Saya L. Jacob, MD
Medical Oncology
Accepting new patients
Sees patients age 18 and up
Rena Rowan Breast Center
Penn Medicine Provider

About me

  • Assistant Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania

Education and training

  • Medical School: Northwestern University Feinberg School of Medicine
  • Residency: Northwestern Memorial Hospital
  • Fellowship: University of California San Francisco

What my patients think about me

Average Rating

62 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

November 2025
great bedside manner and knowledgeable
November 2025
she was very engaging, enaddition to being informed
October 2025
dr. jacob is great. this was my first time meeting her.
October 2025
she cares about you from her heart !!!!

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Dr. Jacob is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Jacob S, Fisch S, Face C, Blum K, Chengappa M, Chaudhry S, LeVee A, Baclig NV, Soliman A, Huppert LA, Quandt Z, Quintal L, Idossa D, Melisko M, Chien AJ, Kim MO, Mortimer J, McCann K, Blaes A, Rugo HS. Multi-institutional analysis of incidence and risks for late-onset immune toxicity in breast cancer , NPJ Breast Cancer: 2025


Huppert LA, Mahtani R, Fisch S, Dempsey N, Premji S, Raimonde A, Jacob S, Quintal L, Melisko M, Chien J, Sandoval A, Carcas L, Ahluwalia M, Harpalani N, Hoppenworth J, Blaes A, Blum K, Kim MO, Idossa D, Rao R, Giridhar KV, Rugo HS. Multicenter retrospective cohort study of the sequential use of the antibody-drug conjugates (ADCs) trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) in patients with HER2-low metastatic breast cancer (MBC) , NPJ Breast Cancer, 11: 2025,34


Jacob S, Christofferson A, Fisch S, Norwood P, Castillo P, Yu H, Hirst G, Soliman H, Nanda R, Mukhtar RA, Ewing C, Majure M, Melisko M, Rugo HS, Esserman L, Price E, Chien AJ. Regional lymph node changes on breast MRI in patients with early-stage breast cancer receiving neoadjuvant chemo-immunotherapy , Breast Cancer Res Treat: 2024


Zhang Q, Cai Z, Gerratana L, Davis AA, D'Amico P, Chawla A, Jacob S, Zhang Y, Jiao J, Qin W, Reduzzi C, Flaum L, Shah A, Gradishar WJ. Early Evaluation of Risk Stratification and Clinical Outcomes for Patients with Advanced Breast Cancer through Combined Monitoring of Baseline Circulating Tumor Cells and DNA. , Clin Cancer Res: 2024


Quandt Z, Jacob S, Fadlullah MZH, Wu C, Wu C, Huppert L, Levine LS, Sison P, Tsai KK, Chow M, Kang JH, Hwang J, Lee JC, Oglesby A, Venegas J, Brintz BJ, Tan AC, Anderson MS, Rosenblum MD, Young A, Daud AI. Phase II trial of pembrolizumab, ipilimumab, and aspirin in melanoma: clinical outcomes and translational predictors of response , BJC Rep, 2: 2024,46


Jacob S, Johnson M, Roque B, Quintal L, Rugo HS, Melisko M, and Chien AJ. “Crofelemer for the Management of Neratinib-Associated Diarrhea in Patients With HER2+ Early-Stage Breast Cancer.” , Clin Breast Cancer , 23(7): 2023,721-728


Saya Jacob, Edward Maldando, Meera Ragavan, Vanessa Kennedy, Rahul Banerjee, Amy Lin, Ana Velazquez. Development of Implementation of a Fertility Preservation Order Set In Comprehensive Cancer Center: A Quality and Equity Initiative. , American Society of Clinical Oncology Quality Symposium, Boston, MA.: 2023


Gerratana L, Reduzzi C, D'Amico P, Mazzeo R, Jacob S, Qiang W, Cristofanilli M. Clinical Perspectives in the Use of Liquid Biopsy in Metastatic Breast Cancer. , Current Cancer Research : 2023,10.1007/978-3-031-22903-9_21.


Jacob S, Johnson M, Roque B, Quintal L, Rugo HS, Melisko M, Chien AJ. Crofelemer for the Management of Neratinib-Associated Diarrhea in Patients With HER2+ Early-Stage Breast Cancer. , Clin Breast Cancer: 2023


Saya Jacob, Zoe Quandt, Michelle Melisko, Melanie Majure, Amy Jo Chien, Anne Blaes, Diane Heditsian, Laura Esserman, Hope Rugo. Delayed immune toxicities in patients with breast cancer receiving immune checkpoint inhibitors. , American Society of Clinical Oncology Annual Meeting, Chicago, IL. : 2023