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Ronald P. DeMatteo, MD, FACS

Ronald P. DeMatteo, MD, FACS Physician

Chair, Department of Surgery John Rhea Barton Professor of Surgery

Dr. DeMatteo is employed by Penn Medicine.

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About Dr. Ronald P. DeMatteo

Dr. DeMatteo is the Chairman of the Department of Surgery and a Surgical Oncologist who specializes in treating diseases of the liver, bile duct, gallbladder, pancreas and abdominal sarcomas (GIST). 

His clinical research has focused on liver, bile duct, gallbladder, and pancreas cancers. In addition, he has led several national trials testing the benefit of imatinib mesylate (Gleevec) following surgery for gastrointestinal stromal tumor (GIST), a tumor that usually begins in the stomach or intestine. 

In the laboratory he and his colleagues study the immune environment of the liver and tumor immunology, working to develop immune therapies to help prevent tumors from returning after surgery.


  • 2016 — Jeroen Pit Science Award, The GIST Life Raft Support Group
  • 2015 - present — Castle Connolly/Newsweek America's Top Doctors for Cancer
  • 2014 - present — New York Magazine Best Doctors
  • 2013 - present — Castle Connolly/U.S. News and World Report's America's Top Doctors
  • 2008 - 2010 — Society of Surgical Oncology Clinical Investigator Award

Clinical Specialties


  • Endocrine and Oncologic Surgery

Programs & Centers:

Board Certification:

  • Surgery, 1998

Clinical Expertise:

  • Ampullary Cancer
  • Bile Duct Cancer
  • Bile Duct Surgery
  • Bile Duct Tumor
  • Biliary Stricture (Bile Duct Stricture)
  • Biliary Surgery
  • Gallbladder Cancer
  • Gallbladder Surgery
  • Gallstones
  • Gastrointestinal Carcinoid Tumor
  • Gastrointestinal Stromal Tumors (GIST)
  • Hepatobiliary Surgery
  • Hepatocellular Carcinoma (HCC)
  • Intra-arterial Chemotherapy for Liver Cancer
  • Laparoscopic Diagnosis - Minimally Invasive
  • Laparoscopic Gallbladder Surgery
  • Laparoscopy Staging
  • Liver Cancer
  • Liver Cancer Surgery
  • Liver Metastases (Secondary Liver Cancer)
  • Liver Resection Surgery (Partial Hepatectomy)
  • Liver Tumors
  • Minimally Invasive Liver Resection Surgery
  • Neuroendocrine Tumors
  • Pancreatic Cancer
  • Pancreatic Cyst
  • Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)
  • Pancreatic Surgery
  • Pheocromocytoma
  • Stomach Removal Surgery (Gastrectomy)

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Cornell University
Residency: Hospital of the University of Pennsylvania
Residency: Memorial Sloan-Kettering Cancer Center


Alliance for Cancer Gene Therapy, National American Association for Cancer Research Cancer Progress Report 2015 Steering Committee, National American Association for Cancer Research, National American Association for Study of Liver Diseases, National American Association of Immunologists, National American College of Surgeons Oncology Group, National American College of Surgeons, National American Hepatopancreatobiliary Association, National American Joint Commission on Cancer (AJC) Staging Guidelines for GIST (Leader), National American Society of Clinical Investigation, National American Society of Clinical Oncology, National American Surgical Association, National Association of Academic Surgeons, National Cancer Immunology and Immunotherapy (CII) Study Section, NIH, National European Society of Medical Oncology Consensus Guidelines for the Treatment of GIST, International External Advisory Board, T32 in Hematology/Medical Oncology, Columbia University, Local Gastrointestinal Stromal Tumor Task Force, National Cancer Institute, National Gastrointestinal Stromal Tumor Working Group, National Cancer Institute, National Gleevec Medical Affairs Gastrointestinal Stromal Tumor Advisory Board, Novartis, International Grant Reviewer, Empire Clinical Research Investigator Program (ECRIP), New York State, Local Grant Reviewer, French National Cancer Institute (INCa), International Grant Reviewer, German Research Foundation, International Grant Reviewer, Ontario Institute for Cancer Research Clinician Scientist Investigator Award, International Grant Reviewer, Pancreatic Cancer Action Network (PanCAN)- AACR Grants, National Hepatobiliary Pathophysiology (HBPP) Study Section, (NIH), National International Surgical Group (ISG), International James IV Association of Surgeons, International K08 Committee for Steven Katz, Roger Williams Cancer Center, National National Comprehensive Cancer Network (NCCN) Guidelines Committee for the Treatment of Gastrointestinal Stromal Tumor, National National Comprehensive Cancer Network (NCCN) Guidelines Committee for the Treatment of Hepatobiliary Cancer, National National Institutes of Health (NIH) Conference on STI571 for Gastrointestinal Stromal Tumor , National National Institutes of Health (NIH) Workshop on Gastrointestinal Stromal Tumors, National P01 Review Panel, National Institute of Diabetes and Digestive and Kidney Diseases(NIDDK), National Society for Immunotherapy of Cancer , National Society for Surgery of Alimentary Tract, National Society of Clinical Surgery, National Society of Surgical Oncology, National Society of University Surgeons, National State of the Science Meeting on Sarcoma, National Institutes of Health(NIH), National Surgical Biology Club I, National

