Description of Research Expertise:
The Axelsen laboratory is focused on the pathogenesis of Alzheimer's disease, particularly in the roles of oxidative stress and protein lipid interactions. A variety of whole-animal models and in vitro systems are used, as well as a large repository of human brain samples. The laboratory has developed novel isotope-based techniques for characterizing oxidative stress in brain using mass spectrometry and various forms of optical spectroscopy, including infrared, fluorescence, and internal reflection spectroscopy.
Furman, R, Lee, JV, Axelsen, PH: Analysis of eicosanoid oxidation products in Alzheimer brain by LC-MS with uniformly 13C-labeled internal standards free radical biology and medicine 118 : 108-118,2018.
Eskici, G, Axelsen, PH: Mass Exchange and Equilibration Processes in AOT Reverse Micelles langmuir 34 (7): 2522-2530,2018.
Grasso, G, Axelsen, PH: Effects of covalentmodification by 4-hydroxy-2-nonenal on the noncovalent oligomerization of ubiquitin journal of mass spectrometry 52 (1): 36-42,2017.
Grasso, G, Komatsu, H, Axelsen, PH: Covalent modifications of the amyloid beta peptide by hydroxynonenal: Effects on metal ion binding by monomers and insights into the fibril topology journal of inorganic biochemistry 174 : 130-136,2017.
Eskici, G, Axelsen, PH: Amyloid Beta Peptide Folding in Reverse Micelles journal of the american chemical society 139 (28): 9566-9575,2017.
Eskici, G, Axelsen, PH: The Size of AOT Reverse Micelles journal of physical chemistry b 120 (44): 11337-11347,2016.
Axelsen, PH, Murphy, RC, Igarashi, M, Rapoport, SI: Increased omega 6-Containing Phospholipids and Primary omega 6 Oxidation Products in the Brain Tissue of Rats on an omega 3-Deficient Diet plos one 11 (10): 2016.
Furman, R, Murray, IVJ, Schall, HE, Liu, QW, Ghiwot, Y, Axelsen, PH: Amyloid Plaque-Associated Oxidative Degradation of Uniformly Radiolabeled Arachidonic Acid acs chemical neuroscience 7 (3): 367-377,2016.
Klinger, AL, Kiselar, J, Ilchenko, S, Komatsu, H, Chance, MR, Axelsen, PH: A Synchrotron-Based Hydroxyl Radical Footprinting Analysis of Amyloid Fibrils and Prefibrillar Intermediates with Residue-Specific Resolution biochemistry 53 (49): 7724-7734,2014.
Komatsu, H, Feingold-Link, E, Sharp, KA, Rastogi, T, Axelsen, PH: Intrinsic Linear Heterogeneity of Amyloid beta Protein Fibrils Revealed by Higher Resolution Mass-per-length Determinations journal of biological chemistry 285 (53): 41843-41851,2010.
Axelsen, PH, Komatsu, H, Murray, IVJ: Oxidative Stress and Cell Membranes in the Pathogenesis of Alzheimer''s Disease physiology 26 (1): 54-69,2011.
Murphy, RC, Axelsen, PH: MASS SPECTROMETRIC ANALYSIS OF LONG-CHAIN LIPIDS mass spectrometry reviews 30 (4): 579-599,2011.
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