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Steven M. Albelda, MD

Steven M. Albelda, MD Physician

Vice Chief and Director, Lung Research, Pulmonary and Critical Care Medicine William Maul Measey Professor of Medicine

Dr. Albelda is a Penn Medicine employed physician.

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Clinical Specialties

Specialty:

  • Pulmonary Medicine

Programs & Centers:

Board Certification:

  • Pulmonary Disease, 1984

Clinical Expertise:

  • Gene Therapy
  • Mesothelioma

Practice Locations and Appointments

  • Harron Lung Center

    Perelman Center for Advanced Medicine West Pavilion, 1st Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Cancer Society Research Grant Review Committee (Cell Biology and Metastasis) (6/1997 - 2000), National American Heart Association: Southeastern Pennsylvania Peer Review Committee, National American Lung Association: National Research Grant Review Committee, National American Society for Clinical Investigation, National American Society of Gene Therapy, 2004-2008 Committee Member, Cancer Gene Therapy Committee, National American Society of Gene Therapy, 2006-2008 Chairman, Cancer Gene Therapy Program, National American Thoracic Society, National Laenec Society of Pulmonary Physicians, Local Member of Executive Committee, International Mesothelioma Interest Group, International Mesothelioma Applied Research Foundation Grant Review Committee, National National Cancer Institute: Ad Hoc Study Reviewer: Cancer Immunology and Immunotherapy, National National Cancer Institute: Ad Hoc Study Reviewer: Cancer Immunology and Immunotherapy, National National Cancer Institute: Ad Hoc Study Reviewer: Cancer Therapeutics, National National Cancer Institute: Ad Hoc Study Reviewer: Cancer Therapeutics, National National Cancer Institute: Ad Hoc Study Reviewer: Tumor Microenvironment (2/10), National National Cancer Institute: Ad Hoc Study Reviewer: Tumor Microenvironment (2008), National National Cancer Institute: Ad Hoc Study Section "Contemporary Approaches to Ovarian Cancer Biology Research" (12/92), National National Cancer Institute: Ad Hoc Study Section for Review of the Johns Hopkins Comprehensive Cancer Center (10/00), National National Cancer Institute: Ad Hoc Study Section to Review Loan Repayment Applications (3/06), National National Cancer Institute: Ad Hoc Study Section to Review Loan Repayment Applications (3/07), National National Cancer Institute: Ad Hoc Study Section to Review Lung and Prostate SPORE grants (10/00), National National Cancer Institute: Ad Hoc Study Section to Review Lung SPORE grants (02/09), National National Cancer Institute: Ad Hoc Study Section to Review Lung SPORE grants (10/02), National National Cancer Institute: Ad Hoc Study Section to Review Program Project (1/03), National National Cancer Institute: Ad Hoc Study Section to Review Program Project (2/04), National National Cancer Institute: Ad Hoc Study Section to Review R21 grants (7/03), National National Cancer Institute: Ad Hoc Study Section to Review RC3 and R43 grants (11/09), National National Cancer Institute: Ad Hoc Study Section to Review RFA in Inflammation and Lung Cancer (2007), National National Cancer Institute: Internal Thoracic and GI Program Reviewer, National National Institutes of Health (NHLBI): Ad Hoc Study Section to Review T32 Training grants (11/05), National National Institutes of Health: Ad Hoc Study Section - NHLBI (10/96), SCOR Grant for Atherosclerosis and Biology of the Vessel Wall , National National Institutes of Health: Ad Hoc Study Section (1/98), Program Project for NHLBI , National National Institutes of Health: Ad Hoc Study Section (12/93), "Program Project in Arthritis and Rheumatologic Diseases", National National Institutes of Health: Ad Hoc Study Section (3/93) - "Asthma, and Allergic, and Immunological Disease Cooperative Research Centers", National National Institutes of Health: Ad Hoc Study Section (3/95), "Asthma, and Allergic, and Immunological Disease Cooperative Research Centers", National National Institutes of Health: Ad Hoc Study Section (8/96), "Program Project in Characterization and Inhibiting Astrocytoma Growth", National National Institutes of Health: Ad Hoc Study Section 9/96 - Internal Review of the Medicine Branch, National National Institutes of Health: Lung Biology and Pathology Study Section (10/93) , National National Institutes of Health: Lung Biology and Pathology Study Section, Ad Hoc Member (10/98), National National Institutes of Health: Lung Biology Special Emphasis Panel, (3/99) Ad Hoc Member, National National Institutes of Health: Member - Recombinant DNA Advisory Council (9/04-9/08), National Sigma Xi, Research Society of North America, Associate Member, National

