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Ron C. Anafi, MD, PhD

Ron C. Anafi, MD, PhD Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Anafi is employed by Penn Medicine.

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Clinical Specialties


  • Sleep Medicine

Programs & Centers:

Board Certification:

  • Internal Medicine, 2007
  • Sleep Medicine (ABIM), 2009
  • Sleep Medicine (ABSM), 2009

Clinical Expertise:

  • Circadian Rhythm Disorders
  • Delayed Sleep Phase Syndrome (DSPD)
  • Excessive Daytime Sleepiness
  • Idiopathic Hypersomnolence
  • Insomnia
  • Narcolepsy
  • Restless Leg Syndrome (RLS)
  • Sleep Apnea
  • Sleep Disorders
  • Sleep Disorders in the Elderly
  • Sleep Study

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Minnesota Medical School
Residency: University of Vermont Medical Center
Fellowship: Hospital of the University of Pennsylvania


Member, American Academy of Sleep Medicine, National Member, Society for Research on Biological Rhythms, National

Hospital Affiliation

Dr. Anafi is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Selected Publications:

Anafi Ron C, Francey Lauren J, Hogenesch John B: CYCLOPS reveals human transcriptional rhythms in health and disease. Proceedings of the National Academy of Sciences of the United States of America : 2017.

Krishnaiah Saikumari Y, Wu Gang, Altman Brian J, Growe Jacqueline, Rhoades Seth D, Coldren Faith, Venkataraman Anand, Olarerin-George Anthony O, Francey Lauren J, Mukherjee Sarmistha, Girish Saiveda, Selby Christopher P, Cal Sibel, Er Ubeydullah, Sianati Bahareh, Sengupta Arjun, Anafi Ron C, Kavakli I Halil, Sancar Aziz, Baur Joseph A, Dang Chi V, Hogenesch John B: Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism. Cell metabolism 25 (4): 961-974.e4,2017.

Wu G, Anafi RC, Hughes ME, Kornacker K: MetaCycle: an integrated R package to evaluate periodicity in large scale data. Bioinformatics 32 (21): 3351-3353,2016.

Zhang Ray, Podtelezhnikov Alexei A, Hogenesch John B: Discovering Biology in Periodic Data through Phase Set Enrichment Analysis (PSEA). Journal of biological rhythms 31 (3): 244-57,2016.

Arnardottir Erna S, Nikonova Elena V, Shockley Keith R, Podtelezhnikov Alexei A, Anafi Ron C, Tanis Keith Q, Maislin Greg, Stone David J, Renger John J, Winrow Christopher J: Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation. Sleep 37 (10): 1589-600,2014.

Anafi Ron C, Lee Yool, Sato Trey K, Venkataraman Anand, Ramanathan Chidambaram, Kavakli Ibrahim H, Hughes Michael E, Baggs Julie E, Growe Jacqueline, Liu Andrew C, Kim Junhyong: Machine learning helps identify CHRONO as a circadian clock component. PLoS biology 12 (4): e1001840,2014.

Deckard Anastasia, Anafi Ron C, Hogenesch John B, Haase Steven B: Design and analysis of large-scale biological rhythm studies: a comparison of algorithms for detecting periodic signals in biological data. Bioinformatics (Oxford, England) 29 (24): 3174-80,2013.

Anafi Ron C, Pellegrino Renata, Shockley Keith R, Romer Micah, Tufik Sergio: Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues. BMC genomics 14 : 362,2013.

Schwartz BL, Anafi RC, Aliyeva M, Thompson-Figueroa JA, Allen GB, Lundblad LKA: Effects of central airway shunting on the mechanical impedance of the mouse lung Annals of Biomedical Engineering 39 (1): 497-507,2011.

Anafi RC: Balancing robustness against the dangers of multiple attractors in a Hopfield-type model of biological attractors PLoS One 5 (12): e14413,2010.

Academic Contact Info

Translational Research Laboratories, Suite 2100
125 South 31st Street

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)

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