Description of Research Expertise

My research interests center around the study of the complications of HIV and its treatment, and currently in the evaluation of strategies for the cure of HIV infection.
I am the director and the PI of the AIDS clinical trial unit of the University of Pennsylvania.
I am one of the founding members of the HIV Reservoirs and Viral Eradication (Cure) Transformative Science Group (TSG) of the AIDS clinical trial group. In addition to my ACTG work, I am involved (as PI of the clinical project) in several early phase trials of new compounds developed in conjunction with the NIH in several IPCP grants, including a Phase I study evaluating the antiviral activity of aprepitant (an NK-1R antagonist that down-regulates the expression of CCR5), a phase I study evaluating the immunogenicity of a therapeutic DNA vaccine administered by intramuscular electroporation in collaboration with David Weiner and several gene therapy studies evaluating the therapeutic use of lentiviral vectors in the management of HIV infection (including the use of VIRxSYS 496 –antisense approach-, the first in humans Sangamo’s zinc finger nuclease for CCR5 edition, in collaboration with Dr. Carl June.

Selected Publications

Parzych, E. M., Du, J., Ali, A. R., Schultheis, K., Frase, D., Smith, T. R. F., Cui, J., Chokkalingam, N., Tursi, N. J., Andrade, V. M., Warner, B. M., Gary, E. N., Li, Y., Choi, J., Eisenhauer, J., Maricic, I., Kulkarni, A., Chu, J. D., Villafana, G., Rosenthal, K., Ren, K., Francica, J. R., Wootton, S. K., Tebas, P., Kobasa, D., Broderick, K. E., Boyer, J. D., Esser, M. T., Pallesen, J., Kulp, D. W., Patel, A., Weiner, D. B.: DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2 Nat Commun 13 (1): 5886,2022.

Neergaard, R., Jones, N. L., Roebuck, C., Rendle, K. A., Barbati, Z., Peterson, B., Tebas, P., Mounzer, K., Metzger, D., Montaner, L. J., Dube, K., Barg, F. K.: "I Know That I Was a Part of Making a Difference": Participant Motivations for Joining a Cure-Directed HIV Trial with an Analytical Treatment Interruption AIDS Res Hum Retroviruses : 2022.

Schnittman, S. R., Lu, M. T., Mayrhofer, T., Burdo, T. H., Fitch, K. V., McCallum, S., Fulda, E. S., Zanni, M. V., Borek, F., Malvestutto, C., Fichtenbaum, C. J., Aberg, J. A., Bloomfield, G. S., Overton, E. T., Currier, J., Tebas, P., Sha, B. E., Ribaudo, H. J., Flynn, J. M., Douglas, P. S., Erlandson, K. M., Grinspoon, S. K.: Cytomegalovirus IgG Titer and Coronary Artery Disease in People with HIV Clin Infect Dis : 2022.

Dube, K., Agarwal, H., Carter, W. B., Dee, L., Taylor, J., Roebuck, C., Peterson, B., Patel, H., Ndukwe, S., Lynn, K. M., Lalley-Chareczko, L., Hiserodt, E., Kim, S., Rosenbloom, D., Evans, B. R., Anderson, M., Hazuda, D. J., Bateman, K., Howell, B. J., Azzoni, L., Mounzer, K., Tebas, P., Montaner, L. J.: Participant experiences using novel home-based blood collection device for viral load testing in the HIV cure trials with analytical treatment interruptions HIV Res Clin Pract 23 (1): 76-90,2022.

Fintzi, J., Bonnett, T., Tebas, P., Marconi, V. C., Levine, C. B., El Sahly, H. M., McLellan, S. L. F., Benson, C. A., Rostad, C. A., Ganesan, A., Huprikar, N., Frank, M. G., Mularski, R. A., Atmar, R. L., Park, P. K., Short, W. R., Beigel, J. H., Mehta, A. K., Sweeney, D. A.: Unraveling the Treatment Effect of Baricitinib on Clinical Progression and Resource Utilization in Hospitalized COVID-19 Patients: Secondary Analysis of the Adaptive COVID-19 Treatment Randomized Trial-2 Open Forum Infect Dis 9 (7): ofac219,2022.

Daniell, H., Nair, S. K., Guan, H., Guo, Y., Kulchar, R. J., Torres, M. D. T., Shahed-Al-Mahmud, M., Wakade, G., Liu, Y. M., Marques, A. D., Graham-Wooten, J., Zhou, W., Wang, P., Molugu, S. K., de Araujo, W. R., de la Fuente-Nunez, C., Ma, C., Short, W. R., Tebas, P., Margulies, K. B., Bushman, F. D., Mante, F. K., Ricciardi, R. P., Collman, R. G., Wolff, M. S.: Debulking different Corona (SARS-CoV-2 delta, omicron, OC43) and Influenza (H1N1, H3N2) virus strains by plant viral trap proteins in chewing gums to decrease infection and transmission Biomaterials 288 : 121671,2022.

Fintzi, J., Bonnett, T., Sweeney, D. A., Huprikar, N. A., Ganesan, A., Frank, M. G., McLellan, S. L. F., Dodd, L. E., Tebas, P., Mehta, A. K.: Deconstructing the Treatment Effect of Remdesivir in the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1: Implications for Critical Care Resource Utilization Clin Infect Dis 74 (12): 2209-2217,2022.

Pedersen, S. F., Collora, J. A., Kim, R. N., Yang, K., Razmi, A., Catalano, A. A., Yeh, Y. J., Mounzer, K., Tebas, P., Montaner, L. J., Ho, Y. C.: Inhibition of a Chromatin and Transcription Modulator, SLTM, Increases HIV-1 Reactivation Identified by a CRISPR Inhibition Screen J Virol 96 (13): e0057722,2022.

Blumberg, E. A., Noll, J. H., Tebas, P., Fraietta, J. A., Frank, I., Marshall, A., Chew, A., Veloso, E. A., Carulli, A., Rogal, W., Gaymon, A. L., Schmidt, A. H., Barnette, T., Jurek, R., Martins, R., Hudson, B. M., Chavda, K., Bailey, C. M., Church, S. E., Noorchashm, H., Hwang, W. T., June, C. H., Hexner, E. O.: A phase I trial of cyclosporine for hospitalized patients with COVID-19 JCI Insight 7 (11): 2022.

Dube, K., Kanazawa, J., Roebuck, C., Johnson, S., Carter, W. B., Dee, L., Peterson, B., Lynn, K. M., Lalley-Chareczko, L., Hiserodt, E., Kim, S., Rosenbloom, D., Evans, B. R., Anderson, M., Hazuda, D. J., Shipley, L., Bateman, K., Howell, B. J., Mounzer, K., Tebas, P., Montaner, L. J.: "We are looking at the future right now": community acceptability of a home-based viral load test device in the context of HIV cure-related research with analytical treatment interruptions in the United States HIV Res Clin Pract : 1-16,2022.

Academic Contact Information

Academic Address: 502 Johnson Pavilion
Clinical Office: 4 Perelman Center for Advanced Medicine, 3600 Civic Center Boulevard
Philadelphia, PA 19104
Phone: 215-349-8092
Patient appointments: 800-789-7366