Description of Research Expertise:
Dr. Meyer’s research uses genetic and molecular risk factors for acute respiratory distress syndrome (ARDS) and organ dysfunction during sepsis to better understand the pathophysiology of these conditions and to seek novel treatments. The goal of her work is to develop personalized therapy for sepsis and ARDS. Her research program includes:
1) A large observational cohort of critically ill subjects with sepsis phenotyped for infection subtype, comborbidities, survival, ARDS, acute kidney injury (AKI), and cognitive impairment
2) Discovery and validation of genetic and molecular risk factors for sepsis-associated organ dysfunction
3) Clinical trials for ARDS and sepsis [Active: MultiStem for ARDS]
Meyer Nuala J, Reilly John P, Anderson Brian J, Palakshappa Jessica A, Jones Tiffanie K, Dunn Thomas G, Shashaty Michael G S, Feng Rui, Christie Jason D, Opal Steven M: Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration. Critical care medicine 46 (1): 21-28,2018.
Meyer Nuala J, Reilly John P, Feng Rui, Christie Jason D, Hazen Stanley L, Albert Carolyn J, Franke Jacob D, Hartman Celine L, McHowat Jane, Ford David A: Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome. JCI insight 2 (23): e96432,2017.
Meyer Nuala J, Ferguson Jane F, Feng Rui, Wang Fan, Patel Parth N, Li Mingyao, Xue Chenyi, Qu Liming, Liu Yichuan, Boyd John H, Russell James A, Christie Jason D, Walley Keith R, Reilly Muredach P: A Functional Synonymous Coding Variant in the IL1RN Gene Associates with Survival in Septic Shock. Am. J. Respir. Crit. Care Med. 190 (6): 656-664,2014.
Nuala J Meyer, Rui Feng, Mingyao Li, Yang Zhou, Chau-Chun Sheu, Paula Tejera, Robert Gallop, Scarlett Bellamy, Melanie Rushefski, Paul N. Lanken, Richard Aplenc, Grant E. O'Keefe, Mark M Wurfel, David C Christiani, and Jason D. Christie: IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL1RA American Journal of Respiratory and Critical Care Medicine 187 (9): 950-9,2013.
Meyer Nuala J, Li Mingyao, Feng Rui, Bradfield Jonathan, Gallop Robert, Bellamy Scarlett, Fuchs Barry D, Lanken Paul N, Albelda Steven M, Rushefski Melanie, Aplenc Richard, Abramova Helen, Atochina-Vasserman Elena N, Beers Michael F, Calfee Carolyn S, Cohen Mitchell J, Pittet Jean-Francois, Christiani David C, O'Keefe Grant E, Ware Lorraine B, May Addison K, Wurfel Mark M, Hakonarson Hakon, Christie Jason D: ANGPT2 Genetic Variant Is Associated with Trauma-associated Acute Lung Injury and Altered Plasma Angiopoietin-2 Isoform Ratio. American Journal of Respiratory and Critical Care Medicine 183 (10): 1344-53,2011.
Meyer, Nuala J.: Future Clinical Applications of Genomics to Acute Respiratory Distress Syndrome Lancet Resp Med 1 (10): 793-803,2013.
Palakshappa Jessica A, Meyer Nuala J: Which Patients with ARDS Benefit from Lung Biopsy? Chest 148 (4): 1073-1082,2015.
Meyer, Nuala J and Christie, Jason D: Genetic Heterogeneity and Risk of ARDS Seminars in Respiratory and Critical Care Medicine 34 (4): 459-74,2013.
Reilly JP, Anderson BJ, Hudock KM, Dunn TG, Kazi A, Charles D, Shashaty MG, Mikkelsen ME, Christie JD, Meyer NJ: Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis Crit Care 20 (1): 222,2016.
Meyer Nuala J, Calfee Carolyn S: Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome. The Lancet. Respiratory medicine 5 (6): 512-523,2017.
Reilly John P, Christie Jason D, Meyer Nuala J: Fifty Years of Research in ARDS. Genomic Contributions and Opportunities. American journal of respiratory and critical care medicine 196 (9): 1113-1121,2017.
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