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Ravi K. Amaravadi, MD

Ravi K. Amaravadi, MD Physician

Co-Leader of the Cancer Therapeutics Program, Abramson Cancer Center Associate Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Amaravadi is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Medical Oncology

Programs & Centers:

Board Certification:

  • Medical Oncology, 2006

Clinical Expertise:

  • Basal Cell Carcinoma
  • Biological Targeted Therapy
  • Cancer Chemotherapy
  • Clinical Trials
  • Dermatofibrosarcoma Protruberans
  • Eccrine Carcinoma
  • Head and Neck Melanoma
  • Immunotherapy
  • Malignant Neoplasm of Skin Appendages
  • Melanoma Genomics
  • Merkel Cell Carcinoma
  • Metastatic Melanoma
  • Mucosal Melanoma
  • Non-Melanoma Skin Cancer
  • Squamous Cell Carcinoma of the Skin
  • Sweat Gland Carcinoma
  • Targeted Molecular Therapy
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Johns Hopkins University School of Medicine
Residency: Brigham and Women's Hospital
Fellowship: Hospital of the University of Pennsylvania


American Association for Cancer Research, National American Association for the Advancement of Science, National American Society of Clinical Oncology, National Austrian Science Fund (FWF),, International Beyond Batten Disease Foundation, International FWO Belgium Cancer Research, International Health Frontiers Science Program, France, International Health Research Ireland, International Icelandic Research Fund, International Immunaccel Biosciences, National Melanoma Research Foundation Breakthrough Consortium, National Melanoma Research Foundation, National NCI-J special emphasis panel study section for K awards, National Newcastle University, UK, International NIH Loan repayment program, National OPUS, National Science Center, OPUS, International PDX (patient-derived xenografts) Development and Trial Centers Research Network (PDXNet), National Presage Biosciences, National Sprint Biosciences, International The Research Foundation FWO, Belgium, International Welcome Trust DBT alliance Post doctoral fellowships, India, International Wistar Institute, Cancer Center, Tumor Microenvironment and Metastases Program, Local

Hospital Affiliation

Dr. Amaravadi is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Autophagy, Mechanisms of Cell Death, Developmental Therapeutics

Selected Publications:

Sanseviero Emilio, O'Brien Erin M, Karras Jenna R, Shabaneh Tamer B, Aksoy Bulent Arman, Xu Wei, Zheng Cathy, Yin Xiangfan, Xu Xiaowei, Karakousis Giorgos C, Amaravadi Ravi K, Nam Brian, Turk Mary Jo, Hammerbacher Jeff, Rubinstein Mark P, Schuchter Lynn M, Mitchell Tara C, Liu Qin, Stone Erica L: Anti-CTLA-4 Activates Intratumoral NK Cells and Combined with IL15/IL15Rα Complexes Enhances Tumor Control. Cancer immunology research 7 (8): 1371-1380,2019.

Song Yun, Tieniber Andrew D, Gimotty Phyllis A, Mitchell Tara C, Amaravadi Ravi K, Schuchter Lynn M, Fraker Douglas L, Karakousis Giorgos C: Survival Outcomes of Patients with Clinical Stage III Melanoma in the Era of Novel Systemic Therapies. Annals of surgical oncology : 2019.

Karasic Thomas B, O'Hara Mark H, Loaiza-Bonilla Arturo, Reiss Kim A, Teitelbaum Ursina R, Borazanci Erkut, De Jesus-Acosta Ana, Redlinger Colleen, Burrell Jessica A, Laheru Daniel A, Von Hoff Daniel D, Amaravadi Ravi K, Drebin Jeffrey A, O'Dwyer Peter J: Effect of Gemcitabine and nab-Paclitaxel With or Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer: A Phase 2 Randomized Clinical Trial. JAMA oncology 5 (7): 993-998,2019.

Tameire Feven, Verginadis Ioannis I, Leli Nektaria Maria, Polte Christine, Conn Crystal S, Ojha Rani, Salas Salinas Carlo, Chinga Frank, Monroy Alexandra M, Fu Weixuan, Wang Paul, Kossenkov Andrew, Ye Jiangbin, Amaravadi Ravi K, Ignatova Zoya, Fuchs Serge Y, Diehl J Alan, Ruggero Davide, Koumenis Constantinos: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nature cell biology 21 (7): 889-899,2019.

