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Renyu Liu, MD

Renyu Liu, MD Physician

Associate Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania

Dr. Liu is employed by Penn Medicine.

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Clinical Specialties


  • Anesthesiology

Programs & Centers:

Board Certification:

  • Anesthesiology, 2009

Description of Clinical Expertise

Anesthesia for general surgery patients
Perioperative Medicine
outside OR anesthesia services
optimal opioid usage in perioperative period

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Xuzhou Medical College
Residency: Renji Hospital, Shanghai Second Medical University
Residency: Mercy Fitzgerald Hospital
Residency: Hospital of the University of Pennsylvania


American Society for Biochemistry and Molecular Biology (member ID 15890), National American Society of Anesthesiologists, National Association of University of Anesthesiologists (AUA), National Biophysical Society, National Chinese American Society of Anesthesiology, National Chinese Society of Anesthesiologists, International Pennsylvania Society of Anesthesiology, Local Society for Perioperative Assessment and Quality Improvement, National Society for the Advancement of Geriatric Anesthesia, National Society for Translational Neuroscience, International Society of Neuroscience, International The Chinese Academy of Anesthesiology (ICAA), International

Hospital Affiliation

Dr. Liu is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My major research interests are as follows:
1) To investigate the molecular recognition mechanism of opioids and their receptors using biophysical, biochemical, thermodynamic, protein engineering, and high-resolution structural approaches.
2) Pharmacological effects of opioid receptor agonists.
3) Anesthetic interaction with proteins
4) Preoperative evaluation and outcome

Selected Publications:

Ji F, Wang Z, Ma N, Riley J, Armstead WA, Liu R: Herkinorin dilates cerebral vessels via kappa opioid receptor and cyclic adenosine monophosphate (cAMP) signalling in a piglet model Brain Research 1490 : 95-100,2013.

Perez-Aguilar JM, Saven JG, Liu R: Human µ opioid receptor models with evaluation of the accuracy using the crystal structure of the murine µ opioid receptor. J Anesth Clin Res 3 (218): doi:10.4172/2155-6148.1000218,2012.

Bu W, Liu R, Cheung-Lau JC, Dmochowski IJ, Loll PJ, Eckenhoff RG: Ferritin couples iron and fatty acid metabolism FASEB Journal 26 (6): 2394-23400,2012.

Liu R, Bu W, Xi J, Mortazavi SR, Cheung-Lau J, Dmochowski IJ, Loll PJ: Beyond the detergent effect: A binding site for sodium dodecyl sulfate (SDS) in mammalian apoferritin Acta Crystallographica Section D 68 (5): 497-504,2012.

Liu R, Perez-Aguilar JM, Liang D, Saven JG: Binding site and affinity prediction of general anesthetics to protein targets using docking Anesth Analg 114 (5): 947-955,2012.

Liu R, Garcia PS, Fleisher LA: Interest in anesthesia as reflected by keyword searches using common search engines J Anesthe Clinic Res 3 (1): 192. doi: 10.4172/2155- 6148.1000192,2012.

Oakley S, Vedula S, Bu W, Xi J, Liu R, Eckenhoff RG, Loll PJ: Recognition of anesthetic barbiturates by a protein binding site: A high resolution structural analysis PLOS ONE 7 (7(2):e32070): 2012.

Wang Z, Ma N, Rily J, Armstead WA, Liu R: Salvinorin A administration after global cerebral hypoxia/ischemia preserves cerebrovascular autoregulation via kappa opioid receptor in piglets PLOS ONE 7 (7): e41724. Epub 2012 Jul 24,2012.

Yan Z, Tanner JW, Lin D, Chalian AA, Savino JS, Fleisher LA, Liu R: Airway trauma in an academic cardiac electrophysiology laboratory center with high patient volume Anesth Analg 116 (1): 112-117,2013.

Su D, Reiley J, Armstead W, Liu R: Salvinorin A dilates pial artery by activating NOS, opioid receptor and the KATP channel Anesthesiology : A713,2010.

Su D, Riley J, Kiessling WJ, Armstead WM, Liu R: Salvinorin A pretreatment preserves cerebrovascular autoregulation after brain hypoxic/ischemic injury via ERK/MAPK in piglets Anesth Analg 114 (1): 200-204,2011.

Zhou R, Perez-Aguilar JM, Meng Q, Saven JG, Liu R: Opioid binding sites in human serum albumin Anesth Analg 114 (1): 122-128,2012.

Su D, Riley J, Kiessling WJ, Armstead WM, Liu R: Salvinorin A produces cerebrovasodilation through activation of nitric oxide synthase, κ receptor, and adenosine triphosphate-sensitive potassium channel Anesthesiology 114 (2): 374-379,2011.

View all publications

Academic Contact Info

Department of Anesthesiology and Critical Care
336 John Morgan Building
3620 Hamilton Walk

Philadelphia, PA 19104
Phone: (215) 746-1485
Patient appointments: 800-789-7366 (PENN)

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