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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Hospital of the University of Pennsylvania
Medical/Intermediate Intensive Care, 9 Founders
3400 Spruce Street
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
I am a physician-scientist with a clinical practice in critical care, and a research program focused on syndromes affecting the critically ill. These syndromes include sepsis, the dysregulated host response to infection, and ARDS, Acute Respiratory Distress Syndrome. A comprehensive mechanistic understanding of the host response during sepsis is imperative because the aberrant host response rather than the pathogen itself often drives organ failure and mortality. While other enucleate cells such as platelets play a vital role in innate immunity, astonishingly little is known about RBC immune function. RBCs are the most abundant circulating cell in the body and have a tremendous capacity to modulate inflammatory responses due to their large surface area and constant contact with circulating pathogen and host-derived inflammatory mediators. My lab's overarching long-term objective is to define RBCs' immunomodulatory functions that may alter the immune response to pathogens and sterile injury. My lab has two broad, but related themes focused on innate immunity and inflammation in the vascular compartment.
L.K. Metthew Lam, Sophia Murphy, Dimitra Kokkinaki, Alessandro Venosa, Scott Sherrill-Mix, Carla Casu, Stefano Rivella, Aaron Weiner, Jeongho Park, Sunny Shin, Andrew Vaughan, Beatrice H. Hahn, Audrey R. Odom John, Nuala J. Meyer, Christopher A. Hunter, G. Scott Worthen, Nilam S. Mangalmurti: DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia Science Translational Medicine 13 (616): 2021.
H. Luke Anderson, Igor E. Brodsky, Nilam S. Mangalmurti: The evolving erythrocyte: RBCs as modulators of innate immunity Journal of Immunology 201 (5): 1343-1351,2018.
Meghan J. Hotz, Danielle Qing, Michael G. S. Shashaty, Peggy Zhang, Hilary Faust, Neal Sondheimer, Stefano Rivella, G. Scott Worthen, and Nilam S. Mangalmurti: Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury. American Journal of Respiratory and Critical Care Medicine 197 (4): 470-480,2018.
Qing D, Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS.: Red Blood Cells Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation American Journal of Respiratory and Critical Care Medicine 190 (11): 1243-54,2014.
Mangalmurti Nilam S, Xiong Zeyu, Hulver Mei, Ranganathan Mrunalini, Liu Xiang Hong, Oriss Timothy, Fitzpatrick Meghan, Rubin Marc, Triulzi Darrell, Choi Augustine, Lee Janet S: Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation. Blood 113 (5): 1158-66,2009.
Hilary Faust, Metthew LK Lam, Danielle Qing, Nilam S. Mangalmurti: RAGE Interacts with the Necroptotic Protein RIPK3 and Mediates Transfusion-Induced Danger Signal Release
Vox Sanguinis 115 (8): 2020.
Faust HE, Reilly JP, Anderson BJ, Ittner CAG, Forker CM, Zhang P, Weaver BA, Holena DN, Lanken PN, Christie JD, Meyer NJ, Mangalmurti NS, Shashaty MGS: Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients. Chest 157 (1): 67-76,2020.
Mangalmurti NS, Friedman JL, Wang LC, Stolz DB, Muthukumaran G, Siegel DL, Schmidt AM, Lee JS, Albelda SM: The Receptor for Advanced Glycation End Products Mediates Lung Endothelial Activation by RBCs Am J Physiol Lung Cell Mol Physiol 304 (4): L250-63,2013.
Jeongyun Seo1, David Conegliano1, Megan Farrell, Minseon Cho, Xueting Ding, Thomas Seykora, Danielle Qing, Nilam S. Mangalmurti, Dongeun Huh: A microengineered model of RBC transfusion-induced pulmonary vascular injury Scientific Reports 7 (1): 3413,2017.
Michael G. S. Shashaty, MD, MSCE; John P. Reilly, M.D., M.S.C.E.; Hilary E. Faust, M.D.; Caitlin M. Forker, B.A.; Caroline A. G. Ittner, Ph.D.; Peggy X. Zhang, B.S.; Meghan J. Hotz, B.S.; David Fitzgerald; Wei Yang, Ph.D.; Brian J. Anderson, M.D., M.S.C.E.; Daniel N. Holena, MD, MSCE; Paul N. Lanken, M.D., M.S.C.E.; Jason D. Christie, M.D., M.S.C.E.; Nuala J. Meyer, MD, MS; Nilam S. Mangalmurti, M.D.: Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study Critical Care 23 (1): 2019.
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