Description of Research Expertise

My laboratory focuses on examining the effects of ART on the oocyte, embryo and resulting offspring. Specifically we are examining the role of superovulation on implantation and placentation. My expertise is in examining ooocyte and embryo development following IVF and ART. We are interested in epigenetic changes, specifically DNA methylation, occuring following ART and how this affects placentation, fetal growth and long-term health of the offspring.

Selected Publications

Gordon SM, Nishiguchi MA, Chase JM, Mani S, Mainigi MA, Behrens EM.: Interferons drive development of novel interleukin-15-responsive macrophages. J Immunol 205(4):1113-1124 : 2020.

Segal TR, Amini P, Wang J, Peters G, Skomorovska-Prokvolit Y, Mainigi MA, Goldfarb JM, Mesiano S, Weinerman R: Superovulation with human chorionic gonadotropin (hCG) trigger and gonadotropin releasing hormone agonist (GnRHa) trigger differentially alter levels of essential angiogenic factors in the endometrium in a mouse ART model. Biol Reprod 102(5) : 1122-113,2020.

Mani S, Ghosh J, Coutifaris C, Sapienza C, Mainigi M: Epigenetic changes and Assisted Reproductive Technologies. Epigenetics 15(1-2 : 12-25,2020.

Sullivan-Pyke C, Mani S, Rhon-Calderon EA, Ord T, Coutifaris C, Bartolomei MS, Mainigi M: Timing of exposure to gonadotropins has differential effects on the conceptus: evidence from a mouse model. Biol Reprod : 2020.

Mani S, Ghosh J, Lan Y, Senapati S, Ord T, Sapienza C, Coutifaris C, Mainigi M: Epigenetic changes in preterm birth placenta suggest a role for ADAMTS genes in spontaneous preterm birth. Hum Mol Genet 28(1):84-95 : 2019.

Mainigi MA, Sneha Mani S, Cassidy Blundell C, Park JY, Young R, Huh D: Maternal Decidual Cells Regulate Trophoblast Invasion: Studies from a Novel Organ-on-a-Chip Device, Society for Reproductive Investigation : 2019.

Senapati S, Wang F, Ord T, Coutifaris C, Feng R, Mainigi M: Superovulation Alters the Expression of Endometrial Genes Critical to Tissue Remodeling and Placentation. J Assisted Reprod Genet 35(10):1799-1808 : 2018.

Mani S, Mainigi M.: Embryo Culture Conditions and the Epigenome. Semin Reprod Med 36(3-04) : 211-22,2018.

Sullivan-Pyke C, Mani S, Ord T, Krapp C, Bartolomei M, Mainigi M: Gonadotropin Stimulation has Differential Effects on Oocyte and Embryo Development: Evidence from a Mouse Model, American Society for Reproductive Medicine : 2018.

Segal T, Libby VR, Van Heertum K, Amini P, Mainigi M, Goldfarb J, Mesiano S, Weinerman R: Angiogenic Factors in Early and Mid-Gestation are Altered Following Superovulation with Human Chorionic Gonadotropin (hCG) Trigger and Gonadotropin Releasing Hormone Agonist GnRHa) Trigger in a Mouse ART Model, American Society of Reproductive Medicine : 2018.

Academic Contact Information

Clinical Practice:
PENN Fertility Care
Hospital of the University of Pennsylvania
3701 Market Street, 8th Floor

Lab:
421 Curie Blvd BRB II/III Room 1352
Philadelphia, PA 19104
Phone: 215-662-2972
Patient appointments: 800-789-7366