Description of Research Expertise
My laboratory focuses on examining the effects of ART on the oocyte, embryo and resulting offspring. Specifically we are examining the role of superovulation on implantation and placentation. My expertise is in examining ooocyte and embryo development following IVF and ART. We are interested in epigenetic changes, specifically DNA methylation, occuring following ART and how this affects placentation, fetal growth and long-term health of the offspring.
Selected Publications
Mani S, Ghosh J, Coutifaris C, Sapienza C, Mainigi M: Epigenetic changes and Assisted Reproductive Technologies. Epigenetics 15(1-2 : 12-25,2020.
Mani S, Ghosh J, Lan Y, Senapati S, Ord T, Sapienza C, Coutifaris C, Mainigi M: Epigenetic changes in preterm birth placenta suggest a role for ADAMTS genes in spontaneous preterm birth. Hum Mol Genet 28(1):84-95 : 2019.
Mainigi MA, Sneha Mani S, Cassidy Blundell C, Park JY, Young R, Huh D: Maternal Decidual Cells Regulate Trophoblast Invasion: Studies from a Novel Organ-on-a-Chip Device, Society for Reproductive Investigation : 2019.
Senapati S, Wang F, Ord T, Coutifaris C, Feng R, Mainigi M: Superovulation Alters the Expression of Endometrial Genes Critical to Tissue Remodeling and Placentation. J Assisted Reprod Genet 35(10):1799-1808 : 2018.
Mani S, Mainigi M.: Embryo Culture Conditions and the Epigenome. Semin Reprod Med
36(3-04) : 211-22,2018.
Sullivan-Pyke C, Mani S, Ord T, Krapp C, Bartolomei M, Mainigi M: Gonadotropin Stimulation has Differential Effects on Oocyte and Embryo Development: Evidence from a Mouse Model, American Society for Reproductive Medicine : 2018.
O'Neill K, Mainigi M, Ord T, Lan Y, Simmons R: Obesity and Impaired Oocyte Developmental Competence: Bridging Mouse and Human Studies, Society for Reproductive Investigation : 2018.
Mani SR, Ghosh J, Lan Y, Senapati S, Ord T, Sapienza C, Coutifaris C, Mainigi MA: A Role for Epigenetic Regulation of ADAMTS Genes in Abnormal Placentation and Preterm Birth, Society for the Study of Reproduction : 2018.
Mani S, Ghosh J, Lan Y, Senapati S, Ord T, Sapienza C, Coutifaris C, Mainigi M: A Role for Abnormal Early Implantation in Preterm Birth: Using ART as a Model, Society for Reproductive Investigation : 2018.
Segal T, Libby VR, Van Heertum K, Amini P, Mainigi M, Goldfarb J, Mesiano S, Weinerman R: Angiogenic Factors in Early and Mid-Gestation are Altered Following Superovulation with Human Chorionic Gonadotropin (hCG) Trigger and Gonadotropin Releasing Hormone Agonist GnRHa) Trigger in a Mouse ART Model, American Society of Reproductive Medicine : 2018.
Academic Contact Information
Clinical Practice:
PENN Fertility Care
Hospital of the University of Pennsylvania
3701 Market Street, 8th Floor
Lab:
421 Curie Blvd BRB II/III Room 1352
Philadelphia,
PA
19104
Phone: 215-662-2972
Patient appointments: 800-789-7366