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Perelman Center for Advanced Medicine
Abramson Cancer Center, West Pavilion, 3rd Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
RESEARCH INTERESTS:The Drapkin laboratory focuses on developing a comprehensive understanding of the genetic, molecular and physiological factors that drive the development of cancer, with a special focus on gynecologic malignancies. Recent work from our group and others has implicated the fallopian tube (FT) secretory cell as the likely cell-of-origin for a majority of high-grade serous ovarian carcinomas. This new concept of ovarian tumorigenesis has been a paradigm shift in the field and the Drapkin lab has been at the forefront in developing novel experimental platforms that address the role of the FT epithelium and its susceptibility to neoplastic transformation. These platforms include genetically engineered mouse (GEM) models, fallopian tube-derived cell lines, and patient-derived tumor xenografts. The lab is currently focused on utilizing these models to interrogate how genetic and epigenetic alterations influence lineage dependencies, genomic instability, DNA repair, replicative stress, and metabolism. The goal is to define selective vulnerabilities that can guide novel therapeutic approaches and biomarker development.KEYWORDS: Ovarian cancer, Fallopian tube, Genomics/Epigenomics of precursor lesions, Cyclin E, Replication Stress, BRCA1/2, DNA Repair, Tumor Innervation, Protein complexes, Biomarkers, Animal models.ROTATION PROJECTS:Rotation projects are open to students in each of the areas the lab focuses on. Please see Ronny Drapkin to discuss potential rotation projects.LAB PERSONNEL:Marilyn Mitchell, Lab ManagerNatalia Tulina, Research SpecialistPriyanka Rawat, Bioinformatics SpecialistDaniele Moreira, Pharm PhD, Postdoctoral ResearcherMatthew Knarr, PhD, Postdoctoral ResearcherYasuko Kinose, MD, PhD, Visiting Assistant ProfessorHunter Reavis, Graduate StudentAdam Ferrari, Graduate StudentGrace McKenney, Penn Undergraduate StudentADMINISTRATIVE COORDINATOR:Denise Curley215firstname.lastname@example.org
Hooda J, Novak M, Salomon MP, Matsuba C, Ramos RI, MacDuffie E, Song M, Hirsch MS, Lester J, Parkash V, Karlan BY, Oren M, Hoon DS, Drapkin R.: Early loss of Histone H2B monoubiquitylation alters chromatin accessibility and activates key immune pathways that facilitate progression of ovarian cancer. Cancer Research 79 (4): 760-772,2019.
Lucido CT, Wynja E, Madeo M, Williamson CS, Schwartz LE, Imblum BA, Drapkin R, Vermeer PD.: Innervation of cervical carcinoma is mediated by cancer-derived exosomes. Gynecol Oncol. 154 (1): 228-235,2019.
Labidi-Galy SI, Papp E, Hallberg D, Niknafs N, Adleff V, Noe M, Bhattacharya R, Novak M, Jones S, Phallen J, Hruban CA, Hirsch MS, Lin DI, Schwartz L, Maire CL, Tille JC, Bowden M, Ayhan A, Wood LD, Scharpf RB, Kurman R, Wang TL, Shih IM, Karchin R, Drapkin R*, Velculescu VE*., * Co-senior/corresponding authors: High grade serous ovarian carcinomas originate in the fallopian tube. Nature Communications 8 (1): 1093,2017.
Au-Yeung G, Lang F, Azar WJ, Mitchell C, Jarman KE, Lackovic K, Aziz D, Cullinane C, Pearson RB, Mileshkin L, Rischin D, Karst AM, Drapkin R, Etemadmoghadam D, Bowtell DD.: Selective targeting of Cyclin E1 amplified high grade serous ovarian cancer by cyclin-dependent kinase 2 and AKT inhibition. Clin Can Res 23 (7): 1862-1874,2017.
Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf G, English J, Kirschmeier PT, Velculescu VE, Paweletz CP, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R.: Establishment of patient-derived tumor xenograft models of epithelial ovarian cancer for pre-clinical evaluation of novel therapeutics. Clin Can Res 23 (5): 1263-1273,2017.
Elias KM, Emori MM, Westerling T, Long H, Budina-Kolomets A, Li F, MacDuffie E, Davis MR, Holman A, Lawney B, Freedman ML, Quackenbush J, Brown M, Drapkin R.: Epigenetic remodeling regulates transcriptional changes between ovarian cancer and benign precursors. JCI Insight 1 (13): e87988,2016.
Davidowitz RA, Selfors LM, Iwanicki MP, Karst AM, Piao HY, Ince TA, Dering J, Konecny GE, Matulonis U, Mills GB, Slamon DJ, Drapkin R*, Brugge JS*. Co-senior/corresponding authors.: Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance. J Clin Invest 124(6):2611-25 : 2014.
Karst AM, Jones PM, Vena N, Ligon AH, Liu JF, Hirsch MS, Etemadmoghadam D, Bowtell DD, Drapkin R: Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers. Cancer Res 74 (4): 1141-52,2014.
Perets R, Muto KW, Bijron JG, Poole BB, Chin KT, Kwak S, Chen JYH, Karst AM, Setlur SR, Hirsch MS, Crum CP, Dinulescu DM, Drapkin R: Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models. *Highlighted in Nature Reviews Cancer, Cancer Discovery, and Cancer Research. Cancer Cell 24: 751-65 : 2013.
Karst AM, Levanon K, Drapkin R: Modeling high-grade serous ovarian carcinogenesis from the fallopian tube. *Highlighted in Nature Reviews Cancer and JNCI Proc Natl Acad Sci 108: 7547-7552 : 2011.
University of PennsylvaniaBiomedical Research Building421 Curie Blvd., Rm. 1215
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