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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Recognized by Best Doctors in America 2007 - 2012, 2015 - 2018
Perelman Center for Advanced Medicine
South Pavilion, 4th Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
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My research interests center around the study of the complications of HIV and its treatment, and currently in the evaluation of strategies for the cure of HIV infection.I am the director and the PI of the AIDS clinical trial unit of the University of Pennsylvania. I am one of the founding members of the HIV Reservoirs and Viral Eradication (Cure) Transformative Science Group (TSG) of the AIDS clinical trial group. In addition to my ACTG work, I am involved (as PI of the clinical project) in several early phase trials of new compounds developed in conjunction with the NIH in several IPCP grants, including a Phase I study evaluating the antiviral activity of aprepitant (an NK-1R antagonist that down-regulates the expression of CCR5), a phase I study evaluating the immunogenicity of a therapeutic DNA vaccine administered by intramuscular electroporation in collaboration with David Weiner and several gene therapy studies evaluating the therapeutic use of lentiviral vectors in the management of HIV infection (including the use of VIRxSYS 496 –antisense approach-, the first in humans Sangamo’s zinc finger nuclease for CCR5 edition, in collaboration with Dr. Carl June.
Azzoni, L., Ross, B., Fair, M., Pagliuzza, A., Lada, S., Wu, G., Zuck, P., Tebas, P., Mounzer, K., Kostman, J. R., Abdel –Mohsen, M., Richman, D., Chomont, N., Howell, B.J., Montaner, L. J.: Distinct HIV reservoir measures correlate with defective but not intact proviral DNA 27th Conference on Retrovirus and Opportunistic infections. March 8-11 2020 Boston, Abstract #309 : 2020.
Azzoni, L., Papasavvas, E., Tebas, P., Mounzer, K., Kostman, J., Frank, I., Howell, B.J., Hazuda, D., Holder, D., Chom, N.: Baseline inducible HIV p24 informs viral control during interferon- 27th Conference on Retrovirus and Opportunistic infections. March 8-11 2020 Boston, Abstract #276 : 2020.
Yadav, A., Kossenkov, A. V., Knecht, V. R., Showe, L. C., Ratcliffe, S. J., Montaner, L. J., Tebas, P., Collman, R. G.: Evidence for Persistent Monocyte and Immune Dysregulation After Prolonged Viral Suppression Despite Normalization of Monocyte Subsets, sCD14 and sCD163 in HIV-Infected Individuals Pathog Immun 4 (2): 324-362,2019.
Beigel JH, Aga E, Elie-Turenne MC, Cho J, Tebas P, Clark CL, Metcalf JP, Ozment C, Raviprakash K, Beeler J, Holley HP, Warner S, Chorley C, Lane HC, Hughes MD, Davey RT: Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial Lancet Respir Med 7 (11): 941-950,2019.
DeJesus, E., Villanueva, J. F. A., Lopez, J. R. A., Brinson, C., Crofoot, G., Daar, E. S., Koenig, E., Podzamczer, D., Ramgopal, M., Santana, J., Santiago, L., Tebas, P., Zorrilla, C., Guo, S., Liu, Y. P., Zhong, L., Brainard, D. M., Carter, C. C., Temme, L., Das, M.: Tenofovir alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF) in hispanic/latinx and black participants: Efficacy, bone and renal safety results from a pooled analysis of 7 clinical trials Open Forum Infectious Diseases. IDWEEK, October 2019. Washington DC. 6 : S168-S169,2019.
Bedimo RJ, Mar H, Bosch RJ, Drechsler H, Cyktor JC, Macatangay BJC, Lalama C, Rinaldo C, Collier A, Godfrey C, Hogg E, Hensel C, Eron JJ, Mcmahon DK, Mellors JW, Tebas P, Gandhi RT, A5321 Study Team: Brief Report: No Evidence for an Association between Statin Use and Lower Biomarkers of HIV Persistence or Immune Activation/Inflammation During Effective ART J Acquir Immune Defic Syndr 82 (2): e27-e31,2019.
Bedimo, R. J., Mar, H., Bosch, R. J., Drechsler, H., Cyktor, J. C., Macatangay, B. J. C., Lalama, C., Rinaldo, C., Jr., Collier, A., Godfrey, C., Hogg, E., Hensel, C., Eron, J. J., McMahon, D. K., Mellors, J. W., Tebas, P., Gandhi, R. T., A. Study Team: Brief Report: No Evidence for an Association Between Statin Use and Lower Biomarkers of HIV Persistence or Immune Activation/Inflammation During Effective ART J Acquir Immune Defic Syndr 82 (2): e27-e31,2019.
Papasavvas, E., Azzoni, L., Kossenkov, A. V., Dawany, N., Morales, K. H., Fair, M., Ross, B. N., Lynn, K., Mackiewicz, A., Mounzer, K., Tebas, P., Jacobson, J. M., Kostman, J. R., Showe, L., Montaner, L. J.: NK Response Correlates with HIV Decrease in Pegylated IFN-alpha2a-Treated Antiretroviral Therapy-Suppressed Subjects J Immunol 203 (3): 705-717,2019.
Papasavvas E, Azzoni L, Kossenkov AV, Dawany N, Morales KH, Fair M, Ross BN, Lynn K, Mackiewicz A, Mounzer K, Tebas P, Jacobson JM, Kostman JR, Showe L, Montaner LJ: NK Response Correlates with HIV Decrease in Pegylated IFN-α2a-Treated Antiretroviral Therapy-Suppressed Subjects J Immunol 203 (3): 705-717,2019.
Tomescu, C., Papasavvas, E., Azzoni, L., Colon, K., Tebas, P., Mounzer, K., Kostman, J., Montaner, L.: CD57 expressing mature NK cells negatively correlate with the level of intact and hypermutated pro-viral DNA in HIV-1 infected ART-suppressed subjects 10th IAS Conference on HIV Science. Mexico City July 21-24. Abstract # LBPEA06 : 2019.
Academic Address: 502 Johnson PavilionClinical Office: 4 Perelman Center for Advanced Medicine, 3600 Civic Center Boulevard
Patient appointments: 800-789-7366