Parekh Vishwas, Sobanko Joseph, Miller Christopher J, Karakousis Giorgos, Xu Wei, Letrero Richard, Elenitsas Rosalie, Xu Xiaowei, Elder David E, Amaravadi Ravi, Schuchter Lynn M, Nathanson Katherine L, Wilson Melissa A, Chu Emily Y: NRAS Q61R and BRAF G466A mutations in atypical melanocytic lesions newly arising in advanced melanoma patients treated with vemurafenib. Journal of cutaneous pathology 46 (3): 190-194,2019.

Rebecca Vito W, Nicastri Michael C, Fennelly Colin, Chude Cynthia I, Barber-Rotenberg Julie S, Ronghe Amruta, McAfee Quentin, McLaughlin Noel P, Zhang Gao, Goldman Aaron R, Ojha Rani, Piao Shengfu, Noguera-Ortega Estela, Martorella Alessandra, Alicea Gretchen M, Lee Jennifer J, Schuchter Lynn M, Xu Xiaowei, Herlyn Meenhard, Marmorstein Ronen, Gimotty Phyllis A, Speicher David W, Winkler Jeffrey D, Amaravadi Ravi K: PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. Cancer discovery 9 (2): 220-229,2019.

Haas Naomi B, Appleman Leonard J, Stein Mark, Redlinger Maryann, Wilks Melissa, Xu Xiaowei, Onorati Angelique, Kalavacharla Anusha, Kim Taehyong, Zhen Chao Jie, Kadri Sabah, Segal Jeremy P, Gimotty Phyllis A, Davis Lisa E, Amaravadi Ravi K: Autophagy Inhibition to Augment mTOR Inhibition: a Phase I/II Trial of Everolimus and Hydroxychloroquine in Patients with Previously Treated Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research : 2019.

Khan Omar, Giles Josephine R, McDonald Sierra, Manne Sasikanth, Ngiow Shin Foong, Patel Kunal P, Werner Michael T, Huang Alexander C, Alexander Katherine A, Wu Jennifer E, Attanasio John, Yan Patrick, George Sangeeth M, Bengsch Bertram, Staupe Ryan P, Donahue Greg, Xu Wei, Amaravadi Ravi K, Xu Xiaowei, Karakousis Giorgos C, Mitchell Tara C, Schuchter Lynn M, Kaye Jonathan, Berger Shelley L, Wherry E John: TOX transcriptionally and epigenetically programs CD8 T cell exhaustion. Nature 571 (7764): 211-218,2019.

Ojha Rani, Leli Nektaria M, Onorati Angelique, Piao Shengfu, Verginadis Ioannis I, Tameire Feven, Rebecca Vito W, Chude Cynthia I, Murugan Sengottuvelan, Fennelly Colin, Noguera-Ortega Estela, Liu Shujing, Xu Xiaowei, Krepler Clemens, Xiao Min, Xu Wei, Wei Zhi, Frederick Dennie T, Boland Genevieve, Mitchell Tara C, Karakousis Giorgos C, Schuchter Lynn M, Flaherty Keith T, Zhang Gao, Herlyn Meenhard, Koumenis Constantinos, Amaravadi Ravi K: ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma. Cancer discovery : 2018.

Baquero Pablo, Dawson Amy, Mukhopadhyay Arunima, Kuntz Elodie M, Mitchell Rebecca, Olivares Orianne, Ianniciello Angela, Scott Mary T, Dunn Karen, Nicastri Michael C, Winkler Jeffrey D, Michie Alison M, Ryan Kevin M, Halsey Christina, Gottlieb Eyal, Keaney Erin P, Murphy Leon O, Amaravadi Ravi K, Holyoake Tessa L, Helgason G Vignir: Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia : 2018.

Academic Contact Info

Division of Hematology Oncology
8 BRB - Room 852

Philadelphia, PA 19104
Phone: (215) 769-5159
Patient appointments: 800-789-7366 (PENN)

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