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Ron C. Anafi, MD, PhD

Ron C. Anafi, MD, PhD Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Anafi is a Penn Medicine employed physician.

Clinical Specialties


  • Sleep Medicine

Programs & Centers:

Board Certification:

  • Internal Medicine, 2007
  • Sleep Medicine (ABIM), 2009
  • Sleep Medicine (ABSM), 2009

Clinical Expertise:

  • Circadian Rhythm Disorders
  • Delayed Sleep Phase Syndrome (DSPD)
  • Idiopathic Hypersomnolence
  • Insomnia
  • Narcolepsy
  • Restless Leg Syndrome
  • Sleep Apnea
  • Sleep Disorders
  • Sleep Disorders in the Elderly
  • Sleep Study
  • Sleepiness

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Minnesota Medical School
Residency: Fletcher Allen Health Care
Fellowship: Hospital of the University of Pennsylvania


Member, American Academy of Sleep Medicine, National Member, Society for Research on Biological Rhythms, National

Hospital Affiliation

Dr. Anafi is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Selected Publications:

Arnardottir ES, Nikonova EV, Shockley KR, Podtelezhnikov AA, Anafi R, Tanis KQ, Maislin G, Stone DJ, Renger JJ, Winrow CJ, Pack AI: Interindividual differences in human blood transcriptome in response to sleep deprivation Sleep : 2014.

Anafi RC, Lee Y, Sato TK, Venkataraman A Hughes ME, Baggs JE, Liu AC, Kim J, Hogenesch JB: Machine learning helps identify CHRONO as a circadian clock component PLoS Biology : 2014.

Deckar A, Anafi RC, Hogensch JB, Haase SB, Harer J: Design and analysis of large-sacale biological rhythm studies: a comparison of algorithms fo rdetecting periodic signals in biological data Bioinformatics : 2013.

Anafi R, Pellegrino R, Shockley KR, Romer M, Tufik S, Pack AI: Sleep synchronizes transcription in the lung Sleep 36 : A13,2013.

Anafi RC, Pellegrino R, Shockley KR, Romer M, Tufik S, Pack AI: Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues BMC Genomics 14 (1): 362,2013.

Arnardottir, E.S., Nikonova, E.V., Shockley, K.R., Anafi, R.C., Podtelezhnikov, A.A., Tanis, K., Stone, D.J., Maislin, G., Gislason, T., Renger, J., Winrow, C. and Pack A.I.: Response to sleep deprivation and recovery sleep: human blood biomarkers Journal of Sleep Research 21 (1): 38,2012.

Schwartz BL, Anafi RC, Aliyeva M, Thompson-Figueroa JA, Allen GB, Lundblad LKA, Bates JHT: Effects of central airway shunting on the mechanical impedance of the mouse lung Annals of Biomedical Engineering 39 (1): 497-507,2011.

Anafi RC, Bates JHT: Balancing robustness against the dangers of multiple attractors in a Hopfield-type model of biological attractors PLoS One 5 (12): e14413,2010.

Bates JHT, Bullimore SR, Politi AZ, Sneyd J, Anafi RC, Lauzon AM: Transient oscillatory force-length behavior of activated airway smooth muscle American Journal of Physiology: Lung Cell and Molecular Physiology 297 (2): 362-372,2009.

Anafi RC, Beck KC, Wilson TA: Impedance, gas mixing, and bimodal ventilation in constricted lungs Journal of Applied Physiology 94 (3): 1003-1011,2003.

Academic Contact Info

10-131 Smilow Translational Research Center
3400 Civic Center Boulevard, Building 421

Philadelphia, PA 19104
Patient appointments: 800-789-PENN (7366)

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