Description of Research Expertise:
Tumor Immunology
Chimeric Antigen Receptor T cells
Mouse Models of Human Leukemia
Murine Xenografts
Adoptive Cellular Therapy
Genetic Engineering of T cells
Flow Cytometry
Selected Publications:
Ganetsky Alex, Frey Noelle V, Hexner Elizabeth O, Loren Alison W, Gill Saar I, Luger Selina M, Mangan James K, Martin Mary Ellen, Babushok Daria V, Drobyski William R, Smith Jacqueline, Timlin Colleen, Freyer Craig W, Stadtmauer Edward A, Porter David L: Tocilizumab for the treatment of severe steroid-refractory acute graft-versus-host disease of the lower gastrointestinal tract. Bone marrow transplantation : 2018.
Kim Miriam Y, Yu Kyung-Rok, Kenderian Saad S, Ruella Marco, Chen Shirley, Shin Tae-Hoon, Aljanahi Aisha A, Schreeder Daniel, Klichinsky Michael, Shestova Olga, Kozlowski Miroslaw S, Cummins Katherine D, Shan Xinhe, Shestov Maksim, Bagg Adam, Morrissette Jennifer J D, Sekhri Palak, Lazzarotto Cicera R, Calvo Katherine R, Kuhns Douglas B, Donahue Robert E, Behbehani Gregory K, Tsai Shengdar Q, Dunbar Cynthia E, Gill Saar: Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia. Cell 173 (6): 1439-1453.e19,2018.
Mathew Nimitha R, Baumgartner Francis, Braun Lukas, O'Sullivan David, Thomas Simone, Waterhouse Miguel, Müller Tony A, Hanke Kathrin, Taromi Sanaz, Apostolova Petya, Illert Anna L, Melchinger Wolfgang, Duquesne Sandra, Schmitt-Graeff Annette, Osswald Lena, Yan Kai-Li, Weber Arnim, Tugues Sonia, Spath Sabine, Pfeifer Dietmar, Follo Marie, Claus Rainer, Lübbert Michael, Rummelt Christoph, Bertz Hartmut, Wäsch Ralph, Haag Johanna, Schmidts Andrea, Schultheiss Michael, Bettinger Dominik, Thimme Robert: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nature medicine 24 (3): 282-291,2018.
Hosoya Hitomi, Levine Jeffrey, Abt Peter, Henry David, Porter David L, Gill Saar: Toward dual hematopoietic stem-cell transplantation and solid-organ transplantation for sickle-cell disease. Blood advances 2 (5): 575-585,2018.
Uribe-Herranz Mireia, Bittinger Kyle, Rafail Stavros, Guedan Sonia, Pierini Stefano, Tanes Ceylan, Ganetsky Alex, Morgan Mark A, Gill Saar, Tanyi Janos L, Bushman Frederic D, June Carl H, Facciabene Andrea: Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12. JCI insight 3 (4): 2018.
Cummins KD*, Frey N*, Nelson AM*, Schmidt A*, Luger S, Isaacs RE*, Lacey SF, Hexner E, Melenhorst JJ, June CH, Porter DL, Gill SI.: Treating Relapsed / Refractory (RR) AML with Biodegradable AntiCD123
CAR Modified T Cells American Society for Hematology Annual Meeting, Atlanta, GA : 2017.
Ruella M*, Maude SL*, Engels B*, Barrett DM*, Frey N*, Marcucci K, Shestova O, Singh N, Perazzelli J, Christian DA, Hunter CA, Haagen D, Lacey S, Melenhorst J, Brogdon J, Young R, Porter DL, June CH, Grupp S, Gill S.: Clinical efficacy of anti-CD22 chimeric antigen receptor T cells for B-cell acute lymphoblastic leukemia is correlated with the length of the scFv linker and can be predicted using xenograft models American Society for Hematology Annual Meeting, Atlanta, GA : 2017.
Ruella M, Xu J, Barrett DM*, Kulikovskaya I*, Ambrose DE*, Patel PR*, Reich T*, Scholler J*, Nazimuddin F*, Fraietta JA*, Maude SL, Gill SI, Levine BL, Nobles CL*, Bushman FD*, Orlando E*, Grupp SA, June CH, Melenhorst JJ, Lacey SF.: Iatrogenic Induction of Chimeric Antigen Receptor Therapy Resistance American Society of Hematology Annual Meeting, Atlanta, GA : 2017.
Ruella M, Klichinsky M, Kenderian SS, Shestova O, Ziober A, Kraft DO, Feldman M, Wasik MA, June CH, Gill S: Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells Cancer Discovery 7 (10): 1154-67,2017.
Cummins Katherine D, Gill Saar: Anti-CD123 chimeric antigen receptor T-cells (CART): an evolving treatment strategy for hematological malignancies, and a potential ace-in-the-hole against antigen-negative relapse. Leukemia & lymphoma : 1-15,2017.