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Paul J. L. Zhang, MD

Paul J. L. Zhang, MD Physician

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Dr. Zhang is employed by Penn Medicine.

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Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Anatomic and Clinical Pathology, 1995

Description of Clinical Expertise

Diagnostic pathology in soft tissue tumor, sarcoma and cancers of breast, GYN tract, pulmonary tract, ENT. Diagnostic immmunohistochemical and in-situ hybridization. Evaluation of tumor markers for personalized treatment in surgical specimen.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Guangzhou Medical College
Residency: Aultman Hospital
Fellowship: University of California - San Francisco
Residency: New York University Medical Center
Fellowship: Memorial Sloan-Kettering Cancer Center


Committee on Publication Ethics (COPE), International International Skeletal Society, International American Association for the Advancement of Science, National American Society of Clinical Pathologists (ASCP), National Arthur Purdy Stout Society of Surgical Pathologists, National Chinese American Pathologist Association, National College of American Pathologists, National Connective Tissue Oncology Society, National International Society of Bone and Soft Tissue Pathology, National National Society of Histotechnology, National Pathology Society of Philadelphia, Local United States and Canadian Academy of Pathology (USCAP), National Western New York Pathology Society, Local

Hospital Affiliation

Dr. Zhang is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Various tumor markers in diagnostic and prognositc application. In-situ molecular morphometry in tumor diagnosis and prognosis.
Hypoxia in sarcoma. Translational research in sarcoma. Growth factors receptors in breast cancer. Mechanism of lymphangionesis and lymphatic invasion in cancer. The significance and determination of host immunoresponse on surgical specimen in cancer patients' prognosis.

Selected Publications:

Ase G, Parash TL: WT1 is expressed in serous, but not in endometrioid, clear cell or mucinous carcinomas of the peritoneum, fallopian tube, ovaries and endometrium. Int J Gyn Pathol 23 : 110-118,2004.

Nasuti, JF, Zhang PJ, Feldman M, MD, PhD, Pasha TL, Khurana JS, Gorman J, Gorman R, Narula J: Fibrillin and Other Matrix Proteins in Mitral Valve Prolapse Syndrome. Annals of Thoracic Surgery 77 : 532-535,2004.

Fogt F, Pascha TL, Zhang PJ, Gausas RE, Rahemtulla A: Proliferation of D2-40-expressing intestinal lymphatic vessels in the lamina propria in inflammatory bowel disease Int J Mol Med 13 : 221-214,2004.

Scobie JV, Acs G, Bandera CA, Blank SV, Wheeler JE: C-kit Immunoreactivity in Endometrial Adenocarcinomas and Its Clinicopathologic Significance. Int J Gyn Pathol 22 (2): 149-155,2003.

PJ Zhang, EM Genega, JE Tomaszewski, TL Pasha: The Role of Calretinin, Inhibin, Melan-A, BCL-2 and c-kit in differentiating Adrenal Cortical and Medullary Tumors, An Immunohistochemical Study. Mod Pathol 16 (6): 591-597,2003.

Zhang PJ, Goldblum JR, Pawel BR, Fisher C, Pasha TL: Immunophenotype of Desmoplastic Small Round Cell Tumors as Detected in Cases with EWS-WT1 Gene Fusion Product. Mod Pathol 16 (3): 229-235,2003.

Geza. Acs, Lynn Wang, Puthiyaveettil N. Raghunath: The Role of Different Immunostaining Patterns In Herceptest Interpretation and Their Correlation with Gene Amplification as Determined by Fluorescence in Situ Hybridization Applied Immunohistolochemistry & Molecular Morphology 13 (3): 222-229,2003.

Xu X, Tahan: Expression of Neurotrophin receptor Trk-C in nevi and melanomas, an immunohistochemical study. Journal of Cutaneous Pathology 30 (5): 318-322,2003.

Acs G, Zhang PJ, McGrath CM, Acs P, McBroom J, Mohyeldin A Liu S: Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and tis potential role in cervical carcinogenesis and tumor progression. Am J Pathol 162 (6): 1790-1806,2003.

Zhang PJ, Liang HH, Pasha TL, Weber R: Various Growth Factors, Growth Factor Recptors in Juvenile Nasopharyngeal Angiofibroma; A Comparative Immunhistochemical Study with Nasal Polyps. Arch Pathol Lab Med. 127 (11): 1480-1484,2003.

Academic Contact Info

Department of Pathology and Lab Medicine
Division of Anatomic Pathology
University of Pennsylvania Medical Center
3400 Spruce Street – Six Founders

Philadelphia, PA 19104
Phone: (215) 662-6503
Patient appointments: 800-789-7366 (PENN)