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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
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The primary mission of the Functional and Metabolic Imaging Group (FMIG) is the development and application of novel hyperpolarized MRI techniques to the diagnosis of various pulmonary and metabolic disorders. Hyperpolarization, the process of drastically increasing the population difference between nuclear spin states, provides a platform for imaging lung physiology and metabolic activity with spatial and temporal resolution unattainable with conventional MRI techniques, thus offering the potential for the earlier diagnosis of disease states and the precise monitoring of a patient’s response to medical treatment. This core research theme is executed with an eye toward several ultimate goals: the identification of changes in pulmonary structure and function associated with disease, a more complete understanding of pathogenesis, and the establishment of a more sensitive testing environment to develop treatments for lung disease. To date, significant contributions in these areas include new imagining techniques for the comprehensive description of lung physiology and structure, accurate imaging of the regional pulmonary partial pressure of oxygen in both humans and large and small animals, highly developed imaging of regional ventilation, and a state-of-the-art mechanical ventilation device. Specifically, our research activities at FMIG is divided into four general branches: 1) The development of novel imaging techniques for the quantitative assessment of pulmonary structure and function: 2)The development of novel methods for real-time metabolic imaging: 3)The construction of novel polarization apparatuses: 4) The development and implementation of rapid imaging pulse sequences.
Siddiqui Sarmad, Habertheuer Andreas, Xin Yi, Pourfathi Mehrdad, Tao Jian-Qin, Hamedani Hooman, Kadlecek Stephen, Duncan Ian, Vallabhajosyula Prashanth, Naji Ali, Chatterjee Shampa, Rizi Rahim: Detection of lung transplant rejection in a rat model using hyperpolarized [1- C] pyruvate-based metabolic imaging. NMR in biomedicine : e4107,2019.
Loza Luis A, Kadlecek Stephen J, Pourfathi Mehrdad, Hamedani Hooman, Duncan Ian F, Ruppert Kai, Rizi Rahim R: Quantification of Ventilation and Gas Uptake in Free-Breathing Mice with Hyperpolarized 129Xe MRI. IEEE transactions on medical imaging : 2019.
Ruppert Kai, Amzajerdian Faraz, Hamedani Hooman, Xin Yi, Loza Luis, Achekzai Tahmina, Duncan Ian F, Profka Harrilla, Siddiqui Sarmad, Pourfathi Mehrdad, Sertic Federico, Cereda Maurizio F, Kadlecek Stephen, Rizi Rahim R: Assessment of flip angle-TR equivalence for standardized dissolved-phase imaging of the lung with hyperpolarized 129Xe MRI. Magnetic resonance in medicine 81 (3): 1784-1794,2019.
Ruppert Kai, Xin Yi, Hamedani Hooman, Amzajerdian Faraz, Loza Luis, Achekzai Tahmina, Duncan Ian F, Profka Harrilla, Siddiqui Sarmad, Pourfathi Mehrdad, Sertic Federico, Cereda Maurizio F, Kadlecek Stephen, Rizi Rahim R: Measurement of Regional 2D Gas Transport Efficiency in Rabbit Lung Using Hyperpolarized 129Xe MRI. Scientific reports 9 (1): 2413,2019.
Achekzai Tahmina, Hamedani Hooman, Kadlecek Stephen J, Ruppert Kai, Xin Yi, Baron Ryan J, Duncan Ian F, Sertic Federico, Siddiqui Sarmad, Amzajerdian Faraz, Pourfathi Mehrdad, Loza Luis A, Cereda Maurizio, Rizi Rahim R: Multibreath Hyperpolarized He Imaging Scheme to Measure Alveolar Oxygen Tension and Apparent Diffusion Coefficient. Academic radiology 26 (3): 367-382,2019.
Kurhanewicz John, Vigneron Daniel B, Ardenkjaer-Larsen Jan Henrik, Bankson James A, Brindle Kevin, Cunningham Charles H, Gallagher Ferdia A, Keshari Kayvan R, Kjaer Andreas, Laustsen Christoffer, Mankoff David A, Merritt Matthew E, Nelson Sarah J, Pauly John M, Lee Philips, Ronen Sabrina, Tyler Damian J, Rajan Sunder S, Spielman Daniel M, Wald Lawrence, Zhang Xiaoliang, Malloy Craig R, Rizi Rahim: Hyperpolarized C MRI: Path to Clinical Translation in Oncology. Neoplasia (New York, N.Y.) 21 (1): 1-16,2019.
Cereda Maurizio, Xin Yi, Goffi Alberto, Herrmann Jacob, Kaczka David W, Kavanagh Brian P, Perchiazzi Gaetano, Yoshida Takeshi, Rizi Rahim R: Imaging the Injured Lung: Mechanisms of Action and Clinical Use. Anesthesiology : 2019.
Rizi Rahim R: Foreword: Recent Developments on Imaging Pulmonary System. Academic radiology 26 (3): 304-305,2019.
Baron Ryan J, Hamedani Hooman, Kadlecek Stephen J, Duncan Ian F, Xin Yi, Siddiqui Sarmad, Pourfathi Mehrdad, Cereda Maurizio, Rizi Rahim R: A Model for Predicting Future FEV1 Decline in Smokers Using Hyperpolarized He Magnetic Resonance Imaging. Academic radiology 26 (3): 383-394,2018.
Ruppert Kai, Hamedani Hooman, Amzajerdian Faraz, Xin Yi, Duncan Ian F, Profka Harrilla, Siddiqui Sarmad, Pourfathi Mehrdad, Kadlecek Stephen, Rizi Rahim R: Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging. Scientific reports 8 (1): 7310,2018.
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