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Paul A. Yushkevich, PhD

Paul A. Yushkevich, PhD Researcher

Associate Professor of Radiology

Dr. Yushkevich is employed by Penn Medicine.

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National Institutes of Health, National

Hospital Affiliation

Dr. Yushkevich is employed by Penn Medicine.


Description of Research Expertise:

My research portfolio combines theoretical work on statistical shape characterization using a symmetry-based representation of shape with applied and translational research in multiple areas of biomedical image analysis. I am particularly interested in analysis techniques that are tailored to specific anatomical structures. My key work in this area involves automatic segmentation and morphometry of the hippocampal formation (HF) in magnetic resonance imaging (MRI). The HF plays a central role in memory function and is a site of early neurodegeneration in Alzheimer’s disease. In a broad effort to develop more detailed imaging-based biomarkers for Alzheimer’s disease, my team has developed a first of its kind detailed computational atlas of the HF from postmortem MRI microscopy. With NIH R01 funding, we are now integrating this atlas with histology, leveraging it for the analysis of the HF and its subfields in in vivo MRI, and evaluating MRI-derived subfield-specific as alternative imaging biomarkers in dementia. We recently published a pioneering technique for automatic segmentation of HF subfields in high-resolution, HF-focused T2-weighted in vivo MRI, showing excellent agreement with manual segmentation. Concurrently, we developed and evaluated a strategy for improving the accuracy of general-purpose segmentation techniques using machine learning as a corrective wrapper method. Other recent publications include a surface-based tract-specific strategy for diffusion MRI analysis, for which open-source software is currently being developed, and an automatic cardiac MRI segmentation method with an explicit prior on heart wall thickness.

Selected Publications:

Olsen Rosanna K, Carr Valerie A, Daugherty Ana M, La Joie Renaud, Amaral Robert S C, Amunts Katrin, Augustinack Jean C, Bakker Arnold, Bender Andrew R, Berron David, Boccardi Marina, Bocchetta Martina, Burggren Alison C, Chakravarty M Mallar, Chételat Gaël, de Flores Robin, DeKraker Jordan, Ding Song-Lin, Geerlings Mirjam I, Huang Yushan, Insausti Ricardo, Johnson Elliott G, Kanel Prabesh, Kedo Olga, Kennedy Kristen M, Keresztes Attila, Lee Joshua K, Lindenberger Ulman, Mueller Susanne G, Ofen Noa: Progress update from the hippocampal subfields group. Alzheimer's & dementia (Amsterdam, Netherlands) 11 : 439-449,2019.

Das Sandhitsu R, Xie Long, Wisse Laura E M, Vergnet Nicolas, Ittyerah Ranjit, Cui Salena, Yushkevich Paul A, Wolk David A: In vivo measures of tau burden are associated with atrophy in early Braak stage medial temporal lobe regions in amyloid-negative individuals. Alzheimer's & dementia : the journal of the Alzheimer's Association : 2019.

Xie Long, Wisse Laura E M, Pluta John, de Flores Robin, Piskin Virgine, Manjón Jose V, Wang Hongzhi, Das Sandhitsu R, Ding Song-Lin, Wolk David A, Yushkevich Paul A: Automated segmentation of medial temporal lobe subregions on in vivo T1-weighted MRI in early stages of Alzheimer's disease. Human brain mapping 40 (12): 3431-3451,2019.

Delhaye Emma, Mechanic-Hamilton Dawn, Saad Laura, Das Sandhitsu R, Wisse Laura E M, Yushkevich Paul A, Wolk David A, Bastin Christine: Associative memory for conceptually unitized word pairs in mild cognitive impairment is related to the volume of the perirhinal cortex. Hippocampus 29 (7): 630-638,2019.

Parivash Sherveen N, Goubran Maged, Mills Brian D, Rezaii Paymon, Thaler Christian, Wolman Dylan, Bian Wei, Mitchell Lex A, Boldt Brian, Douglas David, Wilson Eugene W, Choi Jay, Xie Long, Yushkevich Paul A, DiGiacomo Phil, Wongsripuemtet Jitsupa, Parekh Mansi, Fiehler Jens, Do Huy, Lopez Jaime, Rosenberg Jarrett, Camarillo David, Grant Gerald, Wintermark Max, Zeineh Michael: Longitudinal Changes in Hippocampal Subfield Volume Associated with Collegiate Football. Journal of neurotrauma : 2019.

Shah Preya, Bassett Danielle S, Wisse Laura E M, Detre John A, Stein Joel M, Yushkevich Paul A, Shinohara Russell T, Elliott Mark A, Das Sandhitsu R, Davis Kathryn A: Structural and functional asymmetry of medial temporal subregions in unilateral temporal lobe epilepsy: A 7T MRI study. Human brain mapping 40 (8): 2390-2398,2019.

Xie Long, Das Sandhitsu R, Pilania Arun, Daffner Molly, Stockbower Grace E, Dolui Sudipto, Yushkevich Paul A, Detre John A, Wolk David A: Task-enhanced arterial spin labeled perfusion MRI predicts longitudinal neurodegeneration in mild cognitive impairment. Hippocampus 29 (1): 26-36,2019.

Mueller Susanne G, Yushkevich Paul A, Das Sandhitsu, Wang Lei, Van Leemput Koen, Iglesias Juan Eugenio, Alpert Kate, Mezher Adam, Ng Peter, Paz Katrina, Weiner Michael W: Systematic comparison of different techniques to measure hippocampal subfield volumes in ADNI2. NeuroImage. Clinical 17 (27): 1006-1018,2018.

Xie L., Das S., Pilania A., Daffner M., Stockbower G.E., Dolui S, Yushkevich PA, Detre J.A., Wolk D.A.: Task-Enhanced Arterial Spin Labeled Perfusion MRI Predicts Longitudinal Neurodegeneration in Mild Cognitive Impairment Hippocampus : 2018.

Oguz, B.U., Wang, J., Yushkevich, N., Pouch, A., Gee, J.C., Yushkevich, P.A., Schwartz, N., Oguz, I.: Combining Deep Learning and Multi-atlas Label Fusion for Automated Placenta Segmentation from 3DUS Springer, Cham 11076 : 138-148,2018.

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Academic Contact Info

Penn Image Computing and Science Laboratory
Richards Building, 6th Floor, D605
3700 Hamilton Walk

Philadelphia, PA 19104
Phone: (215) 746-6924