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Ramon R. Diaz-Arrastia, MD, PhD

Ramon R. Diaz-Arrastia, MD, PhD Physician

Associate Director for Clinical Research, Center for Neurodegeneration and Repair Director of Traumatic Brain Injury Clinical Research Center Presidential Professor of Neurology

Languages spoken:

  • Spanish

Dr. Diaz-Arrastia is employed by Penn Medicine.

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Clinical Specialties


  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 1993
  • Psych & Neurology/Addiction Psych (AMA)

Clinical Expertise:

  • Traumatic Brain Injury (TBI)

Practice Locations and Appointments

  • Penn Neurology

    Penn Medicine University City 8th Floor 3737 Market Street Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of Penn Presbyterian Medical Center

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Baylor College of Medicine
Residency: Beth Israel Deaconess Medical Center
Residency: NewYork-Presbyterian/Columbia University Medical Center
Fellowship: NewYork-Presbyterian/Columbia University Medical Center


Alzheimer Association of Greater Dallas, Local American Academy of Neurology, National American Epilepsy Society, National American Neurological Association , National Brain Injury Association of America, National Dallas Epilepsy Association, 1993-2011, Local Dallas Epilepsy Association, Local Dallas Morning News Science Fair, Local Department of Defense Combat Casualty Care Research Program. “TBI Pharmacology Review Committee.” , Local Institute of Medicine Committee on Public Health Dimensions of the Epilepsies, Local Institute of Medicine Committee on Traumatic Brain Injury, Local National Institutes of Health/NIA Workshop on “Genetics of Alzheimer’s Disease.” , National National Institutes of Health/NIA Workshop on “Traumatic Brain Injury and the Risk of Dementia.” , Local National Institutes of Health/NINDS Workshop on “Biomarkers of Epileptogenesis.” , National National Institutes of Health/NINDS Workshop on “Subtypes of Traumatic Brain Injury.” , National National Institutes of Health/NINDS Workshop on “Therapy Development for Diffuse Axonal Injury.” , Local National Institutes of Health/NINDS, “NIH Toolbox for Assessment of Neurological and Behavioral Function”, National National Institutes of Health/NINDS/NICHD Workshop on “Combination Therapies for Traumatic Brain Injury.” , Local National Institutes of Health/NINDS/NIDRR/DoD Workshop on “Advancing Integrated Research on Psychological Health and Traumatic Brain Injury: Common Data Elements Workshop, Local National Neurotrauma Society, National Neurocritical Care Society, National Scientific Review Group ANIE (Acute Neural Injury and Epilepsy), National Scientific Review Group NAED (NeuroAIDS and End-Organ diseases), National Scientific Review Group NIA-N (Neurobiology of Aging) , National Scientific Review Group ZAG PCR-7 02 (National Institute of Aging), National Scientific Review Group ZNS1 SRB-P 39 (NINDS), National Scientific Review Group ZRG1 F10 ALTX4, National Scientific Review Panel ZRG1 F10 (29L) F31S, National

Hospital Affiliation

Dr. Diaz-Arrastia is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Wang Kevin K W, Yang Zhihui, Yue John K, Zhang Zhiqun, Winkler Ethan A, Puccio Ava, Diaz-Arrastia Ramon, Lingsma Hester, Yuh Esther Lim, Mukherjee Pratik, Valadka Alex, Gordon Wayne A, Okonkwo David O: Plasma Anti-Glial Fibrillary Acidic Protein (GFAP) Autoantibody Levels During the Acute and Chronic Phases of Traumatic Brain Injury - A TRACK-TBI Pilot Study. Journal of neurotrauma : 2016.

Winkler Ethan A, Yue John K, McAllister Thomas W, Temkin Nancy R, Oh Sam S, Burchard Esteban G, Hu Donglei, Ferguson Adam R, Lingsma Hester F, Burke John F, Sorani Marco D, Rosand Jonathan, Yuh Esther L, Barber Jason, Tarapore Phiroz E, Gardner Raquel C, Sharma Sourabh, Satris Gabriela G, Eng Celeste, Puccio Ava M, Wang Kevin K W, Mukherjee Pratik, Valadka Alex B, Okonkwo David O, Diaz-Arrastia Ramon: COMT Val (158) Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury. Neurogenetics 17 (1): 31-41,2016.

Smitherman Emily, Hernandez Ana, Stavinoha Peter L, Huang Rong, Kernie Steven G, Diaz-Arrastia Ramon: Predicting Outcome after Pediatric Traumatic Brain Injury by Early Magnetic Resonance Imaging Lesion Location and Volume. Journal of neurotrauma 33 (1): 35-48,2016.

Kenney Kimbra, Amyot Franck, Haber Margalit, Pronger Angela, Bogoslovsky Tanya, Moore Carol: Cerebral Vascular Injury in Traumatic Brain Injury. Experimental neurology 275 Pt 3 : 353-66,2016.

Korley Frederick K, Diaz-Arrastia Ramon, Wu Alan H B, Yue John K, Manley Geoffrey T, Sair Haris I, Van Eyk Jennifer, Everett Allen D, Okonkwo David O, Valadka Alex B, Gordon Wayne A, Maas Andrew I R, Mukherjee Pratik, Yuh Esther L, Lingsma Hester F, Puccio Ava M: Circulating Brain-Derived Neurotrophic Factor Has Diagnostic and Prognostic Value in Traumatic Brain Injury. Journal of neurotrauma 33 (2): 215-25,2016.

Barber Robert C, Phillips Nicole R, Tilson Jeffrey L, Huebinger Ryan M, Shewale Shantanu J, Koenig Jessica L, Mitchel Jeffrey S, O'Bryant Sid E, Waring Stephen C, Diaz-Arrastia Ramon, Chasse Scott: Can Genetic Analysis of Putative Blood Alzheimer's Disease Biomarkers Lead to Identification of Susceptibility Loci? PloS one 10 (12): e0142360,2015.

Gatson Joshua W, Stebbins Cari, Mathews Dana, Harris Thomas S, Madden Christopher, Batjer Hunt, Diaz-Arrastia Ramon: Evidence of increased brain amyloid in severe TBI survivors at 1, 12, and 24 months after injury: report of 2 cases. Journal of neurosurgery : 1-8,2015.

Buonora John E, Mousseau Michael, Jacobowitz David M, Lazarus Rachel C, Yarnell Angela M, Olsen Cara H, Pollard Harvey B, Diaz-Arrastia Ramon, Latour Lawrence: Autoimmune Profiling Reveals Peroxiredoxin 6 as a Candidate Traumatic Brain Injury Biomarker. Journal of neurotrauma 32 (22): 1805-14,2015.

Amyot Franck, Arciniegas David B, Brazaitis Michael P, Curley Kenneth C, Diaz-Arrastia Ramon, Gandjbakhche Amir, Herscovitch Peter, Hinds Sidney R, Manley Geoffrey T, Pacifico Anthony, Razumovsky Alexander, Riley Jason, Salzer Wanda, Shih Robert, Smirniotopoulos James G: A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury. Journal of neurotrauma 32 (22): 1693-721,2015.

Olivera Anlys, Lejbman Natasha, Jeromin Andreas, French Louis M, Kim Hyung-Suk, Cashion Ann, Mysliwiec Vincent, Diaz-Arrastia Ramon: Peripheral Total Tau in Military Personnel Who Sustain Traumatic Brain Injuries During Deployment. JAMA neurology 72 (10): 1109-16,2015.

View all publications

Academic Contact Info

Penn Presbyterian Medical Center
51 North 39th Street

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)