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Sees patients age 18 and up
Sees patients age 18 and up
Perelman Center for Advanced Medicine
South Pavilion, 4th Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
My long term research goals are to unravel the mechanisms that drive intestinal mucosal inflammation and its complications. I work under the mentorship of De'Broski Herbert and Christopher Lengner. My current projects focus on understanding how trefoil factor family and their protein receptors regulate mucosal damage repair, regeneration, tumorigenesis and T cell mediated anti-helminth immunity.
Nicole Belle, Christopher Pastore, Lucas Ethgen, De'Broski Herbert: LINGO2 expression on T cells promote anti-helminth immunity DDW 2022 : 2022.
Zullo, K.M, Douglas, B., Maloney N., Yingbiao J, Yun W, Herbine K, Cohen R, Pastore C, Cramer Z, Wang X, Wenjie W, Somsouk M, Hung L.Y., Lengner C, Kohanksi M.H., Cohen N.A and D. R. Herbert: LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis Scand J. Gastroenterology 56 (7): 791-805,2021.
Nicole M Belle, Christopher Pastore, Erin Jean and De'Broski R Herbert: LINGO2 expression on T cells selectively promotes anti-helminth immunity Virtual Immunology : 2021.
Nicole Belle: Model System Has Answered Critical Questions GI & Hepatology News : 2020.
Nicole M Belle, Erin Jean, Joon Park and De’broski Herbert: T cell expression of the transmembrane receptor, LINGO2 controls helminth induced colitis Mucosal Immunology Course & Symposium : 2020.
Belle NM, Ji Y, Wei Y, Park J, Srivatsa S, Hung LY, Young T, Herbine K, Oniskey T, Pastore C, Nieves W, Somsouk M, Herbert DR: TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths Nature Communications 10 (1): 4408,2019.
Maloney NS, Thackray LB, Goel G, Hwang S, Duan E, Vachharajani P, Xavier R, Virgin HW: Essential cell autonomous role for interferon regulatory factor 1 in interferon-γ-mediated inhibition of norovirus replication in macrophages J. Virol 86 (23): 12655-64,2012.
Hwang S, Maloney NS, Bruinsma MW, Goel G, Duan E, Zhang L, Shrestha B, Diamond MS, Dani A, Sosnovtsev SV, Green KY, Lopez-Otin C, Xavier RJ, Thackray LB, Virgin HW: Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma Cell Host Microbe 11 (4): 397-09,2012.
Hwang S, Maloney NS, Thackray LB, Virgin HW: ATG5 is required for interferon γ to control murine norovirus replication Autophagy Keystone, Whistler, BC : 2011.
Cadwell K, Patel KK, Maloney NS, Liu TC, Ng ACY, Storer CE, Head RD, Xavier R, Stappenbeck TS, Virgin HW: Virus plus susceptibility gene interaction determines intestinal phenotypes of the Crohn's disease susceptibility gene Atg16L1 Cell 141 (7): 1135-45,2010.
Perelman Center for Advanced Medicine7 South Pavilion
Patient appointments: 800-789-7366