Description of Research Expertise:
My research interests are in developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for the early diagnosis and quantification of physiological and functional aberrations in pathologies such as arthritis, stroke, cancer and Alzheimer’s disease. Our pulse sequence developmental approaches exploit quadrupolar spin-dynamics, polarization transfer, multiple quantum coherences, indirect detection via chemical exchange and spin-locking T1ρ MRI for studying molecular dynamics in biological tissues in vivo.
Specifically, T1ρ and Sodium MRI techniques are designed to map proteoglycan molecules (e.g. aggrecan) in cartilage as a biomarker for early arthritis in vivo. T1ρ MRI is also targeted to impart novel contrast in various tissue types (brain, connective tissues and tumors), and to detect metabolically produced H217O for studying cerebral blood flow and cerebral oxidative metabolism.
Recent developmental work on chemical exchange saturation transfer (CEST) based MRI methods is focused on measuring endogenous but low concentration metabolites in the brain, such as glutamate, myoinositol and creatine to address central nervous system disorders. In addition, a creatine CEST method is currently being explored to measure high-energy phosphate metabolism in the myocardium in heart disease.
- See more at: http://cmroi.med.upenn.edu/personnel/ravinder-reddy-ph-d/#sthash.qFNreUgo.dpuf
Nanga RPR, DeBrosse C, Kumar D, Roalf D, McGeehan B, D'Aquilla K, Borthakur A, Hariharan H, Reddy D, Elliott M, Detre JA, Epperson CN, Reddy R.: Reproducibility of 2D GluCEST in healthy human volunteers at 7T Magn Reson Med. : 2018.
Puneet Bagga, Stephen Pickup, Rachelle Crescenzi, Daniel Martinez, Arijit Borthakur, Kevin D’Aquilla, Gaurav Verma, John A. Detre, Joel Greenberg, Hari Hariharan and Ravinder Reddy: In vivo GluCEST MRI: Reproducibility, background contribution and source of glutamate changes in the MPTP mouse model of Parkinson’s disease Scientific Reports 8 ((1)): 2883,2018.
Krishnamoorthy G, Nanga RPR, Bagga P, Hariharan H, Reddy R.: High quality three-dimensional gagCEST imaging of in vivo human knee cartilage at 7 Tesla. Magn Reson Med. 77 ((5)): 2017.
Bagga P, Haris M, D'Aquilla K, Wilson NE, Marincola FM, Schnall MD, Hariharan H, Reddy R.: Non-caloric sweetener provides magnetic resonance imaging contrast for cancer detection. J Transl Med. 15 ((1)): 119,2017.
Cai K, Tain RW, Zhou XJ, Damen FC, Scotti AM, Hariharan H, Poptani H, Reddy R.: Creatine CEST MRI for Differentiating Gliomas with Different Degrees of Aggressiveness. Mol Imaging Biol. ((2)): 225,2017.
Crescenzi R, DeBrosse C, Nanga RP, Byrne MD, Krishnamoorthy G, D'Aquilla K, Nath H, Morales KH, Iba M, Hariharan H, Lee VM, Detre JA, Reddy R.: Longitudinal imaging reveals subhippocampal dynamics in glutamate levels associated with histopathologic events in a mouse model of tauopathy and healthy mice. Hippocampus 27 ((3)): 285,2017.
Kogan F, Stafford RB, Englund EK, Gold GE, Hariharan H, Detre JA, Reddy R.: Perfusion has no effect on the in vivo CEST effect from Cr (CrCEST) in skeletal muscle. NMR Biomed. ((1)): 2017.
Shanmugan S, Loughead J, Nanga RP, Elliott M, Hariharan H, Appleby D, Kim D, Ruparel K, Reddy R, Brown TE, Epperson CN.: Lisdexamfetamine Effects on Executive Activation and Neurochemistry in Menopausal Women with Executive Function Difficulties. Neuropsychopharmacology 42 ((2)): 437,2017.
Roalf DR, Nanga RP, Rupert PE, Hariharan H, Quarmley M, Calkins ME, Dress E, Prabhakaran K, Elliott MA, Moberg PJ, Gur RC, Gur RE, Reddy R, Turetsky BI: Glutamate imaging (GluCEST) reveals lower brain GluCEST contrast in patients on the psychosis spectrum. Mol Psychiatry : 2017.
Bagga P, Crescenzi R, Krishnamoorthy G, Verma G, Nanga RP, Reddy D, Greenberg J, Detre JA, Hariharan H, Reddy R.: Mapping the alterations in glutamate with GluCEST MRI in a mouse model of dopamine deficiency J Neurochem. 139 ((3)): 432,2016.
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