Description of Research Expertise

As Co-Director of the Restorative Spinal Therapeutics (ReST) Laboratory, Dr. Malhotra develops restorative approaches to treat disc degeneration. His novel approaches have led to multiple awards and research grants. Through his work, Dr. Malhotra hopes to reduce the need for spinal surgery and offer better treatments for disc degeneration.

Dr. Malhotra's clinical research focuses on mitigating disparities in outcomes. Whether studying spinal chordoma outcomes or the impact of household income, gender, or race on clinical outcomes, Dr. Malhotra leverages his expertise with the electronic health record. Dr. Malhotra founded, and leads, the EpiLog project. The EpiLog team of McKenna statistical fellows and Frazier scholars work to uncover disparities in medical outcomes. Where possible, the lab develops approaches to eliminate avoidable differences in outcome.

Selected Publications

Dimentberg R, Sinha S, Glauser G, Caplan IF, Schuster JM, McClintock SD, Yoon J, Marcotte PJ, Ali Z, Malhotra NR: Short-Term Impact of Bracing in Multi-Level Posterior Lumbar Spinal Fusion Int J Spine Surg 15 (5): 915-920,2021.

Glauser G, Sharma N, Beatson N, Dimentberg R, Savarese F, Gagliardi M, Grady MS, Malhotra NR: Surgical CPT Coding Discrepancies: Analysis of Surgeons and Employed Coders Am J Med Qual 36 (4): 263-269,2021.

Farooqi A, Dimentberg R, Shultz K, McClintock SD, Malhotra NR: Absence of Gender Disparity in 30-Day Morbidity and Mortality After Supratentorial Brain Tumor Resection World Neurosurg 144 : e361-e367,2020.

Detchou DK, Dimentberg R, Vaughan KA, Kolster R, Braslow BM, Malhotra NR: Navigated Ultrasonic Osteotomy to Aid in En Bloc Chordoma Resection via Spondylectomy World Neurosurg 143 : 319-324,2020.

Zhang C, Gullbrand S, Schaer TP, Boorman S, Elliott DM, Chen W, Dodge GR, Mauck RL, Smith LJ*, Malhotra NR*: Combined Hydrogel and Mesenchymal Stem Cell Therapy for Moderate Severity Disc Degeneration in Goats Tissue Eng Part 27 (1-2): 117-128,2021.

Blue R, Yang AI, Zhou C, De Ravin E, Teng CW, Arguelles GR, Huang V, Wathen C, Miranda SP, Marcotte P, Malhotra NR, Welch WC, Lee JYK: Telemedicine in the Era of Coronavirus Disease (COVID-19): A Neurosurgical Perspective World Neurosurg 139 : 549-557,2020.

Gutierrez A, Su YS, Vaughan KA, Miranda S, Chen HI, Petrov D, Malhotra NR, Schuster JM: Penetrating Spinal Column Injuries (pSI): An Institutional Experience with 100 Consecutive Cases in an Urban Trauma Center World Neurosurg 138 : e551-e556,2020.

Blue R, Detchou DK, Dimentberg R, Shultz K, Spadola M, McClintock SD, Malhotra NR: The Influence of Household Income on Survival Following Posterior Fossa Tumor Resection at a Large Academic Medical Center J Neurol Surg B Skull Base 82 (6): 631-637,2020.

Spadola M, Farooqi A, Dimentberg R, Blue R, Shultz K, McClintock SD, Malhotra NR: The Effect of Household Income on Outcomes Following Supratentorial Meningioma Resection Clin Neurol Neurosurg 195 : 106031,2020.

Blue R, Dimentberg R, Detchou DK, Glauser G, Shultz K, McClintock SD, Malhotra NR: The Impact of Household Economics on Short-Term Outcomes in a Posterior Fossa Tumor Population Cureus 12 (7): e8968,2020.

Dimentberg R, Caplan IF, Winter E, Glauser G, Goodrich S, McClintock SD, Hume EL, Malhotra NR: Prediction of Adverse Outcomes Within 90 Days of Surgery in a Heterogeneous Orthopaedic Surgery Population Journal Healthc Qual 43 (4): e53-e63,2021.

Winter E, Dimentberg R, Haldar D, Glauser G, Caplan IF, Shultz K, McClintock SD, Chen HI, Yoon JW, Malhotra NR: Predicting Short Term Outcomes Following Supratentorial Tumor Surgery Clinical Neurology and Neurosurgery 196 : 106016,2020.

Miranda SP, Glauser G, Wathen C, Blue R, Dimentberg R, Welch WC, Grady MS, Schuster JM, Malhotra NR: Letter to the Editor: Incorporating Telehealth to Improve Neurosurgical Training During the COVID-19 Pandemic World Neurosurg 139 : 728-731,2020.

Winter E, Haldar D, Glauser G, Caplan IF, Shultz K, McClintock SD, Chen HI, Yoon J, Malhotra NR: The LACE+ Index as a Predictor of 90-Day Supratentorial Tumor Surgery Outcomes Neurosurgery 87 (7): 1181-1190,2020.

Caplan IF, Winter E, Glauser G, Goodrich S, McClintock SD, Milby AH, Hume EL, Malhotra NR: Composite Score for Prediction of 30-Day Orthopaedic Surgery Outcomes J Orthop Res 38 (10): 2189-2196,2020.

