Description of Research Expertise:
Dr. Meyer’s research uses genetic and molecular risk factors for acute respiratory distress syndrome (ARDS) and organ dysfunction during sepsis to better understand the pathophysiology of these conditions and to seek novel treatments. The goal of her work is to develop personalized therapy for sepsis and ARDS. Her research program includes:
1) A large observational cohort of critically ill subjects with sepsis phenotyped for infection subtype, comborbidities, survival, ARDS, acute kidney injury (AKI), and cognitive impairment
2) Discovery and validation of genetic and molecular risk factors for sepsis-associated organ dysfunction
3) Clinical trials for ARDS and sepsis [Active: VICTAS (Vitamin C, Thiamine, and Steroids for Sepsis); BIO-11006 for ARDS]
Meyer Nuala J, Reilly John P, Anderson Brian J, Palakshappa Jessica A, Jones Tiffanie K, Dunn Thomas G, Shashaty Michael G S, Feng Rui, Christie Jason D, Opal Steven M: Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration. Critical care medicine 46 (1): 21-28,2018.
Reilly John P, Wang Fan, Jones Tiffanie K, Palakshappa Jessica A, Anderson Brian J, Shashaty Michael G S, Dunn Thomas G, Johansson Erik D, Riley Thomas R, Lim Brian, Abbott Jason, Ittner Caroline A G, Cantu Edward, Lin Xihong, Mikacenic Carmen, Wurfel Mark M, Christiani David C, Calfee Carolyn S, Matthay Michael A, Christie Jason D, Feng Rui, Meyer Nuala J: Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive care medicine 44 (11): 1849-1858,2018.
Meyer Nuala J, Reilly John P, Feng Rui, Christie Jason D, Hazen Stanley L, Albert Carolyn J, Franke Jacob D, Hartman Celine L, McHowat Jane, Ford David A: Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome. JCI insight 2 (23): e96432,2017.
Hippensteel Joseph A, Anderson Brian J, Orfila James E, McMurtry Sarah A, Dietz Robert M, Su Guowei, Ford Joshay A, Oshima Kaori, Yang Yimu, Zhang Fuming, Han Xiaorui, Yu Yanlei, Liu Jian, Linhardt Robert J, Meyer Nuala J, Herson Paco S, Schmidt Eric P: Circulating heparan sulfate fragments mediate septic cognitive dysfunction. The Journal of clinical investigation 129 (4): 1779-1784,2019.
Palakshappa Jessica A, Reilly John P, Schweickert William D, Anderson Brian J, Khoury Viviane, Shashaty Michael G, Fitzgerald David, Forker Caitlin, Butler Kelly, Ittner Caroline A, Feng Rui, Files D Clark, Bonk Michael P, Christie Jason D, Meyer Nuala J: Quantitative peripheral muscle ultrasound in sepsis: Muscle area superior to thickness. Journal of critical care 47 : 324-330,2018.
Meyer Nuala J, Calfee Carolyn S: Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome. The Lancet. Respiratory medicine 5 (6): 512-523,2017.
Reilly John P, Christie Jason D, Meyer Nuala J: Fifty Years of Research in ARDS. Genomic Contributions and Opportunities. American journal of respiratory and critical care medicine 196 (9): 1113-1121,2017.
Palakshappa Jessica A, Meyer Nuala J: Which Patients with ARDS Benefit from Lung Biopsy? Chest 148 (4): 1073-1082,2015.
Angela J. Rogers and Nuala J. Meyer: Genomic Contributions to Precision Medicine in Critical Illness: sepsis and acute respiratory distress syndrome Precision Therapy in Pulmonary, Critical Care, and Sleep Medicine : in press,2019.
Wang F, Meyer NJ, Walley KR, Russell JA, Feng R: Causal Genetic Inference Using Haplotypes as Instrumental
Variables Genet Epidemiol 40 (1): 34-44,2016.
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