Hospital Affiliation

Dr. DeMatteo is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Sicklick JK, Babicky M: Resection of non-adenomatous gastric tumors. Operative Endoscopic and Minimally Invasive Surgery. : 2017 (in press).

Cavnar MJ: Perspective on gastrointestinal stromal tumors. Magnicot's Abdominal Operations, 13th Edition. : 2017 (in press).

Cavnar MJ, Turcotte S, Katz SC, Kuk D, Gönen M, Shia J, Allen PJ, Balachandran VP, D'Angelica MI, Kingham TP, Jarnagin WR: Tumor-associated macrophage infiltration in colorectal cancer liver metastases is associated with better outcome. Ann Surg Oncol 24 (7): 1835-1842,2017.

Groot Koerkamp B, Sadot E, Kemeny NE, Gönen M, Leal JN, Allen PJ, Cercek A, DeMatteo RP, Kingham TP, Jarnagin WR: Perioperative hepatic arterial infusion pump chemotherapy is associated with longer survival after resection of colorectal liver metastases: A propensity score analysis. J Clin Oncol 35 (17): 1938-1944,2017.

Creasy JM, Goldman DA, Dudeja V, Lowery MA, Cercek A, Balachandran VP, Allen PJ, DeMatteo RP, Kingham TP, D'Angelica MI: Systemic chemotherapy combined with resection for locally advanced gallbladder carcinoma: Surgical and survival outcomes. J Am Coll Surg 224 (5): 906-916,2017.

Creasy JM, Goldman DA, Gonen M, Dudeja V, Askan G, Basturk O, Balachandran VP, Allen PJ, DeMatteo RP, D'Angelica MI, Jarnagin WR: Predicting residual disease in incidental gallbladder cancer: Risk stratification for modified treatment strategies. J Gastrointest Surg : 2017.

Pak LM, Coit DG, Eaton AA, Allen PJ, D'Angelica MI, DeMatteo RP, Jarnagin WR, Strong VE: Percutaneous peritoneal lavage for the rapid staging of gastric and pancreatic cancer. Ann Surg Oncol 24 (5): 1174-1179,2017.

Langan RC, Goldman DA, D'Angelica MI, DeMatteo RP, Allen PJ, Balachandran VP, Jarnagin WR: Recurrence patterns following irreversible electroporation for hepatic malignancies. J Surg Oncol : 2017.

Pak LM, D'Angelica MI, DeMatteo RP, Kingham TP, Balachandran VP, Jarnagin WR: Natural history of patients followed radiographically with mucinous cysts of the pancreas. J Gastrointest Surg : 2017.

Sorenson EC, Khanin R, Bamboat ZM, Cavnar MJ, Kim TS, Sadot E, Zeng S, Greer JB, Seifert AM, Cohen NA, Crawley MH, Green BL, Klimstra DS: Genome and transcriptome profiling of fibrolamellar hepatocellular carcinoma demonstrates p53 and IGF2BP1 dysregulation. PLoS One 12 (5): e0176562,2017.

Academic Contact Info

Department of Surgery
Perelman School of Medicine, University of Pennsylvania
3400 Spruce Street, 4th Floor Silverstein Pvln.

Philadelphia, PA 19104
Phone: (215) 662-7539
Patient appointments: 800-789-7366 (PENN)