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Steven M. Albelda, MD

Steven M. Albelda, MD Physician

Vice Chief and Director, Lung Research, Pulmonary and Critical Care Medicine William Maul Measey Professor of Medicine

Dr. Albelda is employed by Penn Medicine.

Does not see patients

No Patient Satisfaction Reviews
Why not?

There is no publicly available rating for this medical professional for one of the following reasons:

  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients in a medical practice setting.
  3. He or she sees patients but has not yet received the minimum 30 patient satisfaction reviews in the past 12 months, ensuring that the rating is statistically reliable and a true reflection of patient satisfaction.
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Clinical Specialties

Specialty:

  • Pulmonary Medicine

Programs & Centers:

Board Certification:

  • Pulmonary Disease, 1984

Clinical Expertise:

  • Acute Bronchitis
  • Airway Disorders
  • Airway Obstruction
  • Airway Scarring
  • Allergic Aspergillosis
  • Allergic Pneumonitis
  • Allergic Wheezing
  • Alpha-1 Antitrypsin Deficiency
  • Asbestosis
  • Aspiration Pneumonitis
  • Asthma
  • Asthmatic Bronchitis
  • Atelectasis
  • Autoimmune Pleuritis
  • Bilevel Positive Airway Pressure
  • Bronchiectasis
  • Bronchitis
  • Bronchoscopy
  • Bronchospasm
  • Chronic Bronchitis
  • Chronic Cough
  • Chronic Lung Disease
  • Chronic Obstructive Pulmonary Disease (COPD)
  • Chronic Respiratory Failure
  • Coal Worker's Pneumoconiosis (Black Lung Disease)
  • Continuous Positive Airway Pressure (CPAP)
  • Cryptogenic Organizing Pneumonia
  • Diaphragm Injury
  • Drug-Induced Pulmonary Disease
  • Dyspnea
  • Dyspnea On Exertion
  • Emphysema
  • Empyema
  • Exercise Intolerance
  • Hemoptysis
  • Hepatic Hydrothorax
  • Home Sleep Study
  • Hypercarbia
  • Hypoventilation Syndrome
  • Hypoxia
  • Interstitial Lung Disease
  • Laryngotracheitis
  • Lung Abscess
  • Lung Cancer Screening
  • Lung Disease
  • Lung Infiltrate
  • Lung Nodule
  • Lung Tumors
  • Maternal Respiratory Disease
  • Mechanical Ventilation
  • Needle Procedure
  • Occupational Lung Disease
  • Pleural Diseases
  • Pleural Effusion (Fluid in the Lung)
  • Pleural Thickening
  • Pleural Tuberculosis
  • Pleurisy
  • Pleuritic Pain
  • Pneumonia
  • Pneumonitis
  • Post-Infectious Cough
  • Pulmonary and Cardiac Rehabilitation
  • Pulmonary Arterial Hypertension
  • Pulmonary Bullae
  • Pulmonary Clearance for Surgery
  • Pulmonary Complications of Neurological Diseases
  • Pulmonary Embolism (Pulmonary Embolus)
  • Pulmonary Fibrosis
  • Pulmonary Function Tests
  • Pulmonary Granuloma
  • Pulmonary Hypertension
  • Pulmonary Infections
  • Pulmonary Sarcoid
  • Pulmonary Stent Placement
  • Pulmonary Therapy
  • Radiation Pneumonitis
  • Reactive Airway Disease
  • Recurrent Lung Infections
  • Restrictive Lung Disease
  • Rheumatoid Lung Disease
  • Silicosis
  • Sleep Disorders
  • Smoker's Cough
  • Smoking related Disease
  • Spirometry
  • Stridor
  • Tracheal Mass
  • Tracheal Stenosis
  • Tracheobronchitis
  • Tuberculosis (TB)
  • Wheezing
  • Whooping Cough
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Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • OPR New Jersey Medicaid
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Society for Clinical Investigation, National American Thoracic Society, National Sigma Xi, Research Society of North America, Associate Member, National

