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Stephen Bagley, MD

Stephen Bagley, MD Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Bagley is employed by Penn Medicine.

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Clinical Specialties


  • Medical Oncology

Programs & Centers:

Board Certification:

  • Internal Medicine, 2014

Clinical Expertise:

  • Brain Cancer Gene Therapy
  • Brain Metastasis
  • Brain Tumors
  • Glioblastoma
  • Glioma
  • Spine Cancer

Description of Clinical Expertise

Primary brain tumors, brain metastases, leptomeningeal disease

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Association for Cancer Research, National American Society of Clinical Oncology, National Novocure, National Society for Epidemiologic Research, National Society for Neuro-Oncology (SNO), National Society for Neuro-Oncology, National

Hospital Affiliation

Dr. Bagley is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

I am a medical oncologist with expertise in malignancies of the central nervous system. My research interests include immunotherapeutic approaches to glioblastoma and use of circulating biomarkers for CNS tumors.

Selected Publications:

Aggarwal C, Davis CW, Mick R, Thompson J, Ahmed S, Jeffries S, Bagley SJ, Gabriel P, Evans TL, Bauml JM, Ciunci C, Alley E, Morrissette J, Cohen RB, Carpenter E, and Langer CJ.: Influence of TP53 mutations on survival and transformation to small cell lung cancer in patients with EGFR-mutant advanced non-small cell lung cancer JCO Precision Oncology : 2018.

Binder Zev A, Thorne Amy Haseley, Bakas Spyridon, Wileyto E Paul, Bilello Michel, Akbari Hamed, Rathore Saima, Ha Sung Min, Zhang Logan, Ferguson Cole J, Dahiya Sonika, Bi Wenya Linda, Reardon David A, Idbaih Ahmed, Felsberg Joerg, Hentschel Bettina, Weller Michael, Bagley Stephen J, Morrissette Jennifer J D, Nasrallah MacLean P, Ma Jianhui, Zanca Ciro, Scott Andrew M, Orellana Laura, Davatzikos Christos, Furnari Frank B, O'Rourke Donald M: Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development. Cancer cell 34 (1): 163-177.e7,2018.

Tsai Donald E, Bagley Stephen, Reshef Ran, Shaked Abraham, Bloom Roy D, Ahya Vivek, Goldberg Lee, Chung Albert, Debonera Fotini, Schuster Stephen J, Huntington Scott F: The changing face of adult posttransplant lymphoproliferative disorder: Changes in histology between 1999 and 2013. American journal of hematology 93 (7): 874-881,2018.

Katz Sharyn I, Hammer Mark, Bagley Stephen J, Aggarwal Charu, Bauml Joshua M, Thompson Jeffrey C, Nachiappan Arun C, Simone Charles B, Langer Corey J: Radiologic Pseudoprogression during Anti-PD-1 Therapy for Advanced Non-Small Cell Lung Cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 13 (7): 978-986,2018.

Bagley Stephen J, Desai Arati S, Linette Gerald P, June Carl H, O'Rourke Donald M: CAR T Cell Therapy for Glioblastoma: Recent Clinical Advances and Future Challenges. Neuro-oncology : 2018.

Hammer Mark, Bagley Stephen, Aggarwal Charu, Bauml Joshua, Nachiappan Arun C, Simone Charles B, Langer Corey, Katz Sharyn I: Thoracic Imaging of Non-Small Cell Lung Cancer Treated With Anti-programmed Death Receptor-1 Therapy. Current problems in diagnostic radiology : 2018.

Bagley SJ, Hwang WT, Brem S, Linette GP, O'Rourke DM, and Desai AS: RNA-seq for identification of therapeutically targetable determinants of immune activation in human glioblastoma Journal of Neuro-Oncology : 2018.

Bagley SJ, Kothari S, Aggarwal C, Bauml JM, Alley EW, Evans TL, Kosteva JA, Ciunci CA, Gabriel PE, Thompson JC, Stonehouse-Lee S, Sherry VE, Gilbert E, Eaby-Sandy B, Mutale F, DiLullo G, Cohen RB, Vachani A, Langer CJ: Pretreatment neutrophil-to-lymphocyte ratio as a marker of outcomes in nivolumab-treated patients with advanced non-small-cell lung cancer. Lung cancer 106 : 1-7,2017.

Bagley Stephen J, Vitale Steven, Zhang Suhong, Aggarwal Charu, Evans Tracey L, Alley Evan W, Cohen Roger B, Langer Corey J, Blair Ian A, Vachani Anil, Whitehead Alexander S: Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non-Small-cell Lung Cancer. Clinical Lung Cancer 18 (2): e143-e149,2017.

Bagley SJ, Reynolds WW, Nelson RM.: Is a "wage-payment" model for research participation appropriate for children? Pediatrics 119 (1): 46-51,2007.

Bagley SJ, Sehgal AR, Gill S, Frey NV, Hexner EO, Loren AW, Mangan JK, Porter DL, Stadtmauer EA, Reshef R, Luger SM.: Acute cholecystitis is a common complication after allogeneic stem cell transplantation and is associated with the use of total parenteral nutrition. Biology of Blood and Marrow Transplantation 21 (4): 768-71,2015.

Bagley SJ, Bauml JM, Langer CJ.: PD-1/PD-L1 immune checkpoint blockade in non-small cell lung cancer. Clinical Advances in Hematology & Oncology 13 (10): 676-83,2015.

Weiss JM, Bagley S, Hwang WT, Bauml J, Olson JG, Cohen RB, Hayes DN, Langer C.: Capecitabine and lapatinib for the first-line treatment of metastatic/recurrent head and neck squamous cell carcinoma. Cancer 122 (15): 2350-5,2016.

Thompson JC, Yee SS, Troxel AB, Savitch SL, Fan R, Balli D, Lieberman DB, Morrissette JD, Evans TL, Bauml J, Aggarwal C, Kosteva JA, Alley E, Ciunci C, Cohen RB, Bagley S, Stonehouse-Lee S, Sherry VE, Gilbert E, Langer C, Vachani A, Carpenter EL: Detection of Therapeutically Targetable Driver and Resistance Mutations in Lung Cancer Patients by Next-Generation Sequencing of Cell-Free Circulating Tumor DNA. Clinical Cancer Research 22 (23): 5772-5782,2016.

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Academic Contact Info

10th Floor, South Pavilion
3400 Civic Center Blvd

Philadelphia, PA 19104
Phone: (215) 614-1858
Patient appointments: 800-789-7366 (PENN)