Find a Doctor or Practice Location

You can also search for providers and practices at Penn Medicine Lancaster General Health or Princeton Health.

within
I am searching for a
Reset Form
placeholder image: silhouette of male physician

Paul H. Axelsen, MD Researcher

Professor of Pharmacology Professor of Medicine Professor of Biochemistry and Biophysics

Dr. Axelsen is employed by Penn Medicine.

No Patient Satisfaction Reviews
Why not?

There is no publicly available rating for this medical professional for one of the following reasons:

  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients in a medical practice setting.
  3. He or she sees patients but has not yet received the minimum 30 patient satisfaction reviews in the past 12 months, ensuring that the rating is statistically reliable and a true reflection of patient satisfaction.
X

Clinical Specialties

Programs & Centers:

Memberships

Biophysical Society, National National Institutes of Health, National None, International None, Local

Hospital Affiliation

Dr. Axelsen is employed by Penn Medicine.

Research

Description of Research Expertise:

The Axelsen laboratory is focused on the pathogenesis of Alzheimer's disease, particularly in the roles of oxidative stress and protein lipid interactions. A variety of whole-animal models and in vitro systems are used, as well as a large repository of human brain samples. The laboratory has developed novel isotope-based techniques for characterizing oxidative stress in brain using mass spectrometry and various forms of optical spectroscopy, including infrared, fluorescence, and internal reflection spectroscopy.

Selected Publications:

Furman, R, Lee, JV, Axelsen, PH: Analysis of eicosanoid oxidation products in Alzheimer brain by LC-MS with uniformly 13C-labeled internal standards free radical biology and medicine 118 : 108-118,2018.

Eskici, G, Axelsen, PH: Mass Exchange and Equilibration Processes in AOT Reverse Micelles langmuir 34 (7): 2522-2530,2018.

Grasso, G, Axelsen, PH: Effects of covalentmodification by 4-hydroxy-2-nonenal on the noncovalent oligomerization of ubiquitin journal of mass spectrometry 52 (1): 36-42,2017.

Grasso, G, Komatsu, H, Axelsen, PH: Covalent modifications of the amyloid beta peptide by hydroxynonenal: Effects on metal ion binding by monomers and insights into the fibril topology journal of inorganic biochemistry 174 : 130-136,2017.

Eskici, G, Axelsen, PH: Amyloid Beta Peptide Folding in Reverse Micelles journal of the american chemical society 139 (28): 9566-9575,2017.

Eskici, G, Axelsen, PH: The Size of AOT Reverse Micelles journal of physical chemistry b 120 (44): 11337-11347,2016.

Axelsen, PH, Murphy, RC, Igarashi, M, Rapoport, SI: Increased omega 6-Containing Phospholipids and Primary omega 6 Oxidation Products in the Brain Tissue of Rats on an omega 3-Deficient Diet plos one 11 (10): 2016.

Furman, R, Murray, IVJ, Schall, HE, Liu, QW, Ghiwot, Y, Axelsen, PH: Amyloid Plaque-Associated Oxidative Degradation of Uniformly Radiolabeled Arachidonic Acid acs chemical neuroscience 7 (3): 367-377,2016.

Klinger, AL, Kiselar, J, Ilchenko, S, Komatsu, H, Chance, MR, Axelsen, PH: A Synchrotron-Based Hydroxyl Radical Footprinting Analysis of Amyloid Fibrils and Prefibrillar Intermediates with Residue-Specific Resolution biochemistry 53 (49): 7724-7734,2014.

Komatsu, H, Feingold-Link, E, Sharp, KA, Rastogi, T, Axelsen, PH: Intrinsic Linear Heterogeneity of Amyloid beta Protein Fibrils Revealed by Higher Resolution Mass-per-length Determinations journal of biological chemistry 285 (53): 41843-41851,2010.

Axelsen, PH, Komatsu, H, Murray, IVJ: Oxidative Stress and Cell Membranes in the Pathogenesis of Alzheimer''s Disease physiology 26 (1): 54-69,2011.

Murphy, RC, Axelsen, PH: MASS SPECTROMETRIC ANALYSIS OF LONG-CHAIN LIPIDS mass spectrometry reviews 30 (4): 579-599,2011.

View all publications

Academic Contact Info

1009C Stellar Chance Laboratories, Department of System Pharmacology and Translational Therapeutics

Philadelphia, PA 19104
Phone: (215) 898-9238