Haldar D, Glauser G, Schuster JM, Winter E, Goodrich S, Shultz K, Brem S, McClintock SD, Malhotra NR: Role of Race in Short-Term Outcomes for 1700 Consecutive Patients Undergoing Brain Tumor Resection J Healthc Qual 43 (5): 284-291,2021.

Glauser G, Wathen C, Miranda SP, Blue R, Dimentberg R, Welch WC, Lee JYK, Malhotra NR: Letter to the Editor Regarding "Implementation and Workflow of a Telehealth Clinic in Neurosurgery During the COVID-19 Pandemic" World Neurosurg 139 : 373-375,2020.

Glauser G, Dimentberg R, Shultz K, McClintock SD, Malhotra NR: Survival Disparity Based on Household Income in 1,970 Patients Following Brain Tumor Surgery World Neurosurg 143 : e112-e121,2020.

Glauser G, Winter E, Caplan IF, Goodrich S, McClintock SD, Srinivas SK, Malhotra NR: Composite Score for Outcome Prediction at 30 Days in Gynecologic Surgery Patients J Healthc Qual 43 (4): 163-173,2021.

Glauser G, Winter E, Caplan IF, Goodrich S, McClintock SD, Srinivas SK, Malhotra NR: Predictive Index for 90 Day Postoperative Outcomes Following Gynecologic Surgery Am J Manag Care 26 (7): 303-309,2020.

Winter E, Glauser G, Caplan I, Goodrich S, McClintock SD, Kovach SJ, Fonsnot J, Serletti J, Malhotra NR: The LACE+ Index as a Predictor of 30-Day Patient Outcomes in a Plastic Surgery Population: A Coarsened Exact Match Study Plast Reconstr Surg 146 (3): 296e-305e,2020.

Glauser G, Osiemo B, Goodrich S, McClintock SD, Weber KL, Levin LS, Malhotra NR: Assessment of Short-Term Patient Outcomes Following Overlapping Orthopaedic Surgery at a Large Academic Medical Center J Bone Joint Surg Am 102 (8): 654-663,2020.

Zhang C, Gullbrand SE, Schaer TP, Khai Lau Y, Jiang Z, Dodge GR, Elliott DM, Mauck RL, Malhotra NR, Smith LJ: Inflammatory Cytokine and Catabolic Enzyme Expression in a Goat Model of Intervertebral Disc Degeneration J Orthop Res 38 (11): 2521-2531,2020.

Haldar D, Glauser G, Winter E, Dimentberg R, Goodrich S, Schultz K, Grady MS, McClintock SD, Malhotra NR: The Effect of Race on Short-Term Pituitary Tumor Outcomes World Neurosurg 137 : e447-e453,2020.

Glauser G, Goodrich S, McClintock SD, Dimentberg R, Guzzo TJ, Malhotra NR: Evaluation of Short-term Outcomes Following Overlapping Urologic Surgery at a Large Academic Medical Center Urology 138 : 30-36,2020.

Glauser G, Winter E, Caplan IF, Haldar D, Goodrich S, McClintock SD, Guzzo TJ, Malhotra NR: The LACE+ Index as a Predictor of 90-Day Urologic Surgery Outcomes World J Urol 38 (11): 2783-2790,2020.

Sullivan PZ, Albayar A, Ramayya AG, McShane B, Marcotte P, Malhotra NR, Ali ZS, Chen HI, Janjua MB, Saifi C, Schuster J, Grady MS, Jones J, Ozturk AK: Association of spinal instability due to metastatic disease with increased mortality and a proposed clinical pathway for treatment J Neurosurg Spine : 1-8,2020.

Winter E, Glauser G, Caplan IF, Goodrich S, McClintock SD, Kovach SJ, Fosnot J, Serletti JM, Malhotra NR: LACE+ Index as a Predictor of 90-Day Plastic Surgery Outcomes Am J Manag Care 26 (4): e113-e120,2020.

Caplan IF, Glauser G, Goodrich S, Chen HI, Lucas TH, Lee JYK, McClintock SD, Malhotra NR: Undiagnosed obstructive sleep apnea as a predictor of 90-day readmission for brain tumor patients World Neurosurg 134 : e979-e984,2020.

Glauser G, Malhotra NR: The Importance of Confirming Anecdotal Experience: Assessing Overlapping Surgery (Comment on Recent Suture Time Overlap Article in Neurosurgery) World Neurosurg 130 : 557-558,2019.

Peck SH, Tobias JW, Shore EM, Malhotra NR, Haskins ME, Casal ML, Smith LJ: Molecular profiling of failed endochondral ossification in mucopolysaccharidosis VII Bone 128 : 115042,2019.

Claeson AA, Vresilovic EJ, Showalter BL, Wright AC, Gee JC, Malhotra NR, Elliott DM: Human Disc Nucleotomy Alters Annulus Fibrosus Mechanics at Both Reference and Compressed Loads J Biomech Eng 141 (11): 110011-1100112,2019.

Caplan IF, Zadnik P, Glauser G, O’Rourke DM, Kung D, Choudhri O, Osiemo B, Goodrich S, McClintock SD, Malhotra NR: Predicting 30-90-day Readmission in a Brain Tumor Population with the LACE+ Index American Association of Neurological Surgeons : 2019.

Glauser G, Winter E, Caplan IF, Goodrich S, McClintock SD, Guzzo TJ, Malhotra NR: The LACE+ Index as a Predictor of 30 Day Patient Outcomes in a Urologic Surgery Population: A Coarsened Exact Match Study Urology 134 : 109-115,2019.

