Description of Research Expertise:
Tumor Immunology
Chimeric Antigen Receptor T cells
Mouse Models of Human Leukemia
Murine Xenografts
Adoptive Cellular Therapy
Genetic Engineering of T cells
Flow Cytometry
Selected Publications:
Duell Johannes, Lammers Philip E, Djuretic Ivana, Chunyk Allison G, Alekar Shilpa, Jacobs Ira, Gill Saar: Bispecific Antibodies in the Treatment of Hematologic Malignancies. Clinical pharmacology and therapeutics 106 (4): 781-791,2019.
Cummins Katherine D, Gill Saar: Chimeric antigen receptor T-cell therapy for acute myeloid leukemia: how close to reality? Haematologica 104 (7): 1302-1308,2019.
Kansagra Ankit J, Frey Noelle V, Bar Merav, Laetsch Theodore W, Carpenter Paul A, Savani Bipin N, Heslop Helen E, Bollard Catherine M, Komanduri Krishna V, Gastineau Dennis A, Chabannon Christian, Perales Miguel A, Hudecek Michael, Aljurf Mahmoud, Andritsos Leslie, Barrett John A, Bachanova Veronika, Bonini Chiara, Ghobadi Armin, Gill Saar I, Hill Joshua A, Kenderian Saad, Kebriaei Partow, Nagler Arnon, Maloney David, Liu Hien D, Shah Nirali N, Kharfan-Dabaja Mohamed A, Shpall Elizabeth J, Mufti Ghulam J: Clinical utilization of Chimeric Antigen Receptor T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL)-an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT). Bone marrow transplantation : 2019.
Ganetsky Alex, Han Jennifer H, Hughes Mitchell E, Babushok Daria V, Frey Noelle V, Gill Saar I, Hexner Elizabeth O, Loren Alison W, Luger Selina M, Mangan James K, Martin Mary Ellen, Smith Jacqueline, Freyer Craig W, Gilmar Cheryl, Schuster Mindy, Stadtmauer Edward A, Porter David L: Oral Vancomycin Prophylaxis Is Highly Effective in Preventing Clostridium difficile Infection in Allogeneic Hematopoietic Cell Transplant Recipients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 68 (12): 2003-2009,2019.
Cummins Katherine D, Gill Saar: Will CAR T cell therapy have a role in AML? Promises and pitfalls. Seminars in hematology 56 (2): 155-163,2019.
Petty Nicholas E, Gill Saar I: 21 Century FOX: Toward Gene Therapy for the Regulatory T Cell Deficiency Syndrome IPEX. Cell stem cell 24 (2): 208-209,2019.
Kansagra Ankit J, Frey Noelle V, Bar Merav, Laetsch Theodore W, Carpenter Paul A, Savani Bipin N, Heslop Helen E, Bollard Catherine M, Komanduri Krishna V, Gastineau Dennis A, Chabannon Christian, Perales Miguel A, Hudecek Michael, Aljurf Mahmoud, Andritsos Leslie, Barrett John A, Bachanova Veronika, Bonini Chiara, Ghobadi Armin, Gill Saar I, Hill Joshua, Kenderian Saad, Kebriaei Partow, Nagler Arnon, Maloney David, Liu Hien D, Shah Nirali N, Kharfan-Dabaja Mohamed A, Shpall Elizabeth J, Mufti Ghulam J: Clinical Utilization of Chimeric Antigen Receptor T Cells in B Cell Acute Lymphoblastic Leukemia: An Expert Opinion from the European Society for Blood and Marrow Transplantation and the American Society for Blood and Marrow Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 25 (3): e76-e85,2019.
Ganetsky Alex, Frey Noelle V, Hexner Elizabeth O, Loren Alison W, Gill Saar I, Luger Selina M, Mangan James K, Martin Mary Ellen, Babushok Daria V, Drobyski William R, Smith Jacqueline, Timlin Colleen, Freyer Craig W, Stadtmauer Edward A, Porter David L: Tocilizumab for the treatment of severe steroid-refractory acute graft-versus-host disease of the lower gastrointestinal tract. Bone marrow transplantation 54 (2): 212-217,2018.
Kim Miriam Y, Yu Kyung-Rok, Kenderian Saad S, Ruella Marco, Chen Shirley, Shin Tae-Hoon, Aljanahi Aisha A, Schreeder Daniel, Klichinsky Michael, Shestova Olga, Kozlowski Miroslaw S, Cummins Katherine D, Shan Xinhe, Shestov Maksim, Bagg Adam, Morrissette Jennifer J D, Sekhri Palak, Lazzarotto Cicera R, Calvo Katherine R, Kuhns Douglas B, Donahue Robert E, Behbehani Gregory K, Tsai Shengdar Q, Dunbar Cynthia E, Gill Saar: Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia. Cell 173 (6): 1439-1453.e19,2018.
Mathew Nimitha R, Baumgartner Francis, Braun Lukas, O'Sullivan David, Thomas Simone, Waterhouse Miguel, Müller Tony A, Hanke Kathrin, Taromi Sanaz, Apostolova Petya, Illert Anna L, Melchinger Wolfgang, Duquesne Sandra, Schmitt-Graeff Annette, Osswald Lena, Yan Kai-Li, Weber Arnim, Tugues Sonia, Spath Sabine, Pfeifer Dietmar, Follo Marie, Claus Rainer, Lübbert Michael, Rummelt Christoph, Bertz Hartmut, Wäsch Ralph, Haag Johanna, Schmidts Andrea, Schultheiss Michael, Bettinger Dominik, Thimme Robert: Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nature medicine 24 (4): 526,2018.