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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
My major research interests are as follows:1) To investigate the molecular recognition mechanism of opioids and their receptors using biophysical, biochemical, thermodynamic, protein engineering, and high-resolution structural approaches. 2) Pharmacological effects of opioid receptor agonists. 3) Anesthetic interaction with proteins4) Preoperative evaluation and outcome
Ji F, Wang Z, Ma N, Riley J, Armstead WA, Liu R: Herkinorin dilates cerebral vessels via kappa opioid receptor and cyclic adenosine monophosphate (cAMP) signalling in a piglet model Brain Res 1490 : 95-100,2013.
Perez-Aguilar JM, Saven JG, Liu R: Human µ opioid receptor models with evaluation of the accuracy using the crystal structure of the murine µ opioid receptor. J Anesth Clin Res 3 (218): doi:10.4172/2155-6148.1000218,2012.
Bu W, Liu R, Cheung-Lau JC, Dmochowski IJ, Loll PJ, Eckenhoff RG: Ferritin couples iron and fatty acid metabolism FASEB J 26 (6): 2394-23400,2012.
Liu R, Bu W, Xi J, Mortazavi SR, Cheung-Lau J, Dmochowski IJ, Loll PJ: Beyond the detergent effect: A binding site for sodium dodecyl sulfate (SDS) in mammalian apoferritin Acta Crystallogr D Biol Crystallogr 68 (5): 497-504,2012.
Liu R, Perez-Aguilar JM, Liang D, Saven JG: Binding site and affinity prediction of general anesthetics to protein targets using docking Anesth Analg 114 (5): 947-955,2012.
Liu R, Garcia PS, Fleisher LA: Interest in anesthesia as reflected by keyword searches using common search engines J Anesth Clin Res 3 (1): 192. DOI: 10.4172/2155- 6148.1000192,2012.
Oakley S, Vedula S, Bu W, Xi J, Liu R, Eckenhoff RG, Loll PJ: Recognition of anesthetic barbiturates by a protein binding site: A high
resolution structural analysis PLoS One 7 (2): e32070,2012.
Wang Z, Ma N, Rily J, Armstead WA, Liu R: Salvinorin A administration after global cerebral hypoxia/ischemia preserves cerebrovascular autoregulation via kappa opioid receptor in piglets PLoS One 7 (7): e41724,2012.
Yan Z, Tanner JW, Lin D, Chalian AA, Savino JS, Fleisher LA, Liu R: Airway trauma in an academic cardiac electrophysiology laboratory center with high patient volume Anesth Analg 116 (1): 112-117,2013.
Su D, Reiley J, Armstead W, Liu R: Salvinorin A dilates pial artery by activating NOS, opioid receptor and the KATP channel Anesthesiology : A713,2010.
Su D, Riley J, Kiessling WJ, Armstead WM, Liu R: Salvinorin A pretreatment preserves cerebrovascular autoregulation after brain hypoxic/ischemic injury via ERK/MAPK in piglets Anesth Anal 114 (1): 200-204,2011.
Zhou R, Perez-Aguilar JM, Meng Q, Saven JG, Liu R: Opioid binding sites in human serum albumin Anesth Analg 114 (1): 122-128,2012.
Su D, Riley J, Kiessling WJ, Armstead WM, Liu R: Salvinorin A produces cerebrovasodilation through activation of nitric oxide synthase, κ receptor, and adenosine triphosphate-sensitive potassium channel Anesthesiology 114 (2): 374-379,2011.
Department of Anesthesiology and Critical Care336 John Morgan Building3620 Hamilton Walk