Glauser G, Caplan IF, Winter E, Goodrich S, McClintock SD, Atluri P, Malhotra NR: Evaluation of the LACE+ Index for Short-Term Cardiac Surgery Outcomes: A Coarsened Exact Match Study Ann Thorac Surg 110 (1): :173-182,2020.

Glauser G, Goodrich S, McClintock SD, Szeto WY, Atluri P, Acker MA, Malhotra NR: Association of overlapping cardiac surgery with short-term patient outcomes J Thorac Cardiovasc Surg 162 (1): 155-164.e2,2021.

Glauser G, Ali ZS, Gardiner D, Ramayya AG, Pessoa R, Grady MS, Welch WC, Zager EL, Sim E, Haughey V, Wells B, Restuccia M, Tait G, Fala G, Malhotra NR: Assessing the utility of an IoS application in the perioperative care of spine surgery patients: the NeuroPath Pilot study Mhealth 5 (40): 2019.

Caplan IF, Zadnik P, Glauser G, Ali ZS, O’Rourke DM, Kung DK, Choudhri O, Osiemo B, Goodrich S, McClintock SD, Malhotra NR: The LACE+ index as a predictor of 30-day readmission in a brain tumor population American Association of Neurological Surgeons : 2019.

Caplan IF, Sullivan PZ, Glauser G, Choudhri O, Kung D, O’Rourke DM, Osiemo B, Goodrich S, McClintock SD, Malhotra NR: The LACE+ index fails to predict 30-90 day readmission for supratentorial craniotomy patients: A retrospective series of 238 surgical procedures Clin Neurol Neurosurg 182 : 79-83,2019.

Peck SH, Bendigo JR, Tobias JW, Dodge GR, Malhotra NR, Mauck RL, Smith LJ: Hypoxic Preconditioning Enhances Bone Marrow-Derived Mesenchymal Stem Cell Survival in a Low Oxygen and Nutrient-Limited 3D Microenvironment Cartilage 12 (4): 512-525,2021.

Caplan IF, Sinha S, Osiemo B, McClintock SD, Schuster JM, Smith H, Glauser G, Sharma N, Ozturk AK, Ali ZS, Malhotra, NR: The Utility of Cervical Spine Bracing As a Postoperative Adjunct to Multilevel Anterior Cervical Spine Surgery Int J Spine Surg 14 (2): 151-157,2020.

Sinha S, Caplan IF, Schuster JM, Piazza M, Glauser G, Sharma N, Welch WC, Osiemo B, McClintock SD, Ozturk AK, Malhotra NR: Evaluation of lumbar spine bracing as a postoperative adjunct to single-level posterior lumbar spine surgery Asian J Neurosurg 15 (2): 333-337,2020.

Caplan IF, Glauser G, Goodrich S, Chen HI, Lucas TH, Lee JYK, McClintock SD, Malhotra NR: Undiagnosed obstructive sleep apnea as a predictor of 30-day readmission for brain tumor patients J Neurosurg : 1-6,2019.

Glauser G, Piazza M, Berger I, Osiemo B, McClintock SD, Winter E, Chen HI, Ali ZS, Malhotra NR: The Risk Assessment and Prediction Tool (RAPT) for Discharge Planning in a Posterior Lumbar Fusion Population Neurosurgery 86 (2): E140-E146,2020.

Glauser G, Osiemo B, Goodrich S, McClintock SD, Vollmer C, DeMatteo R, Malhotra NR: Association of Overlapping, Non-Concurrent, Surgery with Patient Outcomes at a Large Academic Medical Center: A Coarsened Exact Matching Study Annals of Surgery 270 (4): 620-629,2019.

Hitti FL, McShane BJ, Yang AI, Rinehart C, Albayar A, Branche M, Malhotra NR, Janjua MB, Ali ZS, Schuster JM, Ozturk AK: Predictors of Failure of Nonoperative Management Following Subaxial Spine Trauma and Creation of Modified Subaxial Injury Classification System World Neurosurg 122 : e1359-e1364,2019.

Ramayya AG, Glauser G, Mcshane B, Branche M, Sinha S, Kvint S, Buch V, Abdullah KG, Kung DK, Chen HI, Malhotra NR, Ozturk AK: Factors Predicting Ventriculostomy Revision at a Large Academic Medical Center World Neurosurg 123 : e509-e514,2019.

Petrov D, Spadola M, Berger C, Glauser G, Mahmoud A, O’Malley B, Malhotra NR: Novel Approach using Ultrasonic Bone Curettage and TransOral Robotic Surgery for En Bloc Resection of Cervical Spine Chordomas J Neurosurg Spine : 1-6,2019.

Ali ZS, Flanders TM, Ozturk AK, Malhotra NR, Leszinsky L, McShane BJ, Gardiner D, Rupich K, Chen HI, Schuster J, Marcotte PJ, Kallan MJ, Grady MS, Fleisher LA, Welch WC: Enhanced recovery after elective spinal and peripheral nerve surgery: pilot study from a single institution J Neurosurg Spine 30 (4): 1-9,2019.

Caplan IF, Sullivan PZ, Kung D, O’Rourke DM, Choudhri O, Glauser G, Osiemo B, Goodrich S, McClintock SD, Malhotra NR: The LACE+ index as a predictor of 30-day readmission in a brain tumor population World Neurosurg 127 : e443-e448,2019.

