Penn Medicine Provider
Radiology
Sophia Rose O'Brien, MD
Call 800-789-7366

About me

  • Associate Program Director, Diagnostic Radiology Residency
  • Assistant Professor of Clinical Radiology

Sophia O'Brien, MD, MSEd is an Assistant Professor of Clinical Radiology in the Divisions of Nuclear Medicine and Breast Imaging. She completed her Diagnostic Radiology residency, integrated Nuclear Radiology Fellowship, and Breast Imaging Fellowship at Penn. She practices clinical nuclear medicine including interpreting general nuclear medicine studies, PET/CTs, and cardiac nuclear medicine studies, and she treats patients with thyroid disease, neuroendocrine tumor, paraganglioma/pheochromocytoma, and prostate cancer via the Nuclear Therapy Clinic.  She also practices breast imaging including reading mammography, breast US, and breast MRI, and performing imaging-guided breast and axillary biopsies.

Dr. O'Brien's research focuses include Fluoroestradiol PET/CT, Radionuclide Therapy, and breast imaging during pregnancy/lactation. She completed her Masters of Medical Education at Penn in 2024 and is passionate about radiology education and education scholarship.

Education and training

  • Medical School: Columbia University
  • Residency: Lankenau Hospital
  • Residency: Hospital of the University of Pennsylvania
  • Fellowship: Hospital of the University of Pennsylvania

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Chester County Hospital: Has privileges to treat patients in the hospital.
Dr. O'Brien is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Meisinger QC, O’Brien S, Itkin M, Nadolski GJ Use of Sequential Pneumatic Compression Devices to Facilitate Propagation of Contrast during Intranodal Lymphangiography. , J Vasc Interv Radiol, 28(11): 2017,1544-1547

Takayama H, Soni L, Kalesan B, Truby LK, Ota T, Cedola S, Khalpey Z, Uriel N, Colombo P, Mancini DM, Jorde UP, and Naka Y. Bridge-to-decision therapy with a continuous-flow external ventricular assist device in refractory cardiogenic shock of various causes. , Circulation: Heart Failure, 7(5): 2014,799-806

Soni LK, Cedola S, Cogan J, Jiang J, Yang J, Takayama H, and Argenziano M. Right atrial lesions do not improve the efficacy of a complete left atrial lesion set in the surgical treatment of atrial fibrillation, but they do increase procedural morbidity. , J Thorac Cardiovasc Surg., 145(2): 2013,356-61