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Stephen Bagley, MD, MSCE

Stephen Bagley, MD, MSCE Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Bagley is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Medical Oncology

Programs & Centers:

Board Certification:

  • Internal Medicine, 2014
  • Medical Oncology, 2017

Clinical Expertise:

  • Acoustic Neuroma (Vestibular Schwannoma)
  • Brain Metastasis
  • Brain Tumors
  • Cauda Equina Syndrome
  • Chordoma
  • Craniopharyngioma
  • Glioblastoma
  • Neurocutaneous Disorders
  • Orbital Tumors
  • Pituitary Tumors
  • Prolactinoma
  • Skull Base Tumors
  • Spinal Cord Cancer
  • Spinal Schwannoma
  • Spinal Tumor

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Association for Cancer Research, National American Society of Clinical Oncology, National Bayer AG, National Northwest Biotherapeutics, National Society for Epidemiologic Research, National Society for Neuro-Oncology, International Society for Neuro-Oncology, National

Hospital Affiliation

Dr. Bagley is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

I am a medical oncologist with expertise in malignancies of the central nervous system. My research interests include immunotherapeutic approaches to glioblastoma and use of circulating biomarkers for CNS tumors.

Selected Publications:

Bagley SJ, Hwang WT, Brem S, Linette GP, O'Rourke DM, and Desai AS: RNA-seq for identification of therapeutically targetable determinants of immune activation in human glioblastoma Journal of Neuro-Oncology 141 (1): 95-102,2019.

Bagley SJ, Schwab RD, Nelson E, Viaene AN, Binder AZ, Lustig RA, O’Rourke DM, Brem S, Desai AS, and Nasrallah MP: Histopathologic quantification of viable tumor versus treatment effect in surgically resected recurrent glioblastoma Journal of Neurooncology 141 (2): 421-429,2019.

Bagley Stephen J, Desai Arati S, Linette Gerald P, June Carl H, O'Rourke Donald M: CAR T Cell Therapy for Glioblastoma: Recent Clinical Advances and Future Challenges. Neuro Oncology 20 (11): 1429-1438,2018.

Binder Zev A, Thorne Amy Haseley, Bakas Spyridon, Wileyto E Paul, Bilello Michel, Akbari Hamed, Rathore Saima, Ha Sung Min, Zhang Logan, Ferguson Cole J, Dahiya Sonika, Bi Wenya Linda, Reardon David A, Idbaih Ahmed, Felsberg Joerg, Hentschel Bettina, Weller Michael, Bagley Stephen J, Morrissette Jennifer J D, Nasrallah MacLean P, Ma Jianhui, Zanca Ciro, Scott Andrew M, Orellana Laura, Davatzikos Christos, Furnari Frank B, O'Rourke Donald M: Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development. Cancer cell 34 (1): 163-177.e7,2018.

Bagley SJ, Talento S, Mitra N, Meropol NJ, Cohen RB, Langer CJ, and Vachani A: Comparative effectiveness of carboplatin-pemetrexed with vs without bevacizumab for advanced non-squamous non-small cell lung cancer. J Natl Compr Canc Netw : 2019.

Aggarwal C, Davis CW, Mick R, Thompson J, Ahmed S, Jeffries S, Bagley SJ, Gabriel P, Evans TL, Bauml JM, Ciunci C, Alley E, Morrissette J, Cohen RB, Carpenter E, and Langer CJ.: Influence of TP53 mutations on survival and transformation to small cell lung cancer in patients with EGFR-mutant advanced non-small cell lung cancer JCO Precision Oncology : 2018.

Bagley SJ, Kothari S, Aggarwal C, Bauml JM, Alley EW, Evans TL, Kosteva JA, Ciunci CA, Gabriel PE, Thompson JC, Stonehouse-Lee S, Sherry VE, Gilbert E, Eaby-Sandy B, Mutale F, DiLullo G, Cohen RB, Vachani A, Langer CJ: Pretreatment neutrophil-to-lymphocyte ratio as a marker of outcomes in nivolumab-treated patients with advanced non-small-cell lung cancer. Lung cancer 106 : 1-7,2017.

Bagley SJ, Till J, Mays JJ, Nabavizadeh SA, Yee SS, Levy SC, Desai AS, and Carpenter EL: Plasma cell free DNA (cfDNA) concentration is independently associated with radiographic tumor burden in newly diagnosed glioblastoma prior to initial surgical resection Neuro Oncol suppl_6 : vi167-vi168,2018.

Katz Sharyn I, Hammer Mark, Bagley Stephen J, Aggarwal Charu, Bauml Joshua M, Thompson Jeffrey C, Nachiappan Arun C, Simone Charles B, Langer Corey J: Radiologic Pseudoprogression during Anti-PD-1 Therapy for Advanced Non-Small Cell Lung Cancer. Journal of Thoracic Oncology 13 (7): 978-986,2018.

