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Ramon R. Diaz-Arrastia, MD, PhD

Ramon R. Diaz-Arrastia, MD, PhD Physician

Associate Director for Clinical Research, Center for Neurodegeneration and Repair Director of Traumatic Brain Injury Clinical Research Center Presidential Professor of Neurology

Languages spoken:

  • Spanish

Dr. Diaz-Arrastia is employed by Penn Medicine.

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Clinical Specialties


  • Neurology
  • Neurology

Programs & Centers:

Board Certification:

  • Addiction Psychiatry, 2013
  • Neurology, 1993

Clinical Expertise:

  • Abnormal EEG
  • Absence Epilepsy
  • Ambulatory EEG
  • Anoxic Encephalopathy
  • Atonic Epilepsy
  • Brain Injury
  • Concussion
  • Convulsion
  • Cryptogenic Epilepsy
  • Deep Brain Stimulation
  • Dementia Related to Concussion
  • Drop Attack
  • Electroencephalography
  • Epilepsy
  • Epilepsy Monitoring Unit Evaluation (Emu)
  • Epileptic Confusional State
  • Epileptic Twilight State
  • Evaluation for Epilepsy Surgery
  • Familial Epilepsy
  • First Seizure Clinic
  • Focal Seizures
  • Frontal Lobe Epilepsy
  • Generalized Seizures
  • Grand Mal Seizures
  • Head Trauma
  • Juvenile Myoclonic Epilepsy
  • Landau-Kleffner Syndrome
  • Lennox-Gastaut Syndrome
  • Maternal Seizures
  • Mesial Temporal Sclerosis
  • Myoclonic Seizures
  • New Onset Seizure
  • Occipital Lobe Epilepsy
  • Parietal Lobe Epilepsy
  • Petit Mal Seizure
  • Post-Traumatic Epilepsy
  • Post-Traumatic Seizure
  • Progressive Myoclonic Epilepsy
  • Responsive Neurostimulation
  • Simple Partial Seizures
  • Status Epilepticus
  • Temporal Lobe Epilepsy
  • Traumatic Brain Injury (TBI)
  • Vagus Nerve Stimulation
  • Visualase MRI-Guided Laser Ablation
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Baylor College of Medicine
Residency: Beth Israel Deaconess Medical Center
Residency: NewYork-Presbyterian/Columbia University Medical Center
Fellowship: NewYork-Presbyterian/Columbia University Medical Center


American Academy of Neurology, National American Epilepsy Society, National American Neurological Association, National Brain Injury Association of America, National Dallas Morning News Science Fair, Local National Neurotrauma Society, National Neurocritical Care Society, National

Hospital Affiliation

Dr. Diaz-Arrastia is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Wang Kevin K W, Yang Zhihui, Yue John K, Zhang Zhiqun, Winkler Ethan A, Puccio Ava, Diaz-Arrastia Ramon, Lingsma Hester, Yuh Esther Lim, Mukherjee Pratik, Valadka Alex, Gordon Wayne A, Okonkwo David O, Manley Geoffrey T: Plasma Anti-Glial Fibrillary Acidic Protein (GFAP) Autoantibody Levels During the Acute and Chronic Phases of Traumatic Brain Injury - A TRACK-TBI Pilot Study. Journal of neurotrauma : 2016.

Winkler Ethan A, Yue John K, McAllister Thomas W, Temkin Nancy R, Oh Sam S, Burchard Esteban G, Hu Donglei, Ferguson Adam R, Lingsma Hester F, Burke John F, Sorani Marco D, Rosand Jonathan, Yuh Esther L, Barber Jason, Tarapore Phiroz E, Gardner Raquel C, Sharma Sourabh, Satris Gabriela G, Eng Celeste, Puccio Ava M, Wang Kevin K W, Mukherjee Pratik, Valadka Alex B, Okonkwo David O, Diaz-Arrastia Ramon, Manley Geoffrey T: COMT Val (158) Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury. Neurogenetics 17 (1): 31-41,2016.

Smitherman Emily, Hernandez Ana, Stavinoha Peter L, Huang Rong, Kernie Steven G, Diaz-Arrastia Ramon, Miles Darryl K: Predicting Outcome after Pediatric Traumatic Brain Injury by Early Magnetic Resonance Imaging Lesion Location and Volume. Journal of neurotrauma 33 (1): 35-48,2016.

Kenney Kimbra, Amyot Franck, Haber Margalit, Pronger Angela, Bogoslovsky Tanya, Moore Carol, Diaz-Arrastia Ramon: Cerebral Vascular Injury in Traumatic Brain Injury. Experimental neurology 275 Pt 3 : 353-66,2016.

Korley Frederick K, Diaz-Arrastia Ramon, Wu Alan H B, Yue John K, Manley Geoffrey T, Sair Haris I, Van Eyk Jennifer, Everett Allen D, Okonkwo David O, Valadka Alex B, Gordon Wayne A, Maas Andrew I R, Mukherjee Pratik, Yuh Esther L, Lingsma Hester F, Puccio Ava M, Schnyer David M: Circulating Brain-Derived Neurotrophic Factor Has Diagnostic and Prognostic Value in Traumatic Brain Injury. Journal of neurotrauma 33 (2): 215-25,2016.

Barber Robert C, Phillips Nicole R, Tilson Jeffrey L, Huebinger Ryan M, Shewale Shantanu J, Koenig Jessica L, Mitchel Jeffrey S, O'Bryant Sid E, Waring Stephen C, Diaz-Arrastia Ramon, Chasse Scott, Wilhelmsen Kirk C: Can Genetic Analysis of Putative Blood Alzheimer's Disease Biomarkers Lead to Identification of Susceptibility Loci? PloS one 10 (12): e0142360,2015.

Gatson Joshua W, Stebbins Cari, Mathews Dana, Harris Thomas S, Madden Christopher, Batjer Hunt, Diaz-Arrastia Ramon, Minei Joseph P: Evidence of increased brain amyloid in severe TBI survivors at 1, 12, and 24 months after injury: report of 2 cases. Journal of neurosurgery : 1-8,2015.

Buonora John E, Mousseau Michael, Jacobowitz David M, Lazarus Rachel C, Yarnell Angela M, Olsen Cara H, Pollard Harvey B, Diaz-Arrastia Ramon, Latour Lawrence, Mueller Gregory P: Autoimmune Profiling Reveals Peroxiredoxin 6 as a Candidate Traumatic Brain Injury Biomarker. Journal of neurotrauma 32 (22): 1805-14,2015.

Amyot Franck, Arciniegas David B, Brazaitis Michael P, Curley Kenneth C, Diaz-Arrastia Ramon, Gandjbakhche Amir, Herscovitch Peter, Hinds Sidney R, Manley Geoffrey T, Pacifico Anthony, Razumovsky Alexander, Riley Jason, Salzer Wanda, Shih Robert, Smirniotopoulos James G, Stocker Derek: A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury. Journal of neurotrauma 32 (22): 1693-721,2015.

Olivera Anlys, Lejbman Natasha, Jeromin Andreas, French Louis M, Kim Hyung-Suk, Cashion Ann, Mysliwiec Vincent, Diaz-Arrastia Ramon, Gill Jessica: Peripheral Total Tau in Military Personnel Who Sustain Traumatic Brain Injuries During Deployment. JAMA neurology 72 (10): 1109-16,2015.

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Academic Contact Info

Penn Presbyterian Medical Center
51 North 39th Street

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)