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Roderic G. Eckenhoff, MD

Roderic G. Eckenhoff, MD Physician

Austin Lamont Professor of Anesthesia

Dr. Eckenhoff is employed by Penn Medicine.

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Clinical Specialties


  • Anesthesiology

Programs & Centers:

Board Certification:

  • Anesthesiology, 1987

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Capital Blue Cross
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Northwestern University Feinberg School of Medicine
Residency: Northwestern Medical Center
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Chemical Society, National American Physiologic Society, National American Society of Anesthesiologists, National Association for the Advancement of Science, National Association of Univeristy Anesthesiologists, National Biophysical Society, National International Anesthesia Research Society, International John Morgan Society (Univ. of Pennsylvania), Local New York Academy of Sciences, National Philadelphia County Society of Anesthesiologists, Local Physiologic Society of Philadelphia, Local Society for Neuroscience, International Undersea and Hyperbaric Medical Society, National

Hospital Affiliation

Dr. Eckenhoff is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.


Description of Research Expertise:

Discovery of the general anesthetics is considered one of the most important medical advances of all time. They are used in over 100 million patients every year, and yet remain the most toxic and poorly understood of all drugs. The goal of my laboratory is a translational understanding of general anesthetic pharmacology, but focused at the most fundamental molecular level. This is a critical foundation on which the subsequent superstructure of molecular, cellular and organism understanding will be built. We have developed a wide variety of experimental approaches to study anesthetic binding to proteins, and the structural and dynamic consequences. Thus, photoaffinity labeling, fluorescence spectroscopy, amide hydrogen exchange, low-affinity elution chromatography and differential/isothermal calorimetry have all been introduced and validated for this purpose. We have moved from simple protein and peptide models to the most relevant and complex ion channels, enzymes, and receptors. We collaborate with Penn Chemistry (William Dailey, Ivan Dmochowski) to introduce novel reagents into our campaign to understand molecular anesthesia. Wide collaborations with many other departments and institutions have facilitated a rapid, multidisciplinary attack on some of the most fundamental questions in anesthetic pharmacology.

Our studies of general anesthetics have led to the observation that they can potently promote aggregation of selected peptides and proteins, as well as modulate the immune response. Since a common feature of most neurodegenerative disorders is aggregation of endogenous peptide, and neuroinflammation, the general anesthetics may accelerate the onset of neurodegeneration. Examination of the effects of anesthesia and surgery in a fully translational manner is a growing focus of our laboratory.

Selected Publications:

Woll Kellie A, Zhou Xiaojuan, Bhanu Natarajan V, Garcia Benjamin A, Covarrubias Manuel, Miller Keith W, Eckenhoff Roderic G: Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32 (8): 4172-4189,2018.

Bensel Brandon M, Guzik-Lendrum Stephanie, Masucci Erin M, Woll Kellie A, Eckenhoff Roderic G, Gilbert Susan P: Common general anesthetic propofol impairs kinesin processivity. Proceedings of the National Academy of Sciences of the United States of America 114 (21): E4281-E4287,2017.

Woll Kellie A, Murlidaran Sruthi, Pinch Benika J, Hénin Jérôme, Wang Xiaoshi, Salari Reza, Covarrubias Manuel, Dailey William P, Brannigan Grace, Garcia Benjamin A, Eckenhoff Roderic G: A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in Synaptosomes. The Journal of biological chemistry 291 (39): 20473-86,2016.

Ho J, Perez-Aguilar JM, Gao L, Saven JG, Matsunami H, Eckenhoff RG: Molecular recognition of ketamine by a subset of olfactory G protein–coupled receptors. Sci. Signal. 8 (370): 2015.

Weiser Brian P, Eckenhoff Roderic G: Propofol Inhibits SIRT2 Deacetylase through a Conformation-specific, Allosteric Site. The Journal of biological chemistry 290 (13): 8559-68,2015.

Tang Junxia X, Mardini Feras, Janik Luke S, Garrity Sean T, Li Rosie Q, Bachlani Gulnaz, Eckenhoff Roderic G, Eckenhoff Maryellen F: Modulation of murine Alzheimer pathogenesis and behavior by surgery. Annals of surgery 257 (3): 439-48,2013.

Emerson DJ, Weiser BP, Psonis J, Liao Z, Taratula O, Fiamengo A, Wang X, Sugasawa K, Smith A, Eckenhoff RG, Dmochowski IJ.: Direct modulation of microtubule stability contributes to anthracene general anesthesia. J. Am. Chem. Soc. : 2013.

Hall Michael A, Xi Jin, Lor Chong, Dai Shuiping, Pearce Robert, Dailey William P, Eckenhoff Roderic G: m-Azipropofol (AziPm) a photoactive analogue of the intravenous general anesthetic propofol. Journal of medicinal chemistry 53 (15): 5667-75,2010.

Liu R, Loll PJ, Eckenhoff RG: Structural basis for high-affinity volatile anesthetic binding in a natural 4-helix bundle protein. FASEB J. 19 (6): 567-76,2005.

Eckenhoff RG, Johansson JS, Wei H, Carnini A, Kang B, Wei W, Pidikiti R, Keller JM, Eckenhoff MF: Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity. Anesthesiology 101 (3): 703-9,2004.

View all publications

Academic Contact Info

311A John Morgan Building
3620 Hamilton Walk

Philadelphia, PA 19104-6112
Phone: (215) 746-8699
Patient appointments: 800-789-7366 (PENN)

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