Penn Medicine Provider
Ronny Drapkin, MD, PhD
Jordan Center for Gynecologic Cancers

About me

  • Director, Ovarian Cancer Research Center
  • Director, Gynecologic Cancer Research, Basser Center for BRCA
  • Franklin Payne Professor of Pathology in Obstetrics & Gynecology

Education and training

  • Residency: Massachusetts General Hospital/Brigham and Women’s Hospital
  • Fellowship: Dana-Farber Cancer Institute

My Locations

Qualifications and experience

My research

de Santiago PR, Sato S, Zhang SJ, Dougher MC, Devins KM, Bilecz AJ, Rayamajhi S, Mingo G, Rendulich HS, Feng Y, Wu C, Taylor MS, Zhuravlev Y, Jung E, Omran DK, Wang TL, Shih IM, Schwartz LE, Kim S, Morgan MA, Tanyi JL, Burns KH, Lengyel E, Parra-Herran C, Godwin AK, Walt DR, Drapkin R. LINE-1 ORF1p expression occurs in clear cell ovarian carcinoma precursors and is a candidate blood biomarker , NPJ Precis Oncology, 9(1): 2025,62


Kader T, Lin JR, Hug CB, Coy S, Chen YA, de Bruijn I, Shih N, Jung E, Pelletier RJ, Lopez Leon M, Mingo G, Omran DK, Lee JS, Yapp C, Satravada BA, Kundra R, Xu Y, Chan S, Tefft JB, Muhlich JL, Kim SH, Gysler SM, Agudo J, Heath JR, Schultz N, Drescher CW, Sorger PK, Drapkin R*, Santagata S*., *co-senior authors Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma , Cancer Discovery: Online ahead of print


Beddows I, Djirackor S, Omran DK, Jung E, Shih NN, Roy R, Hechmer A, Olshen A, Adelmant G, Tom A, Morrison J, Adams M, Rohrer DC, Schwartz LE, Pearce CL, Auman H, Marto JA, Drescher CW*, Drapkin R*, Shen H*., * denotes co-corresponding senior authors Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube , Nature Communications, 16(1): 2025,2981


Knarr MJ, Moon J, Rawat P, DiFeo A, Hoon DSB, Drapkin R. Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas , Science Signaling, 17(863): 2024,eado8303


Reavis HD, Gysler SM, McKenney GB, Knarr M, Lusk HJ, Rawat P, Rendulich HS, Mitchell MA, Berger DS, Moon JS, Ryu S, Mainigi M, Iwanicki MP, Hoon DS, Sanchez LM, Drapkin R. Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells. , JCI Insight, 9(5): 2024,e170961


Taylor MS, Wu C, Fridy PC, Zhang SJ, Senussi Y, Wolters JC, Cajuso T, Cheng WC, Heaps JD, Miller BD, Mori K, Cohen L, Jiang H, Molloy KR, Chait BT, Goggins MG, Bhan I, Franses JW, Yang X, Taplin ME, Wang X, Christiani DC, Johnson BE, Meyerson M, Uppaluri R, Egloff AM, Denault EN, Spring LM, Wang TL, Shih IM, Fairman JE, Jung E, Arora KS, Yilmaz OH, Cohen S, Sharova T, Chi G, Norden BL, Song Y, Nieman LT, Pappas L, Parikh AR, Strickland MR, Corcoran RB, Mustelin T, Eng G, Yilmaz OH, Matulonis UA, Skates SJ, Rueda BR, Drapkin R, Klempner SJ, Deshpande V, Ting DT, Rout MP, LaCava J, Walt DR, Burns KH Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. , Cancer Discov, 13(12): 2023,2532-2547


Chaves-Moreira D, Mitchell MA, Arruza C, Rawat P, Sidoli S, Nameki R, Reddy J, Corona RI, Afeyan LK, Klein IA, Ma S, Winterhoff B, Konecny GE, Garcia BA, Brady DC, Lawrenson K, Morin PJ, Drapkin R The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17. , Science Signaling, 15(728): 2022,eabm2496


Gysler SM, Drapkin R Tumor innervation: peripheral nerves take control of the tumor microenvironment. , J Clin Invest, 131(11): 2021


Labidi-Galy SI, Papp E, Hallberg D, Niknafs N, Adleff V, Noe M, Bhattacharya R, Novak M, Jones S, Phallen J, Hruban CA, Hirsch MS, Lin DI, Schwartz L, Maire CL, Tille JC, Bowden M, Ayhan A, Wood LD, Scharpf RB, Kurman R, Wang TL, Shih IM, Karchin R, Drapkin R*, Velculescu VE*., * Co-senior/corresponding authors High grade serous ovarian carcinomas originate in the fallopian tube. , Nature Communications, 8(1): 2017,1093


Perets R, Muto KW, Bijron JG, Poole BB, Chin KT, Kwak S, Chen JYH, Karst AM, Setlur SR, Hirsch MS, Crum CP, Dinulescu DM, Drapkin R Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models. *Highlighted in Nature Reviews Cancer, Cancer Discovery, and Cancer Research. , Cancer Cell, 24: 751-65: 2013


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