  • Brain Metastasis
  • Brain Tumors
  • Cancer Clinical Trials
  • Cancer Surgery
  • Gamma Knife
  • Glioma
  • Meningioma
  • Radiosurgery
  • Skull Base Cancer
  • Spinal Tumor
  • Spondylosis

Description of Clinical Expertise

Complex Brain Tumor Surgery; Surgery of Intrinsic and Metastatic Brain Tumors; Pituitary Tumors; Acoustic Neuromas; Meningiomas; Skull Base Surgery; Brain Mapping; Health Outcomes; Evidence-Based Medicine;

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Harvard University
Residency: Massachusetts General Hospital
Fellowship: NewYork-Presbyterian/Weill Cornell Medical Center
Fellowship: University of California, Los Angeles

Memberships

Advisory Board, Institute of Surgical Excellence, National American Brain Tumor Association, National American College of Surgeons, National Angiogenesis and Invasion Committee, NABTT CNS Brain Tumor Consortium, National Appointed to NCI Comprehensive Cancer Core Grant , National Appointed to NCI Program Project Review Panel, ZCA1 GRB-P, Discovery, Imaging, and Therapeutics, National Appointed to NIH Review Panel, ZRG1 OTC-T(12)B, Small Business: Cancer Diagnostics and Treatments, National Brain Tumor Action Network, National Central Brain Tumor Registry of the United States (CBTRUS), National Co-Chair, AACR/SNO - Neuro Tumor Club, National Florida Brain Tumor Research Center (House Bill 1449), National Florida Center for Brain Tumor Research, National International Society of Environmental Toxicology and Cancer, International NABTT Consortium, National Cancer Institute and Participating Medical Centers, National NCI Review Panel, Cancer Center Support Grant, P30, MD Anderson Comprehensive Cancer Center, National NCI Review Panel, Cancer Center Support Grant, P30, UCSF, National NCI SPORE Review Panel II, ZCA1 RPRB-0, National NCI/NIH Review Committee – SPORE Grants for Brain, Head/Neck and Lung Tumors, National NIH / NCI, Brain Tumor Program Project Grant, National NIH / NCI, Clinical Studies Subcommittee D, National NIH Review Panel, ZRG1 OTC-T(12)B, Small Business: Cancer Diagnostics and Treatments, National NIH/NCATS Bench Testing Therapeutic/Indication Pairing Strategies (HU2/UH3) Review Special Emphasis Panel, National NIH/NCATS-ZTR1 CI-6 - New Therapeutic Uses (NU) X02 Special Emphasis Panel - Grant Review, National NIH/NCI Spore Review - ZCA1 RPRB-7(MI) Group, National NIH/NCI, National Society of Neuro-Oncology, National

Hospital Affiliation

Dr. Brem is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Angiogenesis, Neuro-Oncology, Translational Drug Discovery, Personalized Medicine, Genomics, Biomarkers, Experimental Therapeutics, Brain Mapping, Health Outcomes, Brain Metastases, Clinical Guidelines, Clinical Pathways, Glioma Invasion, Targeted Brain Tumor Therapies

Selected Publications:

Prateek Agarwal, Arka N. Mallela, Nicholas Goel, Joseph Durgin, Donald M. O’Rourke, Kalil G. Abdullah: Factors Associated with Ventriculoperitoneal Shunt Dependency Following Glioblastoma Resection Proceedings of AANS : 2018.

Ahmed FI, Abdullah KG, Durgin J, Jayaram M, Biggiani G, O’Rourke DM: Evaluating the Association Between Extent of Resection and Survival in Gliosarcoma Proceedings of AANS : 2018.

Snyder KJG, Ahmed FI, Brem S: Use of decision analytics modeling to assist in neurosurgical decision making: a feasibility study in elderly patients undergoing glioblastoma resection versus biopsy Proceedings of AANS : 2018.

Kalil G. Abdullah1, Nicholas J. Goel1, Prateek Agarwal1, Arka N. Mallela, Eileen Maloney Wilensky, Donald M. O’Rourke: Factors associated with increased survival in patients undergoing 3 or more resections of recurrent glioblastoma Proceedings of AANS : 2018.

Kalil G. Abdullah, Nicholas J. Goel, Prateek Agarwal, Arka N. Mallela, Eileen Maloney Wilensky, Donald M. O’Rourke: Factors associated with increased survival in patients undergoing 3 or more resections of recurrent glioblastoma Proceedings of AANS : 2018.

Ahmed FI, Durgin J, Agarwal P, MacFawn, O, Barrow M, O’Rourke DM, Abdullah KG: Quantifying Extent of Resection Thresholds for Increased Survival in Elderly Patients with Glioblastoma Proceedings of AANS : 2018.

O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL: A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Science Translational Medicine 9 (399): 2017.

Thawani Jayesh P, Singh Nickpreet, Pisapia Jared M, Abdullah Kalil G, Parker Drew, Pukenas Bryan A, Zager Eric L, Verma Ragini: Three-Dimensional Printed Modeling of Diffuse Low-Grade Gliomas and Associated White Matter Tract Anatomy. Neurosurgery 80 (4): 635-645,2017.

Spaethling Jennifer M, Na Young-Ji, Lee Jaehee, Ulyanova Alexandra V, Baltuch Gordon H, Bell Thomas J, Brem Steven, Chen H Isaac, Dueck Hannah, Fisher Stephen A, Garcia Marcela P, Khaladkar Mugdha, Kung David K, Lucas Timothy H, O'Rourke Donald M, Stefanik Derek, Wang Jinhui, Wolf John A, Bartfai Tamas, Grady M Sean, Sul Jai-Yoon, Kim Junhyong: Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics. Cell reports 18 (3): 791-803,2017.

Strickland-Marmol Leah B, Brem Steven, Rojiani Amyn M: Vessel morphometric parameters-correlation with histologic grade and VEGF expression in oligodendroglioma. American journal of cancer research 7 (4): 973-981,2017.

Academic Contact Info

3400 Spruce Street, 3rd Floor Silverstein
Department of Neurosurgery

Philadelphia, PA 19104
Phone: (215) 662-3487
Patient appointments: 800-789-7366 (PENN)

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