Penn Medicine Provider
Hematology
Scott Alan Peslak, MD, PhD
he/him/his
4.9
(63)
Accepting new patients
Sees patients age 18 and up
Penn Blood Disorders Center

About me

  • Gene Therapy Lead, Comprehensive Sickle Cell Program and Comprehensive Adult Thalassemia Program
  • Assistant Professor of Medicine (Hematology-Oncology)
  • Assistant Professor of Pediatrics (Hematology-Oncology)

I am a physician-scientist at the University of Pennsylvania and I care for patients in the Penn Medicine Comprehensive Sickle Cell Disease Program and Comprehensive Adult Thalassemia Program. In addition to my clinical focus on red cell disorders, I also run a laboratory studying novel regulators of fetal hemoglobin and new genetic and pharmacologic therapies for the treatment of sickle cell disease.

Education and training

  • Medical School: University of Rochester School of Medicine
  • Residency: Hospital of the University of Pennsylvania
  • Fellowship: Hospital of the University of Pennsylvania

What my patients think about me

Average Rating
4.9

63 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

April 2025
5.0
5.0
anyone would be lucky to have a doctor like dr. peslak.
February 2025
5.0
5.0
answered all my questions, very thorough with explaining everything
February 2025
5.0
5.0
dr peslak is the best on the field
January 2025
5.0
5.0
very caring

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Dr. Peslak is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Al Ta’ani, O.; Mayrer, B.M.; Luche, N.M.; Siddique, S.M., Peslak, S.A.; Anderson, T.S.; Vajravelu, R.K. Impact of Diagnostic Serum Ferritin Thresholds on Prevalence of Iron Deficiency Anemia: A Cross-Sectional Analysis of U.S. Adults , JAMA Internal Medicine, In Press: 2025


Huang, P., Peslak, S.A., Shehu, V., Keller, C.A., Giardine, B., Shi, J., Hardison, R.C., Blobel, G.A., Khandros, E. Let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching , Blood, 143(19): 2024,1980-1991


Peslak S.A., Abbas T., Khandros E., Traxler E.A., Abdulmalik O., Giardine B.M., Keller C.A., Hardison R.C., Shi J., Blobel G.A. Protein Phosphatase 6 Complex: Novel Regulator of Fetal Hemoglobin and Potential Therapeutic Target in Sickle Cell Disease. , American Society of Hematology Annual Meeting, San Diego, CA: 2023


Cheng A., Traxler E.A., Peslak S.A., Cohen J., Russell J.E., Sayani F. Patients with Non-Transfusion-Dependent Thalassemia May Evolve to Transfusion-Dependent Thalassemia in Adulthood , American Society of Hematology Annual Meeting, San Diego, CA: 2023


Li C, Shin H, Bhavanasi D, Liu M, Yu X, Peslak SA, Liu X, Alvarez-Dominguez JR, Blobel GA, Gregory BD, Huang J, Klein PS Expansion of human hematopoietic stem cells by inhibiting translation , bioRxiv: 2023


Peslak, S.A., Akins, A.B., Foxwell, A.M., Iannelli, M., Grande, C., Breen, D., Russell, J.E., Uritsky, T.J., Sayani, F.A. A novel, effective, and efficient strategy for treating sickle cell vaso-occlusive events in the infusion center setting. , Blood Adv , 7(3): 2023,410-413


Peslak, S.A.*, Demirci, S.*, Chandra, V., Ryu, B., Bhardwaj, S.K., Jiang, J., Rupon, J.W., Throm, R.E., Uchida, N., Leonard, A., Essawi, K., Bonifacino, A.C., Krouse, A.E., Linde, N.S., Donahue, R.E., Ferrera, F., Wielgosz, M., Abdulmalik, O., Hamagami, N., Germino-Watnick, P., Le, A., Chu, R., Hinds, M., Weiss, M.J., Tong, W., Tisdale, J.F., Blobel, G.A. Forced enhancer-promoter rewiring to alter gene expression in animal models. , Mol Ther Nucleic Acids , 32: 2023,452-465


Wakabayashi, A., Kihiu, M., Sharma, M., Thrasher, J., Saari, M., Quesnel-Vallieres M., Abdulmalik, O., Peslak, S.A., Khandros, E., Keller, C.A., Giardine, B.M., Hardison, R.C., Shi, J., Blobel, G.A. Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression , Blood Adv , 6(23): 2022,5956-5968


Peslak S.A., Khandros E., Huang P., Wakabayashi A., Abbas T., Abdulmalik O., Keller C.A., Hardison R.C., Shi J., Blobel G.A. Regulation of Fetal Hemoglobin Production in Adult Erythroid Cells by Protein Phosphatase 6C (PPP6C). , American Society of Hematology Annual Meeting. Atlanta, GA.: 2022


Adema, V., Ma, F, Kanagal-Shamanna, R., Thongon, N., Montalban-Bravo, G., Yang, H., Peslak, S.A. Wang, F., Acha, P., Sole, F., Lockyer, P., Cassari, M., Maciejewski, J.P., Visconte, V., Ganan-Gomez, I., Song, Y., Bueso-Ramos, C., Pellegrini, M., Tuyet, M.T., Bejar, R., Carew, J.S., Halene, S., Santini, V., Al-Atrash, G., Clise-Dwyer, K., Garcia-Manero, G., Blobel, G.A., Colla, S. Targeting the EIF2AK1 signaling pathway rescues red blood cell production in SF3B1-mutant myelodysplastic syndromes with ringed sideroblasts. , Blood Cancer Discov , 3(6): 2022,554-567


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