Thompson JC, Yee SS, Troxel AB, Savitch SL, Fan R, Balli D, Lieberman DB, Morrissette JD, Evans TL, Bauml J, Aggarwal C, Kosteva JA, Alley E, Ciunci C, Cohen RB, Bagley S, Stonehouse-Lee S, Sherry VE, Gilbert E, Langer C, Vachani A, Carpenter EL: Detection of Therapeutically Targetable Driver and Resistance Mutations in Lung Cancer Patients by Next-Generation Sequencing of Cell-Free Circulating Tumor DNA. Clinical Cancer Research 22 (23): 5772-5782,2016.

Nabavizadeh SA, Akbari H, Ware JB, Nasrallah M, Guiry S, Bagley SJ, Desai A, Levy S, Sarchiapone W, Prior T, Detre J, Wolf RL, O'Rourke DM, Brem S, Davatzikos C.: Arterial Spin Labeling and Dynamic Susceptibility Contrast-enhanced MRI Imaging for evaluation of arteriovenous shunting and tumor hypoxia in glioblastoma Scientific Reports 9 (1): 8747,2019.

Bagley SJ: Role of temozolomide in the treatment of cancers involving the central nervous system. Commentary. Oncology 32 (11): 569,2018.

Bagley SJ, Mays JJ, Nabavizadeh SA, Yee SS, Levy SC, Desai AS, and Carpenter EL.: Plasma cell-free DNA concentration and radiographic tumor burden in patients with glioblastoma Journal of Clinical Oncology 36 (15_suppl): 2048,2018.

Tsai Donald E, Bagley Stephen, Reshef Ran, Shaked Abraham, Bloom Roy D, Ahya Vivek, Goldberg Lee, Chung Albert, Debonera Fotini, Schuster Stephen J, Huntington Scott F: The changing face of adult posttransplant lymphoproliferative disorder: Changes in histology between 1999 and 2013. American Journal of Hematology 93 (7): 874-881,2018.

Bagley SJ, Dhopeshwarkare, Narayan V, Meropol NJ, Mamtani R, and Boursi B.: Impact of antibiotics on overall survival in patients with advanced non-small cell lung cancer and melanoma treated with first-line immune checkpoint inhibition J Clin Oncol 37 (suppl; abstr e20643): e20643,2019.

Rathore S, Bakas S, Nasrallah MP, Bagley SJ, Akbari H, Ha SM, Mamourian EC, Watt C, and Davatzikos C.: Non-invasive determination of the O6-methylguanine-DNA-methyltransferase promoter methylation status in glioblastoma using magnetic resonance imaging. Journal of Clinical Oncology 36 (15_suppl): 2018.

Weiss JM, Bagley S, Hwang WT, Bauml J, Olson JG, Cohen RB, Hayes DN, Langer C.: Capecitabine and lapatinib for the first-line treatment of metastatic/recurrent head and neck squamous cell carcinoma. Cancer 122 (15): 2350-5,2016.

Bagley SJ, Kosteva JA, Evans TL, and Langer CJ.: Immune thrombocytopenia exacerbated by nivolumab in a patient with non-small cell lung cancer. Cancer Treatment Research and Communications 6 : 20-23,2016.

Rosenberg SA, Baschnagel AM, Bagley SJ, Housri N.: Strategies for Translating Evidence-Based Medicine in Lung Cancer into Community Practice. Current Oncology Reports 19 (1): 5,2017.

Hammer Mark, Bagley Stephen, Aggarwal Charu, Bauml Joshua, Nachiappan Arun C, Simone Charles B, Langer Corey, Katz Sharyn I: Thoracic Imaging of Non-Small Cell Lung Cancer Treated With Anti-programmed Death Receptor-1 Therapy. Current problems in diagnostic radiology 48 (2): 142-147,2019.

Bagley SJ, Reynolds WW, Nelson RM.: Is a "wage-payment" model for research participation appropriate for children? Pediatrics 119 (1): 46-51,2007.

Bagley SJ, Sehgal AR, Gill S, Frey NV, Hexner EO, Loren AW, Mangan JK, Porter DL, Stadtmauer EA, Reshef R, Luger SM.: Acute cholecystitis is a common complication after allogeneic stem cell transplantation and is associated with the use of total parenteral nutrition. Biology of Blood and Marrow Transplantation 21 (4): 768-71,2015.

Bagley SJ, Bauml JM, Langer CJ.: PD-1/PD-L1 immune checkpoint blockade in non-small cell lung cancer. Clinical Advances in Hematology & Oncology 13 (10): 676-83,2015.

Bagley Stephen J, Vitale Steven, Zhang Suhong, Aggarwal Charu, Evans Tracey L, Alley Evan W, Cohen Roger B, Langer Corey J, Blair Ian A, Vachani Anil, Whitehead Alexander S: Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non-Small-cell Lung Cancer. Clinical Lung Cancer 18 (2): e143-e149,2017.

View all publications

Academic Contact Info

10th Floor, South Pavilion
3400 Civic Center Blvd

Philadelphia, PA 19104
Phone: (215) 614-1858
Patient appointments: 800-789-7366 (PENN)