Hospital Affiliation

Dr. Albelda is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Immuno-gene Therapy for Thoracic Malignancies
Lung cancer and other thoracic malignancies are the leading cause of cancer deaths in the United States today. The Thoracic Oncology Research Laboratory is focusing on the design of new treatment strategies for lung cancer and mesothelioma based on the rapidly evolving disciplines of molecular biology, immunotherapy, and gene therapy.
Dr. Albelda’s research is translational in focus and includes animal models, work with human tumor samples, and the conduct of clinical trials. This work is primarily funded through a recently renewed Program Project from the National Cancer Institute and participation in a number of RO1 grants.
The tumor microenvironment is one area of active study. Studies are underway with the goals of 1) a better understanding of the biology of the tumor microenvironment with a focus on the immunuosuppressive activities of white blood cells and fibroblasts, 2) novel approaches to alter the tumor microenvironment to enhance immunotherapy including studying effects using COX-2 inhibitors, TGFbeta inhibitors, T-regulatory cell inhibitors., antibodies against B-cells, and chemotherapeutic drugs. A second area of interest in the lab is the use of adoptive T cell transfer to treat lung malignancies. Studies are underway to modify T cells in order to make them traffic more efficiently into tumors, to have better killing function, and to resist inactivation by the tumor microenvironment. A T cells targeting cancer-associated fibroblasts is being developed. In addition, Dr. Albelda is closely involved with a number of immunogene clinical trials at Penn using an adenovirus expressing the immune-activator interferon-alpha that is instilled into the pleural space of mesothelioma patients (in collaboration with Dr. Daniel Sterman) and T cells altered to attack the mesothelioma tumor target, mesothelin (in collaboration with Drs. Carl June and Andrew Haas).



Selected Publications:

Bengsch Bertram, Ohtani Takuya, Khan Omar, Setty Manu, Manne Sasikanth, O'Brien Shaun, Gherardini Pier Federico, Herati Ramin Sedaghat, Huang Alexander C, Chang Kyong-Mi, Newell Evan W, Bovenschen Niels, Pe'er Dana, Albelda Steven M, Wherry E John: Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells. Immunity 48 (5): 1029-1045.e5,2018.

Aggarwal Charu, Haas Andrew R, Metzger Susan, Aguilar Laura K, Aguilar-Cordova Estuardo, Manzanera Andrea G, Gómez-Hernández Gregoria, Katz Sharyn I, Alley Evan W, Evans Tracey L, Bauml Joshua M, Cohen Roger B, Langer Corey J, Albelda Steven M, Sterman Daniel H: Phase I Study of Intrapleural Gene-Mediated Cytotoxic Immunotherapy in Patients with Malignant Pleural Effusion. Molecular therapy : the journal of the American Society of Gene Therapy 26 (5): 1198-1205,2018.

Scherpereel Arnaud, Wallyn Frederic, Albelda Steven M, Munck Camille: Novel therapies for malignant pleural mesothelioma. The Lancet. Oncology 19 (3): e161-e172,2018.

Negorev Dmitri, Beier Ulf H, Zhang Tianyi, Quatromoni Jon G, Bhojnagarwala Pratik, Albelda Steven M, Singhal Sunil, Eruslanov Evgeniy, Lohoff Falk W, Levine Matthew H, Diamond Joshua M, Christie Jason D, Hancock Wayne W, Akimova Tatiana: Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms. Scientific reports 8 (1): 3135,2018.

Moon Edmund K, Wang Liang-Chuan S, Bekdache Kheng, Lynn Rachel C, Lo Albert, Thorne Stephen H, Albelda Steven M: Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines. Oncoimmunology 7 (3): e1395997,2018.

Aggarwal Charu, Wang Xingmei, Ranganathan Anjana, Torigian Drew, Troxel Andrea, Evans Tracey, Cohen Roger B, Vaidya Bhavesh, Rao Chandra, Connelly Mark, Vachani Anil, Langer Corey, Albelda Steven: Circulating tumor cells as a predictive biomarker in patients with small cell lung cancer undergoing chemotherapy. Lung cancer (Amsterdam, Netherlands) 112 : 118-125,2017.