Jivraj I, Liu GT, Sharma N, Glauser G, Grady MS, Malhotra NR: Resolution of Papilledema associated with Chiari I Malformation with Ventriculoperitoneal Shunting Asian J Neurosurg 14 (2): 598-601,2019.

Glauser G, Agarwal P, Ramayya AG, Chen HI, Lee JYK, Schuster JM, Osiemo B, Goodrich S, Smith LJ, McClintock SD, Malhotra NR: Association of Surgical Overlap During Wound Closure with Patient Outcomes Among Neurological Surgery Patients at a Large Academic Medical Center Neurosurgery 85 (5): E882-E888,2019.

Agarwal P, Ramayya AG, Osiemo B, Goodrich S, Glauser G, McClintock SD, Chen HI, Schuster JM, Grady MS, Malhotra NR: Association of Overlapping Neurosurgery with Patient Outcomes at a Large Academic Medical Center Neurosurgery 85 (6): E1050-E1058,2019.

Ramayya AG, Chen HI, Marcotte PJ, Brem S, Zager EL, Osiemo B, Piazza M, Sharma N, McClintock SD, Schuster JM, Ali ZS, Connolly P, Heuer GG, Grady MS, Kung DK, Ozturk AK, O’Rourke DM, Malhotra NR: Assessing variability in surgical decision making among attending neurosurgeons at an academic center J Neurosurg 132 (6): 1970-1976,2019.

Berger I, Piazza M, Sharma N, Glauser G, Osiemo B, McClintock SD, Lee JYK, Schuster JM, Ali ZS, Malhotra NR: Evaluation of the Risk Assessment and Prediction Tool for Post-Operative Disposition Needs After Cervical Spine Surgery Neurosurgery 85 (5): E902-E909,2019.

Malhotra NR, Piazza M, Demoor R, McClintock SD, Hamilton K, Sharma N, Osiemo B, Berger I, Hossain E, Borovskiy Y, Maloney E, Smith LJ, Grady MS: Impact of Reduced Pre-incision Antibiotic Infusion Time on Surgical Site Infection Rates: A Retrospective Cohort Study Annals of Surgery 271 (4): 774-780,2020.

Piazza M, Peck SH, Gullbrand SE, Bendigo JR, Arginteanu T, Zhang Y, Smith HE, Smith LJ*, Malhotra NR*: Quantitative MRI correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration J Orthop Res 36 (10): 2771-2779,2018.

Piazza M, Sharma N, Osiemo B, McClintock S, Missimer E, Gardiner D, Maloney E, Callahan D, Smith JL, Welch W, Schuster J, Grady MS, Malhotra NR: Initial Assessment of the Risk Assessment and Prediction Tool in a Heterogeneous Neurosurgical Patient Population Neurosurgery 85 (1): 50-57,2019.

Goel NJ, Agarwal P, Mallela AN, Abdullah KG, Ali ZS, Ozturk AK, Malhotra NR, Schuster JM, Chen HI: Liver disease is an independent predictor of poor 30-day outcomes following surgery for degenerative disease of the cervical spine Spine J 19 (3): 448-460,2019.

Kvint S, Malhotra NR, Cox M, Mondschein JI, Pukenas BA, Bagley LJ: Giant Iliac Artery Pseudoaneurysm Mimicking Postoperative Fluid Collection and Discitis World Neurosurg 136 : 253-257,2020.

Christian Terwiesch: Cobotics in Surgery-En Bloc Resection of Spinal Cancers Sirius XM: Wharton Business Radio : 2018.

Zadnik-Sullivan P, Sanborn M, Smith LJ, Malhotra NR: Spinal Cord and Spinal Column The Trauma Manual: Trauma and Acute Care Surgery 5th Edition-in press : 360-380,2020.

Smith LJ, Silverman L, Sakai D, Lotz JC, Le Maitre CL, Malhotra NR, Mauck RL, Buckley CT: Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic JOR Spine 1 (4): e1036,2018.

Baker M, Malhotra NR: En Bloc Spondylectomy and Trans Oral Robotic Surgery for Cervical Chordoma Clinical Briefing : 2018.

McCann AC, Berger C, Mahmoud AF, Kuan EC, Malhotra NR, O'Malley BW Jr: Novel approach using transoral robotic surgery for resection of cervical spine chordoma Laryngoscope 129(6):1395-1399 : 2018.

Sharma N, Piazza M, Marcotte PJ, Welch W, Ozturk AK, Chen HI, Ali ZS, Schuster J, Malhotra NR: Implications of anesthetic approach, spinal vs general, for the treatment of spinal disc herniation J Neurosurg Spine 30 (1): 78-82,2018.

Ali ZS, Ma TS, Ozturk AK, Malhotra NR, Schuster JM, Marcotte PJ, Grady MS, Welch WC: Pre-optimization of Spinal Surgery Patients: Development of a Neurosurgical Enhanced Recovery After Surgery (ERAS) Protocol Clin Neurol Neurosurg 164:142-153 : 2018.

Nayak NR, Piazza M, Milby A, Thawani JP, Smith LJ, Stein SC, Malhotra NR: Surgical Approaches for the Treatment of Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: Results of a Decision Analysis World Neurosurg 112:e375-e384 : 2018.

Tong W, Tian Z, Qin L, Motomi EI, Mauck RL, Smith HE, Smith LJ, Malhotra NR, Heyworth MF, Caldera F, Zhang Y: Cell Therapy for the Degenerating Intervertebral Disc Transl Res 181 : 49-58,2017.

