Description of Research Expertise

Dr. Schwab’s research has focused on the pathogenesis of obstructive sleep apnea utilizing novel upper airway imaging techniques. His studies help elucidate the role of the motion of key structures of the upper airway in mediating airway closure. By examining dynamic state-related changes in the upper airway and soft tissue structures surrounding the upper airway he has begun to understand the biomechanics of apneic events. He has studied patients with both magnetic resonance imaging and electronic beam computed tomography during wakefulness and sleep. Several novel findings have resulted from these studies: 1) the anatomic significance of the lateral pharyngeal walls in mediating airway caliber in normals and apneics; and 2) the characterization of the changes in upper airway caliber during the respiratory cycle and the importance of end-expiratory airway narrowing. Dr. Schwab collaborates closely with members of the Departments of Radiology and Biomechanical and Computer Engineering. They have developed state-of-the-art, computer graphics-based analysis software to help model in three dimensions the biomechanical interrelationships between the soft tissue structures and the upper airway.

Selected Publications

Weaver TE, Pepin JL, Schwab R, Shapiro C, Hedner J, Ahmed M, Foldvary-Schaefer N, Strollo PJ, Mayer G, Sarmiento K, Baladi M, Bron M, Chandler P, Lee L, Malhotra A: Long-term effects of solriamfetol on quality of life and work productivity in participants with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea J Clin Sleep Med : 2021.

Keenan BT, Webster JC, Wiemken AS, Lavi-Romer N, Nguyen T, Svenson KL, Galante RJ, Churchill GA, Pickup S, Pack AI, Schwab RJ: Heritability of fat distributions in male mice from the founder strains of the Diversity Outbred mouse population G3 (Bethesda) : 2021.

Xu L, Keenan BT, Maislin D, Gislason T, Benediktsdóttir B, Gudmundsdóttir S, Gardarsdottir M, Staley B, Pack FM, Guo X, Feng Y, Chahwala J, Manaktala P, Hussein A, Reddy-Koppula M, Hashmath Z, Lee J, Townsend RR, Schwab RJ, Pack AI, Kuna ST, Chirinos JA: Effect of Obstructive Sleep Apnea and Positive Airway Pressure Therapy on Cardiac Remodeling as Assessed by Cardiac Biomarker and Magnetic Resonance Imaging in Nonobese and Obese Adults Hypertension : 2021.

Keenan BT, Schwab RJ: Using the Remote Monitoring Framework to Promote Adherence to Continuous Positive Airway Pressure Sleep Med Clin. : 2021.

Cielo CM, Keenan BT, Wiemken A, Tapia IE, Kelly A, Schwab RJ: Neck fat and obstructive sleep apnea in obese adolescents Sleep : 2021.

Laharnar N, Herberger S, Prochnow LK, Chen NH, Cistulli PA, Pack AI, Schwab R, Keenan BT, Mazzotti DR, Fietze I, Penzel T: Simple and Unbiased OSA Prescreening: Introduction of a New Morphologic OSA Prediction Score Nat Sci Sleep : 2021.

Lee CH, Seay EG, Reese JW, Wu X, Schwab RJ, Keenan B, Dedhia RC: Clinical Radiographic Predictors of Response to Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea Otolaryngol Head Neck Surg. : 2021.

Holfinger SJ, Lyons MM, Keenan BT, Mazzotti DR, Mindel J, Maislin G, Cistulli PA, Sutherland K, McArdle N, Singh B, Chen NH, Gislason T, Penzel T, Han F, Li QY, Schwab R, Pack AI, Magalang UJ: Diagnostic Performance of Machine Learning-Derived Obstructive Sleep Apnea Prediction Tools in Large Clinical and Community-based Samples Chest : 2021.

Victoria S. Sprung, Graham J. Kemp, John PH. Wilding, Valerie Adams, Kieran Murphy, Malcolm Burgess, Stephen Emegbo, Matthew Thomas, Alexander J. Needham, Andrew Weimken, Richard J. Schwab, Ari Manuel, Sonya E. Craig, Daniel J. Cuthbertson: Randomised, cOntrolled Multicentre trial of 26 weeks subcutaneous liraglutide (a glucagon-like peptide-1 receptor Agonist), with or without contiNuous positive airway pressure (CPAP), in patients with type 2 diabetes mellitus (T2DM) and obstructive sleep apnoEa (OSA) (ROMANCE): study protocol assessing the effects of weight loss on the apnea–hypnoea index (AHI) BMJ Open : 2020.

Carolyn M Jenks, MD; Jason L. Yu, MD; Katherine A. Schmitt, BSN; Richard J. Schwab, MD; Erica R. Thaler, MD: Prospective Determination of Airway Response to Upper Airway Stimulation: A New Opportunity for Advanced Device Titration The Laryngoscope : 2020.

Academic Contact Information

University of Pennsylvania Medical Center
3624 Market Street, Suite 205
Philadelphia, PA 19104
Phone: 215-662-7772
Patient appointments: 800-789-7366