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Nuala J. Meyer, MD, MS

Nuala J. Meyer, MD, MS Physician

Director, Center for Translational Lung Biology Associate Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Meyer is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Pulmonary Medicine

Programs & Centers:

Clinical Expertise:

  • Acute Respiratory Distress Syndrome (ARDS)
  • Asthma
  • Cardiogenic Shock
  • Chronic Obstructive Pulmonary Disease (COPD)
  • CT Scan (Computed Tomography)
  • Dyspnea
  • Hypoxia
  • Lung Disease
  • Needle Procedure
  • Obstructive Sleep Apnea
  • Pleural Effusion (Fluid in the Lung)
  • Pneumonia
  • Pulmonary Embolism (Pulmonary Embolus)
  • Respiratory Failure
  • Sepsis (Septicemia)

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Chicago
Residency: University of Chicago Medical Center
Fellowship: University of Chicago Medical Center

Memberships

American College of Chest Physicians, National American Thoracic Society, National CDPRMRP (Congressionally Directed Peer Reviewed Medical Research Program), Study Section Member, National Society of Critical Care Medicine, National

Hospital Affiliation

Dr. Meyer is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Dr. Meyer’s research uses genetic and molecular risk factors for acute respiratory distress syndrome (ARDS) and organ dysfunction during sepsis to better understand the pathophysiology of these conditions and to seek novel treatments. The goal of her work is to develop personalized therapy for sepsis and ARDS. Her research program includes:

1) A large observational cohort of critically ill subjects with sepsis phenotyped for infection subtype, comborbidities, survival, ARDS, acute kidney injury (AKI), and cognitive impairment
2) Discovery and validation of genetic and molecular risk factors for sepsis-associated organ dysfunction
3) Clinical trials for ARDS and sepsis [Active: VICTAS (Vitamin C, Thiamine, and Steroids for Sepsis); BIO-11006 for ARDS]

Selected Publications:

Meyer Nuala J, Reilly John P, Anderson Brian J, Palakshappa Jessica A, Jones Tiffanie K, Dunn Thomas G, Shashaty Michael G S, Feng Rui, Christie Jason D, Opal Steven M: Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration. Critical care medicine 46 (1): 21-28,2018.

Reilly John P, Wang Fan, Jones Tiffanie K, Palakshappa Jessica A, Anderson Brian J, Shashaty Michael G S, Dunn Thomas G, Johansson Erik D, Riley Thomas R, Lim Brian, Abbott Jason, Ittner Caroline A G, Cantu Edward, Lin Xihong, Mikacenic Carmen, Wurfel Mark M, Christiani David C, Calfee Carolyn S, Matthay Michael A, Christie Jason D, Feng Rui, Meyer Nuala J: Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive care medicine 44 (11): 1849-1858,2018.

Meyer Nuala J, Reilly John P, Feng Rui, Christie Jason D, Hazen Stanley L, Albert Carolyn J, Franke Jacob D, Hartman Celine L, McHowat Jane, Ford David A: Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome. JCI insight 2 (23): e96432,2017.

Hippensteel Joseph A, Anderson Brian J, Orfila James E, McMurtry Sarah A, Dietz Robert M, Su Guowei, Ford Joshay A, Oshima Kaori, Yang Yimu, Zhang Fuming, Han Xiaorui, Yu Yanlei, Liu Jian, Linhardt Robert J, Meyer Nuala J, Herson Paco S, Schmidt Eric P: Circulating heparan sulfate fragments mediate septic cognitive dysfunction. The Journal of clinical investigation 129 (4): 1779-1784,2019.

Palakshappa Jessica A, Reilly John P, Schweickert William D, Anderson Brian J, Khoury Viviane, Shashaty Michael G, Fitzgerald David, Forker Caitlin, Butler Kelly, Ittner Caroline A, Feng Rui, Files D Clark, Bonk Michael P, Christie Jason D, Meyer Nuala J: Quantitative peripheral muscle ultrasound in sepsis: Muscle area superior to thickness. Journal of critical care 47 : 324-330,2018.

Meyer Nuala J, Calfee Carolyn S: Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome. The Lancet. Respiratory medicine 5 (6): 512-523,2017.

Reilly John P, Christie Jason D, Meyer Nuala J: Fifty Years of Research in ARDS. Genomic Contributions and Opportunities. American journal of respiratory and critical care medicine 196 (9): 1113-1121,2017.

Palakshappa Jessica A, Meyer Nuala J: Which Patients with ARDS Benefit from Lung Biopsy? Chest 148 (4): 1073-1082,2015.

Angela J. Rogers and Nuala J. Meyer: Genomic Contributions to Precision Medicine in Critical Illness: sepsis and acute respiratory distress syndrome Precision Therapy in Pulmonary, Critical Care, and Sleep Medicine : in press,2019.

Wang F, Meyer NJ, Walley KR, Russell JA, Feng R: Causal Genetic Inference Using Haplotypes as Instrumental Variables Genet Epidemiol 40 (1): 34-44,2016.

View all publications

Academic Contact Info

Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
3400 Spruce Street
5039 Gates Building

Philadelphia, PA 19104
Phone: (215) 662-7049
Patient appointments: 800-789-7366 (PENN)