Monica A. Mainigi, MD

she/her/hers
Reproductive Endocrinology and Infertility
LGBTQ+ affirming provider
Accepting new patients
Sees patients age 4 to 65
Penn Fertility Care
Make an appointmentCall 800-789-7366
Headshot of Monica A. Mainigi, MD
Penn Medicine Provider

About me

  • Program Director, Fellowship in Reproductive Endocrinology and Infertility
  • Associate Professor of Obstetrics and Gynecology at the Hospital of the University of Pennsylvania

My education and training

  • Medical School: New York University School of Medicine
  • Residency: University of Pennsylvania Health System
  • Fellowship: University of Pennsylvania Health System

Spoken languages

English
English
हिन्दी
Hindi

Reviews

Average Rating

112 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Anonymous
May 2026
dr. mainigi always takes her time answering all my questions and is very thoughtful
Anonymous
January 2026
excellent doctor who really cares
Anonymous
December 2025
she is very professional.
Anonymous
November 2025
she asks questions, she educates, she seems to care

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Lancaster General Hospital: Has privileges to treat patients in the hospital.
  • Princeton Medical Center: Has privileges to treat patients in the hospital.
Dr. Mainigi is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

Research

Publications

Lee IT, Koelper N, Mainigi M, Berger DS, Senapati S. Racial/ethnic variation in ovarian responsiveness and live birth after in vitro fertilization. , Fertil Steril., Online ahead of print: 2026

Merlino MS, Barksdale B, Negatu SG, Clements RL, Miller-Ensminger T, Lopez AH, Mani S, Mainigi M, Hunter CA, Jurado KA. Interleukin-27 is antiviral against Zika virus at the maternal-fetal interface. , Nature Communication, 17(1):652: 2025

Mani S, Kim S, Flock R, Huh D, Mainigi M Microfluidic organ-on-chip device: a unique platform for investigating implantation and placentation , Fertil Steril , 124(6): 2025,1162-1177

Pollie MP, Peipert B, Kim S, Mainigi MA. Isolated Inhibin-Producing Granulosa Cell Tumor Causing Primary Amenorrhea: A Case Report. , J Pediatr Adolesc Gynecol, 38(4): 2025,532-536

Thea N Golden, Sneha Mani, Rebecca L Linn, Rita Leite, Natalie A Trigg, Annette Wilson, Lauren Anton, Monica Mainigi, Colin C Conine, Brett A Kaufman, Jerome F Strauss, Samuel Parry, Rebecca A Simmons Extracellular vesicles alter trophoblast function in pregnancies complicated by COVID-19 , J Extracell Vesicles 2025: 2025

Simoni MK, Negatu SG, Park JY, Mani S, Arreguin MC, Amses KR, Huh DD, Mainigi M*, Jurado KA* Type I interferon exposure of an implantation-on-a-chip device alters invasive extravillous trophoblast function. , Cell Rep Med. , 6(3):101991: 2025

Leigh A Humphries, Jeremy Applebaum, Monica A Mainigi, Caitlin E Martin, Divya K Shah Predicting a successful match among applicants to reproductive endocrinology and infertility fellowship. , Fertility and Sterility , 123(2): 2025,333-341

Chen X, Tober J, Dominguez M, Tang AT, Bockman J, Yang J, Mani S, Lee CN, Chen M, Thillaikumaran T, Mericko-Ishizuka P, Mainigi M, Speck NA, Kahn ML. Lineage tracing studies suggest that the placenta is not a de novo source of hematopoietic stem cells. , PLoS Biol. , 23(1):e3003003: 2025

Leigh A Humphries, Jeremy Applebaum, Monica A Mainigi, Caitlin Martin, Divya K Shah Predicting a successful match among applicants to reproductive endocrinology and infertility fellowship , Fertil Steril , Epub: 2024

Sneha Mani, James Garifallou, Se-jeong Kim, Michael K. Simoni, Dan Dongeun Huh, Scott M. Gordon and Monica Mainigi Uterine macrophages and NK cells exhibit population and gene-level changes after implantation but maintain pro-invasive properties , Frontiers in Immunology, 15:1364036: 2024