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Monica A. Mainigi, MD

Monica A. Mainigi, MD Physician

William Shippen, Jr. Assistant Professor of Human Reproduction

Languages spoken:

  • Hindi

Dr. Mainigi is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Reproductive Endocrinology and Infertility

Programs & Centers:

Board Certification:

  • Obstetrics and Gynecology - Reproductive Endocrinology/Infertility, 2012
  • Obstetrics and Gynecology, 2007

Clinical Expertise:

  • Abnormal Uterine Bleeding
  • Adolescent Gynecology Care
  • Anovulation
  • Cancer and Fertility (Oncofertility)
  • Donor Insemination
  • Ectopic Pregnancy
  • Egg Donation
  • Endometriosis
  • Hirsutism
  • In Vitro Fertilization (IVF)
  • Infertility
  • Lesbian, Gay, Bisexual and Transgender Health (LGBT)
  • Menstrual Disorders
  • Miscarriage (Spontaneous Abortion)
  • Ovarian Failure - Premature
  • Painful Menstrual (Dysmenorrhea)
  • Pituitary Gland Disorders
  • Polycystic Ovary Syndrome (PCOS)
  • Recurrent Pregnancy Loss (Recurrent Miscarriage)
  • Reproductive Endocrinology
  • Tubal Diseases

Description of Clinical Expertise

Clincally I see patients with infertilty as well as gynecologic issues including endometriosis and polycystic ovary disease. Additionally I have focused a portion of my clinical practice on adolescent gynecology, focusing on surgical treatment of structural disorders of the reproductive tract and endocrine disorders of puberty and menstruation. I see adolescent patients both at my office at 3701 Market Street as well as during office hours at the Children's Hospital of Philadelphia.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: New York University School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


Fellow, American College of Obstetrics and Gynecology, National Member, American Society for Reproductive Medicine, National Member, Society for Reproductive Endocrinology and Infertility, National Member, Society for the Study of Reproduction, National Society for Reproductive Investigation (formerly called Society for Gynecologic Investigation-SGI), International

Hospital Affiliation

Dr. Mainigi is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My laboratory focuses on examining the effects of ART on the oocyte, embryo and resulting offspring. Specifically we are examining the role of superovulation on implantation and placentation. My expertise is in examining ooocyte and embryo development following IVF and ART. We are interested in epigenetic changes, specifically DNA methylation, occuring following ART and how this affects placentation, fetal growth and long-term health of the offspring.

Academic Contact Info

Clinical Practice:
PENN Fertility Care
Hospital of the University of Pennsylvania
3701 Market Street, 8th Floor

421 Curie Blvd BRB II/III Room 1352

Philadelphia, PA 19104
Phone: (215) 662-2972
Patient appointments: 800-789-7366 (PENN)

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