Description of Research Expertise

My laboratory focuses on examining the effects of the maternal environment on early implantation and placentation. For example, we are examining the role of ART technologies such as superovulation and frozen embryo transfer on implantation and placentation, as a model for how the maternal hormonal milieu affects early placentation. We arealos interested in epigenetic changes, specifically DNA methylation, occuring following ART and how this affects placentation, fetal growth and long-term health of the offspring. In addition, we have developed novel methods to study early human embryo implantation, including a "implantation-on-a-chip" device which is being used to study cells and factors regulating early trophoblast invasion at the earliest point of pregnancy establishment.

Selected Publications

Kanter J, Gordon SM, Mani S, Sokalska A, Park JY, Senapati S, Huh DD, Mainigi M.: Hormonal stimulation reduces numbers and impairs function of human uterine natural killer cells during implantation. Hum Reproduction 38(6) : 1047-1059,2023.

Michael Simoni, Sneha Mani, Se-jeong Kim, Dan Huh, Scott Gordon, Monica Mainigi: Pregnancy changes the abundance, gene expression and function of uterine immune cell populations Society of Reproductive Investigation : 2023.

Bollig KJ, Mainigi M, Senapati S, Lin AE, Levitsky LL, Bamba V.: Turner syndrome: fertility counselling in childhood and through the reproductive lifespan. Curr Opin Endocrinol Diabetes Obes. 30(1):16-26 : 2023.

Huttler A, Koelper N, Mainigi M, Gracia C, Senapati S.: Impact of the COVID-19 pandemic on perception of planned oocyte cryopreservation in the United States. Fertility and Sterility Reports. 3(2):145-152. : 2022 .

Sneha Mani, Jayashri Ghosh, Eric A. Rhon-Calderon, Yemin Lan, Teri Ord, Charikleia Kalliora, Joe Chan, Bryant Schultz, Elaine Vaughan-Williams, Christos Coutifaris, Carmen Sapienza, Suneeta Senapati, Marisa S. Bartolomei, Monica Mainigi: Embryo Cryopreservation leads to sex-specific DNA methylation perturbations in both human and mouse placentas Human Molecular Genetics 31(22):3855-3872 : 2022.

Bollig KJ, Mainigi M, Senapati S, Lin AE, Levitsky LL, Bamba V.: Turner syndrome: fertility counseling in childhood and through the reproductive lifespan. Curr Opin Endocrinol Diabetes Obes Epub ahead of print : 2022.

Iris T. Lee, Dara S. Berger, Monica Ailawadi Mainigi: Effect of race on ovarian response to gonadotropin stimulation in in vitro fertilization ASRM Annual Meeting: Oral Presentation (Prize Paper Candidate) : 2022.

Kassie Jean Bollig, Suneeta Senapati, Nathan C. Koelper, Aimee Morrison, Monica Ailawadi Mainigi: Follicle stimulating hormone level as a predictor of spontaneous menarche: a retrospective cohort study of 133 patients with Turner Syndrome ASRM Annual Meeting: Oral Presentation : 2022.

Kassie Jean Bollig, Monica Ailawadi Mainigi, Nathan C. Koelper, Aimee Morrison, Suneeta Senapati: Follicle Stimulating Hormone Trends in patients with Turner Syndrome are associated with more than karyotype and spontaneous menarche status: race matters ASRM Annual Meeting: Oral Presentation : 2022.

Kassie Jean Bollig, Suneeta Senapati, Nathan C. Koelper, Aimee Morrison, Monica Ailawadi Mainigi: Time to postmenopausal follicle stimulating hormone levels and karyotype: a longitudinal study of patients with Turner Syndrome ASRM Annual Meeting: Oral Presentation : 2022.

Academic Contact Information

Clinical Practice:
PENN Fertility Care
Hospital of the University of Pennsylvania
3701 Market Street, 8th Floor

Lab:
421 Curie Blvd BRB II/III Room 1352
Philadelphia, PA 19104
Phone: 215-662-2972
Patient appointments: 800-789-7366