Description of Research Expertise:
My research interests center around the study of the complications of HIV and its treatment, and currently in the evaluation of strategies for the cure of HIV infection.
I am the director and the PI of the AIDS clinical trial unit of the University of Pennsylvania.
I am one of the founding members of the HIV Reservoirs and Viral Eradication (Cure) Transformative Science Group (TSG) of the AIDS clinical trial group. In addition to my ACTG work, I am involved (as PI of the clinical project) in several early phase trials of new compounds developed in conjunction with the NIH in several IPCP grants, including a Phase I study evaluating the antiviral activity of aprepitant (an NK-1R antagonist that down-regulates the expression of CCR5), a phase I study evaluating the immunogenicity of a therapeutic DNA vaccine administered by intramuscular electroporation in collaboration with David Weiner and several gene therapy studies evaluating the therapeutic use of lentiviral vectors in the management of HIV infection (including the use of VIRxSYS 496 –antisense approach-, the first in humans Sangamo’s zinc finger nuclease for CCR5 edition, in collaboration with Dr. Carl June.
Bedimo, R. J., Adams-Huet, B., Poindexter, J., Brown, G., Farukhi, I., Castanon, R., Turner, D., Moore, T., Tebas, P., Maalouf, N. M.: The Differential Effects of HIV and HCV on Bone Micro-Architecture and Fracture risk Clin Infect Dis : 2017.
George, V., Harrison, L., Roach, M., Li, X. D., Tierney, C., Fischl, M. A., Aberg, J., Tebas, P., Asmuth, D. M., Pollard, R. B., Godfrey, C., Pahwa, S., Aids Clinical Trials Group A Study Team: Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome J Infect Dis : 2017.
Tebas, P., Roberts, C. C., Muthumani, K., Reuschel, E. L., Kudchodkar, S. B., Zaidi, F. I., White, S., Khan, A. S., Racine, T., Choi, H., Boyer, J., Park, Y. K., Trottier, S., Remigio, C., Krieger, D., Spruill, S. E., Bagarazzi, M., Kobinger, G. P., Weiner, D. B., Maslow, J. N.: Safety and Immunogenicity of an Anti-Zika Virus DNA Vaccine - Preliminary Report N Engl J Med : 2017.
Gallant J, Lazzarin A, Mills A, Orkin C, Podzamczer D, Tebas P, Girard PM, Brar I, Daar ES, Wohl D, Rockstroh J, Wei X, Custodio J, White K, Martin H, Cheng A, Quirk E: Bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1 infection (GS-US-380-1489): a double-blind, multicentre, phase 3, randomised controlled non-inferiority trial Lancet 36 (17): 32299-7,2017.
Kelly, B. J., Tebas, P.: Clinical Practice and Infrastructure Review of Fecal Microbiota Transplantation for Clostridium difficile Infection Chest : 2017.
Herati RS, Muselman A, Vella L, Bengsch B, Parkhouse K, Del Alcazar D, Kotzin J, Doyle SA, Tebas P, Hensley SE, Su LF, Schmader KE, Wherry EJ: Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells Sci Immunol 2 (8): 2017.
Yin MT, Chan ES, Brown TT, Tebas P, McComsey GA, Melbourne K, Napoli A, Hardin R, Ribaudo HJ, Overton ET, A Study Team: Racial differences in calculated bioavailable vitamin D with vitamin D/calcium supplementation: ACTG A5280 AIDS : 2017.
Koenig HC, Mounzer K, Daughtridge GW, Sloan CE, Lalley-Chareczko L, Moorthy GS, Conyngham SC, Zuppa AF, Montaner LJ, Tebas P: Urine assay for tenofovir to monitor adherence in real time to tenofovir disoproxil fumarate/emtricitabine as pre-exposure prophylaxis HIV Med 18 (6): 412-418,2017.
Beigel JH, Tebas P, Elie-Turenne MC, Bajwa E, Bell TE, Cairns CB, Shoham S, Deville JG, Feucht E, Feinberg J, Luke T, Raviprakash K, Danko J, O'Neil D, Metcalf JA, King K, Burgess TH, Aga E, Lane HC, Hughes MD, Davey RT, IRC Study Team: Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study Lancet Respir Med 5 (6): 500-511,2017.
Drechsler, H., Ayers, C., Cutrell, J., Maalouf, N., Tebas, P., Bedimo, R.: Current use of statins reduces risk of HIV rebound on suppressive HAART PLoS One 12 (3): e0172175,2017.