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The primary mission of the Functional and Metabolic Imaging Group (FMIG) is the development and application of novel hyperpolarized MRI techniques to the diagnosis of various pulmonary and metabolic disorders. Hyperpolarization, the process of drastically increasing the population difference between nuclear spin states, provides a platform for imaging lung physiology and metabolic activity with spatial and temporal resolution unattainable with conventional MRI techniques, thus offering the potential for the earlier diagnosis of disease states and the precise monitoring of a patient’s response to medical treatment. This core research theme is executed with an eye toward several ultimate goals: the identification of changes in pulmonary structure and function associated with disease, a more complete understanding of pathogenesis, and the establishment of a more sensitive testing environment to develop treatments for lung disease. To date, significant contributions in these areas include new imagining techniques for the comprehensive description of lung physiology and structure, accurate imaging of the regional pulmonary partial pressure of oxygen in both humans and large and small animals, highly developed imaging of regional ventilation, and a state-of-the-art mechanical ventilation device. Specifically, our research activities at FMIG is divided into four general branches: 1) The development of novel imaging techniques for the quantitative assessment of pulmonary structure and function: 2)The development of novel methods for real-time metabolic imaging: 3)The construction of novel polarization apparatuses: 4) The development and implementation of rapid imaging pulse sequences.
Nomani A, Li G, Yousefi S, Wu S, Malekshah OM, Nikkhoi SK, Pourfathi M, Rizi R, Hatefi A.: Gadolinium-labeled affibody-XTEN recombinant vector for detection of HER2+ lesions of ovarian cancer lung metastasis using quantitative MRI J Control Release 337 : 132-143,2021.
Baron R, Kadlecek S, Loza L, Xin Y, Amzajerdian F, Duncan I, Hamedani H, Rizi R.: Deriving Regionally Specific Biomarkers of Emphysema and Small Airways Disease Using Variable Threshold Parametric Response Mapping on Volumetric Lung CT Images Acad Radiol : 2021.
Hamedani H, Kadlecek S, Ruppert K, Xin Y, Duncan I, Rizi RR.: Ventilation heterogeneity imaged by multibreath wash-ins of hyperpolarized (3) He and (129) Xe in healthy rabbits J Physiol : 2021.
Ball L, Robba C, Herrmann J, Gerard SE, Xin Y, Mandelli M, Battaglini D, Brunetti I, Minetti G, Seitun S, Bovio G, Vena A, Giacobbe DR, Bassetti M, Rocco PRM, Cereda M, Rizi RR, Castellan L, Patroniti N, Pelosi P; Collaborators of the GECOVID Group.: Lung distribution of gas and blood volume in critically ill COVID-19 patients: a quantitative dual-energy computed tomography study Crit Care 25 : 214,2021.
Habertheuer A, Ram C, Schmierer M, Chatterjee S, Hu R, Freas A, Zielinski P, Rogers W, Silvestro EM, McGrane M, Moore JS, Korutla L, Siddiqui S, Xin Y, Rizi R, Tao JQ, Kreisel D, Naji A, Ochiya T, Vallabhajosyula P.: Circulating Donor Lung-Specific Exosome Profiles Enable Noninvasive Monitoring of Acute Rejection in a Rodent Orthotopic Lung Transplantation Model Transplantation : 2021.
Xin Y, Martin K, Morais CCA, Delvecchio P, Gerard SE, Hamedani H, Herrmann J, Abate N, Lenart A, Humayun S, Sidhu U, Petrov M, Reutlinger K, Mandelbaum T, Duncan I, Tustison N, Kadlecek S, Chatterjee S, Gee JC, Rizi RR, Berra L, Cereda M.: Diminishing Efficacy of Prone Positioning With Late Application in Evolving Lung Injury Crit Care Med rit Care Med : 2021.
Amzajerdian F, Ruppert K, Hamedani H, Baron R, Xin Y, Loza L, Achekzai T, Duncan IF, Qian Y, Pourfathi M, Kadlecek S, Rizi RR.: Measuring pulmonary gas exchange using compartment-selective xenon-polarization transfer contrast (XTC) MRI Magn Reson Med 85 : 2709-2722,2021.
Kai Ruppert, Faraz Amzajerdian, Yi Xin, Hooman Hamedani, Luis Loza, Tahmina Achekzai, Ian F Duncan, Harrilla Profka, Yiwen Qian, Mehrdad Pourfathi, Stephen Kadlecek, Rahim R Rizi: Investigating biases in the measurement of apparent alveolar septal wall thickness with hyperpolarized 129Xe MRI Magnetic Resonance in Medicine 84 : 3027-3039,2020.
Rizi RR, Hamedani H, Cereda M.: In Chronic Obstructive Pulmonary Disease Progression, Is It Airway Narrowing or Airway Loss? Am J Respir Crit Care Med 203 : 154-155,2021.
Xin Y, Cereda M, Hamedani H, Martin KT, Tustison NJ, Pourfathi M, Kadlecek S, Siddiqui S, Amzajerdian F, Connell M, Abate N, Kajanaku A, Duncan I, Gee JC, Rizi RR.: Positional Therapy and Regional Pulmonary Ventilation Anesthesiology 133 : 1093-1105,2020.
Mehrdad Pourfathi, Yi Xin, Michael Rosalino, Maurizio Cereda, Stephen Kadlecek, Ian Duncan, Harrilla Profka, Hooman Hamedani, Sarmad Siddiqui, Kai Ruppert, Shampa Chatterjee, Rahim R Rizi: Pulmonary pyruvate metabolism as an index of inflammation and injury in a rat model of acute respiratory distress syndrome NMR in biomedicine 33 : e4380,2020.
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