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Reed E. Pyeritz, MD, PhD

Reed E. Pyeritz, MD, PhD Physician

Vice Chair for Academic Affairs, Department of Medicine
William Smilow Professor
Professor of Genetics

Dr. Pyeritz is a Penn Medicine employed physician.

About Dr. Reed E. Pyeritz

Recognized annually in Philadelphia Magazine's Top Docs issue from 2004 through 2016

Recognized by America's Top Doctors, 2007, 2008, 2009, 2010, 2012-14

Recognized by Best Doctors in America 2005-2006, 2007-2008, 2009-2010, 2011-2012, 2013-2014

Clinical Specialties

Specialty:

  • Medicine
    • Medical Genetics

Programs & Centers:

Board Certification:

  • Internal Medicine, 1978
  • Medical Genetics - Clinical Genetics, 1982

Clinical Expertise:

  • Aneurysms
  • Aortic Aneurysm
  • Congenital Heart Disease in Adult
  • Ehlers-Danlos Syndrome - Vascular Type
  • Familial Aortic Aneurysm
  • Genetic and Rare Diseases Treatments and Procedures
  • Genetic Counseling
  • Genetic Testing
  • Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu Syndrome)
  • Homocystinuria
  • Kidney Polycystic Diseases
  • Long QT Syndrome (LQTS)
  • Osteogenesis Imperfecta
  • Turner Syndrome
  • Vascular Malformations

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Harvard Medical School
Residency: Peter Bent Brigham Hospital
Fellowship: Johns Hopkins Hospital

Memberships

American Association for the Advancement of Science, National American Board of Medical Genetics, National American College of Medical Genetics Foundation, National American College of Medical Genetics, National American College of Physicians, National American Federation for Medical Research, National American Heart Association, National American Heart Association, Pennsylvania Affiliate, Local American Medical Association, National American Society for Clinical Investigation, National American Society of Human Genetics, National Association of American Physicians, National Association of Professors of Human and Medical Genetics, National Canadian Institutes of Health Research, International Canadian Marfan Association, International Center for Disease Control and Prevention, National Coriell Institute for Medical Research, National Food and Drug Administration, National Hereditary Hemorrhagic Telangiectasia Foundation International, International Maryland State Athletic Commission, Local Middle Atlantic Regional Human Genetics Network, Local National Cancer Institute, National National Heart, Lung and Blood Institute, National National Marfan Foundation, National National Neurofibromatosis Foundation, National National Organization for Rare Disorders, National National Surgical Adjuvant Breast and Bowel Project, National New York State Health Department, Local Office of Technology Assessment, National Osteogenesis Imperfecta, National Capital Area, Local Pittsburgh Regional Science & Engineering Fair, Local Robert Wood Johnson Foundation, National The Jackson Laboratory, Local University of Delaware, Local Venezolano de Medicina Interna, National Wayne State University, Center for Molecular Medicine and Genetics, Local

Hospital Affiliation

Dr. Pyeritz is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Dr. Pyeritz focuses his research in two areas: Mendelian disorders of the cardiovascular system, especially those involving defects of connective tissue; and, ethical, legal and social implications of the human genetics. He is continuing his studies, begun over 20 years ago, of Marfan syndrome and related conditions, diseases in which the aorta and occasionally major arterial branches, gradually enlarge and dissect, leading to early demise if untreated. Current efforts include a multicenter trial of angiotensin receptor blockade in Marfan syndrome, the identification of additional genes that predispose to arteriopathy, and improving methods for diagnosing and treating arterio-venous malformations, especially in hereditary hemorrhagic telangiectasia (HHT).

Dr. Pyeritz directs Penn CIGHT, the Center for the Integration of Genetic Healthcare Technologies. Supported by the ELSI Branch of the National Human Genome Research Institute, this center conducts research in the broad area of ‘uncertainty’ as related to the introduction of evolving approaches to assaying a patient’s genotype. Penn CIGHT also provides pilot grants to faculty and postdoctoral fellowships. Dr. Pyeritz is specifically addressing how molecular genetic testing for HHT impacts the acceptance and costs of screening relatives who are at-risk.