Pisapia JM, Nayak NR, Salinas RD, Macyszyn L, Lee JY, Lucas TH, Malhotra NR, Chen IH, Schuster JM: Navigated Odontoid Screw Placement Using the O-arm J Neurosurg Spine 26 (1): 10-18,2017.

Peck SH, McKee KK, Tobias JW, Malhotra NR, Harfe BD, Smith LJ: Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus Sci Rep 7(1):10504 : 2017.

Hitti FL, Hudgins ED, Chen HI, Malhotra NR, Zager EL, Schuster JM: Intraoperative Navigation Is Associated with Reduced Blood Loss During C1-C2 Posterior Cervical Fixation World Neurosurg 107:574-578 : 2017.

Gullbrand SE, Schaer TP, Agarwal P, Bendigo JR, Dodge G, Chen W, Elliott D, Mauck RL, Smith LJ*, Malhotra NR*: Translation of an Injectable Triple-Interpenetrating-Network Hydrogel for Intervertebral Disc Regeneration in a Goat Model Acta Biomater 60 : 201-209,2017.

Piazza M, Nayak N, Ali Z, Heuer G, Sanborn M, Stein S, Schuster J, Grady MS, Malhotra NR: Trends in Resident Operative Teaching Opportunities for Treatment of Intracranial Aneurysms World Neurosurg 103 : 194-200,2017.

Berger I, Nayak N, Schuster JM, Lee JYK, Stein S, Malhotra NR: Microvascular Decompression Versus Stereotactic Radiosurgery for Trigeminal Neuralgia: A Decision Analysis Cureus 9 (1): e1000,2017.

Jiang X, Orton M, Feng R, Hossain E, Malhotra NR, Zager EL, Liu R: Chronic Opioid Usage in Surgical Patients in a Large Academic Center Annals of Surgery 265(4):722-727 : 2017.

Gullbrand SE, Malhotra NR, Schaer TP, Zawacki Z, Martin JT, Bendigo JR, Milby AH, Dodge GR, Vresilovic EJ, Elliott DM, Mauck RL, Smith LJ: A Large Animal Model that Recapitulates the Spectrum of Human Intervertebral Disc Degeneration Osteoarthritis Cartilage 25 (1): 146-156,2017.

Nayak NR, Bauman JA, Stein SC, Thawani JP, Malhotra NR: Surgical Approaches for the Treatment of Thoracic Disk Herniation: Results of a Decision Analysis Clin Spine Surg 30 (7): 901-908,2017.

Nayak NR, Richard CE, Martinez-Lage M, Smith H, Malhotra N: Synovial-Type Giant Cell Tumors of the Axial Spine J Neurosurg Sci 61(1):106-109 : 2017.

Lorraine L. Janeczko: Statin Shows Promise as Alternative to Surgery for Chronic Brain Bleeds Reuters Health News : 2018.

Ali ZS, Flanders TM, Ozturk A, Malhotra NR, McShane B, Kallan M, Grady MS, Welch WC: Enhanced Recovery After Surgery (ERAS) decreases postoperative opioid use in elective spinal and peripheral nerve surgery – a single institution,one-year study American Academy of Neurological Surgery : 2018.

Louisa Shepard: Robot Revolution Bellwether Magazine : 2016.

Syre P, Malhotra NR: Chronic Back Pain and Degenerative Disc Disease Clinical Decision Support in Spine Surgery : 2016.

Syre P, Macyszyn, Nyirjesy S, Millhouse PW, Koerner J, Vaccaro AR, Malhotra NR: Advanced Anterior Cervical Foraminotomy Technique Spine Surgery: Tricks of the Trade, 3rd ed. : 2016.

Malhotra NR: Degenerative Disc Disease and Low Back Pain Clinical Decision Support System on Spine Surgery : 2016.

Nayak NR, Stephen JH, Abdullah KG, Stein SC, Malhotra NR: Comparing Utility Scores in Common Spinal Radiculopathies: Results of a Prospective Valuation Study Global Spine J 6 (3): 270-6,2016.

Agarwal P, Burke JF, Abdullah KG, Piazza M, Smith BP, Thawani JP, Malhotra NR: Stab wound to the intramedullary spinal cord: Presurgical and surgical management options for a retained blade to optimize neurological preservation Surgical Neurol Int 7 (Suppl 42): S1096-S1098,2016.

Gorth DJ, Lothstein KE, Chiaro JA, Farrell MJ, Dodge GR, Elliott DM, Malhotra NR, Mauck RL, Smith LJ: Hypoxic Regulation of Functional Extracellular Matrix Elaboration by Nucleus Pulposus Cells in Long-Term Agarose Culture J Orthop Res 33 (5): 747-54,2015.

Showalter BL, Elliott DM, Chen W, Malhotra NR: Evaluation of an In Situ Gelable and Injectable Hydrogel Treatment to Preserve Human Disc Mechanical Function Undergoing Physiologic Cyclic Loading Followed by Hydrated Recovery J Biomech Eng 137 (8): 081008,2015.

Whitmore RG, Curran JN, Ali ZS, Mummaneni PV, Shaffrey CI, Heary RF, Kaiser MG, Asher AL, Malhotra NR, Cheng JS, Hurlbert J, Smith JS, Magge SN, Steinmetz MP, Resnick DK, Ghogawala Z: Predictive Value of 3-Month Lumbar Discectomy Outcomes in the NeuroPoint-SD J Neurosurg Spine 23 (4): 459-66,2015.

