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My research interests are in developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for the early diagnosis and quantification of physiological and functional aberrations in pathologies such as arthritis, stroke, cancer and Alzheimer’s disease. Our pulse sequence developmental approaches exploit quadrupolar spin-dynamics, polarization transfer, multiple quantum coherences, indirect detection via chemical exchange and spin-locking T1ρ MRI for studying molecular dynamics in biological tissues in vivo.Specifically, T1ρ and Sodium MRI techniques are designed to map proteoglycan molecules (e.g. aggrecan) in cartilage as a biomarker for early arthritis in vivo. T1ρ MRI is also targeted to impart novel contrast in various tissue types (brain, connective tissues and tumors), and to detect metabolically produced H217O for studying cerebral blood flow and cerebral oxidative metabolism.Recent developmental work on chemical exchange saturation transfer (CEST) based MRI methods is focused on measuring endogenous but low concentration metabolites in the brain, such as glutamate, myoinositol and creatine to address central nervous system disorders. In addition, a creatine CEST method is currently being explored to measure high-energy phosphate metabolism in the myocardium in heart disease.
Zamani P, Proto EA, Wilson N, Fazelinia H, Ding H, Spruce LA, Davila A Jr, Hanff TC, Mazurek JA, Prenner SB, Desjardins B, Margulies KB, Kelly DP, Arany Z, Doulias PT, Elrod JW, Allen ME, McCormack SE, Schur GM, D'Aquilla K, Kumar D, Thakuri D, Prabhakaran K, Langham MC, Poole DC, Seeholzer SH, Reddy R, Ischiropoulos H, Chirinos JA.: Multimodality assessment of heart failure with preserved ejection fraction skeletal muscle reveals differences in the machinery of energy fuel metabolism.
ESC Heart Fail. 8 ((4)): 2698,2021.
Hadar PN, Kini LG, Nanga RPR, Shinohara RT, Chen SH, Shah P, Wisse LEM, Elliott MA, Hariharan H, Reddy R, Detre JA, Stein JM, Das S, Davis KA.: Volumetric glutamate imaging (GluCEST) using 7T MRI can lateralize nonlesional temporal lobe epilepsy: A preliminary study.
Brain Behav. 11 ((8)): e02134,2021.
Amjad S, Nisar S, Bhat AA, Shah AR, Frenneaux MP, Fakhro K, Haris M, Reddy R, Patay Z, Baur J, Bagga P.: Role of NAD+ in regulating cellular and metabolic signaling pathways.
Mol Metab. 49 : 101195,2021.
Cember ATJ, Hariharan H, Kumar D, Nanga RPR, Reddy R.: Improved method for post-processing correction of B1 inhomogeneity in glutamate-weighted CEST images of the human brain.
NMR Biomed. 34 ((6)): e4503,2021.
Yadav SK, Bhat AA, Hashem S, Nisar S, Kamal M, Syed N, Temanni MR, Gupta RK, Kamran S, Azeem MW, Srivastava AK, Bagga P, Chawla S, Reddy R, Frenneaux MP, Fakhro K, Haris M.: Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder.
Transl Psychiatry 11 ((1)): 349,2021.
Datta R, Bacchus MK, Kumar D, Elliott MA, Rao A, Dolui S, Reddy R, Banwell BL, Saranathan M.: Fast automatic segmentation of thalamic nuclei from MP2RAGE acquisition at 7 Tesla.
Magn Reson Med. 85 ((5)): 2781,2021.
Nicolo JP, Moffat B, Wright DK, Sinclair B, Neal A, Lui E, Desmond P, Glarin R, Davis KA, Reddy R, Yan B, O'Brien TJ, Kwan P.: 7T Magnetic Resonance Imaging Quantification of Brain Glutamate in Acute Ischaemic Stroke.
J Stroke. 23 ((2)): 281,2021.
Debnath A, Gupta RK, Reddy R, Singh A.: Effect of offset-frequency step size and interpolation methods on chemical exchange saturation transfer MRI computation in human brain.
NMR Biomed. 34 ((4)): e4468,2021.
Kumar D, Nanga RPR, Thakuri D, Wilson N, Cember A, Martin ML, Zhu D, Shinohara RT, Qin Q, Hariharan H, Reddy R.: Recovery kinetics of creatine in mild plantar flexion exercise using 3D creatine CEST imaging at 7 Tesla.
Magn Reson Med. 2021 85 ((2)): 802,2021.
Nisar S, Bhat AA, Singh M, Karedath T, Rizwan A, Hashem S, Bagga P, Reddy R, Jamal F, Uddin S, Chand G, Bedognetti D, El-Rifai W, Frenneaux MP, Macha MA, Ahmed I, Haris M.: Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies.
Front Cell Dev Biol. 9 : 617281,2021.
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