Selected Publications:

Lacro RV, Dietz HC, Sleeper LA, Yetman AT, Bradley TJ, Colan SD, Pearson GD, Selamet Tierney ES, Levine JC, Atz AM, Benson DW, Braverman AC, Chen S, De Backer J, Gelb BD, Grossfeld PD, Klein GL, Lai WW, Liou A, Loeys BL, Markham LW, Olson AK, Paridon SM, Pemberton VL, Pierpont ME, Pyeritz RE, Radojewski E, Roman MJ, Sharkey AM, Stylianou MP, Wechsler SB, Young LT, Mahony L; Pediatric Heart Network Investigators: Atenolol versus losartan in children and young adults with Marfan's syndrome. N Engl J Med 371 (22): 2061-2071,2014.

Pyeritz RE: What is the optimal medical therapy for Marfan syndrome? J Pediatr 165 (5): 889-890,2014.

Dean JH, Woznicki EM, O'Gara P, Montgomery DG, Trimarchi S, Myrmel T, Pyeritz RE, Harris KM, Suzuki T, Braverman AC, Hughes GC, Kline-Rogers E, Nienaber CA, Isselbacher EM, Eagle KA, Bossone E: Cocaine-related aortic dissection: lessons from the International Registry of Acute Aortic Dissection. Am J Med 127 (9): 878-885,2014.

Reiff M, Mueller R, Mulchandani S, Spinner NB, Pyeritz RE, Bernhardt BA: A qualitative study of healthcare providers' perspectives on the implications of genome-wide testing in pediatric clinical practice. J Genet Couns 23 (4): 474-488,2014.

Hoff E, Eagle T, Pyeritz RE, Ehrlich M, Voehringer M, Bossone E, Hutchison S, Peterson MD, Suzuki T, Greason K, Forteza A, Montgomery DG, Isselbacher EM, Nienaber CA, Eagle KA: Pulse pressure and type A acute aortic dissection in-hospital outcomes (from the International Registry of Acute Aortic Dissection). Am J Cardiol 113 (y): 1255-1259,2014.

Cook JR, Carta L, Bénard L, Chemaly ER, Chiu E, Rao SK, Hampton TG, Yurchenco P; GenTAC Registry Consortium, Costa KD, Hajjar RJ, Ramirez F: Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome. J Clin Invest 124 (3): 1229-1339,2014.

Wagner JK, Mozersky JT, Pyeritz RE: Use it or lose it, as an alternative approach to protect genetic privacy in personalized medicine. Urol Oncol 32 (2): 198-201,2014.

Pyeritz RE: Heritable thoracic aortic disorders. Curr Opin Cardiol 29 (1): 97-102,2014.

Revencu N, Boon LM, Mendola A, Cordisco MR, Dubois J, Clapuyt P, Hammer F, Amor DJ, Irvine AD, Baselga E, Dompmartin A, Syed S, Martin-Santiago A, Ades L, Collins F, Smith J, Sandaradura S, Barrio VR, Burrows PE, Blei F, Cozzolino M, Brunetti-Pierri N, Vicente A, Abramowicz M, Désir J, Vilain C, Chung WK, Wilson A, Gardiner CA, Dwight Y, Lord DJ, Fishman L, Cytrynbaum C, Chamlin S, Ghali F, Gilaberte Y, Joss S, Boente Mdel C, Léauté-Labrèze C, Delrue MA, Bayliss S, Martorell L, González-Enseñat MA, Mazereeu: RASA1 mutations and associated phenotypes in 68 families with capillary malformation-arteriovenous malformation. Hum Mutat 34 (12): 1632-1641,2013.

Woodward CS, Pyeritz RE, Chittams JL, Trerotola SO: Treated pulmonary arteriovenous malformations: patterns of persistence and associated retreatment success. Radiology 269 (3): 919-926,2013.

View all publications

Academic Contact Info

Division of Translational Medicine and Human Genetics
University of Pennsylvania School of Medicine
11-133 Smilow Center for Translational Research, 3400 Civic Center Blvd

Philadelphia, PA 19104-4283
Phone: (215) 662-4740
Fax: (215) 614-0298
Patient appointments: 800-789-PENN (7366)

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