Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Recognized by Best Doctors in America 2007 - 2012, 2015 - 2018
Infectious Disease, 2005
Internal Medicine, 2004
Perelman Center for Advanced Medicine
South Pavilion, 4th Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
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My research interests center around the study of the complications of HIV and its treatment, and currently in the evaluation of strategies for the cure of HIV infection.I am the director and the PI of the AIDS clinical trial unit of the University of Pennsylvania. I am one of the founding members of the HIV Reservoirs and Viral Eradication (Cure) Transformative Science Group (TSG) of the AIDS clinical trial group. In addition to my ACTG work, I am involved (as PI of the clinical project) in several early phase trials of new compounds developed in conjunction with the NIH in several IPCP grants, including a Phase I study evaluating the antiviral activity of aprepitant (an NK-1R antagonist that down-regulates the expression of CCR5), a phase I study evaluating the immunogenicity of a therapeutic DNA vaccine administered by intramuscular electroporation in collaboration with David Weiner and several gene therapy studies evaluating the therapeutic use of lentiviral vectors in the management of HIV infection (including the use of VIRxSYS 496 –antisense approach-, the first in humans Sangamo’s zinc finger nuclease for CCR5 edition, in collaboration with Dr. Carl June.
Beigel JH, Aga E, Elie-Turenne MC, Cho J, Tebas P, Clark CL, Metcalf JP, Ozment C, Raviprakash K, Beeler J, Holley HP, Warner S, Chorley C, Lane HC, Hughes MD, Davey RT: Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial Lancet Respir Med 7 (11): 941-950,2019.
Bedimo RJ, Mar H, Bosch RJ, Drechsler H, Cyktor JC, Macatangay BJC, Lalama C, Rinaldo C, Collier A, Godfrey C, Hogg E, Hensel C, Eron JJ, Mcmahon DK, Mellors JW, Tebas P, Gandhi RT, A5321 Study Team: Brief Report: No Evidence for an Association between Statin Use and Lower Biomarkers of HIV Persistence or Immune Activation/Inflammation During Effective ART J Acquir Immune Defic Syndr 82 (2): e27-e31,2019.
Papasavvas E, Azzoni L, Kossenkov AV, Dawany N, Morales KH, Fair M, Ross BN, Lynn K, Mackiewicz A, Mounzer K, Tebas P, Jacobson JM, Kostman JR, Showe L, Montaner LJ: NK Response Correlates with HIV Decrease in Pegylated IFN-α2a-Treated Antiretroviral Therapy-Suppressed Subjects J Immunol 203 (3): 705-717,2019.
Tebas P, Kraynyak KA, Patel A, Maslow JN, Morrow MP, Sylvester AJ, Knoblock D, Gillespie E, Amante D, Racine T, McMullan T, Jeong M, Roberts CC, Park YK, Boyer J, Broderick KE, Kobinger GP, Bagarazzi M, Weiner DB, Sardesai NY, White SM: Intradermal SynCon® Ebola GP DNA Vaccine is Temperature Stable and Safely Demonstrates Cellular and Humoral Immunogenicity Advantages in Healthy Volunteers J Infect Dis 220 (3): 400-410,2019.
Julg B, Dee L, Ananworanich J, Barouch DH, Bar K, Caskey M, Colby DJ, Dawson L, Dong KL, Dubé K, Eron J, Frater J, Gandhi RT, Geleziunas R, Goulder P, Hanna GJ, Jefferys R, Johnston R, Kuritzkes D, Li JZ, Likhitwonnawut U, van Lunzen J, Martinez-Picado J, Miller V, Montaner LJ, Nixon DF, Palm D, Pantaleo G, Peay H, Persaud D, Salzwedel J, Salzwedel K, Schacker T, Sheikh V, Søgaard OS, Spudich S, Stephenson K, Sugarman J, Taylor J, Tebas P, Tiemessen CT, Tressler R, Weiss CD, Zheng L, Robb ML, Michael NL, Mellors JW, Deeks SG, Walker BD: Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting Lancet HIV 6 (4): e259-e268,2019.
Choi H, Kudchodkar SB, Reuschel EL, Asija K, Borole P, Ho M, Wojtak K, Reed C, Ramos S, Bopp NE, Aguilar PV, Weaver SC, Kim JJ, Humeau L, Tebas P, Weiner DB, Muthumani K: Protective immunity by an engineered DNA vaccine for Mayaro virus PLoS Neglec Trop Dis 13 (2): e0007042,2019.
Benson CA, Andersen JW, Macatangay BJC, Mailliard RB, Rinald CR Jr, Read S, Bozzolo DR, Purdue L, Jennings C, Keefer MC, Glesby M, Tebas P, Russell AF, Martin J, Annunziato P, Popmihajlov Z, Lennox JL: Safety and Immunogenicity of Zoster Vaccine Live in HIV-Infected Adults with CD4+ Cell Counts Above 200 Cells/mL Virologically Suppressed on Antiretroviral Therapy Clin Infect Dis 67 (11): 1712-1719,2018.
Bertagnolli, L. N., White, J. A., Simonetti, F. R., Beg, S. A., Lai, J., Tomescu, C., Murray, A. J., Antar, A. A. R., Zhang, H., Margolick, J. B., Hoh, R., Deeks, S. G., Tebas, P., Montaner, L. J., Siliciano, R. F., Laird, G. M., Siliciano, J. D.: The role of CD32 during HIV-1 infection Nature 561 (7723): E17-E19,2018.
Namazi, G., Fajnzylber, J. M., Aga, E., Bosch, R., Acosta, E. P., Sharaf, R., Hartogensis, W., Jacobson, J. M., Connick, E., Volberding, P., Skiest, D., Margolis, D., Sneller, M. C., Little, S. J., Gianella, S., Smith, D., Kuritzkes, D. R., Gulick, R. M., Mellors, J. W., Mehraj, V., Gandhi, R. T., Mitsuyasu, R., Schooley, R. T., Henry, K., Tebas, P., Deeks, S., Chun, T. W., Collier, A. C., Routy, J. P., Hecht, F. M., Walker, B. D., Li, J. Z.: The Control of HIV after Antiretroviral Medication Pause (CHAMP) study: post-treatment controllers identified from 14 clinical studies J Infect Dis : doi: 10.1093/infdis/jiy479,2018.
Salantes, D. B., Zheng, Y., Mampe, F., Srivastava, T., Beg, S., Lai, J., Li, J. Z., Tressler, R. L., Koup, R. A., Hoxie, J., Abdel-Mohsen, M., Sherrill-Mix, S., McCormick, K., Overton, E. T., Bushman, F. D., Learn, G. H., Siliciano, R. F., Siliciano, J. M., Tebas, P., Bar, K. J.: HIV-1 latent reservoir size and diversity are stable following brief treatment interruption J Clin Invest 128 (7): 3102-3115,2018.
Academic Address: 502 Johnson PavilionClinical Office: 4 Perelman Center for Advanced Medicine, 3600 Civic Center Boulevard
Phone: (215) 349-8092
Patient appointments: 800-789-7366