Penn Medicine Provider
Endocrine and Oncologic Surgery
Ronald P. DeMatteo, MD, FACS
5.0
(250)
Accepting new patients
Sees patients age 18 and up
Penn Endocrine and Oncologic Surgery Perelman 4th Floor
View 1 additional location

About me

  • Chair, Department of Surgery
  • John Rhea Barton Professor of Surgery

Dr. DeMatteo is the Chairman of the Department of Surgery and a Surgical Oncologist who specializes in treating diseases of the liver, bile duct, gallbladder, pancreas and abdominal sarcomas (GIST).

His clinical research has focused on liver, bile duct, gallbladder, and pancreas cancers. In addition, he has led several national trials testing the benefit of imatinib mesylate (Gleevec) following surgery for gastrointestinal stromal tumor (GIST), a tumor that usually begins in the stomach or intestine.

In the laboratory he and his colleagues study the immune environment of the liver and tumor immunology, working to develop immune therapies to help prevent tumors from returning after surgery.

Honors

  • Recognized by America's Top Doctors for 2017 and 2018
  • Recognized by New York magazine Top Doctors issue:  2014, 2015, 2016
  • Castle Connolly America's Top Doctors for Cancer (digital guide): 2016, 2017, 2018, 2019, 2020, 2021
  • Recognized in Philadelphia magazine's annual Top Docs issues: 2018, 2019, 2020 and  2021
  • 2016:  Jeroen Pit Science Award, The GIST Life Raft Support Group
  • 2008 - 2010:  Society of Surgical Oncology Clinical Investigator Award

Education and training

  • Medical School: Cornell University
  • Residency: Hospital of the University of Pennsylvania
  • Residency: Memorial Sloan-Kettering Cancer Center

What my patients think about me

Average Rating
5.0

250 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

May 2025
5.0
5.0
very knowledgeable
May 2025
5.0
5.0
provided clear explanation and expectations
May 2025
5.0
5.0
excellent surgeon
May 2025
5.0
5.0
he's an excellent doctor with an excellent personality

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. DeMatteo is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Butler PD, Aarons CB, Ahn J, Wein AJ, Ruckenstein MJ, Lett LA, DeMatteo RP, Serletti JM. Leading from the Front: An approach to increasing racial and ethnic diversity in surgical training programs. , Ann Surg: 2019


Ganesh K, Wu C, O'Rourke KP, Szeglin BC, Zheng Y, Sauve CG, Adileh M, Wasserman I, Macro MR, Kim AS, Shady M, Sanchez-Vega F, Karthaus WR, Won HH, Choi SH, Pelossof R, Barlas A, Ntiamoah P, Pappou E, Elghouayel A, Strong JS, Chen CT, Harris JW, Weisser MR, Nash GM, Guillem JG, Wei IH, Kolesnick RN, Veeraraghavan H, Ortiz EJ, Petkovska I, Cercek A, Manova-Todorova KO, Saltz LB, Lavery JA, DeMatteo RP, Massague J, Paty PB, Yaeger R, Chen X, Patil S, Clevers H, Berger MF, Lowe SW, Shia J, Romesser PB, Dow LE, Garcia-Aguilar J, Sawyers CL, Smith JJ. A rectal cancer organoid platform to study individual responses to chemoradiation. , Nat Med, 25: 2019,1607-14


Medina BD, Vitiello GA, Seifert AM, Liu M, Bowler T, Zhang JQ, Cavnar MJ, Loo JK, Param NJ, Maltbaek JH, Rossi F, Balachandran VP, DeMatteo RP. Oncogenic kinase inhibition limits Batf3-dependent dendritic cell development and anti-tumor immunity. , J Exp Med: 2019


Cercek A, Boerner T, Tan BR, Chou JF, Gonen M, Boucher TM, Hauser HF, Do RKG, Lowery MA, Harding JJ, Varghese AM, Reidy-Lagunes D, Saltz L, Schultz N, Kingham TP, D'Angelica MI, DeMatteo RP, Drebin JA, Allen PJ, Balachandran VP, Lim KH, Sanchez-Vega F, Vachharajani N, Majella Doyle MB, Fields RC, Hawkins WG, Strasberg SM, Chapman WC, Diaz LA Jr, Kemeny NE, Jarnagin WR. Assessment of hepatic arterial infusion of floxuridine in combination with systemic gemcitabine and oxaliplatin in patients with unresectable intrahepatic cholangiocarcinoma: A phase 2 clinical trial. , JAMA Oncol: 2019


Gholami S, Kemeny NE, Boucher TM, Gonen M, Cercek A, Kingham TP, Balachandran V, Allen P, DeMatteo RP, Drebin J, Jarnagin W, D'Angelica M. Adjuvant hepatic artery infusion chemotherapy is associated with improved survival regardless of KRAS mutation status in patients with resected colorectal liver metastases: A retrospective analysis of 674 patients. , Ann Surg: 2019


Park LM, Gagniere J, Allen PJ, Balachandran VP, D'Angelica MI, DeMatteo RP, Jarnagin WR, Simpson AL, Kingham TP. Utility of image guidance in the localization of disappearing colorectal liver metastases. , J GI Surg: 2019


Song Y, Ecker BL, Tang R, Maggino L, Roses RE, DeMatteo RP, Fraker DL, Karakousis GC. Trends in practice patterns and outcomes: A decade of sarcoma care in the United States. , Surg Oncol, 29: 2019,168-77


Samstein RM, Lee CH, Shoushtari AN, Hellman MD, Shen R, Janjigian YY, Barron DA, Zehir A, Jordan EJ, Omuro A, Kaley TJ, Kendall SM, Motzer RJ, Hakimi AA, Voss MH, Russo P, Rosenberg J, Iyer G, Bochner BH, Bajorin DF, Al-Ahmadie HA, Chaft JE, Rudin CM, Riely GJ, Baxi S, Ho AL, Wong RJ, Pfister DG, Wolchok JG, Barker CA, Gutin PH, Brennan CW, Tabar V, Mellinghoff IK, DeAngelis LM, Ariyan CE, Lee N, Tap WD, Gounder MM, D'Angelo SP, Saltz L, Stadler ZK, Scher HI, Baselga J, Razavi P, Klebanoff CA, Yaeger R, Segal NH, Ku GY, DeMatteo RP, Ladanyi M, Rizvi NA, Berger MF, Riaz N, Solit DB, Chan TA, Morris LGT. Tumor mutational load predicts survival after immunotherapy across multiple cancer types. , Nat Genet, 51: 2019,202-6


Gamboa AC, Aveson VG, Zaidi MY, Lee RM, Jarnagin WR, Allen PJ, Drebin JA, Peter Kinghamm T, DeMatteo RP, Sarmiento JM, Russell MC, Cardona K, Kooby DA, D'Angelica MI, Maithel SK. Lending a hand for laparoscopic distal pancreatectomy: the optimal approach? , HPB: 2019


Glauser G, Osiemo B, Goodrich S, McClintock SD, Vollmer C, DeMatteo RP, Malhotra NR. Association of Overlapping, nonconcurrent, surgery with patient outcomes at a large academic medical center: A coarsened exact matching study. , Ann Surg, 270: 2019,620-9