Nayak NR, Coats JM, Abdullah KG, Stein SC, Malhotra NR: Tracking Patient-Reported Outcomes in Spinal Disorders Surg Neurol Int 6 (Suppl 19): S490-9,2015.

Smith LJ, Gorth DJ, Showalter BL, Chiaro JA, Beattie EE, Elliott DM, Mauck RL, Chen, Malhotra NR: In Vitro Characterization of a Stem-Cell-Seeded Triple-Interpenetrating-Network Hydrogel for Functional Regeneration of the Nucleus Pulposus Tissue Eng Part A 20 (13-14): 1841-1849,2014.

Ellen Czajkowski: Surviving the Knife. A Surgeon Removes a Knife from a Patients Spinal Cord and the Patient Miraculously Walks Again CBS Eyewitness News : 2014.

Robert Linnehan: Enhanced EMRs May Support Better Treatments and Translational Research Orthopedics / Spine Surgery Today : 2014.

Peck SH, Casal ML, Malhotra NR, Ficicioglu C, Smith LJ: Pathogenesis and Treatment of Spine Disease in the Mucopolysaccharidoses. Featured Cover Article Mol Genet Metab 118 (4): 232-43,2016.

Gorth DG, Martin JT, Dodge GR, Malhotra NR, Elliott DM, Mauck RL, Smith LJ: In Vivo Retention and Bioactivity of IL-1ra Microspheres in the Rat Intervertebral Disc: a Preliminary Investigation J Exp Orthop 1 (1): 15,2014.

Peck SH, O'Donnell PJ, Kang JL, Malhotra NR, Dodge GR, Pacifici M, Shore EM, Haskins ME, Smith LJ: Delayed Hypertrophic Differentiation of Epiphyseal Chondrocytes Contributes to Failed Secondary Ossification in Mucopolysaccharidosis VII Dogs Mol Genet Metab 116 (3): 195-203,2015.

Lewis DJ, Attiah MA, Malhotra NR, Burnett MG, Stein SC: Anterior Surgical Management of Single-Level Cervical Disc Disease: A Cost-Effectiveness Analysis Spine (Phila Pa 1976) 39 (25): 2084-92,2014.

Malhotra NR: Health-Real Life Drama: Neurosurgeon Saves Spinal Cord and a Patient Walks Again CBS 3 Television News, Sweeps Week : 2014.

Stein SC, Malhotra NR, Burnett MG: Cost-Effectiveness Analysis J Neurosurg Spine 20 (4): 474,2014.

Kelz M, Malhotra NR: The Neurosurgical Operative Experience, a Patients Perspective WHYY “The Pulse”, Host: Maiken Scott : 2014.

Malhotra NR: Improving Surgical Care of the Spinal Disorders: The Osteoporotic Spine J Osteopor Phys Act : 2013.

Schuster JM, Malhotra NR: Posterior Thoracic Instrumentation Youmans Neurological Surgery. Ed 6. : 3061-3068,2011.

Malhotra NR, Kosty J, Sanborn M, Bekisz JM, Mooncai TW, Neustein TM, Ou J, Zhu A, Bernstein A, Stein SC: Optimal Approach to Circumferential Decompression and Reconstruction for Thoracic Spine Metastatic Disease Ann Surg Oncol 21 (9): 2864-2872,2014.

Nestorovski D, Milby AH, Pallavi G, Smith LJ, Smith HE, Malhotra NR: Combined Treatment Approach for Rare Occipito-Cervical Spinal Lesions: Leiomyosarcoma J Spine & Neurosurg S1 (003): 2013.

Bohman LE, Stephen JH, Ramakrishna R, Schuster JM, Malhotra NR: Postoperative Ambulatory Status Predicts Survival in Patients with Glioblastoma Multiforme J Spine & Neurosurg S1 (001): 1-3,2013.

Chen HI, Lang SS, Coyne TM, Malhotra NR, Schuster JM: Intramedullary Spinal Sarcoidosis Masquerading as Cervical Stenosis World Neurosurg 80 (6): 375-380,2013.

Clement RC, Carr BG, Kallan MJ, Wolff C, Reilly PM, Malhotra NR: Volume-Outcome Relationship in Neurotrauma Care J Neurosurg 118 (3): 687-93,2013.

Macyszyn L, Lega B, Bohman LE, Latefi A, Smith MJ, Malhotra NR, Welch WC, Grady MS: Implementation of a Departmental Picture Archiving and Communication System: a Productivity and Cost Analysis. Neurosurgery 73 (3): 528-33,2013.

Syre P, Petrov D, Malhotra NR: Management of Upper Cervical Spine Injuries J Neurosurg Sci 57 (3): 219-40,2013.

Syre P, Rodriguez-Cruz L, Desai R, Greene KA, Hurst R, Schuster J, Malhotra NR, Marcotte P: Civilian Gunshot Wounds to the Atlantoaxial Spine: a Report of 10 Cases Treated Using a Multidisciplinary Approach J Neurosurg Spine 19 (6): 759-766,2013.

Ghogawala Z, Shaffrey CI, Asher AL, Heary RF, Logvinenko T, Malhotra NR, Dante SJ, Hurlbert RJ, Douglas AF, Magge SN, Mummaneni PV, Cheng JS, Smith JS, Kaiser MG, Abbed KM, Sciubba DM, Resnick DK: The Efficacy of Lumbar Discectomy and Single-Level Fusion for Spondylolisthesis: Results from the NeuroPoint-SD Registry J Neurosurg Spine 19 (5): 555-63,2013.