Hospital Affiliation

Dr. Albelda is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Immuno-gene Therapy for Thoracic Malignancies
Lung cancer and other thoracic malignancies are the leading cause of cancer deaths in the United States today. The Thoracic Oncology Research Laboratory is focusing on the design of new treatment strategies for lung cancer and mesothelioma based on the rapidly evolving disciplines of molecular biology, immunotherapy, and gene therapy.
Dr. Albelda’s research is translational in focus and includes animal models, work with human tumor samples, and the conduct of clinical trials. This work is primarily funded through a recently renewed Program Project from the National Cancer Institute and participation in a number of RO1 grants.
The tumor microenvironment is one area of active study. Studies are underway with the goals of 1) a better understanding of the biology of the tumor microenvironment with a focus on the immunuosuppressive activities of white blood cells and fibroblasts, 2) novel approaches to alter the tumor microenvironment to enhance immunotherapy including studying effects using COX-2 inhibitors, TGFbeta inhibitors, T-regulatory cell inhibitors., antibodies against B-cells, and chemotherapeutic drugs. A second area of interest in the lab is the use of adoptive T cell transfer to treat lung malignancies. Studies are underway to modify T cells in order to make them traffic more efficiently into tumors, to have better killing function, and to resist inactivation by the tumor microenvironment. A T cells targeting cancer-associated fibroblasts is being developed. In addition, Dr. Albelda is closely involved with a number of immunogene clinical trials at Penn using an adenovirus expressing the immune-activator interferon-alpha that is instilled into the pleural space of mesothelioma patients (in collaboration with Dr. Daniel Sterman) and T cells altered to attack the mesothelioma tumor target, mesothelin (in collaboration with Drs. Carl June and Andrew Haas).

Selected Publications:

Moon Edmund K, Langer Corey J, Albelda Steven M: The Era of Checkpoint Blockade in Lung Cancer: Taking the Brakes Off the Immune System. Annals of the American Thoracic Society : 2017.

Chen Xiao, Yang Yizeng, Berger Ian, Khalid Urooj, Patel Akash, Cai Jenny, Farwell Michael D, Langer Corey, Aggarwal Charu, Albelda Steven M, Katz Sharyn I: Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging. Oncotarget 8 (15): 24213-24223,2017.

Wang Liqing, Kumar Suresh, Dahiya Satinder, Wang Feng, Wu Jian, Newick Kheng, Han Rongxiang, Samanta Arabinda, Beier Ulf H, Akimova Tatiana, Bhatti Tricia R, Nicholson Benjamin, Kodrasov Mathew P, Agarwal Saket, Sterner David E, Gu Wei, Weinstock Joseph, Butt Tauseef R, Albelda Steven M, Hancock Wayne W: Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity. EBioMedicine 13 : 99-112,2016.

Shaul Merav E, Levy Liran, Sun Jing, Mishalian Inbal, Singhal Sunil, Kapoor Veena, Horng Wenhwai, Fridlender Gil, Albelda Steven M, Fridlender Zvi G: Tumor-associated neutrophils display a distinct N1 profile following TGFβ modulation: A transcriptomics analysis of pro- vs. antitumor TANs. Oncoimmunology 5 (11): e1232221,2016.

Sterman DH, Alley E, Stevenson JP, Friedberg J, Metzger S, Recio A, Moon EK, Haas AR, Vachani A, Katz SI, Sun J, Heitjan DF, Hwang WT, Litzky L, Yearley JH, Tan KS, Papasavvas E, Kennedy P, Montaner LJ, Cengel KA, Simone CB, Culligan M, Langer CJ, Albelda SM: Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-Interferon-alpha Combined with Chemotherapy Clinical Cancer Research 22 (15): 3791-3800,2016.

Condamine Thomas, Dominguez George A, Youn Je-In, Kossenkov Andrew V, Mony Sridevi, Alicea-Torres Kevin, Tcyganov Evgenii, Hashimoto Ayumi, Nefedova Yulia, Lin Cindy, Partlova Simona, Garfall Alfred, Vogl Dan T, Xu Xiaowei, Knight Stella C, Malietzis George, Lee Gui Han, Eruslanov Evgeniy, Albelda Steven M, Wang Xianwei, Mehta Jawahar L, Bewtra Meenakshi, Rustgi Anil, Hockstein Neil, Witt Robert, Masters Gregory, Nam Brian, Smirnov Denis, Sepulveda Manuel A, Gabrilovich Dmitry I: Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients. Science immunology 1 (2): 2016.

Singhal Sunil, Bhojnagarwala Pratik S, O'Brien Shaun, Moon Edmund K, Garfall Alfred L, Rao Abhishek S, Quatromoni Jon G, Stephen Tom Li, Litzky Leslie, Deshpande Charuhas, Feldman Michael D, Hancock Wayne W, Conejo-Garcia Jose R, Albelda Steven M, Eruslanov Evgeniy B: Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer. Cancer cell 30 (1): 120-35,2016.

Newick Kheng, O'Brien Shaun, Sun Jing, Kapoor Veena, Maceyko Steven, Lo Albert, Pure Ellen, Moon Edmund K, Albelda Steven M: Augmentation of CAR T cell trafficking and antitumor efficacy by blocking protein kinase A (PKA) localization. Cancer immunology research 4 (6): 541-51,2016.

Newick K, Moon E, Albelda SM: Chimeric Antigen Receptor T Cell Therapy for Solid Tumors Molecular Therapy Oncolytics 3 : 16006,2016.

Pietrofesa Ralph A, Velalopoulou Anastasia, Albelda Steven M, Christofidou-Solomidou Melpo: Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605). International journal of molecular sciences 17 (3): 322,2016.

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Academic Contact Info

228 Stemmler Hall
3450 Hamilton Walk

Philadelphia, PA 19104-6118
Phone: (215) 573-9933
Fax: (215) 746-0376
Patient appointments: 800-789-7366 (PENN)

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