Pietrofesa RA, Woodruff P, Hwang WT, Patel P, Chatterjee S, Albelda SM, Christofidou-Solomidou M: The synthetic lignan secoisolariciresinol diglucoside prevents asbestos-induced NLRP3 inflammasome activation in murine macrophages. Oxidative medicine and cellular longevity 2017 : 7395238,2017.

Moon EK, Langer CJ, Albelda SM: The era of checkpoint blockade in lung cancer: taking the brakes off the immune system. Annals of the American Thoracic Society 14 (8): 1248-1260,2017.

Newick Kheng, O'Brien Shaun, Moon Edmund, Albelda Steven M: CAR T Cell Therapy for Solid Tumors. Annual review of medicine 68 : 139-52,2016.

Singhal Sunil, Bhojnagarwala Pratik S, O'Brien Shaun, Moon Edmund K, Garfall Alfred L, Rao Abhishek S, Quatromoni Jon G, Stephen Tom Li, Litzky Leslie, Deshpande Charuhas, Feldman Michael D, Hancock Wayne W, Conejo-Garcia Jose R, Albelda Steven M, Eruslanov Evgeniy B: Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer. Cancer cell 30 (1): 120-35,2016.

Newick Kheng, O'Brien Shaun, Sun Jing, Kapoor Veena, Maceyko Steven, Lo Albert, Pure Ellen, Moon Edmund K, Albelda Steven M: Augmentation of CAR T cell trafficking and antitumor efficacy by blocking protein kinase A (PKA) localization. Cancer immunology research 4 (6): 541-51,2016.

Sterman DH, Alley E, Stevenson JP, Friedberg J, Metzger S, Recio A, Moon EK, Haas AR, Vachani A, Katz SI, Sun J, Heitjan DF, Hwang WT, Litzky L, Yearley JH, Tan KS, Papasavvas E, Kennedy P, Montaner LJ, Cengel KA, Simone CB, Culligan M, Langer CJ, Albelda SM: Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-Interferon-alpha Combined with Chemotherapy Clinical Cancer Research 22 (15): 3791-3800,2016.

Lo Albert, Wang Liang-Chuan S, Scholler John, Monslow James, Avery Diana, Newick Kheng, O'Brien Shaun, Evans Rebecca A, Bajor David J, Clendenin Cynthia, Durham Amy C, Buza Elizabeth L, Vonderheide Robert H, June Carl H, Albelda Steven M, Puré Ellen: Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells. Cancer research 75 (14): 2800-10,2015.

Moon Edmund K, Ranganathan Raghuveer, Eruslanov Evgeniy, Kim Soyeon, Newick Kheng, O'Brien Shaun, Lo Albert, Liu Xiaojun, Zhao Yangbing, Albelda Steven M: Blockade of Programmed Death 1 Augments the Ability of Human T Cells Engineered to Target NY-ESO-1 to Control Tumor Growth after Adoptive Transfer. Clinical Cancer Research : an official journal of the American Association for Cancer Research 22 (2): 436-47,2016.

Moon EK1, Wang LC2, Dolfi DV3, Wilson CB4, Ranganathan R2, Sun J2, Kapoor V2, Scholler J4, Puré E5, Milone MC4, June CH4, Riley JL3, Wherry EJ3, Albelda SM2.: Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors. Clinical Cancer Research 20 (16): 1-12,2014.

Wang Liang-Chuan S, Lo Albert, Scholler John, Sun Jing, Majumdar Rajrupa S, Kapoor Veena, Antzis Michael, Cotner Cody E, Johnson Laura A, Durham Amy C, Solomides Charalambos C, June Carl H, Puré Ellen, Albelda Steven M: Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity. Cancer immunology research 2 (2): 154-66,2014.

Akimova T, Zhang T, Negorev D, Singhal S, Stadanlick J, Rao A, Annunziata M, Levine MH, Beier UH, Diamond JM, Christie JD, Albelda SM, Eruslanov EB, Hancock WW: Human lung tumor FOXP3+ Tregs upregulate four "Treg-locking" transcription factors. JCI Insight 2 (16): pii 94075,2017.

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Academic Contact Info

228 Stemmler Hall
3450 Hamilton Walk

Philadelphia, PA 19104-6118
Phone: (215) 573-9933

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