Malhotra NR: Medical Breakthrough: Spinal Surgery Today XM National Radio-ReachMD : 2011.

Mummaneni PV, Whitmore RG, Curran JN, Ziewacz JE, Wadhwa R, Shaffrey CI, Asher AL, Heary RF, Cheng JS, Hurlbert RJ, Douglas AF, Smith JS, Malhotra NR, Dante SJ, Magge SN, Kaiser MG, Abbed KM, Resnick DK, Ghogawala Z: Cost-Effectiveness of Lumbar Discectomy and Single Level Fusion for Spondylolisthesis: Experience with the NeuroPoint SD Registry Neurosurg Focus 36 (6): E3,2014.

Malhotra NR, Lotier L, Becker W, Smith LJ: The Neurosurgery Quality Improvement Initiative Supports Precision Medicine, QI, and Research Epic International Physician Advisory Council : 2014.

Sanborn M, Smith LJ, Malhotra NR: Spinal Cord and Spinal Column The Trauma Manual: Trauma and Acute Care Surgery 4th Edition : 287-307,2012.

Clement RC, Carr BG, Kallan MJ, Wolff C, Reilly PM, Malhotra NR: Volume-Outcome Relationship in Neurotrauma Care J Neurosurg : 2012.

Malhotra NR, Whitmore R, Smith LJ, Welch WC, Schuster JM, Marcotte P, Dante S, Arlet V, Brem S, Grady MS: Future Directions in Spine: An Opportunity to Accelerate Quality Improvement J Spine Neurosurg 1 (2): doi: 10.4172.2325-9701.1000e105,2012.

Lang SS, Malhotra NR: Interviewing for Pediatric Fellowship: Finding the Right Work-Work Balance AANS Neurosurgeon 23 (1): 2014.

Sanborn MR, Abdullah K, Smith MJ, Grady MS, Malhotra NR: Improving Core Residency Education: An Argument for Increased Incorporation of Endovascular Surgical Training AANS Neurosurgeon 21 (4): 2012.

Bohman LE, Malhotra NR: The Value of an “Infolded” Fellowship AANS Neurosurgeon 21 (3): 2012.

Macyszyn L, Malhotra NR: Counterpoint: The Intensivist is in Charge AANS Neurosurgeon 21 (3): 2012.

Hwang SW, Malhotra NR, Shaffrey CI, Samdani AF: Intraoperative Neurophysiological Monitoring in Spine Deformity Surgery (Invited Review) Spine Deformity 1 (Suppl 1): 64-70,2012.

Malhotra NR, Bhomick D, Hardesty D, Whitfield P: Intramedullary Spinal Cord Tumors: Diagnosis, Treatment and Outcomes (Invited Review) Advances in Clinical Neuroscience and Rehabilitation (ACNR) 10 (4): 21-26,2010.

Lang SS, Chen HI, Koch MJ, Kurash L, McGill-Armento KR, Palella JM, Stein SC, Malhotra NR: Development of an Outpatient Protocol for Lumbar Discectomy World Neurosurg 82 (5): 897-901,2014.

Chiaro JA, O'Donnell P, Shore EM, Malhotra NR, Ponder KP, Haskins ME, Smith LJ: Effects of Neonatal Enzyme Replacement Therapy and Simvastatin Treatment on Cervical Spine Disease in Mucopolysaccharidosis I Dogs J Bone Miner Res 29 (12): 2610-2617,2014.

Showalter BL, Malhotra NR, Vresilovic EJ, Elliott DM: Nucleotomy Reduces the Effects of Cyclic Compressive Loading with Unloaded Recovery on Human Intervertebral Discs J Biomech 47 (11): 2633-2640,2014.

Ali Z, Barkley A, Malhotra NR: Acute Spinal Subdural Hematoma Subsequent To Posterior Lumbar Fusion J Osteopor Phys 1 (1): 2013.

Lang SS, Schuster JM, Smith LJ, Dwyer-Joyce L, Welch W, Marcotte P, Winkelstein B, Malhotra NR: Hemorrhage into Synovial Cysts as a Cause of Acute Radicular Symptoms. A report of 7 Cases and Review of Literature. J Spine Neurosurg 2 (1): EPUB only,2013.

Malhotra NR, Han WM, Beckstein J, Cloyd J, Chen W, Elliott DM: An Injectable Nucleus Pulposus Implant Restores Compressive Range of Motion in the Ovine Disc Spine (Phila Pa 1976) 37 (18): E1099-105,2012.

Sanborn MR, Thawani JP, Whitmore RG, Shmulevich M, Hardy B, Benedetto C, Malhotra NR, Marcotte P, Welch W, Dante S, Stein SC: Cost-Effectiveness of Confirmatory Techniques for the Placement of Lumbar Pedicle Screws. Neurosurg Focus 33 (1): E12,2012.

Lega BC, Danish SF, Malhotra NR, Sonnad SS, Stein SC: Choosing the Best Operation for Chronic Subdural Hematoma: a Decision Analysis J Neurosurg 113 (3): 615-21,2010.

Malhotra NR, Shaffrey CI: Intraoperative Electrophysiological Monitoring in Spine Surgery (Invited Review) Spine (Phila Pa 1976) 35 (25): 2167-79,2010.

