Description of Research Expertise:
Dr. Schwab’s research has focused on the pathogenesis of obstructive sleep apnea utilizing novel upper airway imaging techniques. His studies help elucidate the role of the motion of key structures of the upper airway in mediating airway closure. By examining dynamic state-related changes in the upper airway and soft tissue structures surrounding the upper airway he has begun to understand the biomechanics of apneic events. He has studied patients with both magnetic resonance imaging and electronic beam computed tomography during wakefulness and sleep. Several novel findings have resulted from these studies: 1) the anatomic significance of the lateral pharyngeal walls in mediating airway caliber in normals and apneics; and 2) the characterization of the changes in upper airway caliber during the respiratory cycle and the importance of end-expiratory airway narrowing. Dr. Schwab collaborates closely with members of the Departments of Radiology and Biomechanical and Computer Engineering. They have developed state-of-the-art, computer graphics-based analysis software to help model in three dimensions the biomechanical interrelationships between the soft tissue structures and the upper airway.
Selected Publications:
Ackrivo J, Hansen-Flaschen J, Jones BL, Wileyto EP, Schwab RJ, Elman L, Kawut SM: Classifying Patients with Amyotrophic Lateral Sclerosis by Changes in FVC. A Group-based Trajectory Analysis Am J Respir Crit Care Med 200 (12): 2019.
Xu L, Keenan BT, Wiemken AS, Chi L, Staley B, Wang Z, Wang J, Benedikstdottir B, Juliusson S, Pack AI, Gislason T, Schwab RJ: Differences in Three-Dimensional Upper Airway Anatomy between Asian and European Patients with Obstructive Sleep Apnea SLEEP : 2019.
Kuna ST, Townsend RR, Keenan BT, Maislin D, Gislason T, Benediktsdóttir B, Gudmundsdóttir S, Arnardóttir ES, Sifferman A, Staley B, Pack FM, Guo X, Schwab RJ, Maislin G, Chirinos JA, Pack AI: Blood pressure response to treatment of obese vs non-obese adults with sleep apnea J Clin Hypertens (Greenwich) : 2019.
Wu PH, Rodríguez-Soto AE, Rodgers ZB, Englund EK, Wiemken A, Langham MC, Detre JA, Schwab RJ, Guo W, Wehrli FW: MRI evaluation of cerebrovascular reactivity in obstructive sleep apnea J Cereb Blood Flow Metab : 2019.
Jason Ackrivo, John Hansen-Flaschen, E. Paul Wileyto, Richard J. Schwab, Lauren Elman, Steven M. Kawut: Development of a prognostic model of respiratory insufficiency or death in amyotrophic lateral sclerosis Eur Respir J 53 (4): 2019.
Sutherland K, Keenan BT, Bittencourt L, Chen NH, Gislason T, Leinwand S, Magalang UJ, Maislin G, Mazzotti DR, McArdle N, Mindel J, Pack AI, Penzel T, Singh B, Tufik S, Schwab RJ, Cistulli PA: A Global Comparison of Anatomic Risk Factors and Their Relationship to Obstructive Sleep Apnea Severity in Clinical Samples J Clin Sleep Med 15 (4): 2019.
Clemens Heiser, Armin Steffen, Maurits Boon, Benedikt Hofauer, Karl Doghramji, Joachim T. Maurer, J. Ulrich Sommer, Ryan Soose, Patrick J. Strollo Jr, Richard Schwab, Erica Thaler, Kirk Withrow, Alan Kominsky, Christopher Larsen, Eric J. Kezirian, Jennifer Hsia, Stanley Chia, John Harwick, Kingman Strohl and Reena Mehra: Post-approval upper airway stimulation predictors of treatment efficacy in the ADHERE registry Eur Respir J : 2019.
Yuan Feng, Brendan T Keenan, Stephen Wang, Sarah Leinwand, Andrew Wiemken, Allan I Pack, and Richard J. Schwab: Dynamic Upper Airway Imaging During Wakefulness in Obese Subjects with and without Sleep Apnea Am J Respir Crit Care Med 198 (11): 2018.
Yaeger A, Cash NR, Parham T, Frankel DS, Deo R, Schaller RD, Santangeli P, Nazarian S, Supple GE, Arkles J, Riley MP, Garcia FC, Lin D, Epstein AE, Callans DJ, Marchlinski FE, Kolansky DM, Mora JI, Amaro 3, Schwab R, Pack A, Dixit S: A Nurse-Led Limited Risk Factor Modification Program to Address Obesity and Obstructive Sleep Apnea in Atrial Fibrillation Patients Journal of the American Heart Association : 2018.
Turnbull CD, Wang SH, Manuel AR, Keenan BT, McIntyre AG, Schwab RJ, Stradling JR: Relationships between MRI fat distributions and sleep apnea and obesity hypoventilation syndrome in very obese patients. Sleep & Breathing 22 (3): 673-681,2018.