Penn Medicine Provider
Gastroenterology
Nicole Belle, MD, PhD
Accepting new patients
Sees patients age 18 and up
Penn Gastroenterology Perelman

About me

  • Assistant Professor of Medicine (Gastroenterology)

Dr. Belle performs procedures only.

Education and training

  • Medical School: Washington University in St. Louis
  • Residency: Hospital of the University of Pennsylvania
  • Fellowship: Hospital of the University of Pennsylvania

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Belle is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Belle NM M1 and M2 Macrophages Differentially Regulate Colonic Crypt Renewal , PracticeUpdate website: 2024


Lucas M Ethgen, Christopher Pastore, Cailu Lin, Danielle R Reed, Li-Yin Hung, Bonnie Douglas, Dominic Sinker, De'Broski R Herbert, Nicole M Belle A Trefoil factor 3- Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infection , Mucosal Immunology, 17(2): 2024,238-256


Nicole Belle, Christopher Pastore, Lucas Ethgen, De'Broski Herbert LINGO2 expression on T cells promote anti-helminth immunity , DDW 2022: 2022


Zullo, K.M, Douglas, B., Maloney N., Yingbiao J, Yun W, Herbine K, Cohen R, Pastore C, Cramer Z, Wang X, Wenjie W, Somsouk M, Hung L.Y., Lengner C, Kohanksi M.H., Cohen N.A and D. R. Herbert LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis , Scand J. Gastroenterology, 56(7): 2021,791-805


Nicole M Belle, Christopher Pastore, Erin Jean and De'Broski R Herbert LINGO2 expression on T cells selectively promotes anti-helminth immunity , Virtual Immunology: 2021


Nicole Belle Model System Has Answered Critical Questions , GI & Hepatology News: 2020


Nicole M Belle, Erin Jean, Joon Park and De’broski Herbert T cell expression of the transmembrane receptor, LINGO2 controls helminth induced colitis , Mucosal Immunology Course & Symposium : 2020


Belle NM, Ji Y, Wei Y, Park J, Srivatsa S, Hung LY, Young T, Herbine K, Oniskey T, Pastore C, Nieves W, Somsouk M, Herbert DR TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths , Nature Communications, 10(1): 2019,4408


Maloney NS, Thackray LB, Goel G, Hwang S, Duan E, Vachharajani P, Xavier R, Virgin HW Essential cell autonomous role for interferon regulatory factor 1 in interferon-γ-mediated inhibition of norovirus replication in macrophages , J. Virol, 86(23): 2012,12655-64


Hwang S, Maloney NS, Bruinsma MW, Goel G, Duan E, Zhang L, Shrestha B, Diamond MS, Dani A, Sosnovtsev SV, Green KY, Lopez-Otin C, Xavier RJ, Thackray LB, Virgin HW Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma , Cell Host Microbe, 11(4): 2012,397-09