O'Connell Grace D, Malhotra Neil R, Vresilovic Edward J, Elliott Dawn M: The Effect of Nucleotomy and the Dependence of Degeneration of Human Intervertebral Disc Strain in Axial Compression. Spine (Phila Pa 1976) 36 (21): 1765-1771,2011.

Wendell LC, Khan A, Raser J, Lang SS, Malhotra NR, Kofke WA, LeRoux P, Park S, Levine JM.: Successful Management of Refractory Intracranial Hypertension from Acute Hyperammonemic Encephalopathy in a Woman with Ornithine Transcarbamylase Deficiency Neurocrit Care 13 (1): 113-117,2010.

Malhotra NR, Piazza M, DeMoor R, McClintock SS, Hamiliton K, Sharma N, Osiemo B, Berger I, Hossain E, Borovskiy Y, Marcotte PJ, Maloney E, Smith LJ, Grady MS: Compliance with Timing Standards for Pre-incision Antibiotic Prophylaxis and Implications for Surgical Site Infections Congress of Neurological Surgeons : 2018.

Caplan I, Sinha S, Schuster JM, Piazza M, Welch WC, Sharma N, Ozturk AK, Malhotra NR: The Utility of Cervical Spine Bracing as a Postoperative Adjunct to Single-level Anterior Cervical Spine Surgery Congress of Neurological Surgeons : 2018.

Sinha S, Caplan I, Schuster JM, Sharma N, Piazza M, Welch WC, Ozturk AK, Malhotra NR: The Utility of Lumbar Spine Bracing as a Postoperative Adjunct to Single-level Posterior Lumbar Spine Surgery Congress of Neurological Surgeons : 2018.

Hunt J, Fang K, Snyder A, Malhotra NR, Gaston BM: Ammonia Depletion in Asthma Diminishes Buffering of Endogenous Airway Acid Journal of Allergy and Clinical Immunology 105 (1): S193,2000.

Malhotra NR, Cloyd J, Beckstein J, Chen W, Elliott DM: An In-Situ Polymerizing Hydrogel to Mimic Nucleus Pulposus Ex Vivo and In Vitro. (Society Scientific Paper of the Year Award) Pennsylvania Neurosurgical Society : 2008.

Plaha P, Malhotra NR, Heuer G, Whitfield P: Management of Chronic Subdural Hematoma Advances in Clinical Neuroscience and Rehabilitation (ACNR) 8 (5): 12-15,2008.

Cloyd JM, Malhotra NR, Weng L, Chen W, Mauck RL, Elliott DM: Material Properties in Unconfined Compression of Human Nucleus Pulposus, Injectable Hyaluronic Acid-Based Hydrogels and Tissue Engineering Scaffolds. Eur Spine J 16 (11): 1892-1898,2007.

Espinoza Orías AA, Malhotra NR, Elliott DM: Rat Disc Torsional Mechanics: Effect of Lumbar and Caudal Levels and Axial Compression Load Spine J 9 (3): 204-209,2009.

Lega B, Malhotra NR, Danish S, Stein S: The Best Operation for Chronic Subdural Hematoma: A Decision Analysis (Best Scientific Poster Award / 1st Place) Pennsylvania Neurosurgical Society : 2008.

Malhotra NR, Grady MS: Anterior Cervical Foraminotomy Technique Spine Surgery: Tricks of the Trade, 2nd ed. : 54-56,2009.

Thomas P, Malhotra NR, Grady MS: Injury to the Spinal Cord Trauma: Contemporary Principles and Therapy : 289-297,2008.

Malhotra NR, Thomas P, Grady MS: Injury to the Spine Trauma: Contemporary Principles and Therapy : 297-304,2008.

Malhotra NR, Whitfield P: Review of “The Legacy of Harvey Cushing” Advances in Clinical Neuroscience and Rehabilitation (ACNR) 8 (3): 2008.

Hunt JF, Fang K, Malik R, Snyder A, Malhotra NR, Platts-Mills TA, Gaston B: Endogenous Airway Acidification. Implications for Asthma Pathophysiology Am J Respir Crit Care Med 161 (3 part 1): 694-699,2000.

Hunt JF, Erwin E, Palmer L, Vaughan J, Malhotra NR, Platts-Mills TA, Gaston B: Expression and Activity of pH-Regulatory Glutaminase in the Human Airway Epithelium Am J Respir Crit Care Med 165 (1): 101-7,2002.

Gaston B, Ratjen F, Vaughan JW, Malhotra NR, Canady RG, Snyder AH, Hunt JF, Gaertig S, Goldberg JB: Nitrogen Redox Balance in the Cystic Fibrosis Airway: Effects of Antipseudomonal Therapy Am J Respir Crit Care Med 165 (3): 387-90,2002.

Boockvar JA, Stiefel M, Malhotra NR, Dolinskas C, Dwyer-Joyce C, LeRoux PD: Dural Cavernous Angioma of the Posterior Sagittal Sinus Surg Neurol 63 (2): 178-181,2005.

Chen HI, Malhotra NR, Oddo M, Heuer GG, Levine JM, LeRoux PD: Barbiturate Infusion for Intractable Intracranial Hypertension and its Effect on Brain Oxygenation Neurosurgery 63 (5): 880-886,2008.

Academic Contact Information

Chief of Neurosurgery
Hospital of the University of Pennsylvania
Professor, Neurological Surgery

PCAM, 3400 Civic Center Blvd, 15th Floor - South Tower
Philadelphia, PA 19104
Phone: 215-662-3487
Patient appointments: 800-789-7366